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    23.
    发明专利
    未知

    公开(公告)号：DE2505608A1

    公开(公告)日：1975-08-14

    申请号：DE2505608

    申请日：1975-02-11

    Applicant: COULTER ELECTRONICS

    Inventor： HOGG WALTER ROBERT

    IPC: G01N27/00 ,  H03K3/013 ,  H03K21/02 ,  G01N15/00 ,  G06M11/02

    Abstract: A method and apparatus for automatically generating error corrected pulses in response to particle pulses which are subject to error due to coincidence. The subject apparatus includes a generator for generating error corrected pulses which has a variable pulse repetition rate controlled via an applied variable control signal. A pulse duration modifying circuit receives the particle pulses and develops first pulses each having a duration equal to a predetermined function of the duration of a particle pulse. A control circuit receives the error corrected pulses and develops a second signal in response thereto. The development of the second signal via the control circuit is inhibited in response to the presence of first pulses coupled thereto from the pulse duration modifying circuit. A comparison circuit develops the control signal which varies in accordance with the difference between the repetition rate of the particle pulses and the third signal.

    24.
    发明专利
    未知

    公开(公告)号：DE2504755A1

    公开(公告)日：1975-08-07

    申请号：DE2504755

    申请日：1975-02-05

    Applicant: COULTER ELECTRONICS

    Inventor： COULTER WALLACE HENRY ,  HOGG WALTER ROBERT

    IPC: G01N15/12 ,  G06M11/00 ,  G01N15/06

    Abstract: An apparatus for studying particles of widely different sizes includes a vessel and a fluid medium in the vessel with the particles suspended thereon. First and second aperture tubes are suspended in the vessel at a first height, and a third aperture tube is suspended at a second lower height. The first aperture tube has an aperture of substantially smaller size than the second and third aperture tubes. The rate of entry through the aperture and into the second tube, of particles large enough to cause blockage of the first aperture in the first tube, is detected. When this rate drops below a first particular rate, indicating that substantially all particles greater than that size have settled below this particular height in the beaker, control circuitry is actuated to enable the fluid to enter into the first tube via the aperture therein for analyzing particles received therein via Coulter type detectors.

    25.
    发明专利
    未知

    公开(公告)号：DE2445411A1

    公开(公告)日：1975-05-07

    申请号：DE2445411

    申请日：1974-09-23

    Applicant: COULTER ELECTRONICS

    Inventor： HOGG WALTER ROBERT ,  COULTER WALLACE HENRY ,  GINSBERG GUENTER ,  PRONI OSCAR ,  GODIN THOMAS J

    IPC: G01N1/38 ,  G01N15/12 ,  G01N15/00

    Abstract: 1479901 Electro-physical measurement; particle analysis COULTER ELECTRONICS Ltd 23 Sept 1974 [26 Sept 1973] 41368/74 Heading G1N(C) In a Coulter type particle analyzer, a "twochamber" tube is provided whereby clean electrolyte can be flowed past the aperture to waste, in a manner similar to that disclosed in Specification 1341336 and a constriction in the flow-path is arranged to increase the velocity behind the aperture. OVERALL SYSTEM FIG. 1. A double tube 13 is sealed into a coupling block 19 attached by screws 59 to the head-block 58, for easy interchange. The electrolyte system is electrically isolated from waste 42 and supply reservoir 52 by drip feed tanks 24, 29. The sample and electrolyte are moved through the apparatus by vacuum applied to the waste drip tank 24. The clean electrolyte flow is regulated by a constriction 27. Several variations of double tube construction are disclosed with reference to Figs. 2 ... 13 which are substantially self explanatory. Figs. 2, 5, 6, 7 only are shown as typical.

    28.
    发明专利
    未知

    公开(公告)号：DE1524570B1

    公开(公告)日：1972-01-20

    申请号：DE1524570

    申请日：1966-10-20

    Applicant: COULTER ELECTRONICS

    Inventor： COULTER WALLACE HENRY ,  HOGG WALTER ROBERT

    IPC: G01N15/12 ,  G01N33/487 ,  G01N33/49 ,  G01N33/16

    Abstract: 1,162,941. Measuring hematocrit index of blood electrically. COULTER ELECTRONICS Ltd. Oct. 13, 1966 [Oct. 20, 1965], No.45896/66. Heading G1N. Apparatus for automatically measuring the ratio of the total volume of red cells of a given sample of whole blood to the total volume of that sample comprises a Coulter type of cell counting and sizing apparatus 10, having a first output channel 38 which delivers cell counting information to an integrator 23 and a second output channel 34 which delivers cell counting and cell sizing information to a mean cell volume computer 22, and an analog computer 75 for multiplying the cell count by the mean cell volume thereby to determine the hematocrit index. As shown in Fig. 1, a metering device 20, such as described in Specification 865, 069, delivers a known volume of a sample comprising blood diluted with an electrolyte to a Coulter scanner 12, such as described in Specification 907, 028. The output of integrator 23 is corrected in accordance with known statistics for coincidence (two cells being detected together) before being applied across terminals 71, 72 of a potentiometer 58. The wiper of the potentiometer is driven by a motor 49 forming part of a servoamplifier and its position is dependent on the mean cell volume whereby the voltage of the wiper tap 60 is proportional to the hematocrit index. This voltage is passed to a second servo-amplifier wherein the angular position of a scale 83 relative to an index mark 84 indicates the hematocrit index. A common reference voltage 63 is used for both servo-amplifiers. The integrator 23 may be arranged to de-energize the detecting means when the integrator has become saturated.

    Apparatus for Particle Classification and Analysis
    29.
    发明专利
    Apparatus for Particle Classification and Analysis 未知

    公开(公告)号：GB1185898A

    公开(公告)日：1970-03-25

    申请号：GB4413867

    申请日：1967-09-28

    Applicant: COULTER ELECTRONICS

    Inventor： COULTER WALLACE HENRY ,  HOGG WALTER ROBERT

    IPC: G01N15/12 ,  G01R27/02 ,  H03K5/26

    Abstract: 1,185,898. Particle counting apparatus. COULTER ELECTRONICS Ltd. (W.H. Coulter). Sept.28, 1967, No.44138/67. Heading G1N. In a "Coulter counter" it has been found that the impedance of different kinds of particle varies with the supply frequency, especially at R.F. The Specification describes at length how this may be used to derive "signatures" for different kinds of particles using pulse counting and phase/ frequency measuring techniques. In a simple case the "gap" may be energized with a single R.F. and measurements made of either the resistive and reactive components using a phase sensitive detector, or the frequency modulation and amplitude modulation components of the signal. Pulses, (due to the passage of a particle), for each component of the signal having an amplitude within predetermined limits may be counted. In a more sophisticated arrangement three frequencies are applied simultaneously e.g. a D.C. or low frequency and two different R. F. S. The signal is analyzed into the amplitude of the D. C. and the quadrature components of each R. F. to provide a detailed signature. Compensation for source impedance may be provided by tuning the sensing zone to anti-resonance at the supply frequency.

    30.
    发明专利
    未知

    公开(公告)号：DE2748564A1

    公开(公告)日：1978-09-14

    申请号：DE2748564

    申请日：1977-10-28

    Applicant: COULTER ELECTRONICS

    Inventor： HOGG WALTER ROBERT

    IPC: G01N15/10 ,  G01N1/28 ,  G01N15/14 ,  G01N15/00

    Abstract: A method and apparatus for obtaining information on and identifying particles in a liquid suspension wherein the particles in suspension are moved in a stream through a plurality of sensing zones such that each particle passes through the sensing zones serially. As each particle passes through a sensing zone a particular characteristic of the particle will be measured and its time relationship with the preceding and succeeding particle passing through that zone will also be preserved to form a pattern of time relationships. The pattern of time relationships and the particle characteristics at a particular sensing zone will be correlated with the pattern of time relationships and particle characteristics at either a preceding or succeeding sensing zone in order to correlate all of the characteristics for the particle. The stream may also be passed to a substrate and the particles laid out on the substrate in a particular spatial pattern. The spatial pattern is also correlated with the time relationships and particle characteristics at the last sensing zone preceding the substrate in order to correlate the particle on the substrate with all of its measured characteristics.

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