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    22.
    发明专利
    未知

    公开(公告)号：DE59915085D1

    公开(公告)日：2009-11-05

    申请号：DE59915085

    申请日：1999-01-28

    Applicant: LEICA MICROSYSTEMS

    Inventor： ENGELHARDT JOHANN ,  ULRICH HEINRICH ,  GUGEL HILMAR

    IPC: G01J3/04 ,  G01J3/14 ,  G02B5/00 ,  G02B5/04 ,  G02B21/00

    Abstract: The invention relates to an optical arrangement provided for a spectral fanning out of a light beam (1), preferably the detection beam path of a confocal microscope, especially for the subsequent splitting of the fanned out beam (2) out of the dispersion plane thereof. The optical arrangment is also provided for detecting the fanned out spectral regions (4), whereby the incoming light beam (1) is focused on a pinhole (7). The invention is characterized in that the pinhole (7) has a polygonal passageway (8) in order to realize a high dynamic response when the light beam is split into spectral regions (4) or into spectral colors.

    Method for high spatial resolution examination of sample, involves providing optical signal in the form of focal line with cross-sectional profile having intensity zero point with laterally neighboring intensity maxima
    24.
    发明专利
    Method for high spatial resolution examination of sample, involves providing optical signal in the form of focal line with cross-sectional profile having intensity zero point with laterally neighboring intensity maxima 未知

    公开(公告)号：DE102006009831A1

    公开(公告)日：2007-09-13

    申请号：DE102006009831

    申请日：2006-03-01

    Applicant: LEICA MICROSYSTEMS

    Inventor： DYBA MARCUS ,  GUGEL HILMAR

    IPC: G01N21/64 ,  G02B21/00

    Abstract: A method for high spatial resolution examination of samples (1), involves bringing a substance in the sample region (P) into a first state (e.g. fluorescence-capable state) (Z1, A); inducing a second state (e.g. non-fluorescence-capable state) (Z2, B) using an optical signal (4) that is provided in the form of a focal line with a cross-sectional profile having at least one intensity zero point (5) with laterally neighboring intensity maxima (9) ; and recording spatially delimited sub-regions specifically excluded within the sample region. A method for high spatial resolution examination of samples (1), involves bringing a substance in the sample region (P) into a first state (e.g. fluorescence-capable state) (Z1, A); inducing a second state (e.g. non-fluorescence-capable state) (Z2, B) that is differ from the first state in at least one optical property using an optical signal (4); and recording spatially delimited sub-regions specifically excluded within the sample region. The optical signal is provided in the form of a focal line with a cross-sectional profile having at least one intensity zero point (5) with laterally neighboring intensity maxima (9). The focal line is produced using a linear illumination in a pupil plane conjugate with the pupil of the objective-pupil line and by suitable phase modulation along the pupil line. The phase modulation is undertaken in such a way that phase jumps are introduced along the pupil line. The phase jump is introduced at the pupil midpoint. The phase modulation along the pupil line is implemented using a spatial liquid-based phase modulator in an intermediate image of the pupil. The pupil line is produced by focusing an illuminating light beam of an illuminating light source with a cylindrical lens or a Powell lens; by imaging a split diaphragm into the pupil plane; or using holographic elements. The pupil line is coupled into the beam path using an Achrogate filter. The method uses a laser is used as an illuminating light source for providing the optical signal. The pulsed light sources are synchronized. An independent claim is included for a microscope, in particular a laser scanning fluorescence microscope, for high spatial resolution examination of samples comprising an optical signal that can be provided in the form of a focal line with a cross-sectional profile having at least one intensity zero point with laterally neighboring intensity maxima.

    25.
    发明专利
    未知

    公开(公告)号：DE102006009830A1

    公开(公告)日：2007-09-06

    申请号：DE102006009830

    申请日：2006-03-01

    Applicant: LEICA MICROSYSTEMS

    Inventor： GUGEL HILMAR ,  DYBA MARCUS ,  SEYFRIED VOLKER

    IPC: G01N21/64 ,  G02B21/00

    Abstract: A method for high spatial resolution examination of a sample, the sample to be examined including a substance that can be repeatedly converted from a first state into a second state, the first and the second states differing from one another in at least one optical property. The method includes: a) bringing the substance into the first state by means of a switching signal in a sample region to be recorded, b)inducing the second state by means of an optical signal, spatially delimited subregions being specifically excluded within the sample region to be recorded, c) reading out the remaining first states, and d) steps a) to c) are repeated, the optical signal being displaced upon each repetition in order to scan the sample, wherein the individual steps a) to d) are carried out in a sequence adapted to the respective measuring situation.

    Durchstimmbares akusto-optisches Filterelement, einstellbare Lichtquelle, Mikroskop und akusto-optischer Strahlteiler
    27.
    发明专利
    Durchstimmbares akusto-optisches Filterelement, einstellbare Lichtquelle, Mikroskop und akusto-optischer Strahlteiler 未知

    公开(公告)号：DE102007024075B4

    公开(公告)日：2022-06-09

    申请号：DE102007024075

    申请日：2007-05-22

    Applicant: LEICA MICROSYSTEMS

    Inventor： GUGEL HILMAR ,  SEYFRIED VOLKER

    IPC: G02B27/00 ,  F21V9/40 ,  G02B6/32 ,  G02B21/06 ,  G02B27/10 ,  G02F1/11

    Abstract: Akusto-optisches Filterelement (114), umfassend einen akusto-optischen Kristall (118) mit einem akustischen Signalgeber (120) zur Erzeugung akustischer Signale in dem akusto-optischen Kristall (118), wobei der akusto-optische Kristall (118) eingerichtet ist, um entsprechend einer an den akustischen Signalgeber (120) applizierten Hochfrequenz durch Beugung selektiv Licht einer Zielwellenlänge aus einem in den akusto-optischen Kristall (118) eintretenden Eingangslichtstrahl (116) räumlich in eine vorbestimmte Beugungsordnung abzulenken und dadurch einen Ziellichtstrahl (126) mit der Zielwellenlänge zu erzeugen, ferner umfassend ein im Ziellichtstrahl (126) angeordnetes Raumfilterelement (132), wobei das Raumfilterelement (132) ausgestaltet ist, um in einer Ebene senkrecht zur Ausbreitungsrichtung des Ziellichtstrahls (126) selektiv die Intensität des Ziellichtstrahls (126) zu unterdrücken, und wobei das Raumfilterelement (132) derart eingestellt ist, dass Nebenmaxima einer höheren Ordnung als 2 einer räumlichen Intensitätsverteilung des in die vorbestimmte Beugungsordnung abgelenkten Ziellichtstrahls (126) unterdrückt werden.

    Elemento filtrante acusto-óptico sintonizable
    28.
    发明专利
    Elemento filtrante acusto-óptico sintonizable 未知

    公开(公告)号：ES2672633T3

    公开(公告)日：2018-06-15

    申请号：ES08749935

    申请日：2008-04-30

    Applicant: LEICA MICROSYSTEMS

    Inventor： GUGEL HILMAR ,  SEYFRIED VOLKER

    IPC: G02F1/11 ,  F21V9/40 ,  G02B21/00

    Abstract: Elemento filtrante acusto-óptico (114) que comprende un cristal acusto-óptico (118) que presenta un generador de señal acústica (120p0) para la generación de señales acústicas en el cristal acusto-óptico 118), estando el cristal acusto-óptico (118) configurado de acuerdo con una alta frecuencia aplicada al generador de señal acústica (120) para desviar selectivamente espacialmente la luz con una longitud de onda objetivo a partir de un haz de luz de entrada (116) que entra en el cristal acusto-óptico (118) y generar un haz de luz objetivo (126) con la longitud de onda objetivo, caracterizado por un elemento filtrante espacial (132) dispuesto en el haz de luz objetivo (126), estando el elemento filtrante espacial (132) configurado para atenuar selectivamente la intensidad del haz de luz objetivo (126) en un plano perpendicular a la dirección de propagación del haz de luz objetivo (126) y el elemento filtrante espacial (132) comprende un elemento de lente (134, 138) con una longitud focal variable, en particular con una longitud focal ajustable de forma motorizada y/o electrónica, y/o con un diafragma ajustable (136), en particular un diafragma (136) que presenta una abertura ajustable electrónicamente.

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