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    INTEGRATED FLUID MANIPULATION CARTRIDGE
    21.
    发明专利
    INTEGRATED FLUID MANIPULATION CARTRIDGE 未知

    公开(公告)号：CA2312102A1

    公开(公告)日：1999-07-08

    申请号：CA2312102

    申请日：1998-12-24

    Applicant: CEPHEID

    Inventor： CHRISTEL LEE ALLAN ,  NORTHRUP M ALLEN ,  POURAHMADI FARZAD ,  PETERSEN KURT E ,  KOVACS GREGORY T A ,  CHING JESUS ,  MCMILLAN WIILIAM A ,  CHANG RONALD

    IPC: G01N31/20 ,  B01D11/00 ,  B01J19/00 ,  B01L3/00 ,  B01L7/00 ,  C12M1/00 ,  C12M1/26 ,  C12M1/33 ,  C12M1/34 ,  C40B60/14 ,  G01N1/28 ,  G01N30/60 ,  G01N33/50 ,  G01N35/08 ,  G01N37/00

    Abstract: A cartridge (101) for separating a desired analyte from a fluid sample includes a sample port (103) and a sample flow path extending from the port through the body of the cartridge. The sample flow path includes at least one flow-through component (122), e.g., filter paper or a microfabricated chip, for capturing the desired analyte from the sample as the sample flows through the cartridge. The cartridge also includes an elution flow path for carrying elution fluid through the component (122) to release captured analyte from the component into the elution fluid. The elution flow path diverges from the sample flow path after passing through the component (122). Flow controllers (41A and 41B) direct the remaining fluid sample into a waste chamber (139) after the sample flows through the component (122) and direct the elution fluid and eluted analyte into a reagent chamber (141) and reaction chamber (143). The continuous-flow design of the cartridge permits the rapid processing of a fluid sample that is larger in volume than any interactive region within the cartridge, allowing increased sensitivity in the detection of low copy concentrations of analytes, such as nucleic acid.

    Microstructures for the manipulation of fluid samples
    22.
    发明专利
    Microstructures for the manipulation of fluid samples 未知

    公开(公告)号：AU8906698A

    公开(公告)日：1999-03-08

    申请号：AU8906698

    申请日：1998-08-13

    Applicant: CEPHEID

    Inventor： CHRISTEL LEE ALLAN ,  KOVACS GREGORY T A ,  MCMILLAN WILLIAM A ,  NORTHRUP M ALLEN ,  PETERSEN KURT E ,  POURAHMADI FARZAD

    IPC: G01N31/20 ,  B01D15/08 ,  B01F5/04 ,  B01F5/06 ,  B01F13/00 ,  B01J19/00 ,  B01L3/00 ,  B01L7/00 ,  C07H1/00 ,  C07H21/00 ,  G01N1/34 ,  G01N27/447 ,  G01N33/53 ,  G01N37/00

    Abstract: The invention presents a microfluidic device and method for separating a desired material, such as nucleic acid, from other materials in a fluid sample. In a preferred embodiment, the device comprises a microfabricated chip (20) having an inlet port (28), an outlet port (30), and an extraction chamber (26) in fluid communication with the ports. The chamber (26) has internal attachment surfaces for capturing the desired material from the fluid sample as the sample flows continuously through the chamber. The captured material may then be eluted by forcing an elution fluid to flow through the chamber (26), thus releasing the material from the internal surfaces into the elution fluid. The flow-through design of the device allows target material from a relatively large volume of fluid sample to be concentrated into a much smaller volume of elution fluid. The internal surfaces are preferably formed by an array of columns (32) integrally formed with a wall of the chamber (26) and extending into the chamber (26). The collumns (32) provide a large surface area for capturing the desired material. The device also preferably includes an integrated heater (34) for increasing elution efficiency.

    MULTI-CHANNEL OPTICAL DETECTION SYSTEM
    26.
    发明专利
    MULTI-CHANNEL OPTICAL DETECTION SYSTEM 未知

    公开(公告)号：CA2331678C

    公开(公告)日：2009-09-15

    申请号：CA2331678

    申请日：1999-05-19

    Applicant: CEPHEID

    Inventor： DORITY DOUGLAS B ,  CHANG RONALD ,  NORTHRUP M ALLEN ,  CHRISTEL LEE A ,  YOUNG STEVEN J ,  PETERSEN KURT E ,  KOVACS GREGORY T A ,  KINTZ GREGORY J ,  HEBERT RAYMOND ,  MCMILLAN WILLIAM A

    IPC: G01N21/63 ,  G01N21/64 ,  G01N21/01 ,  G01N21/03

    Abstract: An apparatus for thermally controlling and optically interrogating a reaction mixture includes a vessel (2) having a chamber (10) for holding the mixture. The apparatus also includes a heat-exchanging module (37) having a pair of opposing thermal plates (34A, 34B) for receiving the vessel (2) between them and for heating and/or cooling the mixture contained in the vessel. The module (37) also includes optical excitation and detection assemblies (46, 48) positioned to optically interrogate the mixture. The excitation assembly (46) includes multiple light sources (100) and a set of filters for sequentially illuminating labeled analytes in the mixture with excitation beams in multiple excitation wavelength ranges. The detection assembly (48) includes multiple detectors (102) and a second set of filters for detecting light emitted from the chamber (10) in multiple emission wavelength ranges. The optics assemblies (46, 48) thus provide a multi-channel system for detcting a plurality of different target analytes in the mixture.

    Microstructures for the manipulation of fluid samples
    28.
    发明专利
    Microstructures for the manipulation of fluid samples 未知

    公开(公告)号：AU745989B2

    公开(公告)日：2002-04-11

    申请号：AU8906698

    申请日：1998-08-13

    Applicant: CEPHEID

    Inventor： CHRISTEL LEE ALLAN ,  KOVACS GREGORY T A ,  MCMILLAN WILLIAM A ,  NORTHRUP M ALLEN ,  PETERSEN KURT E ,  POURAHMADI FARZAD

    IPC: G01N31/20 ,  B01D15/08 ,  B01F5/04 ,  B01F5/06 ,  B01F13/00 ,  B01J19/00 ,  B01L3/00 ,  B01L7/00 ,  C07H1/00 ,  C07H21/00 ,  G01N1/34 ,  G01N27/447 ,  G01N33/53 ,  G01N37/00

    Abstract: The invention presents a microfluidic device and method for separating a desired material, such as nucleic acid, from other materials in a fluid sample. In a preferred embodiment, the device comprises a microfabricated chip (20) having an inlet port (28), an outlet port (30), and an extraction chamber (26) in fluid communication with the ports. The chamber (26) has internal attachment surfaces for capturing the desired material from the fluid sample as the sample flows continuously through the chamber. The captured material may then be eluted by forcing an elution fluid to flow through the chamber (26), thus releasing the material from the internal surfaces into the elution fluid. The flow-through design of the device allows target material from a relatively large volume of fluid sample to be concentrated into a much smaller volume of elution fluid. The internal surfaces are preferably formed by an array of columns (32) integrally formed with a wall of the chamber (26) and extending into the chamber (26). The collumns (32) provide a large surface area for capturing the desired material. The device also preferably includes an integrated heater (34) for increasing elution efficiency.

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