公开(公告)号：AU760456B2

公开(公告)日：2003-05-15

申请号：AU4376299

申请日：1999-06-29

Applicant: SERVIER LAB

Inventor： CASARA PATRICK ,  CHOLLET ANNE-MARIE ,  DIGUARHER THIERRY LE ,  ATASSI GHANEM ,  BONNET JACQUELINE ,  PIERRE ALAIN ,  SABATINI MASSIMO ,  TUCKER GORDON ,  GUILBAUD NICOLAS

IPC: C07D253/04 ,  A61K31/18 ,  A61K31/197 ,  A61K31/403 ,  A61K31/4035 ,  A61K31/425 ,  A61K31/426 ,  A61K31/428 ,  A61K31/517 ,  A61K31/53 ,  A61K31/535 ,  A61K31/536 ,  A61K31/537 ,  A61P19/02 ,  A61P29/00 ,  A61P35/00 ,  A61P35/04 ,  A61P43/00 ,  C07C233/82 ,  C07C233/83 ,  C07C259/10 ,  C07C311/29 ,  C07D209/48 ,  C07D209/66 ,  C07D231/22 ,  C07D233/72 ,  C07D233/74 ,  C07D237/32 ,  C07D239/96 ,  C07D253/08 ,  C07D265/06 ,  C07D265/16 ,  C07D275/04 ,  C07D275/06 ,  C07D277/20 ,  C07D277/34 ,  C07D401/12 ,  C07D403/12 ,  C07D409/12 ,  C07D471/04 ,  A61K31/40 ,  C07D209/46 ,  C07D221/14 ,  C07D263/44 ,  C07D265/26

公开(公告)号：AT239021T

公开(公告)日：2003-05-15

申请号：AT00401864

申请日：2000-06-30

Applicant: SERVIER LAB

Inventor： DE NANTEUIL GUILLAUME ,  BENOIST ALAIN ,  BONNET JACQUELINE ,  SABATINI MASSIMO ,  ATASSI GHANEM ,  PIERRE ALAIN

IPC: C07D307/77 ,  A61K31/4355 ,  A61K31/4406 ,  A61K31/4409 ,  A61K31/4453 ,  A61K31/506 ,  A61K31/5377 ,  A61P9/10 ,  A61P19/02 ,  A61P29/00 ,  A61P35/00 ,  A61P43/00 ,  C07D491/04 ,  C07D491/048 ,  C07D307/00 ,  C07D221/00

Abstract: N-Arylsulfonyl tetrahydrofuropyridine carboxylic acid derivatives (I), their isomers and acid and base addition salts, their preparation and compositions containing them. N-Arylsulfonyl tetrahydrofuropyridine carboxylic acid derivatives of formula (I), their isomers and acid and base addition salts, their preparation and compositions containing them: R1 = H, halogen, 1-6C alkyl or alkoxy; R2 = OH, 1-6C alkoxy, or NHOH; Ar1 = phenylene or biphenylene; X = O, S, NR, -OC- or a bond; R = H, or 1-6C alkyl; n = 0-6; Ar2 = phenyl substituted by heteroaryl, biphenyl substituted by heteroaryl, pyridinyl substituted by heteroaryl, or a heterocycle

公开(公告)号：NO20016177L

公开(公告)日：2002-06-24

申请号：NO20016177

申请日：2001-12-18

Applicant: SERVIER LAB

Inventor： NANTEUIL GUILLAUME DE ,  BENOIST ALAIN ,  PASTOUREAU PHILIPPE ,  SABATINI MASSIMO ,  HICKMAN JOHN ,  PIERRE ALAIN ,  TUCKER GORDON

IPC: C07D491/048 ,  A61K31/4433 ,  A61K31/444 ,  A61K31/541 ,  A61P9/10 ,  A61P19/02 ,  A61P29/00 ,  A61P35/00 ,  A61P43/00 ,  C07D405/14 ,  C07D417/14 ,  C07D491/04 ,  C07D411/04 ,  C07D413/04 ,  A61K31/44

Abstract: 5-Sulfonyl-2-(4-pyridinyl)-benzofuran, benzothiophene or indole derivatives (I), containing a hydroxamic acid function, are new. Benzofuran, benzothiophene or indole derivatives of formula (I) and their isomers, N-oxides and acid or base addition salts are new. R1 = H, halo, 1-6C alkyl or 1-6C alkoxy; X = O, S or NR; R = H or 1-6C alkyl; A = N-hydroxy-carboxamido-substituted tetrahydrofuropyridine, thiomorpholine or tetrahydropyranylmethyl group of formula (i)-(iii); Ra = H, halo, 1-6C alkyl or 1-6C alkoxy; Rb, Rc = H or 1-6C alkyl; and n = 0-2. An Independent claim is also included for the preparation of (I).

公开(公告)号：NO20016177A

公开(公告)日：2002-06-24

申请号：NO20016177

申请日：2001-12-18

Applicant: SERVIER LAB

Inventor： NANTEUIL GUILLAUME DE ,  BENOIST ALAIN ,  PASTOUREAU PHILIPPE ,  SABATINI MASSIMO ,  HICKMAN JOHN ,  PIERRE ALAIN ,  TUCKER GORDON

IPC: C07D491/048 ,  A61K31/4433 ,  A61K31/444 ,  A61K31/541 ,  A61P9/10 ,  A61P19/02 ,  A61P29/00 ,  A61P35/00 ,  A61P43/00 ,  C07D405/14 ,  C07D417/14 ,  C07D491/04 ,  C07D411/04 ,  A61K31/44 ,  C07D413/04

CPC classification number: C07D417/14 ,  C07D405/14 ,  C07D491/04

公开(公告)号：NO311723B1

公开(公告)日：2002-01-14

申请号：NO985239

申请日：1998-11-10

Applicant: SERVIER LAB

Inventor： NANTEUIL GUILLAUME DE ,  REMOND GEORGES ,  PALADINO JOSEPH ,  ATASSI GHANEM ,  PIERRE ALAIN ,  TUCKER GORDON ,  BONNET JACQUELINE ,  SABATINI MASSIMO

IPC: A61K31/00 ,  A61K31/435 ,  A61K31/4353 ,  A61K31/437 ,  A61P9/00 ,  A61P9/10 ,  A61P29/00 ,  A61P35/00 ,  A61P43/00 ,  C07D471/04 ,  A61K31/44

Abstract: Tetrahydro carboline derivatives of formula (I) and their preparation from D-tryptophan derivatives. Tetrahydrocarboline derivatives of formula (I) their isomers and their salts m = 1, 2,3, or 4; n and p = 0, 1, 2, 3, or 4; X = O, S, or a simple bond; R1 = H, halogen, 1-6C alkyl or trihaloalkyl, OH, 1-6C alkoxy or trihaloalkoxy; R2, R3, and R4 = H or 1-6C alkyl; R5 = H, halogen,1-6C alkoxy, aryloxy or heteroaryloxy; R6, R7, and R8 = H, 1-6C alkyl, or R6 with N and R7 or R8 form a heterocycle; R9 = -SO3H, -COOR10, -CO-NR11R12, or -NR13R14; R10 = H or 1-6C alkyl; R11 and R12 = H or 1-6C alkyl or form an optionally substituted heterocycle with the N atom; R13 and R14 = H or 1-6C alkyl or form an optionally substituted heterocycle with the N atom

公开(公告)号：AU4376299A

公开(公告)日：2000-01-17

申请号：AU4376299

申请日：1999-06-29

Applicant: SERVIER LAB

Inventor： CASARA PATRICK ,  CHOLLET ANNE-MARIE ,  DIGUARHER THIERRY LE ,  ATASSI GHANEM ,  BONNET JACQUELINE ,  PIERRE ALAIN ,  SABATINI MASSIMO ,  TUCKER GORDON ,  GUILBAUD NICOLAS

IPC: C07D253/04 ,  A61K31/18 ,  A61K31/197 ,  A61K31/403 ,  A61K31/4035 ,  A61K31/425 ,  A61K31/426 ,  A61K31/428 ,  A61K31/517 ,  A61K31/53 ,  A61K31/535 ,  A61K31/536 ,  A61K31/537 ,  A61P19/02 ,  A61P29/00 ,  A61P35/00 ,  A61P35/04 ,  A61P43/00 ,  C07C233/82 ,  C07C233/83 ,  C07C259/10 ,  C07C311/29 ,  C07D209/48 ,  C07D209/66 ,  C07D231/22 ,  C07D233/72 ,  C07D233/74 ,  C07D237/32 ,  C07D239/96 ,  C07D253/08 ,  C07D265/06 ,  C07D265/16 ,  C07D275/04 ,  C07D275/06 ,  C07D277/20 ,  C07D277/34 ,  C07D401/12 ,  C07D403/12 ,  C07D409/12 ,  C07D471/04 ,  A61K31/40 ,  C07D209/46 ,  C07D221/14 ,  C07D263/44 ,  C07D265/26

公开(公告)号：AU9237798A

公开(公告)日：1999-06-03

申请号：AU9237798

申请日：1998-11-13

Applicant: SERVIER LAB

Inventor： NANTEUIL GUILLAUME DE ,  REMOND GEORGES ,  PALADINO JOSEPH ,  ATASSI GHANEM ,  PIERRE ALAIN ,  TUCKER GORDON ,  BONNET JACQUELINE ,  SABATINI MASSIMO

IPC: A61K31/00 ,  A61K31/435 ,  A61K31/4353 ,  A61K31/437 ,  A61P9/00 ,  A61P9/10 ,  A61P29/00 ,  A61P35/00 ,  A61P43/00 ,  C07D471/04 ,  A61K31/495

Abstract: Tetrahydro carboline derivatives of formula (I) and their preparation from D-tryptophan derivatives. Tetrahydrocarboline derivatives of formula (I) their isomers and their salts m = 1, 2,3, or 4; n and p = 0, 1, 2, 3, or 4; X = O, S, or a simple bond; R1 = H, halogen, 1-6C alkyl or trihaloalkyl, OH, 1-6C alkoxy or trihaloalkoxy; R2, R3, and R4 = H or 1-6C alkyl; R5 = H, halogen,1-6C alkoxy, aryloxy or heteroaryloxy; R6, R7, and R8 = H, 1-6C alkyl, or R6 with N and R7 or R8 form a heterocycle; R9 = -SO3H, -COOR10, -CO-NR11R12, or -NR13R14; R10 = H or 1-6C alkyl; R11 and R12 = H or 1-6C alkyl or form an optionally substituted heterocycle with the N atom; R13 and R14 = H or 1-6C alkyl or form an optionally substituted heterocycle with the N atom

公开(公告)号：AU4861693A

公开(公告)日：1994-04-14

申请号：AU4861693

申请日：1993-09-28

Applicant: SERVIER LAB

Inventor： BAUT GUILLAUME LE ,  POISSONNET GUILLAUME ,  MONTARBY LUCY DE ,  BELACHMI LARBI ,  BONNET JACQUELINE ,  SABATINI MASSIMO ,  TORDJMAN CHARLES

IPC: A61K31/35 ,  A61K31/352 ,  A61K31/66 ,  A61P3/00 ,  A61P19/10 ,  A61P29/00 ,  A61P43/00 ,  C07D311/12 ,  C07D311/14 ,  C07D311/16 ,  C07D311/18 ,  C07D311/58 ,  C07D311/64 ,  C07D311/70 ,  C07D311/72 ,  C07D405/04 ,  C07D409/04 ,  C07F9/655 ,  C07D405/10 ,  C07D409/10 ,  C07F9/40

公开(公告)号：NO321490B1

公开(公告)日：2006-05-15

申请号：NO20016177

申请日：2001-12-18

Applicant: SERVIER LAB

Inventor： NANTEUIL GUILLAUME DE ,  PIERRE ALAIN ,  PASTOUREAU PHILIPPE ,  TUCKER GORDON ,  SABATINI MASSIMO ,  BENOIST ALAIN ,  HICKMAN JOHN

IPC: C07D491/04 ,  C07D491/048 ,  A61K31/4433 ,  A61K31/444 ,  A61K31/541 ,  A61P9/10 ,  A61P19/02 ,  A61P29/00 ,  A61P35/00 ,  A61P43/00 ,  C07D405/14 ,  C07D417/14

Abstract: 5-Sulfonyl-2-(4-pyridinyl)-benzofuran, benzothiophene or indole derivatives (I), containing a hydroxamic acid function, are new. Benzofuran, benzothiophene or indole derivatives of formula (I) and their isomers, N-oxides and acid or base addition salts are new. R1 = H, halo, 1-6C alkyl or 1-6C alkoxy; X = O, S or NR; R = H or 1-6C alkyl; A = N-hydroxy-carboxamido-substituted tetrahydrofuropyridine, thiomorpholine or tetrahydropyranylmethyl group of formula (i)-(iii); Ra = H, halo, 1-6C alkyl or 1-6C alkoxy; Rb, Rc = H or 1-6C alkyl; and n = 0-2. An Independent claim is also included for the preparation of (I).

公开(公告)号：DK1217002T3

公开(公告)日：2005-01-24

申请号：DK01403333

申请日：2001-12-21

Applicant: SERVIER LAB

Inventor： DE NANTEUIL GUILLAUME ,  HICKMAN JOHN ,  PIERRE ALAIN ,  BENOIST ALAIN ,  PASTOUREAU PHILIPPE ,  SABATINI MASSIMO ,  TUCKER GORDON

IPC: C07D491/048 ,  A61K31/4433 ,  A61K31/444 ,  A61K31/541 ,  A61P9/10 ,  A61P19/02 ,  A61P29/00 ,  A61P35/00 ,  A61P43/00 ,  C07D405/14 ,  C07D417/14 ,  C07D491/04

Abstract: 5-Sulfonyl-2-(4-pyridinyl)-benzofuran, benzothiophene or indole derivatives (I), containing a hydroxamic acid function, are new. Benzofuran, benzothiophene or indole derivatives of formula (I) and their isomers, N-oxides and acid or base addition salts are new. R1 = H, halo, 1-6C alkyl or 1-6C alkoxy; X = O, S or NR; R = H or 1-6C alkyl; A = N-hydroxy-carboxamido-substituted tetrahydrofuropyridine, thiomorpholine or tetrahydropyranylmethyl group of formula (i)-(iii); Ra = H, halo, 1-6C alkyl or 1-6C alkoxy; Rb, Rc = H or 1-6C alkyl; and n = 0-2. An Independent claim is also included for the preparation of (I).