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    Surfaces that resist the adsorption of biological species
    21.
    发明专利
    Surfaces that resist the adsorption of biological species 未知

    公开(公告)号：AU7595701A

    公开(公告)日：2002-01-30

    申请号：AU7595701

    申请日：2001-07-17

    Applicant: HARVARD COLLEGE

    Inventor： CHAPMAN ROBERT G ,  OSTUNI EMANUELE ,  LIANG MICHAEL N ,  YAN LIN ,  WHITESIDES GEORGE M

    IPC: A61F2/28 ,  A61L15/42 ,  A61L27/34 ,  A61L27/50 ,  A61L31/10 ,  B32B27/06 ,  C08J7/12 ,  C09D5/14

    Abstract: The present invention provides articles resistant to the adsorption of proteins, cells and bacteria. The articles can either have a chemical chain bonded thereon where the chemical chain can comprise a terminal group free of a hydrogen bond donor or where a hydrogen bond donor is sufficiently buried such that an exposed surface of the article including the chemical chain is free of a hydrogen bond donor. The chemical chain, or plurality of chemical chains, can comprise a monolayer such as a self-assembled monolayer (SAM) which can be homogeneous (one type of SAM) or mixed, i.e. or more different types of SAMs. Other more specific examples of chemical chains are provided. The plurality of chemical chains can comprise a polymer such as a polyamine. In many aspects, the plurality of chemical chains is sufficiently free of cross-linking or branching. The present invention also provides an article capable of specific binding of a desired biomolecule while preventing non-specific binding of biomolecules.

    CELL PATTERNING TECHNIQUE
    22.
    发明专利
    CELL PATTERNING TECHNIQUE 未知

    公开(公告)号：CA2402737A1

    公开(公告)日：2001-09-27

    申请号：CA2402737

    申请日：2001-03-15

    Applicant: HARVARD COLLEGE

    Inventor： JACKMAN REBECCA J ,  WHITESIDES GEORGE M ,  DUFFY DAVID C ,  OSTUNI EMANUELE ,  KANE RAVI

    IPC: G01N33/48 ,  B01J19/00 ,  C12N1/00 ,  C12N11/06 ,  C40B60/14 ,  G01N33/543

    Abstract: The present invention provides a masking system for selectively applying cel ls to predetermined regions of a surface. A mask is positioned adjacent to a surface to cover some portions of the surface while allowing other portions of the surface to remain uncovered. Cells then are applied to uncovered portion s of the surface and the mask removed. Alternatively, a cell-adhesion promoter is applied to uncovered portions of the surface, and then cells are applied to the surface before or after removal of the mask from the surface. The maskin g system can be pre-coated, at least on those surfaces which will come into contact with cells, with a cell-adhesion inhibitor to resist absorption of cells and thereby avoid cell damage when the mask is removed (if cells are deposited prior to removal of the mask). A polymeric elastomeric mask that comes into cohesive-conformal contact with a surface to be patterned can be used.

    Microcontact printing of catalytic colloids
    25.
    发明专利
    Microcontact printing of catalytic colloids 未知

    公开(公告)号：AU2532497A

    公开(公告)日：1997-10-01

    申请号：AU2532497

    申请日：1997-03-14

    Applicant: HARVARD COLLEGE

    Inventor： HIDBER PIRMIN ,  HELBIG WOLFGANG ,  WHITESIDES GEORGE M ,  KIM ENOCH

    IPC: C23C18/16 ,  G03F7/00 ,  H05K3/18

    Abstract: A method of transferring a chemical activating agent from an applicator to a substrate surface involves providing an applicator having a raised application surface, applying a chemical activating agent to the application surface, contacting the substrate surface with the application surface, and removing the applicator. The chemical activating agent is transferred in a form in which it is capable of effecting a chemical reaction, such as catalysis, at the surface. Thus, following transfer of the chemical activating agent to the surface in a pattern, a metal can be plated at the substrate surface in the pattern. The applicator can be an elastomeric stamp having a raised portion defining a stamping surface.

    METHOD OF FORMING ARTICLES AND PATTERNING SURFACES VIA CAPILLARY MICROMOLDING
    26.
    发明专利
    METHOD OF FORMING ARTICLES AND PATTERNING SURFACES VIA CAPILLARY MICROMOLDING 未知

    公开(公告)号：CA2248576A1

    公开(公告)日：1997-09-18

    申请号：CA2248576

    申请日：1997-03-14

    Applicant: HARVARD COLLEGE

    Inventor： MRKSICH MILAN ,  XIA YOUNAN ,  KIM ENOCH ,  WHITESIDES GEORGE M ,  JACKMAN REBECCA JANE

    IPC: A61K9/51 ,  A61K47/48 ,  B01J19/00 ,  B29C31/04 ,  B29C33/42 ,  B29C37/00 ,  B29C39/24 ,  B29C67/24 ,  B81C1/00 ,  C40B60/14 ,  H05K3/00 ,  H05K3/06 ,  G01N33/543

    Abstract: Techniques for patterning chemically or biochemically active agents on a substrate surface involve providing a micromold having a contoured surface including indentations defining a pattern and forming, on a substrate surface, a chemically or biochemically active agent or fluid precursor of a structure on the surface. A chemically or biochemically active agent or fluid precursor also can be transferred from indentations in an applicator to a substrate surface. The substrate surface can be planar or non-planar. Fluid precursors of polymeric structures, inorganic ceramics and salts, and the like can be employed to form patterned polymeric articles, inorganic salts and ceramics, etc. at the surface. The articles, according to one aspect, are formed in a pattern including a portion having a lateral dimension of less than about 1 millimeter. Smaller dimensions can be achieved. The indentation pattern of the applicator can be used to transfer separate, distinct chemically or biochemically active agents or fluid precursors to separate, isolated regions of a substrate surface. The invention provides for inexpensive and simple synthesis of a combinatorial chemical or biochemical library.

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