公开(公告)号：AU2015289999A1

公开(公告)日：2017-03-09

申请号：AU2015289999

申请日：2015-07-10

Applicant: HARVARD COLLEGE

Inventor： HINOJOSA CHRISTOPHER DAVID ,  SLIZ JOSIAH ,  THOMPSON GUY ,  GEISLER HUBERT ,  FERNANDEZ-ALCON JOSE ,  INGBER DONALD E ,  LEVNER DANIEL

IPC: B82Y15/00 ,  C12M1/00 ,  C12Q1/02

Abstract: Systems and methods for improved flow properties in fluidic and microfluidic systems are disclosed. The system includes a microfluidic device having a first microchannel, a fluid reservoir having a working fluid and a pressurized gas, a pump in communication with the fluid reservoir to maintain a desired pressure of the pressurized gas, and a fluid-resistance element located within a fluid path between the fluid reservoir and the first microchannel. The fluid-resistance element includes a first fluidic resistance that is substantially larger than a second fluidic resistance associated with the first microchannel.

公开(公告)号：AU2011296133B2

公开(公告)日：2015-12-17

申请号：AU2011296133

申请日：2011-08-30

Applicant: HARVARD COLLEGE

Inventor： INGBER DONALD E ,  FERNANDEZ JAVIER GOMEZ

IPC: A61F2/02 ,  A61F13/00 ,  A61L27/20 ,  A61L27/22 ,  A61L27/34 ,  A61L27/54 ,  A61L27/56

Abstract: The present invention is directed to a composite laminar material with high mechanical strength and methods of fabricating the material. The invention also provides a method of attaching a medical implant device to tissue.

公开(公告)号：AU2011337139A1

公开(公告)日：2013-02-28

申请号：AU2011337139

申请日：2011-08-30

Applicant: HARVARD COLLEGE

Inventor： INGBER DONALD E ,  KORIN NETANEL ,  KANAPATHIPILLAI MATHUMAI

IPC: A61K47/48

Abstract: The invention provides compositions and methods for treating or imaging stenosis, stenotic lesions, occluded lumens, embolic phenomena or thrombotic disorders. The invention further provides compositions and methods for treating internal hemorrhage.

公开(公告)号：CA3149018A1

公开(公告)日：2013-01-24

申请号：CA3149018

申请日：2012-07-18

Applicant: HARVARD COLLEGE

Inventor： BERTHET JULIA B ,  CARTWRIGHT MARK J ,  INGBER DONALD E ,  ROTTMAN MARTIN M ,  SUPER DINAH R ,  SUPER MICHAEL ,  WATTERS ALEXANDER ,  WAY JEFFREY CHARLES

Abstract: Described herein are engineered microbe-targeting or microbe-binding molecules, kits comprising the same and uses thereof. Some particular embodiments of the microbe-targeting or microbe-binding molecules comprise a carbohydrate recognition domain of mannose-binding lectin, or a fragment thereof, linked to a portion of a Fc region. In some embodiments, the microbe-targeting molecules or microbe-binding molecules can be conjugated to a substrate, e.g., a magnetic microbead, forming a microbe-targeting substrate (e.g., a microbe-targeting magnetic microbead). Such microbe-targeting molecules and/or substrates and the kits comprising the same can bind and/or capture of a microbe and/or microbial matter thereof, and can thus be used in various applications, e.g., diagnosis and/or treatment of an infection caused by microbes such as sepsis in a subject or any environmental surface. Microbe-targeting molecules and/or substrates can be regenerated after use by washing with a low pH buffer or buffer in which calcium is insoluble.

公开(公告)号：AU2011207626A2

公开(公告)日：2012-10-04

申请号：AU2011207626

申请日：2011-01-19

Applicant: HARVARD COLLEGE

Inventor： SUPER MICHAEL ,  WAY JEFFREY CHARLES ,  INGBER DONALD E

IPC: C07K19/00

Abstract: The present invention provides for engineered molecular opsonins that may be used to bind biological pathogens or identify subclasses or specific pathogen species for use in devices and systems for treatment and diagnosis of patients with infectious diseases, blood-borne infections or sepsis. An aspect of the invention provides for mannose-binding lectin (MBL), which is an abundant natural serum protein that is part of the innate immune system. The ability of this protein lectin to bind to surface molecules on virtually all classes of biopathogens (viruses, bacteria, fungi, protozoans) make engineered forms of MBL extremely useful in diagnosing and treating infectious diseases and sepsis.

公开(公告)号：CA2787376A1

公开(公告)日：2011-07-28

申请号：CA2787376

申请日：2011-01-19

Applicant: HARVARD COLLEGE

Inventor： SUPER MICHAEL ,  WAY JEFFREY CHARLES ,  INGBER DONALD E

IPC: C07K19/00

Abstract: The present invention provides for engineered molecular opsonins that may be used to bind biological pathogens or identify subclasses or specific pathogen species for use in devices and systems for treatment and diagnosis of patients with infectious diseases, blood-borne infections or sepsis. An aspect of the invention provides for mannose-binding lectin (MBL), which is an abundant natural serum protein that is part of the innate immune system. The ability of this protein lectin to bind to surface molecules on virtually all classes of biopathogens (viruses, bacteria, fungi, protozoans) make engineered forms of MBL extremely useful in diagnosing and treating infectious diseases and sepsis.

公开(公告)号：AU9278701A

公开(公告)日：2002-03-26

申请号：AU9278701

申请日：2001-09-18

Applicant: HARVARD COLLEGE

Inventor： TAKAYAMA SHUICHI ,  OSTUNI EMANUELE ,  LEDUC PHILIP ,  NARUSE KEIJI ,  INGBER DONALD E ,  WHITESIDES GEORGE M

IPC: G01N37/00 ,  A61K35/12 ,  B81B1/00 ,  C12N5/00 ,  C12N5/071 ,  G01N33/50 ,  G01N33/52

Abstract: The present invention is directed, in certain embodiments, to improved, small scale systems and methods able to selectively treat parts of a single cell, including, in certain embodiments, portions of a main body portion of a single cell, and able, in certain embodiments, to establish long-term gradients of active substances within subcellular regions of a single cell. The present invention provides, in some embodiments, techniques for selectively contacting a portion of the surface of a biological cell with a fluid or fluid component carrying a particular potential for a biophysical or biochemical interaction with the cell, and simultaneously contacting a different portion of the surface of the cell with another fluid or fluid component having a different potential for the biophysical or biochemical interaction with the cell.

公开(公告)号：CA2422762A1

公开(公告)日：2002-03-21

申请号：CA2422762

申请日：2001-09-18

Applicant: HARVARD COLLEGE ,  CHILDRENS MEDICAL CENTER

Inventor： OSTUNI EMANUELE ,  NARUSE KEIJI ,  INGBER DONALD E ,  LEDUC PHILIP ,  WHITESIDES GEORGE M ,  TAKAYAMA SHUICHI

IPC: G01N37/00 ,  A61K35/12 ,  B81B1/00 ,  C12N5/00 ,  C12N5/071 ,  G01N33/50 ,  G01N33/52 ,  C12Q1/02 ,  C12N1/38

Abstract: The present invention is directed, in certain embodiments, to improved, smal l scale systems and methods able to selectively treat parts of a single cell, including, in certain embodiments, portions of a main body portion of a sing le cell, and able, in certain embodiments, to establish long-term gradients of active substances within subcellular regions of a single cell. The present invention provides, in some embodiments, techniques for selectively contacti ng a portion of the surface of a biological cell with a fluid or fluid componen t carrying a particular potential for a physiological or biochemical interacti on with the cell, and simultaneously contacting a different portion of the surface of the cell with another fluid or fluid component having a different portion of the surface of the cell with another fluid or fluid component having a different potential for the biophysical or biochemical interaction with the cell.

公开(公告)号：AU2021265723A1

公开(公告)日：2022-12-01

申请号：AU2021265723

申请日：2021-03-19

Applicant: HARVARD COLLEGE

Inventor： NOVAK RICHARD ,  INGBER DONALD E ,  MARTÍNEZ FLORES MANUEL RAMSÉS

IPC: G01N1/02

Abstract: The technology described herein is directed to a swab for sample collection. In one aspect, the swab comprises a sample collection head, which comprises a plurality of spaced annular rings. In one embodiment, the swab further comprises a tapered neck and a handle. In one embodiment, the swab is injection-molded using polypropylene. In other aspects, described herein are swabs comprising a water-soluble or biodegradable material. In additional aspects, described herein are kits comprising said swabs and methods of using said swabs.

公开(公告)号：AU2019247650A1

公开(公告)日：2020-10-29

申请号：AU2019247650

申请日：2019-04-02

Applicant: HARVARD COLLEGE

Inventor： NOVAK RICHARD ,  JALILI-FIROOZINEZHAD SASAN ,  GAZZANIGA FRANCESCA S ,  CALAMARI ELIZABETH L ,  CAMACHO DIOGO M ,  NESTOR BRET A ,  FADEL CICELY ,  CRONCE MICHAEL L ,  KASPER DENNIS L ,  INGBER DONALD E ,  BEIN AMIR

IPC: C12M1/12 ,  C12M3/06 ,  G01N33/48 ,  G01N33/50

Abstract: A microfluidic device is directed to sustaining a complex microbial community in direct and indirect contact with living human intestinal cells in vitro. The device includes a first microchannel having cultured cells of a human intestinal epithelium and microbiota, the first microchannel further having a first level of oxygen. The device further includes a second microchannel having cultured cells of a vascular endothelium, the second microchannel further having a second level of oxygen. The device also includes a membrane located at an interface region between the first microchannel and the second microchannel, the membrane being composed of an oxygen-permeable material or further having pores via which oxygen flows between the first microchannel and the second microchannel to form a physiologically-relevant oxygen gradient.