公开(公告)号：DE69927720T2

公开(公告)日：2006-05-04

申请号：DE69927720

申请日：1999-08-12

Applicant: SYMYX TECHNOLOGIES INC

Inventor： TURNER HOWARD ,  DALES G CAMERON ,  VAN ERDEN LYNN ,  VAN BEEK JOHANNES A M ,  HAJDUK DAMIAN A ,  NIELSEN RALPH B ,  MANSKY PAUL ,  MATSIEV LEONID ,  WANG PEI ,  MCFARLAND ERIC

IPC: B01J19/00 ,  B01J19/18 ,  B01F13/06 ,  B01F13/08 ,  B01F15/00 ,  B01J19/26 ,  B01L3/00 ,  B01L7/00 ,  C40B40/14 ,  C40B40/18 ,  F28F27/00 ,  G01K13/00 ,  G01N21/25 ,  G01N35/10 ,  G05B23/02 ,  G05D21/00

Abstract: An apparatus and method for carrying out and monitoring the progress and properties of multiple reactions is disclosed. The method and apparatus are especially useful for synthesizing, screening, and characterizing combinatorial libraries, but also offer significant advantages over conventional experimental reactors as well. The apparatus generally includes multiple vessels for containing reaction mixtures, and systems for controlling the stirring rate and temperature of individual reaction mixtures or groups of reaction mixtures. In addition, the apparatus may include provisions for independently controlling pressure in each vessel, and a system for injecting liquids into the vessels at a pressure different than ambient pressure. In situ monitoring of individual reaction mixtures provides feedback for process controllers, and also provides data for determining reaction rates, product yields, and various properties of the reaction products, including viscosity and molecular weight.

公开(公告)号：AT306316T

公开(公告)日：2005-10-15

申请号：AT01116401

申请日：1999-08-12

Applicant: SYMYX TECHNOLOGIES INC

Inventor： TURNER HOWARD ,  DALES G CAMERON ,  VAN ERDEN LYNN ,  VAN BEEK JOHANNES A M ,  HAJDUK DAMIAN A ,  NIELSEN RALPH B ,  MANSKY PAUL ,  MATSIEV LEONID ,  WANG PEI ,  MCFARLAND ERIC

IPC: B01J19/18 ,  B01F13/06 ,  B01F13/08 ,  B01F15/00 ,  B01J19/00 ,  B01J19/26 ,  B01L3/00 ,  B01L7/00 ,  C40B40/14 ,  C40B40/18 ,  F28F27/00 ,  G01K13/00 ,  G01N21/25 ,  G01N35/10 ,  G05B23/02 ,  G05D21/00

Abstract: An apparatus and method for carrying out and monitoring the progress and properties of multiple reactions is disclosed. The method and apparatus are especially useful for synthesizing, screening, and characterizing combinatorial libraries, but also offer significant advantages over conventional experimental reactors as well. The apparatus generally includes multiple vessels for containing reaction mixtures, and systems for controlling the stirring rate and temperature of individual reaction mixtures or groups of reaction mixtures. In addition, the apparatus may include provisions for independently controlling pressure in each vessel, and a system for injecting liquids into the vessels at a pressure different than ambient pressure. In situ monitoring of individual reaction mixtures provides feedback for process controllers, and also provides data for determining reaction rates, product yields, and various properties of the reaction products, including viscosity and molecular weight.

公开(公告)号：DE69921367D1

公开(公告)日：2004-11-25

申请号：DE69921367

申请日：1999-08-12

Applicant: SYMYX TECHNOLOGIES INC

Inventor： TURNER HOWARD ,  DALES G CAMERON ,  VAN ERDEN LYNN ,  VAN BEEK JOHANNES A M ,  HAJDUK DAMIAN A ,  NIELSEN RALPH B ,  MANSKY PAUL ,  MATSIEV LEONID ,  WANG PEI ,  MCFARLAND ERIC

IPC: B01J19/18 ,  B01F13/06 ,  B01F13/08 ,  B01F15/00 ,  B01J19/00 ,  B01J19/26 ,  B01L3/00 ,  B01L7/00 ,  C40B40/14 ,  C40B40/18 ,  F28F27/00 ,  G01K13/00 ,  G01N21/25 ,  G01N35/10 ,  G05B23/02 ,  G05D21/00 ,  B01F7/16

Abstract: An apparatus and method for carrying out and monitoring the progress and properties of multiple reactions is disclosed. The method and apparatus are especially useful for synthesizing, screening, and characterizing combinatorial libraries, but also offer significant advantages over conventional experimental reactors as well. The apparatus generally includes multiple vessels for containing reaction mixtures, and systems for controlling the stirring rate and temperature of individual reaction mixtures or groups of reaction mixtures. In addition, the apparatus may include provisions for independently controlling pressure in each vessel, and a system for injecting liquids into the vessels at a pressure different than ambient pressure. In situ monitoring of individual reaction mixtures provides feedback for process controllers, and also provides data for determining reaction rates, product yields, and various properties of the reaction products, including viscosity and molecular weight.

公开(公告)号：CA2381014C

公开(公告)日：2003-07-08

申请号：CA2381014

申请日：1999-08-12

Applicant: SYMYX TECHNOLOGIES INC

Inventor： MATSIEV LEONID ,  TURNER HOWARD ,  DALES G CAMERON ,  WANG PEI ,  VAN ERDEN LYNN ,  MANSKY PAUL ,  MCFARLAND ERIC ,  NIELSEN RALPH B ,  HAJDUK DAMIAN A ,  VAN BEEK JOHANNES A M

IPC: B01J19/00 ,  B01J19/18 ,  G01N31/00 ,  G01N33/00 ,  G05B19/042 ,  G05D23/19

Abstract: Devices and methods for controlling and monitoring the progress and properties of multiple reactions are disclosed. The method and apparatus are especially useful for synthesizing, screening, and characterizing combinatorial libraries, but also offer significant advantages over conventional experimental reactors as well. The apparatus generally includes multiple vessels for containing reaction mixtures, and systems for controlling the stirring rate and temperature of individual reaction mixtures or groups of reaction mixtures. In addition, the apparatus may include provisions for independently controlling pressure in each vessel, and a system for injecting liquids into the vessels at a pressure different than ambient pressure. In situ monitoring of individual reaction mixtures provides feedback for process controllers, and also provides data for determining reaction rates, product yields, and various properties of the reaction products, including viscosity and molecular weight. Computer-based methods are disclosed for process monitoring and control, and for data display and analysis.

公开(公告)号：AT241427T

公开(公告)日：2003-06-15

申请号：AT99942147

申请日：1999-08-12

Applicant: SYMYX TECHNOLOGIES INC

Inventor： TURNER HOWARD ,  DALES G CAMERON ,  VAN ERDEN LYNN ,  VAN BEEK JOHANNES A M ,  HAJDUK DAMIAN A ,  NIELSEN RALPH B ,  MANSKY PAUL ,  MATSIEV LEONID ,  WANG PEI ,  MCFARLAND ERIC

IPC: B01J19/18 ,  B01F13/06 ,  B01F13/08 ,  B01F15/00 ,  B01J19/00 ,  B01J19/26 ,  B01L3/00 ,  B01L7/00 ,  C40B40/14 ,  C40B40/18 ,  F28F27/00 ,  G01K13/00 ,  G01N21/25 ,  G01N35/10 ,  G05B23/02 ,  G05D21/00

Abstract: An apparatus and method for carrying out and monitoring the progress and properties of multiple reactions is disclosed. The method and apparatus are especially useful for synthesizing, screening, and characterizing combinatorial libraries, but also offer significant advantages over conventional experimental reactors as well. The apparatus generally includes multiple vessels for containing reaction mixtures, and systems for controlling the stirring rate and temperature of individual reaction mixtures or groups of reaction mixtures. In addition, the apparatus may include provisions for independently controlling pressure in each vessel, and a system for injecting liquids into the vessels at a pressure different than ambient pressure. In situ monitoring of individual reaction mixtures provides feedback for process controllers, and also provides data for determining reaction rates, product yields, and various properties of the reaction products, including viscosity and molecular weight.

公开(公告)号：CA2419700A1

公开(公告)日：2000-02-24

申请号：CA2419700

申请日：1999-08-12

Applicant: SYMYX TECHNOLOGIES INC

Inventor： VAN ERDEN LYNN ,  VAN BEEK JOHANNES A M ,  TURNER HOWARD ,  DALES G CAMERON ,  NIELSEN RALPH B ,  HAJDUK DAMIAN A ,  MATSIEV LEONID ,  MANSKY PAUL ,  WANG PEI ,  MCFARLAND ERIC

IPC: B01J19/00 ,  B01J19/18 ,  G01N31/00 ,  G01N33/00 ,  G05B19/042 ,  G05D23/19

公开(公告)号：CA2290394C

公开(公告)日：2006-02-28

申请号：CA2290394

申请日：1999-04-02

Applicant: SYMYX TECHNOLOGIES INC

Inventor： LEE THOMAS S ,  NIELSEN RALPH B ,  FRECHET JEAN M J ,  SAFIR ADAM ,  BENNETT JAMES ,  CARLSON ERIC ,  DALES G CAMERON ,  KUEBLER SIGRID C ,  PETRO MIROSLAV

IPC: G01N30/02 ,  G01N37/00 ,  B01D15/08 ,  B01D15/26 ,  B01D15/32 ,  B01D15/34 ,  B01J19/00 ,  B01J19/26 ,  C40B40/14 ,  C40B40/18 ,  G01N1/00 ,  G01N1/14 ,  G01N15/02 ,  G01N21/53 ,  G01N30/16 ,  G01N30/24 ,  G01N30/30 ,  G01N30/32 ,  G01N30/46 ,  G01N30/54 ,  G01N30/60 ,  G01N30/74 ,  G01N30/88 ,  G01N30/90 ,  G01N33/44 ,  G01N35/08

Abstract: Rapid characterization and screening of polymer samples to determine average molecular weight, molecular weight distribution and other properties is disclosed. Rapid flow characterization systems and methods, including liquid chromatography and flow-injection analysis systems and methods are preferably employed. High throughput, automated sampling systems and methods, high-temperature characterization systems and methods, and rapid, indirect calibration compositions and methods are also disclosed. The described methods, systems, and devices have primary applications in combinatorial polymer research and in industrial process control.

公开(公告)号：DE69927720D1

公开(公告)日：2006-02-23

申请号：DE69927720

申请日：1999-08-12

Applicant: SYMYX TECHNOLOGIES INC

Inventor： TURNER HOWARD ,  DALES G CAMERON ,  VAN ERDEN LYNN ,  VAN BEEK JOHANNES A M ,  HAJDUK DAMIAN A ,  NIELSEN RALPH B ,  MANSKY PAUL ,  MATSIEV LEONID ,  WANG PEI ,  MCFARLAND ERIC

IPC: B01J19/18 ,  B01F13/06 ,  B01F13/08 ,  B01F15/00 ,  B01J19/00 ,  B01J19/26 ,  B01L3/00 ,  B01L7/00 ,  C40B40/14 ,  C40B40/18 ,  F28F27/00 ,  G01K13/00 ,  G01N21/25 ,  G01N35/10 ,  G05B23/02 ,  G05D21/00

Abstract: An apparatus and method for carrying out and monitoring the progress and properties of multiple reactions is disclosed. The method and apparatus are especially useful for synthesizing, screening, and characterizing combinatorial libraries, but also offer significant advantages over conventional experimental reactors as well. The apparatus generally includes multiple vessels for containing reaction mixtures, and systems for controlling the stirring rate and temperature of individual reaction mixtures or groups of reaction mixtures. In addition, the apparatus may include provisions for independently controlling pressure in each vessel, and a system for injecting liquids into the vessels at a pressure different than ambient pressure. In situ monitoring of individual reaction mixtures provides feedback for process controllers, and also provides data for determining reaction rates, product yields, and various properties of the reaction products, including viscosity and molecular weight.

公开(公告)号：DE69921197T2

公开(公告)日：2005-02-17

申请号：DE69921197

申请日：1999-08-12

Applicant: SYMYX TECHNOLOGIES INC

Inventor： TURNER HOWARD ,  DALES G CAMERON ,  VAN ERDEN LYNN ,  VAN BEEK JOHANNES A M ,  HAJDUK DAMIAN A ,  NIELSEN RALPH B ,  MANSKY PAUL ,  MATSIEV LEONID ,  WANG PEI ,  MCFARLAND ERIC

IPC: B01J19/18 ,  B01F13/06 ,  B01F13/08 ,  B01F15/00 ,  B01J19/00 ,  B01J19/26 ,  B01L3/00 ,  B01L7/00 ,  C40B40/14 ,  C40B40/18 ,  F28F27/00 ,  G01K13/00 ,  G01N21/25 ,  G01N35/10 ,  G05B23/02 ,  G05D21/00 ,  G05D16/00

Abstract: An apparatus and method for carrying out and monitoring the progress and properties of multiple reactions is disclosed. The method and apparatus are especially useful for synthesizing, screening, and characterizing combinatorial libraries, but also offer significant advantages over conventional experimental reactors as well. The apparatus generally includes multiple vessels for containing reaction mixtures, and systems for controlling the stirring rate and temperature of individual reaction mixtures or groups of reaction mixtures. In addition, the apparatus may include provisions for independently controlling pressure in each vessel, and a system for injecting liquids into the vessels at a pressure different than ambient pressure. In situ monitoring of individual reaction mixtures provides feedback for process controllers, and also provides data for determining reaction rates, product yields, and various properties of the reaction products, including viscosity and molecular weight.

公开(公告)号：DE69921197D1

公开(公告)日：2004-11-18

申请号：DE69921197

申请日：1999-08-12

Applicant: SYMYX TECHNOLOGIES INC

Inventor： TURNER HOWARD ,  DALES G CAMERON ,  VAN ERDEN LYNN ,  VAN BEEK JOHANNES A M ,  HAJDUK DAMIAN A ,  NIELSEN RALPH B ,  MANSKY PAUL ,  MATSIEV LEONID ,  WANG PEI ,  MCFARLAND ERIC

IPC: B01J19/18 ,  B01F13/06 ,  B01F13/08 ,  B01F15/00 ,  B01J19/00 ,  B01J19/26 ,  B01L3/00 ,  B01L7/00 ,  C40B40/14 ,  C40B40/18 ,  F28F27/00 ,  G01K13/00 ,  G01N21/25 ,  G01N35/10 ,  G05B23/02 ,  G05D21/00 ,  G05D16/00

Abstract: An apparatus and method for carrying out and monitoring the progress and properties of multiple reactions is disclosed. The method and apparatus are especially useful for synthesizing, screening, and characterizing combinatorial libraries, but also offer significant advantages over conventional experimental reactors as well. The apparatus generally includes multiple vessels for containing reaction mixtures, and systems for controlling the stirring rate and temperature of individual reaction mixtures or groups of reaction mixtures. In addition, the apparatus may include provisions for independently controlling pressure in each vessel, and a system for injecting liquids into the vessels at a pressure different than ambient pressure. In situ monitoring of individual reaction mixtures provides feedback for process controllers, and also provides data for determining reaction rates, product yields, and various properties of the reaction products, including viscosity and molecular weight.