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    IMIDAZO AND TRIAZOLO-THIADIAZINE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS
    21.
    发明专利
    IMIDAZO AND TRIAZOLO-THIADIAZINE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS 未知

    公开(公告)号：NZ223334A

    公开(公告)日：1989-08-29

    申请号：NZ22333488

    申请日：1988-01-28

    Applicant: HOECHST AG

    Inventor： THORWART W ,  GEBERT U ,  SCHLEYERBACH R ,  BARTLETT R R

    IPC: A61K31/54 ,  A61P29/00 ,  A61P37/00 ,  C07D233/54 ,  C07D233/84 ,  C07D233/86 ,  C07D513/04

    Abstract: Imidazo- and triazolothiadiazines of the formula I … … in which R = C1-C4-alkyl,… R = H or C1-C3-alkyl… and the structural element -A-B-… = -CH2-CH2-, -CH=CH-, -CH=N-, -CH2-CO- or -CO-CH2-,… and their physiologically tolerable acid addition salts are prepared by reaction of 2-halo-1-phenylalkanones of the formula II … … with compounds of the formula III … … and, if desired, conversion of the compounds of the formula I formed into their physiologically tolerable acid addition salts by means of suitable acids. … The compounds of the formula I and their physiologically tolerable acid addition salts are mainly suitable for the prevention and treatment of inflammatory diseases - in particular of inflammatory rheumatic diseases. … Some of the intermediates formed during the preparation of the compounds of the formula I are also new, i.e. 1-amino- 2-mercaptoimidazole … … and 1-amino-2-thioxo-5-imidazolidinone … …

    TERTIARY HYDROXYALKYL SUBSTITUTED XANTHINES AND PHARMACEUTICAL COMPOSITIONS
    22.
    发明专利
    TERTIARY HYDROXYALKYL SUBSTITUTED XANTHINES AND PHARMACEUTICAL COMPOSITIONS 未知

    公开(公告)号：NZ216888A

    公开(公告)日：1989-05-29

    申请号：NZ21688886

    申请日：1986-07-17

    Applicant: HOECHST AG

    Inventor： GEBERT U ,  OKYAYUZ-BAKLOUTI I ,  THORWART W

    IPC: A61K31/52 ,  A61K31/522 ,  A61P3/00 ,  A61P9/00 ,  C07D473/00 ,  A61P9/08 ,  A61P25/28 ,  C07D473/04 ,  C07D473/06 ,  C07D473/08

    Abstract: PCT No. PCT/EP86/00401 Sec. 371 Date Mar. 16, 1987 Sec. 102(e) Date Mar. 16, 1987 PCT Filed Jul. 8, 1986 PCT Pub. No. WO87/00523 PCT Pub. Date Jan. 29, 1987.Tertiary hydroxyalkylxanthines having the general formula (I), characterized by the fact that at least one of the residues R1 and R3 represents a tertiary hydroxyalkyl group of formula (Ia) in which R4 represents an alkyl group having up to 3 carbon atoms and n a whole number from 2 to 5; the other residue which may remain R1 or R3 is a hydrogen atom or an aliphatic hydrocarbon residue R5 having up to 6 carbon atoms, in which the carbon chain may be separated by a maximum of two oxygen atoms or be substituted by an oxo group or two hydroxy groups at the most, and R2 represents an alkyl group with 1 to 4 carbon atoms. Also described is a process for manufacturing these compounds, which are suitable for the manufacture of medicines, in particular for use in the prevention and/or treatment of peripheral and/or cerebral irrigation disorders. (I) (Ia)

    23.
    发明专利
    未知

    公开(公告)号：SE433493B

    公开(公告)日：1984-05-28

    申请号：SE7714684

    申请日：1977-12-22

    Applicant: HOECHST AG

    Inventor： GEBERT U ,  GRANZER E ,  GREVE H-G ,  THORWART W

    IPC: C07D295/08 ,  A61K31/445 ,  A61K31/451 ,  A61K31/495 ,  A61P3/06 ,  A61P9/00 ,  A61P9/10 ,  A61P9/12 ,  A61P19/06 ,  C07D209/14 ,  C07D211/14 ,  C07D213/53 ,  C07D213/80 ,  C07D295/088 ,  C07D303/12 ,  C07D303/36 ,  C07D333/22 ,  C07D409/12 ,  C07D295/12

    Abstract: Compounds of general formula (I) wherein R1 represents a member selected from the group consisting of (a) an unsubstituted at most binuclear aryl group having from 6 to 10 carbon atoms, such groups substituted by from 1 to 3 equal or different radicals selected from the group consisting of alkyl, halogenoalkyl, alkoxy, dialkylamino each having up to 4 carbon atoms in the alkyl moiety, halogen phenyl, carboxyl, cyano, nitro and hydroxy groups, (b) a 5- to 6-membered heteroaromatic ring wherein the heteroatom is selected from nitrogen, oxygen and sulfur atoms and such rings anellated to a benzene nucleus; R2 represents a member selected from the group consisting of hydrogen, alkyl having up to 3 carbon atoms, phenyl, cycloalkyl having up to 6 carbon atoms in the ring and cycloalkyl bearing a hydrocarbon bridging radical having up to 2 carbon atoms; R3 represents hydrogen, hydroxy or acyloxy; R4 and R5 are the same or different and each represents a member selected from the group consisting of halogen, alkyl, and halogenoalkyl each having up to 3 carbon atoms, and nitro; and X represents nitrogen or methine and physiologically acceptable acid addition salts thereof and a pharmaceutical composition containing said compounds.

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