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公开(公告)号：AT259794T
公开(公告)日：2004-03-15
申请号：AT00915524
申请日：2000-04-14
Applicant: KANEKA CORP
Inventor： KINOSHITA KOICHI , MOROSHIMA TADASHI , YANAGIDA YOSHIFUMI , NAGASHIMA NOBUO , SAKA YASUHIRO , HONDA TATSUYA , FUSE YOSHIHIDE , UEDA YASUYOSHI
IPC: C07C29/147 , C07C31/42 , C07D307/20
Abstract: The application is concerned with a process for producing a 3-hydroxytetrahydrofuran of the formula (3): by cyclizing a 4-halo-1,3-butanediol of the general formula (2): wherein X represents a halogen atom in an aqueous solution, which comprises carrying out the cyclization reaction under weakly acidic to neutral conditions. Furthermore several methods are disclosed for the isolution of highly pure 3-hydroxytetrahydrofuran.
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公开(公告)号：DE69722111T2
公开(公告)日：2004-02-19
申请号：DE69722111
申请日：1997-01-29
Applicant: KANEKA CORP
Inventor： SUGAWA TADASHI , MOROSHIMA TADASHI , INOUE KENJI , KAN KAZUNORI
IPC: C07B41/02 , C07B53/00 , C07C29/143 , C07C213/00 , C07C269/06 , C07C271/16 , C07C271/22 , C07C319/20 , C07C323/43 , C07C33/22 , C07C215/28 , C07C271/10
Abstract: The present invention provides a process for reducing carbonyl compounds to hydroxy compounds, in particular stereoselectively reducing alpha -aminohaloketone derivatives, under mild conditions in an easy and simple manner, which comprises reacting a carbonyl compound of the general formula (1) with an organoaluminum compound of the general formual (4) to provide the corresponding alcohol compound of the general formula (5).
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23.发明专利
公开(公告)号：CZ293008B6
公开(公告)日：2004-01-14
申请号：CZ20001004
申请日：1999-07-19
Applicant: KANEKA CORP
Inventor： KINOSHITA KOICHI , MOROSHIMA TADASHI , YANAGIDA YOSHIFUMI , FUSE YOSHIHIDE , UEDA YASUYOSHI
Abstract: The present invention relates to a method for crystallizing the maleic acid salt of N-(1(S)-ethoxycarbonyl-3-phenylpropyl)-L-alanyl-L-proline (Enalapril) from an aqueous liquid with ease in good yield, which comprises mixing an aqueous liquid containing N-(1(S)-ethoxycarbonyl-3-phenylpropyl)-L-alanyl-L-proline, maleic acid and a base with an acid in an amount of the acid sufficient to convert the base to a neutral salt, to thereby crystallize N-(1(S)-ethoxycarbonyl-3-phenylpropyl)-L-alanyl-L-proline in the form of a maleic acid salt.
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公开(公告)号：AT240918T
公开(公告)日：2003-06-15
申请号：AT97901761
申请日：1997-01-29
Applicant: KANEKA CORP
Inventor： SUGAWA TADASHI , MOROSHIMA TADASHI , INOUE KENJI , KAN KAZUNORI
IPC: C07B41/02 , C07B53/00 , C07C29/143 , C07C213/00 , C07C269/06 , C07C271/16 , C07C271/22 , C07C319/20 , C07C323/43 , C07C33/22 , C07C215/28 , C07C271/10 , C07M7/00
Abstract: The present invention provides a process for reducing carbonyl compounds to hydroxy compounds, in particular stereoselectively reducing alpha -aminohaloketone derivatives, under mild conditions in an easy and simple manner, which comprises reacting a carbonyl compound of the general formula (1) with an organoaluminum compound of the general formual (4) to provide the corresponding alcohol compound of the general formula (5).
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公开(公告)号：PL350362A1
公开(公告)日：2002-12-02
申请号：PL35036201
申请日：2001-02-16
Applicant: KANEKA CORP
Inventor： SUGAWARA MASANOBU , FUJII AKIO , OKURO KAZUMI , SAKA YASUHIRO , NAGASHIMA NOBUO , INOUE KENJI , TAKEDA TOSHIHIRO , KINOSHITA KOICHI , MOROSHIMA TADASHI , FUSE YOSHIHIDE , UEDA YASUYOSHI
IPC: C07C227/10 , C07C227/32 , C07C227/42 , C07C229/26 , C07C229/30 , C07C303/36 , C07C311/19 , C07D203/08 , C07D203/20 , C07D203/24 , C07C227/04 , C07B53/00
Abstract: An optically active amino acid derivative is produced by N-protecting an optically active 3-haloalanine derivative followed by cyclization, or cyclizing this derivative followed by N-protection to thereby give an optically active N-protected-aziridine-2-carboxylic acid derivative which is protected by a benzenesulfonyl group substituted by nitro at the 2- and/or 4-positions and then treating this product with an organic metal reagent, or by N-protecting an optically active 3-haloalanine derivative to thereby give N-protected-aziridine-2-carboxylic acid which is protected by a benzenesulfonyl group substituted by nitro at the 2- and/or 4-positions and then treating this product with an organic metal reagent. According to this process, natural and unnatural optically active amino acids can be produced from inexpensive materials by using simple procedures.
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Patent Agency Ranking
公开(公告)号：CA2369678A1
公开(公告)日：2001-08-23
申请号：CA2369678
申请日：2001-02-16
Applicant: KANEKA CORP
Inventor： SUGAWARA MASANOBU , FUJII AKIO , KINOSHITA KOICHI , TAKEDA TOSHIHIRO , FUSE YOSHIHIDE , UEDA YASUYOSHI , OKURO KAZUMI , INOUE KENJI , MOROSHIMA TADASHI , NAGASHIMA NOBUO , SAKA YASUHIRO
IPC: C07C227/10 , C07C227/32 , C07C227/42 , C07C229/26 , C07C229/30 , C07C303/36 , C07C311/19 , C07D203/08 , C07D203/20 , C07D203/24 , C07B53/00 , C07C227/04
Abstract: An optically active amino acid derivative is prepared either by subjecting a n optically active 3-haloalanine derivative (1) to N-protection followed by cyclization or cyclization followed by N-protection to prepare an optically active aziridinecarboxylic acid derivative (3) whose imino group is protecte d with 2- and/or 4-nitrated benzenesulfonyl and treating this derivative (3) with an organometallic reagent or by subjecting an optically active 3- haloalanine derivative to N-protection to obtain an optically active 3- haloalanine derivative (4) whose amino group is protected with 2- and/or 4- nitrated benzenesulfonyl and treating this derivative (4) with an organometallic reagent. According to such processes, natural and nonnatural optically active amino acids can be prepared from inexpensive raw materials through simple and easy operation. In said derivatives, X is halogen; R1 and R2 are each hydrogen or the like; * represents an asymmetric carbon atom; an d P1 is 2- and/ or 4- nitrated benzenesulfonyl.
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公开(公告)号：AU3678700A
公开(公告)日：2000-11-02
申请号：AU3678700
申请日：2000-04-14
Applicant: KANEKA CORP
Inventor： KINOSHITA KOICHI , MOROSHIMA TADASHI , YANAGIDA YOSHIFUMI , NAGASHIMA NOBUO , SAKA YASUHIRO , HONDA TATSUYA , FUSE YOSHIHIDE , UEDA YASUYOSHI
IPC: C07C29/147 , C07C31/42 , C07D307/20
Abstract: The application is concerned with a process for producing a 3-hydroxytetrahydrofuran of the formula (3): by cyclizing a 4-halo-1,3-butanediol of the general formula (2): wherein X represents a halogen atom in an aqueous solution, which comprises carrying out the cyclization reaction under weakly acidic to neutral conditions. Furthermore several methods are disclosed for the isolution of highly pure 3-hydroxytetrahydrofuran.
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公开(公告)号：CA2311407A1
公开(公告)日：2000-03-30
申请号：CA2311407
申请日：1999-09-22
Applicant: KANEKA CORP
Inventor： MOROSHIMA TADASHI , UEDA YASUYOSHI , FUSE YOSHIHIDE , YANAGIDA YOSHIFUMI
Abstract: A process for preparing N2-(1(S)-carboxy-3-phenylpropyl)-L-lysyl-L-proline (2) easily, efficiently and industrially advantageously, which comprises: the first step of conducting the alkaline hydrolysis of an N2-(1(S)-alkoxycarbonyl-3-phenylpropyl)-N6-trifluoroacetyl-L-lysyl-L-proline (1) by the use of n molar equivalents (wherein n 3) of an inorganic base per mol of the compound (1) either in a mixture of water with a hydrophilic organic solvent or in water; the second step of neutralizing the resulting reaction mixture with (n-1) to n molar equivalents (wherein n 3) of an inorganic acid, replacing the solvent system by a suitable one to thereby precipitate an inorganic salt formed by the above neutralization, and separating and removing the salt; and the third step of crystallizing the compound (2) present in the liquid mixture left after the above removal of the salt at its isoelectric point and recovering the compound (2) as a crystal, while salts mainly comprising organic acid salts resulting from trifluoroacetic acid remain dissolved in the mother liquor.
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公开(公告)号：JP2010100651A
公开(公告)日：2010-05-06
申请号：JP2010015834
申请日：2010-01-27
Applicant: Kaneka Corp , 株式会社カネカ
Inventor： KINOSHITA KOICHI , MOROSHIMA TADASHI , YANAGIDA YOSHIBUMI , NAGASHIMA NOBUO , SAKA YASUHIRO , HONDA TATSUYA , FUSE YOSHIHIDE , UEDA YASUYOSHI
IPC: C07D307/20
Abstract: PROBLEM TO BE SOLVED: To provide high-purity 3-hydroxytetrahydrofuran in a high yield easily and simply by an industrially advantageous process.
SOLUTION: The process includes: reducing a 4-halo-3-hydroxybutyric acid ester with a boron hydride compound and/or an aluminum hydride compound in an organic solvent immiscible with water; treating the reaction mixture with an acid and water to convert it into the corresponding 4-halo-1, 3-butanediol and at the same time obtaining an aqueous solution containing the compound; carrying out the cyclization reaction in the aqueous solution; extracting the resulting 3-hydroxytetrahydrofuran from the aqueous solution using an organic solvent immiscible with water; and isolating the 3-hydroxytetrahydrofuran by concentration and/or distillation of the solution obtained.
COPYRIGHT: (C)2010,JPO&INPITAbstract translation: 待解决的问题：通过工业上有利的方法容易且简单地提供高产率的高纯度3-羟基四氢呋喃。 解决方案：该方法包括：用氢化硼化合物和/或氢化铝化合物在与水不混溶的有机溶剂中还原4-卤-3-羟基丁酸酯; 用酸和水处理反应混合物，将其转化成相应的4-卤代-1,3-丁二醇，同时得到含有该化合物的水溶液; 在水溶液中进行环化反应; 使用与水不混溶的有机溶剂从水溶液中萃取所得3-羟基四氢呋喃; 并通过所得溶液的浓缩和/或蒸馏分离3-羟基四氢呋喃。 版权所有（C）2010，JPO＆INPIT
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公开(公告)号：AU2012276691B2
公开(公告)日：2016-10-13
申请号：AU2012276691
申请日：2012-06-28
Applicant: KANEKA CORP
Inventor： MOURI TAKU , TAOKA NAOAKI , MOROSHIMA TADASHI , KINOSHITA KOICHI
IPC: C07K5/093 , A61K8/64 , A61K9/08 , A61K9/10 , A61K9/14 , A61K38/00 , A61K47/06 , A61K47/08 , A61K47/10 , A61K47/14 , A61K47/20 , A61P39/02 , C07K5/037
Abstract: A solid oxidized glutathione salt is produced by heating oxidized glutathione to at least 30°C while bringing the oxidized glutathione into contact with an aqueous medium composed of water and/or a water-soluble medium, in the presence of a substance capable of generating at least one type of cation selected from ammonium cations, calcium cations, and magnesium cations, so as to produce a salt of the oxidized glutathione and the cation as a solid.
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