公开(公告)号：GR3032681T3

公开(公告)日：2000-06-30

申请号：GR20000400379

申请日：2000-02-16

Applicant: TORAY INDUSTRIES

Inventor： SUGAYA HIROYUKI ,  MINAGA MASAHIRO ,  TERADA RYOZO ,  TAYAMA TOSHIKAZU ,  TANAKA KAZUMI ,  FUKUI FUMIAKI

IPC: B01D67/00 ,  B01D71/28 ,  B01D71/40 ,  C08F283/06 ,  C08F290/06 ,  C08F299/02 ,  A61M1/16

Abstract: A hydrophilic material comprising a copolymer composed of a monomer (A) having a polyalkylene oxide unit and a polymerizable carbon-carbon double bond in its molecule, a methacrylate or acrylate monomer (B) and another monomer (C) having a polymerizable carbon-carbon double bond in its molecule, which material is characterized by containing the monomer (C) in the proportion of 10 to 90 % by weight. The invention provides a hydrophilic material which is soluble, readily moldable, and excellent in antithrombotic and antifouling properties, and further provides an antithrombotic material and a semipermeable membrane. These materials can be appropriately used in the medical field and as water-absorbent and antifouling materials.

公开(公告)号：ES2807501T3

公开(公告)日：2021-02-23

申请号：ES11854069

申请日：2011-12-27

Applicant: TORAY INDUSTRIES

Inventor： UENO YOSHIYUKI ,  FUJITA MASAKI ,  SUGAYA HIROYUKI ,  HASHIMOTO KAZUYUKI ,  TERASAKA HIROYUKI ,  KOGANEMARU RYO

IPC: A61L33/00 ,  A61M1/18 ,  B01D63/02 ,  B01D65/08 ,  B01D67/00

Abstract: Un módulo de membranas de fibra hueca que comprende: un haz de membranas de fibra hueca que está compuesto de membranas de fibra hueca de un material de polisulfona o polietersulfona, teniendo cada membrana de fibra hueca, en una superficie de la misma que debe estar en contacto con la sangre, un polímero de copolimerización hidrófilo que tiene un tiempo de relajación de agua adsorbida de 2,5 x 10-8 segundos o inferior y 5,0 x 10-10 o superior a -40 °C, en donde el tiempo de relajación del agua adsorbida en el polímero de copolimerización hidrófilo se obtiene mediante una medición de relajación dieléctrica medida de acuerdo con el método divulgado en la descripción; una carcasa de cuerpo principal (10) en la que se almacena el haz de membranas de fibra hueca; paredes divisorias (30,32) que permiten que el haz de membranas de fibra hueca se mantenga en un estado hermético a los líquidos en ambos extremos de la carcasa de cuerpo principal mientras se mantienen las caras del borde de la parte hueca (31,33) en un estado abierto; y colectores (21,23) que están unidos respectivamente a ambos extremos de la carcasa de cuerpo principal y a través de los cuales se puede introducir y extraer sangre; en donde la velocidad de llenado de la membrana de fibra hueca en cada una de las zonas A a H, que son zonas producidas dividiendo una zona situada entre una posición correspondiente al diámetro interno D0 de cada uno de los colectores (21,23) y una posición separada 1 mm de la posición mencionada hacia la periferia interna en 8 partes equiangulares iguales con el centro del eje de la carcasa de cuerpo principal ya que su centro en una cara de borde (31,33) de cada una de las paredes divisorias (30,32) en un lado opuesto a cada uno de los colectores (21,23), está dentro del intervalo del 13 al 40 %, y en donde la velocidad de llenado en la parte del cuerpo de la carcasa de cuerpo principal (10) está dentro del intervalo del 53 % al 64 %, en donde la velocidad de llenado de la membrana de fibra hueca en cada una de las zonas A a H en las caras del borde (31,33) y la velocidad de llenado en la parte del cuerpo se miden respectivamente como se describe en la descripción.

公开(公告)号：ES2737433T3

公开(公告)日：2020-01-14

申请号：ES12183460

申请日：2003-08-20

Applicant: TORAY INDUSTRIES

Inventor： UENO YOSHIYUKI ,  TAKAHASHI HIROSHI ,  SUGAYA HIROYUKI

IPC: A61L33/00 ,  B01D67/00 ,  B01D71/68

Abstract: Un sustrato modificado que comprende un polímero hidrófilo, en donde el sustrato se compone de un material polimérico que es una polisulfona o copolímeros de la misma y el polímero hidrófilo que es una polivinilpirrolidona o un copolímero de polivinilpirrolidona, en donde la relación de polímero hidrófilo soluble, medida tal como se describe en la memoria descriptiva, es del 15 por ciento en peso o menos y un número de plaquetas de sangre humana adherida adheridas en un área de 4,3x103 μm2, medido tal como se describe en la memoria descriptiva, es de 10 o menos, y la relación de polímero hidrófilo en superficie, medida tal como se describe en la memoria descriptiva, es de al menos el 20 por ciento en peso, estando definido el número de plaquetas de sangre adheridas como el número de plaquetas de sangre adheridas sobre la superficie del sustrato modificado cuando se pone en contacto con la sangre durante una hora y en donde el sustrato se puede obtener mediante la irradiación con radiación con una dosis absorbida de al menos 20 kGy, al tiempo que el sustrato se pone en contacto con una solución acuosa del polímero hidrófilo y un antioxidante seleccionado de un alcohol, un sacárido o una sal inorgánica.

公开(公告)号：CA2578202C

公开(公告)日：2013-12-17

申请号：CA2578202

申请日：2005-08-30

Applicant: TORAY INDUSTRIES

Inventor： TANAHASHI KAZUHIRO ,  TAKAHASHI HIROSHI ,  SUGAYA HIROYUKI ,  WADA SHIGEHISA

IPC: C07K1/22 ,  A61J3/00 ,  A61L31/00 ,  A61M1/18 ,  A61M25/00 ,  C07K1/34 ,  C08J7/12 ,  C08L101/00 ,  C12M1/00

Abstract: The present invention discloses a fractionation device used for proteins and/or peptides, which has any of the following features: 1) At least one portion of a substrate surface with which proteins or the like are made in contact has an amount of adsorption of bovine serum albumin of 50 ng/cm2 or less with respect to the substrate surface, when a bovine serum albumin solution is made in contact therewith. 2) At least one portion of a substrate surface with which proteins or the like are made in contact has an amount of adsorption of human .beta.2-microglobulin of 3 ng/cm2 or less with respect to the substrate surface, when a protein aqueous solution consisting of human .beta.2-microglobulin and bovine serum albumin is made in contact with the substrate surface. 3) The fractionation device is provided with: a means for supplying a solution containing proteins or the like; a means for separating proteins or the like from the solution; and a means for concentrating proteins or the like in the solution, and in the fractionation device, at least one portion of the substrate surface with which proteins or the like are made in contact is subjected to a grafting process by using a hydrophilic polymer. By using the above-mentioned device, it becomes possible to reduce non-peculiar adsorption of protein onto the substrate, and consequently to easily provide a sample from which proteins having high-molecular weights have been removed, and which is advantageously used for an analysis.

公开(公告)号：AT540050T

公开(公告)日：2012-01-15

申请号：AT04787627

申请日：2004-09-06

Applicant: TORAY INDUSTRIES

Inventor： WADA SHIGEHISA ,  UTSUMI JUN ,  FUJITA YOSHIJI ,  SUGAYA HIROYUKI ,  YAMADA SATOKO

IPC: C07K1/22 ,  B01D63/02 ,  B01D69/02 ,  C07K1/14 ,  C07K1/34 ,  C07K1/36 ,  C12M1/00 ,  C12P1/00 ,  G01N1/40 ,  G01N33/68

Abstract: The invention provides a method of preparing a biological components-containing solution suitable for clinical proteome analysis by mass spectrometry, electrophoresis, liquid chromatography or the like and an apparatus for the method. The method of the invention is a method for combining two steps among steps of (1) adsorbing proteins having a molecular weight equal to or higher than that of albumin; (2) fractionating proteins having a molecular weight equal to or higher than that of albumin; and (3) concentrating proteins: or a method for preparing the solution by separation using a membrane separation unit having a comparative permeation ratio of 50 or higher for proteins with a molecular weight less than 15, 000 and proteins with a molecular weight of 60, 000 or higher; or a method for preparing the solution by introducing a biological components-containing raw solution into a separation membrane module and successively passing a diluting solution for circulating the solution and passing a portion of the solution through a separation membrane.

公开(公告)号：DE60224425T2

公开(公告)日：2008-12-18

申请号：DE60224425

申请日：2002-10-03

Applicant: TORAY INDUSTRIES

Inventor： SUGAYA HIROYUKI ,  EIKA YOSHIHIRO ,  UENO YOSHIYUKI

IPC: C09K3/00 ,  A61L33/00 ,  A61M1/18 ,  A61M1/36 ,  B01D67/00 ,  B01D69/02 ,  B01D69/08 ,  B01D71/68 ,  B01D71/82 ,  D06M10/10

Abstract: The present invention relates to a hydrophilic substance production method characterized in that polyvinylpyrrolidone-containing material wetted with an aqueous solution of a cationic polymer is treated with radiation. The invention makes it possible to produce material for blood treatment that prevents adsorption of blood platelets.

公开(公告)号：CA2675267A1

公开(公告)日：2008-08-28

申请号：CA2675267

申请日：2008-02-19

Applicant: TORAY INDUSTRIES

Inventor： TANAHASHI KAZUHIRO ,  SUGAYA HIROYUKI ,  ITO AKIHIKO

IPC: C08J7/00 ,  G01N33/543

Abstract: For the purpose of preventing the adsorption of a protein or peptide onto a molded resin article, an aqueous solution of a nonionic surfactant is con tacted with the molded resin article, and subsequently the molded resin arti cle is irradiated with a radioactive ray. The concentration of the surfactan t in the aqueous solution is set to a value 0.05 to 500-fold greater than th e critical micelle concentration of the surfactant at 25~C.

公开(公告)号：CA2676161A1

公开(公告)日：2008-08-07

申请号：CA2676161

申请日：2008-01-29

Applicant: TORAY INDUSTRIES

Inventor： OSABE MASAHIRO ,  NAKAMATSU OSAMU ,  SUGAYA HIROYUKI

IPC: B01D69/08 ,  A61M1/18 ,  B01D63/02 ,  B01D71/38 ,  B01D71/44 ,  B01D71/52 ,  B01D71/68

Abstract: A module size even in a highly packed module can be reduced through a sim ple step while keeping a crimped state in which a dialysis liquid or buffer solution flows well. A hollow-fiber membrane is provided which has, imparted thereto, a crimp having a regular period of 15-25 mm and a crimp angle (.th eta.) determined by the period and amplitude of 0.09-0.32. Also provided is a hollow-fiber-membrane module characterized by having such hollow-fiber mem branes included therein.

公开(公告)号：CA2664299A1

公开(公告)日：2008-03-20

申请号：CA2664299

申请日：2007-09-13

Applicant: TORAY INDUSTRIES

Inventor： SAKAGUCHI HIROKAZU ,  UENO YOSHIYUKI ,  TAKAHASHI HIROSHI ,  SUGAYA HIROYUKI

IPC: A61L33/10 ,  A61L31/00 ,  A61L33/00 ,  A61M1/18

Abstract: Disclosed is a substrate containing a compound having an anticoagulating activity on the blood and a hydrophilic polymeric compound, wherein the amou nt of the compound having an anticoagulating activity on the blood eluted fr om the substrate is less than 0.6 .mu.g/ml. Also disclosed is a method for p roducing a substrate, which comprises the steps of irradiating a substrate w ith a radioactive ray while contacting the substrate with a compound having an anticoagulating activity on the blood and a hydrophilic polymeric compoun d, and washing out the unreacted compounds.

公开(公告)号：CA2792019A1

公开(公告)日：2006-10-05

申请号：CA2792019

申请日：2006-03-28

Applicant: TORAY INDUSTRIES

Inventor： ARAKI MIHO ,  UENO YOSHIYUKI ,  SUGAYA HIROYUKI

IPC: A61L31/04 ,  A61L2/08 ,  A61L33/04 ,  A61M1/16

Abstract: The present invention is characterized in that a base material comprises ester groups in the main chain and/or in the side chain(s), and comprises a polymer having hydrophobic groups. Particularly, the hydrophobic groups can be introduced by irradiating the base material with a radiation during the base material contacts an aqueous solution of a monohydric alcohol or an aqueous solution of an alcohol having not less than 2 hydroxyl groups, which is a monomer or a polymer, and which has one or more carbon atoms between the carbon atoms to each of which the hydroxyl group is bound in the monomer or in each monomer constituting the polymer.