公开(公告)号：CA1340515C

公开(公告)日：1999-04-27

申请号：CA601591

申请日：1989-06-02

Applicant: HOECHST AG

Inventor： DOMINIQUE TRIPIER ,  SAUBER KLAUS ,  BARTSCH KLAUS ,  SCHULZ ARNO

IPC: C12N9/10 ,  C12N11/02 ,  C12N11/08 ,  C12P13/00 ,  C12P13/04 ,  C12R1/19

Abstract: The invention relates to a novel transaminase, the preparation thereof and the use thereof. It has been found that it is possible to isolate from E. coli DH-l a transaminase with the aid of which it is possible with great efficiency to prepare L-phosphinothricin and .gamma.-aminobutyric acid from the appropriate precursors by transferring the amino group from glutamate. The novel transaminase has a molecular weight of 25,000 to 100,000 Dalton, an isoelectric point at a pH between 3.5 and 5.5 and a substrate specificity towards L-phosphinothricin, .gamma.-aminobutyric acid and glutamate as amino-group donor as well as the appropriate keto compounds as amino acceptor.

公开(公告)号：ZA8908553B

公开(公告)日：1990-08-29

申请号：ZA8908553

申请日：1989-11-09

Applicant: HOECHST AG

Inventor： HUCHO FERDINAND ,  FERDINAND HUCHO ,  PRIBILLA IRIS ,  IRIS PRIBILLA ,  SCHIEBLER WERNER ,  WERNER SCHIEBLER ,  TRIPIER DOMINIQUE ,  DOMINIQUE TRIPIER ,  KOGLER HERBERT ,  HERBERT KOGLER

IPC: A61K31/195 ,  A61K31/19 ,  A61P9/00 ,  A61P25/00 ,  A61P29/00 ,  A61P31/12 ,  A61P35/00 ,  A61P43/00 ,  C07C229/16 ,  C07K ,  A61K

CPC classification number: A61K31/19

公开(公告)号：ZA926232B

公开(公告)日：1993-04-28

申请号：ZA926232

申请日：1992-08-19

Applicant: HOECHST AG

Inventor： MUELLER GUENTER ,  GUENTER MUELLER ,  TRIPIER DOMINIQUE ,  DOMINIQUE TRIPIER ,  MUELLNER STEFAN ,  STEFAN MUELLNER

IPC: A61K38/28 ,  A61K31/715 ,  A61K38/00 ,  A61P3/08 ,  A61P3/10 ,  C07K1/22 ,  C07K5/08 ,  C07K5/093 ,  C07K5/10 ,  C07K9/00 ,  C07K14/37 ,  C07K14/41 ,  C07K14/475 ,  C07K14/575 ,  C07K14/62 ,  C07K14/65 ,  C12P19/26 ,  C12P21/00 ,  C12P21/02 ,  C12R1/865 ,  C07K

Abstract: Phosphoinositolglycan peptides, obtainable by cleavage of adenosine-3%,5%-cyclic monophosphate binding protein, which contain glucosamine, galactose, mannose, inositol, phosphoric acid, ethanolamine and a peptide containing the sequence Asn-Cys-Tyr, their preparation and use for the treatment of diabetes mellitus and non-insulin-dependent diabetes are described.

公开(公告)号：ZA8705581B

公开(公告)日：1990-06-27

申请号：ZA8705581

申请日：1987-07-29

Applicant: HOECHST AG ,  RUSH PRESBYTERIAN ST LUKE

Inventor： KUETTNER KLAUS E ,  KLAUS E KUETTNER ,  DIMUZIO MICHAEL T ,  MICHAEL T DIMUZIO ,  BROCKS DIETRICH ,  DIETRICH BROCKS ,  TRIPIER DOMINIQUE ,  DOMINIQUE TRIPIER

IPC: A61K38/55 ,  A61K38/00 ,  A61P7/02 ,  A61P9/10 ,  A61P11/00 ,  A61P13/02 ,  A61P15/00 ,  A61P17/00 ,  A61P29/00 ,  A61P35/00 ,  A61P35/02 ,  C07K14/00 ,  C07K14/81 ,  C12N9/99 ,  C12P21/06 ,  A61K ,  C07K ,  C12N

CPC classification number: C07K14/811 ,  A61K38/00 ,  Y10S514/824 ,  Y10S514/825 ,  Y10S530/84

公开(公告)号：ZA9206232B

公开(公告)日：1993-04-28

申请号：ZA9206232

申请日：1992-08-19

Applicant: HOECHST AG

Inventor： MUELLER GUENTER ,  GUENTER MUELLER ,  TRIPIER DOMINIQUE ,  DOMINIQUE TRIPIER ,  MUELLNER STEFAN ,  STEFAN MUELLNER

IPC: A61K38/28 ,  A61K31/715 ,  A61K38/00 ,  A61P3/08 ,  A61P3/10 ,  C07K1/22 ,  C07K5/08 ,  C07K5/093 ,  C07K5/10 ,  C07K9/00 ,  C07K14/37 ,  C07K14/41 ,  C07K14/475 ,  C07K14/575 ,  C07K14/62 ,  C07K14/65 ,  C12P19/26 ,  C12P21/00 ,  C12P21/02 ,  C12R1/865 ,  C07K

CPC classification number: C07K14/475 ,  A61K38/00 ,  C07K5/0827 ,  C07K5/1027 ,  C07K9/001 ,  C12P19/26

公开(公告)号：ZA898553B

公开(公告)日：1990-08-29

申请号：ZA898553

申请日：1989-11-09

Applicant: HOECHST AG

Inventor： HUCHO FERDINAND ,  FERDINAND HUCHO ,  PRIBILLA IRIS ,  IRIS PRIBILLA ,  SCHIEBLER WERNER ,  WERNER SCHIEBLER ,  TRIPIER DOMINIQUE ,  DOMINIQUE TRIPIER ,  KOGLER HERBERT ,  HERBERT KOGLER

IPC: A61K31/195 ,  A61K31/19 ,  A61P9/00 ,  A61P25/00 ,  A61P29/00 ,  A61P31/12 ,  A61P35/00 ,  A61P43/00 ,  C07C229/16 ,  C07K ,  A61K

Abstract: The present invention relates to the use of EDTA or its analogues as inhibitors of calcium/calmodulin-dependent protein kinase II or of protein kinase C.

公开(公告)号：ZA894179B

公开(公告)日：1990-02-28

申请号：ZA894179

申请日：1989-06-02

Applicant: HOECHST AG

Inventor： SCHULZ ARNO ,  ARNO SCHULZ ,  BARTSCH KLAUS ,  KLAUS BARTSCH ,  TRIPIER DOMINIQUE ,  DOMINIQUE TRIPIER ,  SAUBER KLAUS ,  KLAUS SAUBER

IPC: C12N9/10 ,  C12N11/02 ,  C12N11/08 ,  C12P13/00 ,  C12P13/04 ,  C12R1/19 ,  C12N ,  C12P

Abstract: Transaminase, the preparation thereof and the use thereof. A transaminase can be isolated from E. coli DH-1 and can be used with great efficiency to prepare L-phosphinothricin and gamma -aminobutyric acid from the appropriate precursor by transfer of the amino group from glutamate.

公开(公告)号：AU2110992A

公开(公告)日：1993-02-25

申请号：AU2110992

申请日：1992-08-19

Applicant: HOECHST AG

Inventor： GUNTER MULLER ,  DOMINIQUE TRIPIER ,  STEFAN MULLNER

IPC: A61K38/28 ,  A61K31/715 ,  A61K38/00 ,  A61P3/08 ,  A61P3/10 ,  C07K1/22 ,  C07K5/08 ,  C07K5/093 ,  C07K5/10 ,  C07K9/00 ,  C07K14/37 ,  C07K14/41 ,  C07K14/475 ,  C07K14/575 ,  C07K14/62 ,  C07K14/65 ,  C12P19/26 ,  C12P21/00 ,  C12P21/02 ,  C12R1/865

Abstract: Phosphoinositolglycan peptides, obtainable by cleavage of adenosine-3%,5%-cyclic monophosphate binding protein, which contain glucosamine, galactose, mannose, inositol, phosphoric acid, ethanolamine and a peptide containing the sequence Asn-Cys-Tyr, their preparation and use for the treatment of diabetes mellitus and non-insulin-dependent diabetes are described.

公开(公告)号：ZA875581B

公开(公告)日：1990-06-27

申请号：ZA875581

申请日：1987-07-29

Applicant: HOECHST AG ,  RUSH PRESBYTERIAN ST LUKE

Inventor： KUETTNER KLAUS E ,  KLAUS E KUETTNER ,  DIMUZIO MICHAEL T ,  MICHAEL T DIMUZIO ,  BROCKS DIETRICH ,  DIETRICH BROCKS ,  TRIPIER DOMINIQUE ,  DOMINIQUE TRIPIER

IPC: A61K38/55 ,  A61K38/00 ,  A61P7/02 ,  A61P9/10 ,  A61P11/00 ,  A61P13/02 ,  A61P15/00 ,  A61P17/00 ,  A61P29/00 ,  A61P35/00 ,  A61P35/02 ,  C07K14/00 ,  C07K14/81 ,  C12N9/99 ,  C12P21/06 ,  A61K ,  C07K ,  C12N

Abstract: A protein or a pharmaceutically acceptable salt thereof. The protein has a molecular weight of 10,000-30,000 Dalton, an isoelectric point greater than 9.5, and an N terminus of the sequence H-Lys-X-Phe-Lys-Val-Asp-Val-Leu-Ala-Ala-Leu-X-Phe-Asn-Ala-, wherein X is an amino acid or a tryptic cleavage product which has the sequence -Gly-Ala-Asn-Ala-Val-Asn-. Methods for the isolation and purification of the protein, compositions containing the protein, and methods for the use of the protein and compositions, are also disclosed.

公开(公告)号：ZA8904179B

公开(公告)日：1990-02-28

申请号：ZA8904179

申请日：1989-06-02

Applicant: HOECHST AG

Inventor： SCHULZ ARNO ,  ARNO SCHULZ ,  BARTSCH KLAUS ,  KLAUS BARTSCH ,  TRIPIER DOMINIQUE ,  DOMINIQUE TRIPIER ,  SAUBER KLAUS ,  KLAUS SAUBER

IPC: C12N9/10 ,  C12N11/08 ,  C12P13/04 ,  C12R1/19 ,  C12N ,  C12P

CPC classification number: C12N11/08 ,  C12N9/1096 ,  C12P13/04 ,  Y10S435/849