公开(公告)号：DE69708331T3

公开(公告)日：2010-10-28

申请号：DE69708331

申请日：1997-07-22

Applicant: SYMYX TECHNOLOGIES INC

Inventor： WEINBERG HENRY W ,  MCFARLAND ERIC ,  GOLDWASSER ISY ,  BOUSSIE THOMAS ,  TURNER HOWARD ,  BEEK JOHANNES A M VAN ,  MURPHY VINCE ,  POWERS TIMOTHY

IPC: B01J23/22 ,  C07B61/00 ,  B01J19/00 ,  B01J31/16 ,  B01J31/22 ,  B01J37/00 ,  C07C249/02 ,  C07C251/08 ,  C07C251/16 ,  C07D213/53 ,  C07F15/00 ,  C07F15/04 ,  C07F17/00 ,  C07F19/00 ,  C08F4/00 ,  C08F4/60 ,  C08F4/70 ,  C08F10/00 ,  C08F110/02 ,  C40B40/04 ,  C40B40/18 ,  C40B50/00 ,  C40B60/14 ,  G01N1/10 ,  G01N21/64 ,  G01N29/24 ,  G01N29/34 ,  G01N29/44

公开(公告)号：CA2261305C

公开(公告)日：2006-03-21

申请号：CA2261305

申请日：1997-07-22

Applicant: SYMYX TECHNOLOGIES INC

Inventor： WEINBERG W HENRY ,  MCFARLAND ERIC ,  GOLDWASSER ISY ,  BOUSSIE THOMAS ,  TURNER HOWARD ,  BEEK JOHANNES A M VAN ,  POWERS TIMOTHY ,  MURPHY VINCE

IPC: B01J23/22 ,  C07F17/00 ,  B01J19/00 ,  B01J31/16 ,  B01J31/22 ,  B01J37/00 ,  C07B61/00 ,  C07C249/02 ,  C07C251/08 ,  C07C251/16 ,  C07D213/53 ,  C07F15/00 ,  C07F15/04 ,  C07F19/00 ,  C08F4/00 ,  C08F4/60 ,  C08F4/70 ,  C08F10/00 ,  C08F110/02 ,  C40B40/04 ,  C40B40/18 ,  C40B50/00 ,  C40B60/14 ,  G01N1/10 ,  G01N21/64 ,  G01N29/24 ,  G01N29/34 ,  G01N29/44

Abstract: The present invention relates, Inter alia, to methodologies for the synthesi s, screening and characterization of organometallic compounds and catalysts (e.g., homogeneous catalysts). The methods of the present invention provide for the combinatorial synthesis, screening and characterization of libraries of supported and unsupported organometallic compounds and catalysts (e.g., homogeneous catalysts). The methods of the present invention can be applied to the preparation and screening of large numbers of organometallic compounds which can be used not only as catalysts (e.g., homogeneous catalysts), but also as additives and therapeutic agents.

公开(公告)号：DE69921367T2

公开(公告)日：2005-02-24

申请号：DE69921367

申请日：1999-08-12

Applicant: SYMYX TECHNOLOGIES INC

Inventor： TURNER HOWARD ,  DALES G CAMERON ,  VAN ERDEN LYNN ,  VAN BEEK JOHANNES A M ,  HAJDUK DAMIAN A ,  NIELSEN RALPH B ,  MANSKY PAUL ,  MATSIEV LEONID ,  WANG PEI ,  MCFARLAND ERIC

IPC: B01J19/18 ,  B01F13/06 ,  B01F13/08 ,  B01F15/00 ,  B01J19/00 ,  B01J19/26 ,  B01L3/00 ,  B01L7/00 ,  C40B40/14 ,  C40B40/18 ,  F28F27/00 ,  G01K13/00 ,  G01N21/25 ,  G01N35/10 ,  G05B23/02 ,  G05D21/00 ,  B01F7/16

Abstract: An apparatus and method for carrying out and monitoring the progress and properties of multiple reactions is disclosed. The method and apparatus are especially useful for synthesizing, screening, and characterizing combinatorial libraries, but also offer significant advantages over conventional experimental reactors as well. The apparatus generally includes multiple vessels for containing reaction mixtures, and systems for controlling the stirring rate and temperature of individual reaction mixtures or groups of reaction mixtures. In addition, the apparatus may include provisions for independently controlling pressure in each vessel, and a system for injecting liquids into the vessels at a pressure different than ambient pressure. In situ monitoring of individual reaction mixtures provides feedback for process controllers, and also provides data for determining reaction rates, product yields, and various properties of the reaction products, including viscosity and molecular weight.

公开(公告)号：DE69917946T2

公开(公告)日：2004-10-21

申请号：DE69917946

申请日：1999-08-12

Applicant: SYMYX TECHNOLOGIES INC

Inventor： TURNER HOWARD ,  DALES G CAMERON ,  VAN ERDEN LYNN ,  VAN BEEK JOHANNES A M ,  HAJDUK DAMIAN A ,  NIELSEN RALPH B ,  MANSKY PAUL ,  MATSIEV LEONID ,  WANG PEI ,  MCFARLAND ERIC

IPC: B01J19/18 ,  B01F13/06 ,  B01F13/08 ,  B01F15/00 ,  B01J19/00 ,  B01J19/26 ,  B01L3/00 ,  B01L7/00 ,  C40B40/14 ,  C40B40/18 ,  F28F27/00 ,  G01K13/00 ,  G01N21/25 ,  G01N35/10 ,  G05B23/02 ,  G05D21/00

Abstract: An apparatus and method for carrying out and monitoring the progress and properties of multiple reactions is disclosed. The method and apparatus are especially useful for synthesizing, screening, and characterizing combinatorial libraries, but also offer significant advantages over conventional experimental reactors as well. The apparatus generally includes multiple vessels for containing reaction mixtures, and systems for controlling the stirring rate and temperature of individual reaction mixtures or groups of reaction mixtures. In addition, the apparatus may include provisions for independently controlling pressure in each vessel, and a system for injecting liquids into the vessels at a pressure different than ambient pressure. In situ monitoring of individual reaction mixtures provides feedback for process controllers, and also provides data for determining reaction rates, product yields, and various properties of the reaction products, including viscosity and molecular weight.

公开(公告)号：AT268639T

公开(公告)日：2004-06-15

申请号：AT01116411

申请日：1999-08-12

Applicant: SYMYX TECHNOLOGIES INC

Inventor： TURNER HOWARD ,  DALES G CAMERON ,  VAN ERDEN LYNN ,  VAN BEEK JOHANNES A M ,  HAJDUK DAMIAN A ,  NIELSEN RALPH B ,  MANSKY PAUL ,  MATSIEV LEONID ,  WANG PEI ,  MCFARLAND ERIC

IPC: B01J19/18 ,  B01F13/06 ,  B01F13/08 ,  B01F15/00 ,  B01J19/00 ,  B01J19/26 ,  B01L3/00 ,  B01L7/00 ,  C40B40/14 ,  C40B40/18 ,  F28F27/00 ,  G01K13/00 ,  G01N21/25 ,  G01N35/10 ,  G05B23/02 ,  G05D21/00

Abstract: An apparatus and method for carrying out and monitoring the progress and properties of multiple reactions is disclosed. The method and apparatus are especially useful for synthesizing, screening, and characterizing combinatorial libraries, but also offer significant advantages over conventional experimental reactors as well. The apparatus generally includes multiple vessels for containing reaction mixtures, and systems for controlling the stirring rate and temperature of individual reaction mixtures or groups of reaction mixtures. In addition, the apparatus may include provisions for independently controlling pressure in each vessel, and a system for injecting liquids into the vessels at a pressure different than ambient pressure. In situ monitoring of individual reaction mixtures provides feedback for process controllers, and also provides data for determining reaction rates, product yields, and various properties of the reaction products, including viscosity and molecular weight.

公开(公告)号：ES2168833T3

公开(公告)日：2002-06-16

申请号：ES99203632

申请日：1997-07-22

Applicant: SYMYX TECHNOLOGIES INC

Inventor： WEINBERG HENRY W ,  MCFARLAND ERIC ,  GOLDWASSER ISY ,  BOUSSIE THOMAS ,  TURNER HOWARD ,  BEEK JOHANNES A M VAN

IPC: B01J23/22 ,  B01J19/00 ,  B01J31/16 ,  B01J31/22 ,  B01J37/00 ,  C07B61/00 ,  C07C249/02 ,  C07C251/08 ,  C07C251/16 ,  C07D213/53 ,  C07F15/00 ,  C07F15/04 ,  C07F17/00 ,  C07F19/00 ,  C08F4/00 ,  C08F4/60 ,  C08F4/70 ,  C08F10/00 ,  C08F110/02 ,  C40B40/04 ,  C40B40/18 ,  C40B50/00 ,  C40B60/14 ,  G01N1/10 ,  G01N21/64 ,  G01N29/24 ,  G01N29/34 ,  G01N29/44

Abstract: Methodologies for the synthesis, screening and characterisation of organometallic compounds and catalysts (eg homogenous catalysts), including combinatorial synthesis, screening and characterisation of libraries of supported and unsupported organometallic compounds and catalysts (eg homogenous catalysts). The methods can be applied to the preparation and screening of large numbers of organometallic compounds which can be used not only as catalysts (eg homogeneous catalysts), but also as additives and therapeutic agents.

公开(公告)号：DE69707294T2

公开(公告)日：2002-05-02

申请号：DE69707294

申请日：1997-07-22

Applicant: SYMYX TECHNOLOGIES INC

Inventor： WEINBERG HENRY ,  MCFARLAND ERIC ,  GOLDWASSER ISY ,  BOUSSIE THOMAS ,  TURNER HOWARD ,  BEEK JOHANNES A VAN ,  MURPHY VINCE ,  POWERS TIMOTHY

IPC: B01J23/22 ,  B01J19/00 ,  B01J31/16 ,  B01J31/22 ,  B01J37/00 ,  C07B61/00 ,  C07C249/02 ,  C07C251/08 ,  C07C251/16 ,  C07D213/53 ,  C07F15/00 ,  C07F15/04 ,  C07F17/00 ,  C07F19/00 ,  C08F4/00 ,  C08F4/60 ,  C08F4/70 ,  C08F10/00 ,  C08F110/02 ,  C40B40/04 ,  C40B40/18 ,  C40B50/00 ,  C40B60/14 ,  G01N1/10 ,  G01N21/64 ,  G01N29/24 ,  G01N29/34 ,  G01N29/44

Abstract: Methodologies for the synthesis, screening and characterisation of organometallic compounds and catalysts (eg homogenous catalysts), including combinatorial synthesis, screening and characterisation of libraries of supported and unsupported organometallic compounds and catalysts (eg homogenous catalysts). The methods can be applied to the preparation and screening of large numbers of organometallic compounds which can be used not only as catalysts (eg homogeneous catalysts), but also as additives and therapeutic agents.

公开(公告)号：ES2162682T3

公开(公告)日：2002-01-01

申请号：ES97934335

申请日：1997-07-22

Applicant: SYMYX TECHNOLOGIES INC

Inventor： WEINBERG W HENRY ,  MCFARLAND ERIC ,  GOLDWASSER ISY ,  BOUSSIE THOMAS ,  TURNER HOWARD ,  BEEK JOHANNES A M VAN

IPC: B01J23/22 ,  B01J19/00 ,  B01J31/16 ,  B01J31/22 ,  B01J37/00 ,  C07B61/00 ,  C07C249/02 ,  C07C251/08 ,  C07C251/16 ,  C07D213/53 ,  C07F15/00 ,  C07F15/04 ,  C07F17/00 ,  C07F19/00 ,  C08F4/00 ,  C08F4/60 ,  C08F4/70 ,  C08F10/00 ,  C08F110/02 ,  C40B40/04 ,  C40B40/18 ,  C40B50/00 ,  C40B60/14 ,  G01N1/10 ,  G01N21/64 ,  G01N29/24 ,  G01N29/34 ,  G01N29/44

Abstract: Methodologies for the synthesis, screening and characterisation of organometallic compounds and catalysts (eg homogenous catalysts), including combinatorial synthesis, screening and characterisation of libraries of supported and unsupported organometallic compounds and catalysts (eg homogenous catalysts). The methods can be applied to the preparation and screening of large numbers of organometallic compounds which can be used not only as catalysts (eg homogeneous catalysts), but also as additives and therapeutic agents.

公开(公告)号：DE69927720T2

公开(公告)日：2006-05-04

申请号：DE69927720

申请日：1999-08-12

Applicant: SYMYX TECHNOLOGIES INC

Inventor： TURNER HOWARD ,  DALES G CAMERON ,  VAN ERDEN LYNN ,  VAN BEEK JOHANNES A M ,  HAJDUK DAMIAN A ,  NIELSEN RALPH B ,  MANSKY PAUL ,  MATSIEV LEONID ,  WANG PEI ,  MCFARLAND ERIC

IPC: B01J19/00 ,  B01J19/18 ,  B01F13/06 ,  B01F13/08 ,  B01F15/00 ,  B01J19/26 ,  B01L3/00 ,  B01L7/00 ,  C40B40/14 ,  C40B40/18 ,  F28F27/00 ,  G01K13/00 ,  G01N21/25 ,  G01N35/10 ,  G05B23/02 ,  G05D21/00

Abstract: An apparatus and method for carrying out and monitoring the progress and properties of multiple reactions is disclosed. The method and apparatus are especially useful for synthesizing, screening, and characterizing combinatorial libraries, but also offer significant advantages over conventional experimental reactors as well. The apparatus generally includes multiple vessels for containing reaction mixtures, and systems for controlling the stirring rate and temperature of individual reaction mixtures or groups of reaction mixtures. In addition, the apparatus may include provisions for independently controlling pressure in each vessel, and a system for injecting liquids into the vessels at a pressure different than ambient pressure. In situ monitoring of individual reaction mixtures provides feedback for process controllers, and also provides data for determining reaction rates, product yields, and various properties of the reaction products, including viscosity and molecular weight.

公开(公告)号：AT306316T

公开(公告)日：2005-10-15

申请号：AT01116401

申请日：1999-08-12

Applicant: SYMYX TECHNOLOGIES INC

Inventor： TURNER HOWARD ,  DALES G CAMERON ,  VAN ERDEN LYNN ,  VAN BEEK JOHANNES A M ,  HAJDUK DAMIAN A ,  NIELSEN RALPH B ,  MANSKY PAUL ,  MATSIEV LEONID ,  WANG PEI ,  MCFARLAND ERIC

IPC: B01J19/18 ,  B01F13/06 ,  B01F13/08 ,  B01F15/00 ,  B01J19/00 ,  B01J19/26 ,  B01L3/00 ,  B01L7/00 ,  C40B40/14 ,  C40B40/18 ,  F28F27/00 ,  G01K13/00 ,  G01N21/25 ,  G01N35/10 ,  G05B23/02 ,  G05D21/00

Abstract: An apparatus and method for carrying out and monitoring the progress and properties of multiple reactions is disclosed. The method and apparatus are especially useful for synthesizing, screening, and characterizing combinatorial libraries, but also offer significant advantages over conventional experimental reactors as well. The apparatus generally includes multiple vessels for containing reaction mixtures, and systems for controlling the stirring rate and temperature of individual reaction mixtures or groups of reaction mixtures. In addition, the apparatus may include provisions for independently controlling pressure in each vessel, and a system for injecting liquids into the vessels at a pressure different than ambient pressure. In situ monitoring of individual reaction mixtures provides feedback for process controllers, and also provides data for determining reaction rates, product yields, and various properties of the reaction products, including viscosity and molecular weight.