公开(公告)号：AT241427T

公开(公告)日：2003-06-15

申请号：AT99942147

申请日：1999-08-12

Applicant: SYMYX TECHNOLOGIES INC

Inventor： TURNER HOWARD ,  DALES G CAMERON ,  VAN ERDEN LYNN ,  VAN BEEK JOHANNES A M ,  HAJDUK DAMIAN A ,  NIELSEN RALPH B ,  MANSKY PAUL ,  MATSIEV LEONID ,  WANG PEI ,  MCFARLAND ERIC

IPC: B01J19/18 ,  B01F13/06 ,  B01F13/08 ,  B01F15/00 ,  B01J19/00 ,  B01J19/26 ,  B01L3/00 ,  B01L7/00 ,  C40B40/14 ,  C40B40/18 ,  F28F27/00 ,  G01K13/00 ,  G01N21/25 ,  G01N35/10 ,  G05B23/02 ,  G05D21/00

Abstract: An apparatus and method for carrying out and monitoring the progress and properties of multiple reactions is disclosed. The method and apparatus are especially useful for synthesizing, screening, and characterizing combinatorial libraries, but also offer significant advantages over conventional experimental reactors as well. The apparatus generally includes multiple vessels for containing reaction mixtures, and systems for controlling the stirring rate and temperature of individual reaction mixtures or groups of reaction mixtures. In addition, the apparatus may include provisions for independently controlling pressure in each vessel, and a system for injecting liquids into the vessels at a pressure different than ambient pressure. In situ monitoring of individual reaction mixtures provides feedback for process controllers, and also provides data for determining reaction rates, product yields, and various properties of the reaction products, including viscosity and molecular weight.

公开(公告)号：CA2419700A1

公开(公告)日：2000-02-24

申请号：CA2419700

申请日：1999-08-12

Applicant: SYMYX TECHNOLOGIES INC

Inventor： VAN ERDEN LYNN ,  VAN BEEK JOHANNES A M ,  TURNER HOWARD ,  DALES G CAMERON ,  NIELSEN RALPH B ,  HAJDUK DAMIAN A ,  MATSIEV LEONID ,  MANSKY PAUL ,  WANG PEI ,  MCFARLAND ERIC

IPC: B01J19/00 ,  B01J19/18 ,  G01N31/00 ,  G01N33/00 ,  G05B19/042 ,  G05D23/19

公开(公告)号：AU9599898A

公开(公告)日：1999-04-27

申请号：AU9599898

申请日：1998-10-02

Applicant: SYMYX TECHNOLOGIES INC

Inventor： MATSIEV LEONID ,  BENNETT JAMES ,  MCFARLAND ERIC

IPC: G01H13/00 ,  G01N5/04 ,  G01N9/00 ,  G01N29/02 ,  G01N29/036 ,  G01N29/34 ,  G01N29/42 ,  G01N29/44 ,  H03H9/19

Abstract: A method and apparatus for measuring properties of a liquid composition includes a mechanical resonator, such as a thickness shear mode resonator or a tuning fork resonator, connected to a measurement circuit. The measurement circuit provides a variable frequency input signal to the tuning fork, causing the mechanical resonator to oscillate. To test the properties of a liquid composition, the mechanical resonator is placed inside a sample well containing a small amount of the liquid. The input signal is then sent to the mechanical resonator and swept over a selected frequency range, preferably less than 1 MHz to prevent the liquid being tested from exhibiting gel-like characteristics and causing false readings. The mechanical resonator's response over the frequency range depends on various characteristics of the liquid being tested, such as the temperature, viscosity, and other physical properties. Particular mechanical resonators, such as tuning fork resonators, can also be used to measure a liquid composition's electrical properties, such as the dielectric constant and conductivity, because the tuning fork's structure allows a high degree of electrical coupling between the tuning fork and the surrounding liquid. The mechanical resonator can be covered with a coating to impart additional special detection properties to the resonator, and multiple resonators can be attached together as a single sensor to obtain multiple frequency responses. The invention is particularly suitable for combinatorial chemistry applications, which require rapid analysis of chemical properties for screening.

公开(公告)号：AU4673497A

公开(公告)日：1998-05-05

申请号：AU4673497

申请日：1997-10-08

Applicant: SYMYX TECHNOLOGIES INC

Inventor： MCFARLAND ERIC ,  MATSIEV LEONID

IPC: B01J19/00 ,  C07B61/00 ,  C07F15/00 ,  C07F15/04 ,  C08F10/00 ,  C40B30/08 ,  C40B40/14 ,  C40B40/18 ,  C40B50/14 ,  C40B60/14 ,  G01H13/00 ,  G01J4/00 ,  G01N3/00 ,  G01N9/00 ,  G01N21/21 ,  G01N21/25 ,  G01N21/64 ,  G01N21/66 ,  G01N29/02 ,  G01N29/036 ,  G01N29/24 ,  G01N29/34 ,  G01N29/42 ,  G01N29/44 ,  G01N33/53 ,  G01N33/543 ,  H01J49/00 ,  H01J49/04 ,  H03H9/19

Abstract: A method of characterizing materials comprising the steps of: providing a substrate; synthesizing an array of materials on said substrate; providing at least one reactant gas wherein said reactant gas is in contact with said array of materials; activating at least one of said materials on said array with a heating source; and periodically monitoring an infrared emission from said activated material with an infrared camera, wherein said infrared camera outputs a series of signals corresponding to an emission intensity varying with time of said activated material.

公开(公告)号：DE69921367T2

公开(公告)日：2005-02-24

申请号：DE69921367

申请日：1999-08-12

Applicant: SYMYX TECHNOLOGIES INC

Inventor： TURNER HOWARD ,  DALES G CAMERON ,  VAN ERDEN LYNN ,  VAN BEEK JOHANNES A M ,  HAJDUK DAMIAN A ,  NIELSEN RALPH B ,  MANSKY PAUL ,  MATSIEV LEONID ,  WANG PEI ,  MCFARLAND ERIC

IPC: B01J19/18 ,  B01F13/06 ,  B01F13/08 ,  B01F15/00 ,  B01J19/00 ,  B01J19/26 ,  B01L3/00 ,  B01L7/00 ,  C40B40/14 ,  C40B40/18 ,  F28F27/00 ,  G01K13/00 ,  G01N21/25 ,  G01N35/10 ,  G05B23/02 ,  G05D21/00 ,  B01F7/16

Abstract: An apparatus and method for carrying out and monitoring the progress and properties of multiple reactions is disclosed. The method and apparatus are especially useful for synthesizing, screening, and characterizing combinatorial libraries, but also offer significant advantages over conventional experimental reactors as well. The apparatus generally includes multiple vessels for containing reaction mixtures, and systems for controlling the stirring rate and temperature of individual reaction mixtures or groups of reaction mixtures. In addition, the apparatus may include provisions for independently controlling pressure in each vessel, and a system for injecting liquids into the vessels at a pressure different than ambient pressure. In situ monitoring of individual reaction mixtures provides feedback for process controllers, and also provides data for determining reaction rates, product yields, and various properties of the reaction products, including viscosity and molecular weight.

公开(公告)号：DE69917946T2

公开(公告)日：2004-10-21

申请号：DE69917946

申请日：1999-08-12

Applicant: SYMYX TECHNOLOGIES INC

Inventor： TURNER HOWARD ,  DALES G CAMERON ,  VAN ERDEN LYNN ,  VAN BEEK JOHANNES A M ,  HAJDUK DAMIAN A ,  NIELSEN RALPH B ,  MANSKY PAUL ,  MATSIEV LEONID ,  WANG PEI ,  MCFARLAND ERIC

IPC: B01J19/18 ,  B01F13/06 ,  B01F13/08 ,  B01F15/00 ,  B01J19/00 ,  B01J19/26 ,  B01L3/00 ,  B01L7/00 ,  C40B40/14 ,  C40B40/18 ,  F28F27/00 ,  G01K13/00 ,  G01N21/25 ,  G01N35/10 ,  G05B23/02 ,  G05D21/00

Abstract: An apparatus and method for carrying out and monitoring the progress and properties of multiple reactions is disclosed. The method and apparatus are especially useful for synthesizing, screening, and characterizing combinatorial libraries, but also offer significant advantages over conventional experimental reactors as well. The apparatus generally includes multiple vessels for containing reaction mixtures, and systems for controlling the stirring rate and temperature of individual reaction mixtures or groups of reaction mixtures. In addition, the apparatus may include provisions for independently controlling pressure in each vessel, and a system for injecting liquids into the vessels at a pressure different than ambient pressure. In situ monitoring of individual reaction mixtures provides feedback for process controllers, and also provides data for determining reaction rates, product yields, and various properties of the reaction products, including viscosity and molecular weight.

公开(公告)号：AT268639T

公开(公告)日：2004-06-15

申请号：AT01116411

申请日：1999-08-12

Applicant: SYMYX TECHNOLOGIES INC

Inventor： TURNER HOWARD ,  DALES G CAMERON ,  VAN ERDEN LYNN ,  VAN BEEK JOHANNES A M ,  HAJDUK DAMIAN A ,  NIELSEN RALPH B ,  MANSKY PAUL ,  MATSIEV LEONID ,  WANG PEI ,  MCFARLAND ERIC

IPC: B01J19/18 ,  B01F13/06 ,  B01F13/08 ,  B01F15/00 ,  B01J19/00 ,  B01J19/26 ,  B01L3/00 ,  B01L7/00 ,  C40B40/14 ,  C40B40/18 ,  F28F27/00 ,  G01K13/00 ,  G01N21/25 ,  G01N35/10 ,  G05B23/02 ,  G05D21/00

Abstract: An apparatus and method for carrying out and monitoring the progress and properties of multiple reactions is disclosed. The method and apparatus are especially useful for synthesizing, screening, and characterizing combinatorial libraries, but also offer significant advantages over conventional experimental reactors as well. The apparatus generally includes multiple vessels for containing reaction mixtures, and systems for controlling the stirring rate and temperature of individual reaction mixtures or groups of reaction mixtures. In addition, the apparatus may include provisions for independently controlling pressure in each vessel, and a system for injecting liquids into the vessels at a pressure different than ambient pressure. In situ monitoring of individual reaction mixtures provides feedback for process controllers, and also provides data for determining reaction rates, product yields, and various properties of the reaction products, including viscosity and molecular weight.

公开(公告)号：CA2499298A1

公开(公告)日：2004-04-29

申请号：CA2499298

申请日：2003-10-17

Applicant: SYMYX TECHNOLOGIES INC

Inventor： PINKAS DANIEL M ,  MATSIEV LEONID ,  BENNETT JAMES ,  SPITKOVSKY MIKHAIL ,  KOLOSOV OLEG ,  GUAN SHENHENG

IPC: G01F23/296 ,  G01N9/00 ,  G01N11/16 ,  G01N29/036 ,  G01N29/34 ,  G01N29/02

Abstract: A method for analyzing a fluid contained within a machine, comprising the steps of providing a machine system (100) including a passage (104) for containing a fluid; placing a sensor (106) including a mechanical resonator in the passage; operating the resonator to have a portion thereof translate through the fluid; and monitoring the response of the resonator to the fluid in the passage. One specific sensor includes a tuning fork resonator.

公开(公告)号：DE69814035D1

公开(公告)日：2003-06-05

申请号：DE69814035

申请日：1998-10-02

Applicant: SYMYX TECHNOLOGIES INC

Inventor： MATSIEV LEONID ,  BENNETT JAMES ,  MCFARLAND ERIC

IPC: G01H13/00 ,  G01N5/04 ,  G01N9/00 ,  G01N29/02 ,  G01N29/036 ,  G01N29/34 ,  G01N29/42 ,  G01N29/44 ,  H03H9/19

Abstract: A method and apparatus for measuring properties of a liquid composition includes a mechanical resonator, such as a thickness shear mode resonator or a tuning fork resonator, connected to a measurement circuit. The measurement circuit provides a variable frequency input signal to the tuning fork, causing the mechanical resonator to oscillate. To test the properties of a liquid composition, the mechanical resonator is placed inside a sample well containing a small amount of the liquid. The input signal is then sent to the mechanical resonator and swept over a selected frequency range, preferably less than 1 MHz to prevent the liquid being tested from exhibiting gel-like characteristics and causing false readings. The mechanical resonator's response over the frequency range depends on various characteristics of the liquid being tested, such as the temperature, viscosity, and other physical properties. Particular mechanical resonators, such as tuning fork resonators, can also be used to measure a liquid composition's electrical properties, such as the dielectric constant and conductivity, because the tuning fork's structure allows a high degree of electrical coupling between the tuning fork and the surrounding liquid. The mechanical resonator can be covered with a coating to impart additional special detection properties to the resonator, and multiple resonators can be attached together as a single sensor to obtain multiple frequency responses. The invention is particularly suitable for combinatorial chemistry applications, which require rapid analysis of chemical properties for screening.

公开(公告)号：CA2422914A1

公开(公告)日：2003-01-09

申请号：CA2422914

申请日：2002-06-28

Applicant: SYMYX TECHNOLOGIES INC

Inventor： BOUSSIE THOMAS ,  CREVIER THOMAS J ,  MATSIEV LEONID ,  HALL KEITH A ,  GOH CHRISTOPHER ,  FRANK TREVOR G ,  CHANDLER WILLIAM H

IPC: G01N31/16 ,  B01J19/00 ,  C08F4/00 ,  G01N21/78 ,  G01N25/72 ,  G01N31/10 ,  G01N35/00 ,  G01N35/02 ,  G01N31/00

Abstract: An apparatus for in-situ injection of one or more chemical components into a reaction chamber is disclosed, The apparatus includes a reaction chamber for receiving one or more libraries, each of the libraries comprising two or mor e samples. The reaction chamber is configured to form a sealed enclosure. The apparatus further includes an injection manifold supporting injectors for in - situ injection of one or more chemical components onto respective samples of the one or more libraries in the pressurized sealed reaction chamber.