公开(公告)号：DE69909897T2

公开(公告)日：2004-05-27

申请号：DE69909897

申请日：1999-05-14

Applicant: IDEXX LAB INC

Inventor： GROAT RANDALL G ,  MERMER BRION ,  O'CONNOR THOMAS P

IPC: C07K7/08 ,  C07K14/155 ,  G01N33/569

Abstract: We disclose methods for determining whether a feline is infected with feline immunodeficiency virus ("FIV"). The methods involve the use of an antibody-binding composition that includes two enhanced polypeptides, one containing an immunogenic fragment of the FIV gag precursor p55 and the other containing an immunogenic fragment of the FIV env precursor gp130. Also disclosed are devices for practising these methods.

公开(公告)号：AU757334B2

公开(公告)日：2003-02-13

申请号：AU4044900

申请日：2000-03-30

Applicant: IDEXX LAB INC

Inventor： LAWTON ROBERT ,  MERMER BRION ,  FRANCOEUR GREG

IPC: C12N15/09 ,  A61K38/00 ,  A61K39/395 ,  A61P37/08 ,  C07K14/47 ,  C07K16/42 ,  C12P21/08 ,  A61K39/44

公开(公告)号：AU3310201A

公开(公告)日：2001-08-14

申请号：AU3310201

申请日：2001-01-30

Applicant: IDEXX LAB INC

Inventor： LAWTON ROBERT L ,  AIYAPPA ASHOK P ,  LIU WENDY W ,  MERMER BRION ,  GUO HONGLIANG ,  KRAH EUGENE R III

IPC: C12N15/09 ,  A61K9/08 ,  A61K39/395 ,  A61P37/08 ,  A61P43/00 ,  C07K16/42 ,  C12P21/08

Abstract: The present invention provides methods and compositions for decreasing IgE levels in dogs. The methods and compositions are useful for treating allergic symptoms in dogs. The invention may comprise chimeric canine anti-IgE monoclonal antibody compositions and methods for using the compositions in the treatment of allergy. In preferred embodiments, the compositions of the present invention may act by binding soluble IgE in plasma, or by inhibiting IgE from binding to receptors on mast cells, B cells, and basophils.

公开(公告)号：AU4053600A

公开(公告)日：2000-10-16

申请号：AU4053600

申请日：2000-03-30

Applicant: IDEXX LAB INC

Inventor： LAWTON ROBERT ,  MERMER BRION ,  FRANCOEUR GREG ,  KRAH REGIS

IPC: C12P21/08 ,  A61K38/00 ,  A61K39/00 ,  A61P37/08 ,  C07K7/06 ,  C07K7/08 ,  C07K16/06 ,  C07K16/28 ,  C07K16/44 ,  C12N7/00 ,  A61K39/395

公开(公告)号：CA2329152A1

公开(公告)日：2000-10-05

申请号：CA2329152

申请日：2000-03-30

Applicant: IDEXX LAB INC

Inventor： LAWTON ROBERT ,  KRAH REGIS ,  FRANCOEUR GREG ,  MERMER BRION

IPC: C12P21/08 ,  A61K38/00 ,  A61K39/00 ,  A61P37/08 ,  C07K7/06 ,  C07K7/08 ,  C07K16/06 ,  C07K16/28 ,  C07K16/44 ,  C12N7/00 ,  A61K39/395

Abstract: Disclosed is an isolated and purified peptide comprising a leucine positione d two peptide bonds away from a tyrosine-arginine pair, such as having the configuration: leucine-blank-blank-tyrosine-arginine, tyrosine-arginine-blan k- blank-leucine, or, leucine-blank-blank-tyrosine-arginine-blank-blank-leucine , where blank is any amino acid. Other peptides of the invention include those with the sequence cysteine-blank-blank-proline-histidine-blank-blank-blank- cysteine; cysteine-blank-proline-histidine-blank-proline-blank-blank-cystein e. The peptides can be linked to a carrier such as a multiply antigen protein o r a plant virus particle. Isolated and purified peptides of the invention can be used to induce canine autoantibodies directed to the canine igE molecule.

公开(公告)号：CA2329148A1

公开(公告)日：2000-10-05

申请号：CA2329148

申请日：2000-03-30

Applicant: IDEXX LAB INC

Inventor： MERMER BRION ,  FRANCOEUR GREG ,  LAWTON ROBERT

IPC: C12N15/09 ,  A61K38/00 ,  A61K39/395 ,  A61P37/08 ,  C07K14/47 ,  C07K16/42 ,  C12P21/08 ,  A61K39/44

Abstract: Disclosed are binding proteins that specifically bind to an isolated and purified peptide comprising a leucine positioned two peptide bonds away from a tyrosine-arginine pair. Other binding proteins of the invention include those that specifically bind to an isolated and purified peptide with the sequence cysteine-blank-blank-proline-histidine-blank-blank-blank-cysteine (SEQ ID NO:6) or cysteine-blank-proline-histidine-blank-proline-blank-blank-cysteine (SEQ ID NO:9).