公开(公告)号：JP2000204100A

公开(公告)日：2000-07-25

申请号：JP34223799

申请日：1999-12-01

Applicant: IDEXX LAB INC

Inventor： ANDERSON PHILIP R ANDERSEN ,  O'CONNOR THOMAS P ,  TONELLI QUENTIN J

IPC: A61K38/00 ,  A61K39/00 ,  A61K39/12 ,  A61P31/12 ,  C07K7/08 ,  C07K14/00 ,  C07K14/155 ,  C07K16/00 ,  C07K16/10 ,  C12N15/02 ,  C12N15/09 ,  C12N15/48 ,  C12P21/08 ,  G01N33/53 ,  G01N33/569

Abstract: PROBLEM TO BE SOLVED: To provide a method for detecting FIV(lentivirus) infection in cats and also to provide a polypeptide capable of being used for that purpose. SOLUTION: The detection of FIV infection in cats is conducted by detecting the specific antibody against FIV in cat blood serum or the like. First of all a peptide having antigenicity in FIV is prepared and then is brought into contact with cat blood serum or the like. Based on the formation of an immunocomplex due to the contact, the existence of an antibody and FIV infection can be detected. A glycoprotein in viral envelope protein (e.g. gp 40) or the like can be used as FIV peptide.

公开(公告)号：JP2000002707A

公开(公告)日：2000-01-07

申请号：JP13582899

申请日：1999-05-17

Applicant: IDEXX LAB INC

Inventor： GROAT RANDALL G ,  O'CONNOR THOMAS P ,  MERMER BRION

IPC: C07K7/08 ,  C07K14/155 ,  G01N33/569

Abstract: PROBLEM TO BE SOLVED: To provide a method and an apparatus for diagnosing the presence of a feline immune deficiency. SOLUTION: In this method for deciding whether a feline is infected by a feline immunodeficiency virus(FIV), a biological sample of the feline is given, the sample is brought into contact with an antibody binding capture composition containing (i) a first enhanced capture polypeptide containing an immunogeneic fragment of an FIVgag precursor p55 and (ii) a second enhanced capture polypeptide containing an immunogeneic fragment of an FIVenv precursor gp130, and the reaction of the antibody in the sample is detected by using the capture composition. Here, the generation of the reaction represents that the feline is infected with the FIV.

公开(公告)号：ES2124215T3

公开(公告)日：1999-02-01

申请号：ES90900599

申请日：1989-12-05

Applicant: IDEXX LAB INC

Inventor： O'CONNOR THOMAS P ,  TONELLI QUENTIN J

IPC: A61K39/00 ,  C07K14/15 ,  C07K14/155 ,  C07K16/10 ,  G01N33/569 ,  C12N5/10 ,  C12N15/02 ,  C12P21/08 ,  C12Q1/70 ,  C12R1/91 ,  G01N33/577 ,  G01N33/68

Abstract: Assay methods and devices for detecting antibodies to Feline Immunedeficiency Virus (FIV) using an FIV envelope polypeptide such as recombinant gp40.

公开(公告)号：CA2271449C

公开(公告)日：2010-07-13

申请号：CA2271449

申请日：1999-05-14

Applicant: IDEXX LAB INC

Inventor： GROAT RANDALL G ,  O'CONNOR THOMAS P ,  MERMER BRION

IPC: C12Q1/70 ,  C07K7/08 ,  C07K14/155 ,  G01N33/569 ,  G01N33/577

Abstract: Methods for determining whether a feline is infected with feline immunodeficiency virus ("FIV"). The methods involve the use of an antibody-binding composition that includes two enhanced polypeptides, one containing an immunogenic fragment of the FIV gag precursor p55 and the other containing an immunogenic fragment of the FIV env precursor gp130. Also featured a.re devices for practicing these methods.

公开(公告)号：ES2200472T3

公开(公告)日：2004-03-01

申请号：ES99303760

申请日：1999-05-14

Applicant: IDEXX LAB INC

Inventor： GROAT RANDALL G ,  MERMER BRION ,  O'CONNOR THOMAS P

IPC: C07K7/08 ,  C07K14/155 ,  G01N33/569

Abstract: We disclose methods for determining whether a feline is infected with feline immunodeficiency virus ("FIV"). The methods involve the use of an antibody-binding composition that includes two enhanced polypeptides, one containing an immunogenic fragment of the FIV gag precursor p55 and the other containing an immunogenic fragment of the FIV env precursor gp130. Also disclosed are devices for practising these methods.

公开(公告)号：AT246359T

公开(公告)日：2003-08-15

申请号：AT99303760

申请日：1999-05-14

Applicant: IDEXX LAB INC

Inventor： GROAT RANDALL G ,  MERMER BRION ,  O'CONNOR THOMAS P

IPC: C07K7/08 ,  C07K14/155 ,  G01N33/569

Abstract: We disclose methods for determining whether a feline is infected with feline immunodeficiency virus ("FIV"). The methods involve the use of an antibody-binding composition that includes two enhanced polypeptides, one containing an immunogenic fragment of the FIV gag precursor p55 and the other containing an immunogenic fragment of the FIV env precursor gp130. Also disclosed are devices for practising these methods.

公开(公告)号：GR3018263T3

公开(公告)日：1996-02-29

申请号：GR950403378

申请日：1995-11-30

Applicant: IDEXX LAB INC

Inventor： O'CONNOR THOMAS P ,  TONELLI QUENTIN J

IPC: G01N33/543 ,  G01N33/569 ,  G01N33/576 ,  G01N33/53 ,  G01N33/545 ,  G01N33/552

Abstract: A method for detecting the presence of antibody to FIV in a biological sample. The method includes the steps of providing a first antigen having a first epitope recognized by the antibody, the first antigen being detectable; contacting the first antigen with the sample under conditions under which the antibody can bind to the first antigen to form an immune complex; and detecting the immune complex. An ELISA test for FIV, using purified FIV antigen, is also described.

公开(公告)号：DE68924878D1

公开(公告)日：1996-01-04

申请号：DE68924878

申请日：1989-07-14

Applicant: IDEXX LAB INC

Inventor： O'CONNOR THOMAS P ,  TONELLI QUENTIN J

IPC: G01N33/543 ,  G01N33/569 ,  G01N33/576 ,  G01N33/53 ,  G01N33/545 ,  G01N33/552

Abstract: A method for detecting the presence of antibody to FIV in a biological sample. The method includes the steps of providing a first antigen having a first epitope recognized by the antibody, the first antigen being detectable; contacting the first antigen with the sample under conditions under which the antibody can bind to the first antigen to form an immune complex; and detecting the immune complex. An ELISA test for FIV, using purified FIV antigen, is also described.

公开(公告)号：DE69909897D1

公开(公告)日：2003-09-04

申请号：DE69909897

申请日：1999-05-14

Applicant: IDEXX LAB INC

Inventor： GROAT RANDALL G ,  MERMER BRION ,  O'CONNOR THOMAS P

IPC: C07K7/08 ,  C07K14/155 ,  G01N33/569

Abstract: We disclose methods for determining whether a feline is infected with feline immunodeficiency virus ("FIV"). The methods involve the use of an antibody-binding composition that includes two enhanced polypeptides, one containing an immunogenic fragment of the FIV gag precursor p55 and the other containing an immunogenic fragment of the FIV env precursor gp130. Also disclosed are devices for practising these methods.

公开(公告)号：DE68924878T2

公开(公告)日：1996-04-18

申请号：DE68924878

申请日：1989-07-14

Applicant: IDEXX LAB INC

Inventor： O'CONNOR THOMAS P ,  TONELLI QUENTIN J

IPC: G01N33/543 ,  G01N33/569 ,  G01N33/576 ,  G01N33/53 ,  G01N33/545 ,  G01N33/552

Abstract: A method for detecting the presence of antibody to FIV in a biological sample. The method includes the steps of providing a first antigen having a first epitope recognized by the antibody, the first antigen being detectable; contacting the first antigen with the sample under conditions under which the antibody can bind to the first antigen to form an immune complex; and detecting the immune complex. An ELISA test for FIV, using purified FIV antigen, is also described.