公开(公告)号：HRP940834B1

公开(公告)日：2000-08-31

申请号：HRP940834

申请日：1994-10-26

Applicant: HOECHST AG

Inventor： MUELLER GUENTER ,  TRIPIER DOMINIQUE ,  MUELLNER STEFAN

IPC: A61K38/28 ,  A61K31/715 ,  A61K38/00 ,  A61P3/08 ,  A61P3/10 ,  C07K1/22 ,  C07K5/08 ,  C07K5/093 ,  C07K5/10 ,  C07K9/00 ,  C07K14/37 ,  C07K14/41 ,  C07K14/475 ,  C07K14/575 ,  C07K14/62 ,  C07K14/65 ,  C12P19/26 ,  C12P21/00 ,  C12P21/02 ,  C12R1/865

Abstract: Phosphoinositolglycan peptides, obtainable by cleavage of adenosine-3%,5%-cyclic monophosphate binding protein, which contain glucosamine, galactose, mannose, inositol, phosphoric acid, ethanolamine and a peptide containing the sequence Asn-Cys-Tyr, their preparation and use for the treatment of diabetes mellitus and non-insulin-dependent diabetes are described.

公开(公告)号：PL332458A1

公开(公告)日：1999-09-13

申请号：PL33245897

申请日：1997-09-15

Applicant: HOECHST AG

Inventor： ERTL JOHANN ,  PREIBISCH GERALD ,  MUELLER GUENTER

IPC: C12N15/09 ,  A61K38/00 ,  A61K38/17 ,  A61K38/22 ,  A61K45/00 ,  A61P3/10 ,  A61P5/50 ,  C07K14/575 ,  C07K16/26 ,  C07K19/00 ,  C12P21/02

Abstract: The invention relates to pharmaceutical agents containing leptin antagonists for treating Type II diabetes. One leptin antagonist is based on a murine leptin fragment and comprises amino acids 116 to 167 or 116 to 166. Methods of treating Type II diabetes are also disclosed.

公开(公告)号：BR9711513A

公开(公告)日：1999-08-24

申请号：BR9711513

申请日：1997-09-15

Applicant: HOECHST AG

Inventor： MUELLER GUENTER ,  PREIBISCH GERALD ,  ERTL JOHANN

IPC: C12N15/09 ,  A61K38/00 ,  A61K38/17 ,  A61K38/22 ,  A61K45/00 ,  A61P3/10 ,  A61P5/50 ,  C07K14/575 ,  C07K16/26 ,  C07K19/00 ,  C12P21/02

Abstract: The invention relates to pharmaceutical agents containing leptin antagonists for treating Type II diabetes. One leptin antagonist is based on a murine leptin fragment and comprises amino acids 116 to 167 or 116 to 166. Methods of treating Type II diabetes are also disclosed.

公开(公告)号：NO991186D0

公开(公告)日：1999-03-11

申请号：NO991186

申请日：1999-03-11

Applicant: HOECHST AG

Inventor： ERTL JOHANN ,  PREIBISCH GERALD ,  MUELLER GUENTER

IPC: C12N15/09 ,  A61K38/00 ,  A61K38/17 ,  A61K38/22 ,  A61K45/00 ,  A61P3/10 ,  A61P5/50 ,  C07K14/575 ,  C07K16/26 ,  C07K19/00 ,  C12P21/02 ,  A61K

Abstract: The invention relates to pharmaceutical agents containing leptin antagonists for treating Type II diabetes. One leptin antagonist is based on a murine leptin fragment and comprises amino acids 116 to 167 or 116 to 166. Methods of treating Type II diabetes are also disclosed.

公开(公告)号：NO991186A

公开(公告)日：1999-03-11

申请号：NO991186

申请日：1999-03-11

Applicant: HOECHST AG

Inventor： ERTL JOHANN ,  PREIBISCH GERALD ,  MUELLER GUENTER

IPC: C12N15/09 ,  A61K38/00 ,  A61K38/17 ,  A61K38/22 ,  A61K45/00 ,  A61P3/10 ,  A61P5/50 ,  C07K14/575 ,  C07K16/26 ,  C07K19/00 ,  C12P21/02

CPC classification number: C07K14/5759 ,  A61K38/00

公开(公告)号：CA2266585A1

公开(公告)日：1998-03-26

申请号：CA2266585

申请日：1997-09-15

Applicant: HOECHST AG

Inventor： MUELLER GUENTER ,  PREIBISCH GERALD ,  ERTL JOHANN

IPC: C12N15/09 ,  A61K38/00 ,  A61K38/17 ,  A61K38/22 ,  A61K45/00 ,  A61P3/10 ,  A61P5/50 ,  C07K14/575 ,  C07K16/26 ,  C07K19/00 ,  C12P21/02

Abstract: The invention relates to pharmaceutical agents containing leptin antagonists for treating Type II diabetes. One leptin antagonist is based on a murine leptin fragment and comprises amino acids 116 to 167 or 116 to 166. Methods of treating Type II diabetes are also disclosed.

公开(公告)号：HRP940839A2

公开(公告)日：1997-06-30

申请号：HRP940839

申请日：1994-10-26

Applicant: HOECHST AG ,  RUHRCHEMIE AG

Inventor： MUELLNER STEFAN ,  KOENIG WOLFGANG ,  MUELLER GUENTER

IPC: A61K38/00 ,  A61K38/06 ,  A61K38/28 ,  A61P3/08 ,  A61P3/10 ,  A61P43/00 ,  C07K1/113 ,  C07K5/08 ,  C07K5/087 ,  C07K5/10 ,  C07K7/00 ,  C07K7/06 ,  C07K14/62

Abstract: Short peptides of the formula I X-Y-A-B-C-Cys-D-E (I> in which A and B are an amino acid or a covalent bond, C and D are an amino acid or a substituted amino acid, E is a modified or unmodified amino acid or a covalent bond, X is a radical or hydrogen and Y is leucine or a covalent bond, or dimers of the peptides of the formula I with cystine as dimerisation component, the stereoisomeric forms thereof where appropriate or their physiologically tolerated salts, the preparation thereof, and their use for the treatment of diabetes mellitus are described.

公开(公告)号：SK255392A3

公开(公告)日：1995-02-08

申请号：SK255392

申请日：1992-08-19

Applicant: HOECHST AG

Inventor： MUELLER GUENTER ,  TRIPIER DOMINIQUE ,  MUELLNER STEFAN

IPC: A61K38/28 ,  A61K31/715 ,  A61K38/00 ,  A61P3/08 ,  A61P3/10 ,  C07K1/22 ,  C07K5/08 ,  C07K5/093 ,  C07K5/10 ,  C07K9/00 ,  C07K14/37 ,  C07K14/41 ,  C07K14/475 ,  C07K14/575 ,  C07K14/62 ,  C07K14/65 ,  C12P19/26 ,  C12P21/00 ,  C12P21/02 ,  C12R1/865

Abstract: The present invention discloses phosphoinositolglycan peptides containing phosphoinositolglycan and/or a physiologically acceptable salts thereof, obtainable by cleavage of adenosine-3',5'-cyclic monophosphate binding protein, which contain glucosamine, galactose, mannose, inositol, phosphoric acid, ethanolamine and a peptide containing the sequence Asn-Cys-Tyr, their preparation and use for the treatment of diabetes mellitus and non-insulin-dependent diabetes are described.

公开(公告)号：ZA926232B

公开(公告)日：1993-04-28

申请号：ZA926232

申请日：1992-08-19

Applicant: HOECHST AG

Inventor： MUELLER GUENTER ,  GUENTER MUELLER ,  TRIPIER DOMINIQUE ,  DOMINIQUE TRIPIER ,  MUELLNER STEFAN ,  STEFAN MUELLNER

IPC: A61K38/28 ,  A61K31/715 ,  A61K38/00 ,  A61P3/08 ,  A61P3/10 ,  C07K1/22 ,  C07K5/08 ,  C07K5/093 ,  C07K5/10 ,  C07K9/00 ,  C07K14/37 ,  C07K14/41 ,  C07K14/475 ,  C07K14/575 ,  C07K14/62 ,  C07K14/65 ,  C12P19/26 ,  C12P21/00 ,  C12P21/02 ,  C12R1/865 ,  C07K

Abstract: Phosphoinositolglycan peptides, obtainable by cleavage of adenosine-3%,5%-cyclic monophosphate binding protein, which contain glucosamine, galactose, mannose, inositol, phosphoric acid, ethanolamine and a peptide containing the sequence Asn-Cys-Tyr, their preparation and use for the treatment of diabetes mellitus and non-insulin-dependent diabetes are described.

公开(公告)号：NO923252A

公开(公告)日：1993-02-22

申请号：NO923252

申请日：1992-08-19

Applicant: HOECHST AG

Inventor： MUELLER GUENTER ,  TRIPIER DOMINIQUE ,  MUELLNER STEFAN

IPC: A61K38/28 ,  A61K31/715 ,  A61K38/00 ,  A61P3/08 ,  A61P3/10 ,  C07K1/22 ,  C07K5/08 ,  C07K5/093 ,  C07K5/10 ,  C07K9/00 ,  C07K14/37 ,  C07K14/41 ,  C07K14/475 ,  C07K14/575 ,  C07K14/62 ,  C07K14/65 ,  C12P19/26 ,  C12P21/00 ,  C12P21/02 ,  C12R1/865 ,  C07K15/24 ,  A61K37/16 ,  C07K7/40 ,  C07K15/14

CPC classification number: C07K14/475 ,  A61K38/00 ,  C07K5/0827 ,  C07K5/1027 ,  C07K9/001 ,  C12P19/26