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公开(公告)号：ES2376424T3
公开(公告)日：2012-03-13
申请号：ES10155834
申请日：2006-12-28
Applicant: PHARMACYCLICS INC
Inventor： HONIGBERG LEE , VERNER ERIK , PAN ZHENGYING
IPC: A01N43/90 , A61K31/519 , A61P35/00 , C07D487/04
Abstract: Un compuesto de fórmula (D) que tiene la estructura: en la que: La es CH2, O, NH o S; Ar es un arilo sustituido o no sustituido, o un heteroarilo sustituido o no sustituido; Y es un grupo opcionalmente sustituido seleccionado de entre alquilo, heteroalquilo, cicloalquilo, heterocicloalquilo, arilo y heteroarilo; Z es C(=O), OC(=O), NHC(=O), C(=S), S(=O)x, OS(=O)x, NHS(=O)x, donde x es 1 o 2; R es H o alquilo C1-C6; y R7 y R8 son H o tomados conjuntamente forman un enlace; R6 es H, o una sal farmacéuticamente aceptable del mismo.
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公开(公告)号：CA2681756A1
公开(公告)日：2008-10-09
申请号：CA2681756
申请日：2008-03-27
Applicant: PHARMACYCLICS INC
Inventor： HONIGBERG LEE , CHEN WEI , VERNER ERIK , LOURY DAVID , BUGGY JOSEPH J
IPC: A61K31/52 , A61K31/519 , A61P29/00 , A61P35/00 , C07D253/06
Abstract: Described herein are irreversible kinase inhibitor compounds, methods for synthesizing such irreversible inhibitors, and methods for using such irrev ersible inhibitors in the treatment of diseases. Further described herein ar e methods, assays and systems for determining an appropriate irreversible in hibitor of a protein, including a kinase.
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公开(公告)号：AU2008232762A1
公开(公告)日：2008-10-09
申请号：AU2008232762
申请日：2008-03-27
Applicant: PHARMACYCLICS INC
Inventor： HONIGBERG LEE , CHEN WEI , VERNER ERIK , LOURY DAVID , BUGGY JOSEPH J
IPC: A61K31/519 , A61K31/52 , A61P29/00 , A61P35/00 , C07D253/06 , C07D473/34 , C07D487/04
Abstract: (R)-1-(3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one for use in treating a B-cell proliferative cancer.
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公开(公告)号：CA2847852A1
公开(公告)日：2008-04-03
申请号：CA2847852
申请日：2006-12-28
Applicant: PHARMACYCLICS INC
Inventor： HONIGBERG LEE , VERNER ERIK , PAN ZHENGYING
IPC: C07D487/04 , A61K31/519 , A61P29/00 , A61P35/00 , A61P37/06 , C12N9/12
Abstract: Disclosed herein are compounds that form covalent bonds with Bruton's tyrosine kinase (Btk). Also described are irreversible inhibitors of Btk. Methods for the preparation of the compounds are disclosed. Also disclosed are pharmaceutical compositions that include the compounds. Methods of using the Btk inhibitors are disclosed, alone or in combination with other therapeutic agents, for the treatment of autoimmune diseases or conditions, heteroimmune diseases or conditions, cancer, including lymphoma, and inflammatory diseases or conditions.
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公开(公告)号：HUE025459T2
公开(公告)日：2016-05-30
申请号：HUE12166301
申请日：2006-12-28
Applicant: PHARMACYCLICS INC
Inventor： HONIGBERG LEE , VERNER ERIK , PAN ZHENGYING , MODY TARAK
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Patent Agency Ranking
公开(公告)号：PT2526933E
公开(公告)日：2015-06-23
申请号：PT12166301
申请日：2006-12-28
Applicant: PHARMACYCLICS INC
Inventor： HONIGBERG LEE , VERNER ERIK
IPC: A61K31/00 , A61K31/519 , A61P35/00 , A61P35/02 , C07D487/04
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公开(公告)号：AU2013245503A1
公开(公告)日：2013-11-07
申请号：AU2013245503
申请日：2013-10-17
Applicant: PHARMACYCLICS INC
Inventor： LOURY DAVID , VERNER ERIK , CHEN WEI , HONIGBERG LEE , BUGGY JOSEPH
Abstract: Inhibitors of Bruton's Tyrosine Kinase for the Treatment of Solid Tumors Described herein are irreversible Btk inhibitor compounds, and methods for using such irreversible inhibitors in the treatment of diseases and disorders characterized by the presence or development of solid tumors.
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公开(公告)号：HK1178144A1
公开(公告)日：2013-09-06
申请号：HK13104973
申请日：2013-04-24
Applicant: PHARMACYCLICS INC
Inventor： HONIGBERG LEE , VERNER ERLK , PAN ZHENGYING
IPC: C07D20060101
Abstract: Disclosed herein are compounds that form covalent bonds with Bruton's tyrosine kinase (Btk). Also described are irreversible inhibitors of Btk. Methods for the preparation of the compounds are disclosed. Also disclosed are pharmaceutical compositions that include the compounds. Methods of using the Btk inhibitors are disclosed, alone or in combination with other therapeutic agents, for the treatment of autoimmune diseases or conditions, heteroimmune diseases or conditions, cancer, including lymphoma, and inflammatory diseases or conditions.
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公开(公告)号：ZA201207075B
公开(公告)日：2013-06-26
申请号：ZA201207075
申请日：2012-09-20
Applicant: PHARMACYCLICS INC
Inventor： HONIGBERG LEE , PAN ZHENGYING , VERNER ERIK
IPC: A61K20060101 , A01N20060101 , A61P20060101
Abstract: Disclosed herein are compounds that form covalent bonds with Bruton's tyrosine kinase (Btk). Also described are irreversible inhibitors of Btk. Methods for the preparation of the compounds are disclosed. Also disclosed are pharmaceutical compositions that include the compounds. Methods of using the Btk inhibitors are disclosed, alone or in combination with other therapeutic agents, for the treatment of autoimmune diseases or conditions, heteroimmune diseases or conditions, cancer, including lymphoma, and inflammatory diseases or conditions.
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公开(公告)号：ZA201100893B
公开(公告)日：2013-03-27
申请号：ZA201100893
申请日：2011-02-03
Applicant: PHARMACYCLICS INC
Inventor： HONIGBERG LEE , PAN ZHENGYING , VERNER ERIK
IPC: A61K20060101 , A01N20060101 , A61P20060101
Abstract: Disclosed herein are compounds that form covalent bonds with Bruton's tyrosine kinase (Btk). Also described are irreversible inhibitors of Btk. Methods for the preparation of the compounds are disclosed. Also disclosed are pharmaceutical compositions that include the compounds. Methods of using the Btk inhibitors are disclosed, alone or in combination with other therapeutic agents, for the treatment of autoimmune diseases or conditions, heteroimmune diseases or conditions, cancer, including lymphoma, and inflammatory diseases or conditions.
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