公开(公告)号：PH25937A

公开(公告)日：1991-12-19

申请号：PH38226

申请日：1989-02-21

Applicant: HOECHST AG

Inventor： CRAUSE PETER ,  HABERMANN PAUL ,  TRIPIER DOMINIQUE

IPC: C12P21/02 ,  A61K38/00 ,  A61K38/55 ,  A61P7/02 ,  C07H21/04 ,  C07K1/20 ,  C07K14/00 ,  C07K14/815 ,  C12N15/09 ,  C12R1/865 ,  C07K7/10

公开(公告)号：NZ229401A

公开(公告)日：1991-10-25

申请号：NZ22940189

申请日：1989-06-02

Applicant: HOECHST AG

Inventor： BONIN WERNER ,  HABERMANN PAUL ,  TRIPIER DOMINIQUE ,  WOEHNER ELISABET

IPC: A61K38/55 ,  A61K35/56 ,  A61K38/00 ,  A61P7/02 ,  C07K1/14 ,  C07K1/16 ,  C07K14/00 ,  C07K14/435 ,  C07K14/44 ,  C07K14/81 ,  C07K15/08 ,  A61K37/02

Abstract: The invention relates to a new active substance-amblyommin-for anticoagulant therapy and to a process for the isolation thereof from hard ticks. The isolated protein having a thrombin-inhibitory action has a molecular weight of 20000 to 30000 dalton, an isoelectric point between 5.05 and 5.65 and the partial amino acid sequences Ile-Leu-Phe-Thr-Gln-Gly-Asn-X-Gly-Glu-Leu-Glu-Asn-X-Phe-Glu-, Lys-Ile-Leu-Phe-X-Gln-Gly- and Ala-Ser-Tyr-Ile-Val-X-Ser-Glu-Ser-Ile-Gln-Ile-Leu-X-Leu-Ser-Glu-Gly-Ile- in which each radical X can be identical or different and each represents a naturally occurring amino acid.

公开(公告)号：ZA898553B

公开(公告)日：1990-08-29

申请号：ZA898553

申请日：1989-11-09

Applicant: HOECHST AG

Inventor： HUCHO FERDINAND ,  FERDINAND HUCHO ,  PRIBILLA IRIS ,  IRIS PRIBILLA ,  SCHIEBLER WERNER ,  WERNER SCHIEBLER ,  TRIPIER DOMINIQUE ,  DOMINIQUE TRIPIER ,  KOGLER HERBERT ,  HERBERT KOGLER

IPC: A61K31/195 ,  A61K31/19 ,  A61P9/00 ,  A61P25/00 ,  A61P29/00 ,  A61P31/12 ,  A61P35/00 ,  A61P43/00 ,  C07C229/16 ,  C07K ,  A61K

Abstract: The present invention relates to the use of EDTA or its analogues as inhibitors of calcium/calmodulin-dependent protein kinase II or of protein kinase C.

公开(公告)号：NO163959C

公开(公告)日：1990-08-15

申请号：NO832904

申请日：1983-08-12

Applicant: HOECHST AG

Inventor： SEIPKE GERHARD ,  TRIPIER DOMINIQUE ,  JOHNSCHER GERD

IPC: A61K35/26 ,  A61K38/00 ,  A61K38/22 ,  A61P37/00 ,  C07K1/113 ,  C07K1/20 ,  C07K7/04 ,  C07K14/435 ,  C07K14/47 ,  C07K14/575 ,  C07K15/06

Abstract: The invention relates to a polypeptide which can be isolated from thymus glands and has an action on the immunological system, and which has a molecular weight of 3,480, a UV absorption with a maximum at 205 to 210 nm and an isoelectric point of 3.95+0.15 and a specific aminoacid composition, the N-terminal, if appropriate, carrying an acyl group or an acylglycyl group, processes for its isolation and purification, its use, agents containing this polypeptide, and its cleavage products, their use and agents containing them.

公开(公告)号：ZA894179B

公开(公告)日：1990-02-28

申请号：ZA894179

申请日：1989-06-02

Applicant: HOECHST AG

Inventor： SCHULZ ARNO ,  ARNO SCHULZ ,  BARTSCH KLAUS ,  KLAUS BARTSCH ,  TRIPIER DOMINIQUE ,  DOMINIQUE TRIPIER ,  SAUBER KLAUS ,  KLAUS SAUBER

IPC: C12N9/10 ,  C12N11/02 ,  C12N11/08 ,  C12P13/00 ,  C12P13/04 ,  C12R1/19 ,  C12N ,  C12P

Abstract: Transaminase, the preparation thereof and the use thereof. A transaminase can be isolated from E. coli DH-1 and can be used with great efficiency to prepare L-phosphinothricin and gamma -aminobutyric acid from the appropriate precursor by transfer of the amino group from glutamate.

公开(公告)号：ZA8904181B

公开(公告)日：1990-02-28

申请号：ZA8904181

申请日：1989-06-02

Applicant: HOECHST AG

Inventor： BONIN WERNER ,  HABERMANN PAUL ,  TRIPIER DOMINIQUE ,  WOEHNER ELISABET

IPC: A61K38/55 ,  A61K35/56 ,  A61K38/00 ,  A61P7/02 ,  C07K1/14 ,  C07K1/16 ,  C07K14/00 ,  C07K14/435 ,  C07K14/44 ,  C07K14/81 ,  C07K ,  A61K

CPC classification number: C07K14/43527 ,  A61K35/646 ,  A61K38/00 ,  C07K14/811 ,  Y10S530/855

公开(公告)号：PT85443B

公开(公告)日：1989-12-07

申请号：PT8544387

申请日：1987-07-29

Applicant: HOECHST AG

Inventor： KUETTNER KLAUS E ,  DIMUZIO MICHAEL T ,  BROCKS DIETRICH ,  TRIPIER DOMINIQUE

IPC: A61K38/55 ,  A61K38/00 ,  A61P7/02 ,  A61P9/10 ,  A61P11/00 ,  A61P13/02 ,  A61P15/00 ,  A61P17/00 ,  A61P29/00 ,  A61P35/00 ,  A61P35/02 ,  C07K14/00 ,  C07K14/81 ,  C12N9/99 ,  C12P21/06 ,  C07K7/08 ,  C07K7/10 ,  C07K3/28 ,  C07K15/00

Abstract: A protein or a pharmaceutically acceptable salt thereof. The protein has a molecular weight of 10,000-30,000 Dalton, an isoelectric point greater than 9.5, and an N terminus of the sequence H-Lys-X-Phe-Lys-Val-Asp-Val-Leu-Ala-Ala-Leu-X-Phe-Asn-Ala-, wherein X is an amino acid or a tryptic cleavage product which has the sequence -Gly-Ala-Asn-Ala-Val-Asn-. Methods for the isolation and purification of the protein, compositions containing the protein, and methods for the use of the protein and compositions, are also disclosed.

公开(公告)号：DE3819079A1

公开(公告)日：1989-12-07

申请号：DE3819079

申请日：1988-06-04

Applicant: HOECHST AG

Inventor： CRAUSE PETER ,  HABERMANN PAUL ,  KRAMER MARTIN ,  OBERMEIER RAINER ,  SAUBER KLAUS ,  TRIPIER DOMINIQUE

IPC: C12N9/99 ,  A61K38/00 ,  A61K38/55 ,  A61K47/00 ,  A61K47/48 ,  A61P7/02 ,  C07K1/113 ,  C07K1/20 ,  C07K1/22 ,  C07K14/81 ,  C07K14/815 ,  C07K17/10 ,  C12P21/02 ,  C12R1/645

Abstract: The present invention relates to hirudin derivatives which are formed from hirudin or its physiologically acceptable salt and of a carrier, to a process for the preparation thereof and to the use thereof as thrombin inhibitor.

公开(公告)号：AU3595489A

公开(公告)日：1989-12-07

申请号：AU3595489

申请日：1989-06-01

Applicant: HOECHST AG

Inventor： BONIN WERNER ,  HABERMANN PAUL ,  TRIPIER DOMINIQUE ,  WOEHNER ELISABET

IPC: A61K38/55 ,  A61K35/56 ,  A61K38/00 ,  A61P7/02 ,  C07K1/14 ,  C07K1/16 ,  C07K14/00 ,  C07K14/435 ,  C07K14/44 ,  C07K14/81 ,  C07K15/12 ,  C07K15/02 ,  C12N9/68 ,  A61K37/02

Abstract: The invention relates to a new active substance-amblyommin-for anticoagulant therapy and to a process for the isolation thereof from hard ticks. The isolated protein having a thrombin-inhibitory action has a molecular weight of 20000 to 30000 dalton, an isoelectric point between 5.05 and 5.65 and the partial amino acid sequences Ile-Leu-Phe-Thr-Gln-Gly-Asn-X-Gly-Glu-Leu-Glu-Asn-X-Phe-Glu-, Lys-Ile-Leu-Phe-X-Gln-Gly- and Ala-Ser-Tyr-Ile-Val-X-Ser-Glu-Ser-Ile-Gln-Ile-Leu-X-Leu-Ser-Glu-Gly-Ile- in which each radical X can be identical or different and each represents a naturally occurring amino acid.

公开(公告)号：FI892690A

公开(公告)日：1989-12-05

申请号：FI892690

申请日：1989-06-01

Applicant: HOECHST AG

Inventor： BONIN WERNER ,  HABERMANN PAUL ,  TRIPIER DOMINIQUE ,  WOEHNER ELISABET

IPC: A61K38/55 ,  A61K35/56 ,  A61K38/00 ,  A61P7/02 ,  C07K1/14 ,  C07K1/16 ,  C07K14/00 ,  C07K14/435 ,  C07K14/44 ,  C07K14/81 ,  A61K

Abstract: The invention relates to a new active substance-amblyommin-for anticoagulant therapy and to a process for the isolation thereof from hard ticks. The isolated protein having a thrombin-inhibitory action has a molecular weight of 20000 to 30000 dalton, an isoelectric point between 5.05 and 5.65 and the partial amino acid sequences Ile-Leu-Phe-Thr-Gln-Gly-Asn-X-Gly-Glu-Leu-Glu-Asn-X-Phe-Glu-, Lys-Ile-Leu-Phe-X-Gln-Gly- and Ala-Ser-Tyr-Ile-Val-X-Ser-Glu-Ser-Ile-Gln-Ile-Leu-X-Leu-Ser-Glu-Gly-Ile- in which each radical X can be identical or different and each represents a naturally occurring amino acid.