公开(公告)号：BRPI0414744A

公开(公告)日：2006-11-21

申请号：BRPI0414744

申请日：2004-09-23

Applicant: SOLVAY PHARM GMBH

Inventor： HOELTJE DAGMAR ,  FISCHER YVAN ,  ZIEGLER DIETER ,  WESKE MICHAEL ,  MICHAELIS KATHRIN ,  KARIMI-NEJAD YASMIN ,  MESSINGER JOSEF ,  PAHL AXEL ,  HOEFER CONSTANZE ,  IKONOMIDOU HRISSANTHI ,  TURSKI LECHOSLAW

IPC: A61K38/00 ,  A61P9/12 ,  C07K5/02 ,  C07K5/078 ,  C07K5/06 ,  A61K38/05

Abstract: Described are novel compounds with neutral endopeptidase (NEP) and/or human soluble endopeptidase (hSEP) inhibitory activity of the general formula (I), wherein the substituents R , R , R and R have the meanings given in the description and also medicaments containing these compounds, in particular medicaments suitable for treating or preventing cardiovascular diseases, sexual dysfunction and/or adverse conditions associated with apoptosis.

公开(公告)号：AU2006234295A1

公开(公告)日：2006-10-19

申请号：AU2006234295

申请日：2006-04-11

Applicant: SOLVAY PHARM GMBH

Inventor： WESKE MICHAEL ,  MOLONEY BRIAN ,  FISCHER YVAN ,  MLINARIC MICHAEL ,  WITTE KLAUS ,  ZIEGLER DIETER ,  MARRISON LESTER ,  BRUECKNER REINHARD ,  BOECKER CHRISTIANE

IPC: C07D311/68 ,  A61K31/353 ,  A61K31/4025 ,  A61K31/453 ,  A61K31/497 ,  A61K31/5355 ,  A61P9/00 ,  C07D405/12 ,  C07D413/12

Abstract: Cardiovascular active compounds of the general formula (I), wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , R 9 , R 10 and n have the meanings given in the description, and also a process for the preparation of these compounds and intermediate products of this process are described. Furthermore, pharmaceutical compositions comprising the compounds of Formula (I) are specified.

公开(公告)号：DE112004001659D2

公开(公告)日：2006-08-10

申请号：DE112004001659

申请日：2004-10-14

Applicant: SOLVAY PHARM GMBH

Inventor： SYKES DAVID ,  MOLONEY BRIAN ,  MARRISON LESTER ,  ZIEGLER DIETER ,  MLINARIC MICHAEL ,  BOECKER CHRISTIANE ,  BRUECKNER REINHARD ,  WESKE MICHAEL ,  WITTE KLAUS ,  FISCHER YVAN

IPC: C07D311/68 ,  A61K31/352 ,  A61K31/353 ,  A61P9/00 ,  A61P29/00 ,  A61P37/02 ,  C07D407/12

Abstract: The invention relates to compounds of general formula (I), wherein the meaning of R 1 , R 2 , R 3 , R 4 , R 5 and R 6 is given in a description, to a method for producing said compounds and to intermediate products thereof. Drugs containing the inventive compounds of formula (1) are also disclosed.

公开(公告)号：DE10348298A1

公开(公告)日：2005-05-19

申请号：DE10348298

申请日：2003-10-17

Applicant: SOLVAY PHARM GMBH

Inventor： SYKES DAVID ,  MOLONEY BRIAN ,  MARRISON LESTER ,  ZIEGLER DIETER ,  MLINARIC MICHAEL ,  BOECKER CHRISTIANE ,  BRUECKNER REINHARD ,  WESKE MICHAEL ,  WITTE KLAUS ,  FISCHER YVAN

IPC: A61K31/353 ,  C07D311/68 ,  C07D407/12 ,  A61K31/352

Abstract: The invention relates to compounds of general formula (I), wherein the meaning of R 1 , R 2 , R 3 , R 4 , R 5 and R 6 is given in a description, to a method for producing said compounds and to intermediate products thereof. Drugs containing the inventive compounds of formula (1) are also disclosed.

公开(公告)号：AU2004281195A2

公开(公告)日：2005-04-28

申请号：AU2004281195

申请日：2004-10-14

Applicant: SOLVAY PHARM GMBH

Inventor： MOLONEY BRIAN ,  WESKE MICHAEL ,  SYKES DAVID ,  FISCHER YVAN ,  MLINARIC MICHAEL ,  BOECKER CHRISTIANE ,  BRUECKNER REINHARD ,  WITTE KLAUS ,  MARRISON LESTER ,  ZIEGLER DIETER

IPC: A61K31/353 ,  C07D311/68 ,  C07D407/12

Abstract: The invention relates to compounds of general formula (I), wherein the meaning of R 1 , R 2 , R 3 , R 4 , R 5 and R 6 is given in a description, to a method for producing said compounds and to intermediate products thereof. Drugs containing the inventive compounds of formula (1) are also disclosed.

公开(公告)号：BR0209855A

公开(公告)日：2004-06-15

申请号：BR0209855

申请日：2002-05-14

Applicant: SOLVAY PHARM GMBH

Inventor： BERGER CLAUDIA ,  FISCHER YVAN ,  HOELTJE DAGMAR ,  WALDECK HARALD ,  WESKE MICHAEL ,  ZIEGLER DIETER

IPC: C12N15/09 ,  A61K31/00 ,  A61K31/444 ,  A61K31/55 ,  A61K31/675 ,  A61K45/00 ,  A61P9/00 ,  A61P9/04 ,  A61P9/06 ,  A61P9/08 ,  A61P9/10 ,  A61P9/12 ,  A61P11/00 ,  A61P11/06 ,  A61P13/12 ,  A61P25/04 ,  A61P35/00 ,  A61P43/00 ,  C07D223/16

公开(公告)号：PL201165B1

公开(公告)日：2009-03-31

申请号：PL36351801

申请日：2001-07-12

Applicant: SOLVAY PHARM GMBH

Inventor： HEBEBRAND JOHANNES ,  ANTEL JOCHEN ,  PREUSCHOFF ULF ,  DAVID SAMUEL ,  SANN HOLGER ,  WESKE MICHAEL

IPC: A61P3/04 ,  G01N33/50 ,  A61K45/00 ,  A61P1/00 ,  C12Q1/02 ,  C12Q1/527 ,  G01N33/15

公开(公告)号：HK1117538A1

公开(公告)日：2009-01-16

申请号：HK08108101

申请日：2008-07-23

Applicant: SOLVAY PHARM GMBH

Inventor： MESSINGER JOSEF ,  HEINRICH-HUBERT THOLE H ,  HUSEN BETTINA ,  KOSKIMIES PASI ,  PIRKKALA LILA ,  WESKE MICHAEL

IPC: A61K20060101 ,  A61P20060101 ,  C07J20060101

Abstract: The present invention relates to novel substituted steroid derivatives which represent selectiv inhibitors of the 17ß-hydroxysteroid dehydrogenase type I (17ß-HSD1) and, in addition, which may represent inhibitors of the steroid sulphatase, as well as to their salts, to pharmaceutical preparations containing these compounds and to processes for the preparation of these compounds. Furthermore, the invention concerns the therapeutic use of said novel substituted steroid derivatives, particularly their use in the treatment or prevention of steroid hormone dependent diseases or disorders, such as steroid hormone dependent diseases or disorders requiring the inhibition of 17ß-hydroxysteroid dehydrogenase type I and/or steroid sulphatase enzymes and/or requiring the lowering of the endogenous 17ß-estradiol concentration.

公开(公告)号：HK1116167A1

公开(公告)日：2008-12-19

申请号：HK08105447

申请日：2008-05-16

Applicant: SOLVAY PHARM GMBH

Inventor： MOLONEY BRIAN ,  MARRISON LESTER ,  ZIEGLER DIETER ,  MLINARIC MICHAEL ,  BOECKER CHRISTIANE ,  WESKE MICHAEL ,  WITTE KLAUS ,  FISCHER YVAN ,  BRUECKNER REINHARD

IPC: A61K20060101 ,  A61P20060101 ,  C07D20060101

Abstract: Cardiovascular active compounds of the general formula (I), wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , R 9 , R 10 and n have the meanings given in the description, and also a process for the preparation of these compounds and intermediate products of this process are described. Furthermore, pharmaceutical compositions comprising the compounds of Formula (I) are specified.

公开(公告)号：AT405547T

公开(公告)日：2008-09-15

申请号：AT04817204

申请日：2004-10-14

Applicant: SOLVAY PHARM GMBH

Inventor： SYKES DAVID ,  MOLONEY BRIAN ,  MARRISON LESTER ,  ZIEGLER DIETER ,  MLINARIC MICHAEL ,  BOECKER CHRISTIANE ,  BRUECKNER REINHARD ,  WESKE MICHAEL ,  WITTE KLAUS ,  FISCHER YVAN

IPC: C07D201/00 ,  A61K31/353 ,  C07D311/68 ,  C07D407/12

Abstract: The invention relates to compounds of general formula (I), wherein the meaning of R 1 , R 2 , R 3 , R 4 , R 5 and R 6 is given in a description, to a method for producing said compounds and to intermediate products thereof. Drugs containing the inventive compounds of formula (1) are also disclosed.