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公开(公告)号：CA2687062C
公开(公告)日：2016-04-12
申请号：CA2687062
申请日：2008-05-09
Applicant: PACIFIC BIOSCIENCES CALIFORNIA
Inventor： LUNDQUIST PAUL , ZHONG CHENG-FRANK , ZACCARIN DENIS , ZHAO PEIQIAN , TURNER STEPHEN
Abstract: Mitigative and remedial approaches to reduction of autofluorescence background noise are applied in analytical systems that rely upon sensitive measurement of fluorescent signals from arrays of fluorescent signal sources. Such systems are for particular use in fluorescence based sequencing by incorporation systems that rely upon small numbers or individual fluorescent molecules in detecting incorporation of nucleotides in primer extension reactions. Systems and methods for analyzing highly multiplexed sample arrays using highly multiplexed, high-density optical systems to illuminate high- density sample arrays and/or provide detection and preferably confocal detection off signals emanating from such high-density arrays. Systems and methods are applied in a variety of different analytical operations, including analysis of biological and biochemical reactions, including nucleic acid synthesis and derivation of sequence information from such synthesis.
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公开(公告)号：CA2959518A1
公开(公告)日：2016-03-03
申请号：CA2959518
申请日：2015-08-26
Applicant: PACIFIC BIOSCIENCES CALIFORNIA INC
Inventor： GROT ANNETTE , SAXENA RAVI , LUNDQUIST PAUL
Abstract: Arrays of integrated analytical devices and their methods for production are provided. The arrays are useful in the analysis of highly multiplexed optical reactions in large numbers at high densities, including biochemical reactions, such as nucleic acid sequencing reactions. The devices allow the highly sensitive discrimination of optical signals using features such as spectra, amplitude, and time resolution, or combinations thereof. The devices include an integrated diffractive beam shaping element that provides for the spatial separation of light emitted from the optical reactions.
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公开(公告)号：AU2007289057B2
公开(公告)日：2013-06-13
申请号：AU2007289057
申请日：2007-08-31
Applicant: PACIFIC BIOSCIENCES CALIFORNIA
Inventor： LUNDQUIST PAUL , TURNER STEPHEN
IPC: F21V9/16
Abstract: Substrates, systems and methods for analyzing materials that include waveguide arrays disposed upon or within the substrate such that evanescent fields emanating from the waveguides illuminate materials disposed upon or proximal to the surface of the substrate, permitting analysis of such materials. The substrates, systems and methods are used in a variety of analytical operations, including, inter alia, nucleic acid analysis, including hybridization and sequencing analyses, cellular analyses and other molecular analyses.
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公开(公告)号：CA2974241A1
公开(公告)日：2010-03-25
申请号：CA2974241
申请日：2009-09-15
Applicant: PACIFIC BIOSCIENCES CALIFORNIA INC
Inventor： ZHONG CHENG FRANK , LUNDQUIST PAUL , FOQUET MATHIEU , KORLACH JONAS , BAYANDORIAN HOVIG
IPC: G01N21/17 , B82Y20/00 , C12M1/34 , C12Q1/00 , C12Q1/68 , G01N21/00 , G01N21/63 , G01N21/77 , G02B6/12
Abstract: This specification provides substrates for use in various applications, including single-molecule analytical reactions. Methods for propagating optical energy within a substrate are provided. Devices comprising waveguide substrates and dielectric omnidirectional reflectors are provided. Waveguide substrates with improved uniformity of optical energy intensity across one or more waveguides and enhanced waveguide illumination efficiency within an analytic detection region of the arrays are provided.
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公开(公告)号：CA2687062A1
公开(公告)日：2008-11-20
申请号：CA2687062
申请日：2008-05-09
Applicant: PACIFIC BIOSCIENCES CALIFORNIA
Inventor： TURNER STEPHEN , ZHAO PEGIAN , LUNDQUIST PAUL , ZHONG CHENG-FRANK , ZACCARIN DENIS
Abstract: Mitigative and remedial approaches to reduction of autofluorescence backg round noise are applied in analytical systems that rely upon sensitive measu rement of fluorescent signals from arrays of fluorescent signal sources. Suc h systems are for particular use in fluorescence based sequencing by incorpo ration systems that rely upon small numbers or individual fluorescent molecu les in detecting incorporation of nucleotides in primer extension reactions. Systems and methods for analyzing highly multiplexed sample arrays using hi ghly multiplexed, high-density optical systems to illuminate high- density s ample arrays and/or provide detection and preferably confocal detection off signals emanating from such high-density arrays. Systems and methods are app lied in a variety of different analytical operations, including analysis of biological and biochemical reactions, including nucleic acid synthesis and d erivation of sequence information from such synthesis.
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Patent Agency Ranking26.发明专利
公开(公告)号：CA2642261A1
公开(公告)日：2007-08-23
申请号：CA2642261
申请日：2007-02-09
Applicant: PACIFIC BIOSCIENCES CALIFORNIA
Inventor： DIXON JOHN , LACROIX YVES , TURNER STEPHEN , ZACCARIN DENIS , LUNDQUIST PAUL
IPC: G01J3/30
Abstract: Methods and systems for real-time monitoring of optical signals from arrays of signal sources, and particularly optical signal sources that have spectrally different signal components. Systems include signal source arrays in optical communication with optical trains that direct excitation radiation to and emitted signals from such arrays and image the signals onto detector arrays, from which such signals may be subjected to additional processing.
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27.发明专利
公开(公告)号：CA2642258A1
公开(公告)日：2007-08-23
申请号：CA2642258
申请日：2007-02-09
Applicant: PACIFIC BIOSCIENCES CALIFORNIA
Inventor： LACROIX YVES , TURNER STEPHEN , FOQUET MATHIEU , MAXHAM MARK , LUNDQUIST PAUL , ZACCARIN DENIS
Abstract: Methods and systems for real-time monitoring of optical signals from arrays of signal sources, and particularly optical signal sources that have spectrally different signal components. Systems include signal source arrays in optical communication with optical trains that direct excitation radiation to and emitted signals from such arrays and image the signals onto detector arrays, from which such signals may be subjected to additional processing.
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28.发明专利
公开(公告)号：AU2007215173A1
公开(公告)日：2007-08-23
申请号：AU2007215173
申请日：2007-02-09
Applicant: PACIFIC BIOSCIENCES CALIFORNIA
Inventor： DIXON JOHN , LUNDQUIST PAUL , TURNER STEPHEN , ZACCARIN DENIS , LACROIX YVES
IPC: G01J3/30
Abstract: Methods and systems for real-time monitoring of optical signals from arrays of signal sources, and particularly optical signal sources that have spectrally different signal components. Systems include signal source arrays in optical communication with optical trains that direct excitation radiation to and emitted signals from such arrays and image the signals onto detector arrays, from which such signals may be subjected to additional processing.
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公开(公告)号：AU2015306603A2
公开(公告)日：2017-06-01
申请号：AU2015306603
申请日：2015-08-26
Applicant: PACIFIC BIOSCIENCES CALIFORNIA INC
Inventor： GROT ANNETTE , SAXENA RAVI , LUNDQUIST PAUL
Abstract: Arrays of integrated analytical devices and their methods for production are provided. The arrays are useful in the analysis of highly multiplexed optical reactions in large numbers at high densities, including biochemical reactions, such as nucleic acid sequencing reactions. The devices allow the highly sensitive discrimination of optical signals using features such as spectra, amplitude, and time resolution, or combinations thereof. The devices include an integrated diffractive beam shaping element that provides for the spatial separation of light emitted from the optical reactions.
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公开(公告)号：AU2015306603A1
公开(公告)日：2017-04-13
申请号：AU2015306603
申请日：2015-08-26
Applicant: PACIFIC BIOSCIENCES CALIFORNIA INC
Inventor： GROT ANNETTE , SAXENA RAVI , LUNDQUIST PAUL
Abstract: Arrays of integrated analytical devices and their methods for production are provided. The arrays are useful in the analysis of highly multiplexed optical reactions in large numbers at high densities, including biochemical reactions, such as nucleic acid sequencing reactions. The devices allow the highly sensitive discrimination of optical signals using features such as spectra, amplitude, and time resolution, or combinations thereof. The devices include an integrated diffractive beam shaping element that provides for the spatial separation of light emitted from the optical reactions.
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