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公开(公告)号：WO2007041342A3
公开(公告)日：2007-10-04
申请号：PCT/US2006038133
申请日：2006-09-28
Applicant: PACIFIC BIOSCIENCES CALIFORNIA , XU YUE , WEGENER JEFFEY , BIBILLO AREK
Inventor： XU YUE , WEGENER JEFFEY , BIBILLO AREK
CPC classification number: C07H19/10 , C07H21/00 , C12Q1/6869 , C12Q2533/101 , C12Q2525/117 , C12Q2525/101
Abstract: Labeled nucleotide analogs used in place of naturally occurring nucleoside triphosphates or other analogs in template directed nucleic acid synthesis reactions and other nucleic acid reactions, and various analyses based thereon, including DNA sequencing, single base identification, hybridization assays and others.
Abstract translation: 在模板定向核酸合成反应和其他核酸反应中使用代替天然存在的核苷三磷酸或其他类似物的标记的核苷酸类似物，以及基于其的各种分析，包括DNA测序，单碱基鉴定，杂交测定等。
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公开(公告)号：WO2009145828A2
公开(公告)日：2009-12-03
申请号：PCT/US2009002003
申请日：2009-03-30
Applicant: PACIFIC BIOSCIENCES CALIFORNIA , BJORNSON KEITH , LEE HAROLD , KORLACH JONAS , TURNER STEPHEN , BIBILLO AREK , CHRISTIANS FRED , EMIG ROBIN , HE MOLLY , PARK INSIL , JIA LEI , FEDOROV ANDREI , LYLE JOHN
Inventor： BJORNSON KEITH , LEE HAROLD , KORLACH JONAS , TURNER STEPHEN , BIBILLO AREK , CHRISTIANS FRED , EMIG ROBIN , HE MOLLY , PARK INSIL , JIA LEI , FEDOROV ANDREI , LYLE JOHN
CPC classification number: C12Q1/6869 , C12Q1/6874 , C12Q2527/125 , C12Q2527/119 , C12Q2527/101 , C12Q2565/1015 , C12Q2527/137 , C12Q2521/101
Abstract: Compositions, kits, methods and systems for nucleotide sequencing comprising producing polymerase reactions that exhibit two kinetically observable steps within an observable phase of the polymerase reaction. Two slow step systems can be produced, for example, by selecting the appropriate polymerase enzyme, polymerase reaction conditions including cofactors, and polymerase reaction substrates including the primed template and nucleotides.
Abstract translation: 用于核苷酸测序的组合物，试剂盒，方法和系统，其包括产生聚合酶反应，其在聚合酶反应的可观察期内显示两个动力学可观察步骤。 可以通过例如选择合适的聚合酶，包括辅因子的聚合酶反应条件和包括引发的模板和核苷酸的聚合酶反应底物来产生两个缓慢的步骤系统。
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公开(公告)号：WO2009102470A3
公开(公告)日：2009-11-26
申请号：PCT/US2009000921
申请日：2009-02-12
Applicant: PACIFIC BIOSCIENCES CALIFORNIA , BJORNSON KEITH , BIBILLO AREK , SEBO LUBOMIR
Inventor： BJORNSON KEITH , BIBILLO AREK , SEBO LUBOMIR
CPC classification number: C12Q1/6874 , C12Q2527/127 , C12Q2527/113
Abstract: Compositions, methods, substrates and systems for use in analysis of single molecule reactions and particularly single molecule nucleic acid sequence analysis. Compositions that include non-reactive, distinguishable or undetectable competitive substrates for the reaction system of interest are provided, as well as their use in systems and substrates for such applications, such compounds typically preferably polyphosphate chains or analogous structures.
Abstract translation: 用于分析单分子反应的组合物，方法，底物和系统，特别是单分子核酸序列分析。 提供了包括用于感兴趣的反应体系的非反应性，可区分的或不可检测的竞争性底物的组合物，以及它们在用于此类应用的体系和底物中的用途，所述化合物通常优选多磷酸盐链或类似结构。
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公开(公告)号：WO2008051530A9
公开(公告)日：2008-06-26
申请号：PCT/US2007022459
申请日：2007-10-22
Applicant: PACIFIC BIOSCIENCES CALIFORNIA , RANK DAVID R , BIBILLO AREK , HANZEL DAVID K , PELUSO PAUL , WEGENER JEFF
Inventor： RANK DAVID R , BIBILLO AREK , HANZEL DAVID K , PELUSO PAUL , WEGENER JEFF
CPC classification number: C12N9/1252 , C12P19/34
Abstract: Compositions that include DNA polymerases having increased residence times for nucleotide analogues, particularly modified recombinant F29-type DNA polymerases with such increased residence times, are provided. Methods of making the polymerases and of using the polymerases in sequencing and DNA amplification are also provided. Compositions including a-thiophosphate nucleotide analogues with four or more phosphate groups are described, as are methods for determining the sequence of nucleic acid molecules using such analogues.
Abstract translation: 提供了包含具有增加的核苷酸类似物停留时间的DNA聚合酶的组合物，特别是具有这种增加的停留时间的经修饰的重组F29型DNA聚合酶。 还提供了在测序和DNA扩增中制备聚合酶和使用聚合酶的方法。 描述了包括具有四个或更多个磷酸基团的α-硫代磷酸核苷酸类似物的组合物，以及使用这种类似物测定核酸分子的序列的方法。
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公开(公告)号：WO2007076057A3
公开(公告)日：2008-06-26
申请号：PCT/US2006049122
申请日：2006-12-21
Applicant: PACIFIC BIOSCIENCES CALIFORNIA , HANZEL DAVID K , OTTO GEOFF , MURPHY DEVON , PELUSO PAUL , PHAM THANG , RANK DAVID R , MITSIS PAUL , CHRISTIANS FRED C , BIBILLO AREK , PARK INSIL , CLARK SONYA , LYLE JOHN
Inventor： HANZEL DAVID K , OTTO GEOFF , MURPHY DEVON , PELUSO PAUL , PHAM THANG , RANK DAVID R , MITSIS PAUL , CHRISTIANS FRED C , BIBILLO AREK , PARK INSIL , CLARK SONYA , LYLE JOHN
IPC: C12Q1/68
CPC classification number: C12N9/1252 , C07K2319/20 , C12P19/34 , C12Q1/6827 , C12Q1/6869 , C12Y207/07007 , Y02P20/52
Abstract: Compositions that include polymerases with features for improving entry of nucleotide analogues into active site regions and for coordinating with the nucleotide analogues in the active site region are provided. Methods of making the polymerases and of using the polymerases in sequencing and DNA replication and amplification as well as kinetic models of polymerase activity and computer-implemented methods of using the models are also provided.
Abstract translation: 提供了包含具有改善核苷酸类似物进入活性位点区域并与活性位点区域中的核苷酸类似物配位的特征的聚合酶的组合物。 还提供了制备聚合酶和在测序和DNA复制和扩增中使用聚合酶的方法以及聚合酶活性的动力学模型和使用该模型的计算机实现的方法。
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Patent Agency Ranking
公开(公告)号：EP2255014A4
公开(公告)日：2011-05-18
申请号：EP09711261
申请日：2009-02-12
Applicant: PACIFIC BIOSCIENCES CALIFORNIA
Inventor： BJORNSON KEITH , BIBILLO AREK , SEBO LUBOMIR
CPC classification number: C12Q1/6874 , C12Q2527/127 , C12Q2527/113
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公开(公告)号：EP2274446A4
公开(公告)日：2011-04-20
申请号：EP09755191
申请日：2009-03-30
Applicant: PACIFIC BIOSCIENCES CALIFORNIA
Inventor： BJORNSON KEITH , LEE HAROLD , KORLACH JONAS , TURNER STEPHEN , BIBILLO AREK , CHRISTIANS FRED , EMIG ROBIN , HE MOLLY , PARK INSIL , JIA LEI , FEDOROV ANDREI , LYLE JOHN M
CPC classification number: C12Q1/6869 , C12Q1/6874 , C12Q2527/125 , C12Q2527/119 , C12Q2527/101 , C12Q2565/1015 , C12Q2527/137 , C12Q2521/101
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28.发明公开GENERATION OF MODIFIED POLYMERASES FOR IMPROVED ACCURACY IN SINGLE MOLECULE SEQUENCING 有权单分子测序法提高修饰聚合物的生成精度
公开(公告)号：EP2271751A4
公开(公告)日：2011-09-14
申请号：EP09755183
申请日：2009-03-30
Applicant: PACIFIC BIOSCIENCES CALIFORNIA
Inventor： CLARK SONYA , BIBILLO AREK , PELUSO PAUL , CHRISTIANS FRED , HE MOLLY , PARK INSIL , LEE HAROLD , BJORNSON KEITH , JIA LEI , EMIG ROBIN
CPC classification number: C12N9/1252 , C12Q1/6844 , C12Q1/6869 , C12Q2521/101
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公开(公告)号：EP1963536A4
公开(公告)日：2010-03-03
申请号：EP06848948
申请日：2006-12-21
Applicant: PACIFIC BIOSCIENCES CALIFORNIA
Inventor： HANZEL DAVID K , OTTO GEOFF , MURPHY DEVON , PELUSO PAUL , PHAM THANG , RANK DAVID R , MITSIS PAUL , CHRISTIANS FRED C , BIBILLO AREK , PARK INSIL , CLARK SONYA , LYLE JOHN
IPC: C12Q1/68
CPC classification number: C12N9/1252 , C07K2319/20 , C12P19/34 , C12Q1/6827 , C12Q1/6869 , C12Y207/07007 , Y02P20/52
Abstract: Compositions that include polymerases with features for improving entry of nucleotide analogues into active site regions and for coordinating with the nucleotide analogues in the active site region are provided. Methods of making the polymerases and of using the polymerases in sequencing and DNA replication and amplification as well as kinetic models of polymerase activity and computer-implemented methods of using the models are also provided.
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30.发明公开POLYMERASE ENZYMES AND REAGENTS FOR ENHANCED NUCLEIC ACID SEQUENCING 审中-公开聚合酶及试剂高级NUKEINSÄURESEQUENZIERUNG
公开(公告)号：EP2089517A4
公开(公告)日：2010-10-20
申请号：EP07867267
申请日：2007-10-22
Applicant: PACIFIC BIOSCIENCES CALIFORNIA
Inventor： RANK DAVID R , BIBILLO AREK , HANZEL DAVID K , PELUSO PAUL , WEGENER JEFF
CPC classification number: C12N9/1252 , C12P19/34
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