公开(公告)号：AU2003269873A1

公开(公告)日：2003-12-19

申请号：AU2003269873

申请日：2003-05-13

Applicant: UNIV CALIFORNIA

Inventor： ALLBRITTON NANCY ,  SIMS CHRISTOPHER E ,  HU SHUWEN ,  REN XUEGIN ,  LI GUANN-PYNG ,  BACHMAN MARK

IPC: C08J7/18 ,  G01N27/447 ,  G02B1/04 ,  G02C7/04

Abstract: Polymer-based biomaterials are popular due to ease of fabrication and low costs. However, many polymer substrates have undesirable surface properties. The invention provides a procedure to covalently apply a graft polymer to the surface of a polymer substrate by ultraviolet graft polymerization. The graft polymer is formed from monomers such as PEG, AA, monomethoxy acrylate PEG, HEMA, or DMA. Also, mixed monomers may be used to create the graft and the surface properties of the graft may be tailored for different properties, including hydrophobicity, friction coefficient, electroosmotic mobilities and electrophoretic separations. The invention has particular utility in tailoring surface chemistries in ocular lenses and polymer microdevices. I. II. R: -OH Acrylic Acid(AA) -NH 2 Acrylamide (AM) -N(CH 3 ) 2 Dimethylacrylamide (DMA) -OCH 2 CH 2 OH 2-Hydroxyethylacrylate (HEA) -O(CH 2 CH 2 O) n CH 3 PEG monomethyoxylacrylate (PEG)

公开(公告)号：WO2007127990A3

公开(公告)日：2009-04-23

申请号：PCT/US2007067822

申请日：2007-04-30

Applicant: UNIV CALIFORNIA ,  BACHMAN MARC ,  WANG YULI ,  SIMS CHRISTOPHER E ,  ALLBRITTON NANCY ,  LI GUANN-PYNG

Inventor： BACHMAN MARC ,  WANG YULI ,  SIMS CHRISTOPHER E ,  ALLBRITTON NANCY ,  LI GUANN-PYNG

IPC: B05D3/04

CPC classification number: B01L3/502707 ,  B01L3/5085 ,  B01L3/5088 ,  B01L2200/0647 ,  B01L2300/0636 ,  B01L2300/0822 ,  B01L2300/0829 ,  B01L2300/089 ,  B01L2400/0454 ,  G01N2035/00158

Abstract: A plate manufactured to enable samples of cells, micro-organisms, proteins, DNA, biomolecules and other biological media to be positioned at specific locations or sites on the plate for the purpose of performing addressable analyses on the samples. Preferably, some or all of the sites are built from a removable material or as pallets so that a subset of the samples of interest can be readily isolated from the plate for further processing or analysis. The plate can contain structures or chemical treatments that enhance or promote the attachment and/or function of the samples, and that promote or assist in their analyses.

Abstract translation: 制造的板可使细胞，微生物，蛋白质，DNA，生物分子和其他生物培养基的样品定位在板上的特定位置或位点，以便对样品进行可寻址分析。 优选地，一些或所有的部位由可移除的材料或托盘构建，使得感兴趣的样品的子集可以容易地与板分离以用于进一步的处理或分析。 该板可以包含增强或促进样品的附着和/或功能的结构或化学处理，并且促进或辅助其分析。

公开(公告)号：WO2006121650A3

公开(公告)日：2008-11-06

申请号：PCT/US2006016405

申请日：2006-04-28

Applicant: UNIV CALIFORNIA ,  GAO HUAI ,  ZHANG HAITAO ,  LI GUANN-PYNG

Inventor： GAO HUAI ,  ZHANG HAITAO ,  LI GUANN-PYNG

IPC: H03F1/24

CPC classification number: H03F3/191 ,  H03F1/565 ,  H03F3/195 ,  H03F3/211 ,  H03F3/602 ,  H03F2200/111 ,  H03F2200/225 ,  H03F2200/318 ,  H03F2200/36 ,  H03F2200/391 ,  H03H7/38

Abstract: Provided herein is a power amplifier (100) having a multiple stage power amplifier section (102) and an output matching network section (103).The multiple stage power amplifier section (102) can include multiple power amplifier stage with interstage matching circuits located therebetween. The output matching network (103) can be configured to match the multiple stage power amplifier section (102) at multiple different frequencies or frequency bands. The power amplifier device is capable of selective operation within one of multiple different frequencies or frequency bands.

Abstract translation: 本文提供了具有多级功率放大器部分（102）和输出匹配网络部分（103）的功率放大器（100）。多级功率放大器部分（102）可以包括多个功率放大器级，其间具有位于其间的级间匹配电路 。 输出匹配网络（103）可以被配置为在多个不同的频率或频带上匹配多级功率放大器部分（102）。 功率放大器装置能够在多个不同频率或频带之一内进行选择性操作。

公开(公告)号：WO2006121650A8

公开(公告)日：2007-01-18

申请号：PCT/US2006016405

申请日：2006-04-28

Applicant: UNIV CALIFORNIA ,  GAO HUAI ,  ZHANG HAITAO ,  LI GUANN-PYNG

Inventor： GAO HUAI ,  ZHANG HAITAO ,  LI GUANN-PYNG

IPC: G06F7/00

CPC classification number: H03F3/191 ,  H03F1/565 ,  H03F3/195 ,  H03F3/211 ,  H03F3/602 ,  H03F2200/111 ,  H03F2200/225 ,  H03F2200/318 ,  H03F2200/36 ,  H03F2200/391 ,  H03H7/38

Abstract: Provided herein is a power amplifier having a multiple stage power amplifier section and an output matching network section. The multiple stage power amplifier section can include multiple power amplifier stages with interstage matching circuits located therebetween. The output matching network can be configured to match the multiple stage power amplifier section at multiple different frequencies or frequency bands. The power amplifier device is capable of selective operation within one of multiple different frequencies or frequency bands.

Abstract translation: 本文提供的是具有多级功率放大器部分和输出匹配网络部分的功率放大器。 多级功率放大器部分可以包括多个功率放大器级，其间具有级间匹配电路。 输出匹配网络可以配置为在多个不同频率或频带上匹配多级功率放大器部分。 功率放大器装置能够在多个不同频率或频带之一内进行选择性操作。

公开(公告)号：WO03093791A2

公开(公告)日：2003-11-13

申请号：PCT/US0313599

申请日：2003-05-02

Applicant: UNIV CALIFORNIA

Inventor： ALBRITTON NANCY ,  LI GUANN-PYNG ,  BACHMAN MARK ,  SIMS CHRISTOPHER ,  HAN FUTIAN

IPC: B01L3/00 ,  G01N27/447 ,  G01N33/50 ,  G01N33/559 ,  G01N33/561 ,  G01N

CPC classification number: G01N33/561 ,  B01L3/5027 ,  C12M47/06 ,  G01N27/44743 ,  G01N33/5005 ,  G01N33/559

Abstract: The invention provides apparatus and methods for subsecond lysis of selected cells (58) in a cell chamber (10) using a voltage pulse of 10 ms to 10 µs in duration followed by nearly simultaneous collection of the lysed cellular contents (59) into a capillary electrophoresis tube (42) or other suitable micro-collection device (15). Cell chambers (10) and capillary electrophoresis (42) tubes configured with electrodes (18, 19) for performing the electrical lysis are described. The influence of variables that govern the rate of cell lysis, such as the inter-electrode distance, pulse duration, and pulse strength are also described. The methods are illustrated using fluorophores that are loaded into a cell (10) and then collected following electrical lysis, separated by electrophoresis, and then detected by laser-induced fluorescence detection in a capillary electrophoresis system.

Abstract translation: 本发明提供用于使用10ms至10μs持续时间的电压脉冲在细胞室（10）中亚细胞裂解所选择的细胞（58）的装置和方法，随后裂解的细胞内含物（59）几乎同时收集到毛细管 电泳管（42）或其他合适的微量收集装置（15）。 描述了配置有用于进行电裂解的电极（18,19）的细胞室（10）和毛细管电泳（42）管。 还描述了控制细胞裂解速率的变量的影响，例如电极间距离，脉冲持续时间和脉冲强度。 使用装载到细胞中的荧光团（10），然后在电裂解后收集，通过电泳分离，然后通过毛细管电泳系统中的激光诱导荧光检测来检测方法。

公开(公告)号：CA3073198A1

公开(公告)日：2019-02-21

申请号：CA3073198

申请日：2018-08-16

Applicant: UNIV CALIFORNIA

Inventor： BACHMAN MARK ,  BABIKIAN SARKIS ,  LI GUANN-PYNG

IPC: G01L19/14

Abstract: A miniature wireless pressure sensor has an inductor and a capacitor. The inductor and the capacitor form a L-C resonator with a resonate frequency. The inductor's inductance is affected by a slidable electro-magnetic element. When an outside pressure is applied onto the element, it causes the element to move and such movement changes the inductance of the inductor. Because of that, the resonate frequency is changed. Therefore, the change in resonate frequency indicates a change in the outside pressure. The L-C resonator is calibrated to correlate with the outside pressure. Such a miniature wireless pressure sensor facilitates the monitoring of physiological pressure in different part of human body such as eyes and cranium.

公开(公告)号：CA2625071C

公开(公告)日：2017-04-18

申请号：CA2625071

申请日：2006-10-10

Applicant: UNIV CALIFORNIA

Inventor： WANG YULI ,  BACHMAN MARK ,  SIMS CHRISTOPHER E ,  LI GUANN-PYNG ,  ALLBRITTON NANCY

IPC: C12M1/22 ,  B01L3/00

Abstract: Systems and methods for patterning biological and non-biological material at specific sites on a plate, as well as growing three dimensional structures. Preferred embodiments comprise a plate (6) with regions (16) that will trap gas, usually in the form of bubbles (10), when the plate (6) is submerged in liquid. Other embodiments of the present invention include a method for placing materials on the plate (6) at predetermined locations through the use of trapped gas to prevent materials from collecting at unwante regions. The plate (6) has great utility for plating cells and tissues (5) at specific sites, such as on an array. The disclosed method can also be used to coat the surface of a plate (6) at specific locations for patterned coating applications and to build up materials to produce three dimensional structures, including micromechanical structures where the structures may be formed from living or nonliving material, organic or inorganic, and the like.

公开(公告)号：CA2625071A1

公开(公告)日：2007-10-25

申请号：CA2625071

申请日：2006-10-10

Applicant: UNIV CALIFORNIA

Inventor： ALLBRITTON NANCY ,  SIMS CHRISTOPHER ,  LI GUANN-PYNG ,  WANG YULI ,  BACHMAN MARK

IPC: C12M1/22 ,  B01L3/00

Abstract: Systems and methods are provided for patterning biological and non-biological material at specific sites on a plate, as well as growing three dimensional structures. Preferred embodiments comprise a plate with regions that will trap gas, usually in the form of bubbles, when the plate is submerged in liquid. Other embodiment of the present invention include a method for placing materials on the plate at pre-determined locations through the use of trapped gas to prevent materials from collecting at unwanted regions. The plate has great utility for plating cells and tissues at specific sites, such as on an array. The disclosed method can also be used to coat the surface of a plate with coatings at specific locations for patterned coating applications and to build up materials to produce three dimensional structures, including micro-mechanical structures—where the structures may be formed from living or non-living material, tissue or non-tissue, organic or inorganic, and the like.

公开(公告)号：CA2648778A1

公开(公告)日：2007-10-18

申请号：CA2648778

申请日：2007-04-06

Applicant: UNIV CALIFORNIA

Inventor： LI GUANN-PYNG ,  SIMS CHRISTOPHER E ,  BACHMAN MARK ,  WANG YULI ,  ALLBRITTON NANCY ,  STANBRIDGE ERIC

IPC: C12Q1/24 ,  C12M1/26 ,  C12Q1/04 ,  C12Q1/68 ,  C40B20/00 ,  C40B30/00

Abstract: A plate manufactured to enable samples of cells, micro-organisms, proteins, DNA, biomolecules and other biological media to be positioned at specific locations or sites on the plate for the purpose of performing addressable analyses on the samples. Preferably, some or all of the sites are built from a removable material or as pallets so that a subset of the samples of interest can be readily isolated from the plate for further processing or analysis. T he plate can contain structures or chemical treatments that enhance or promote the attachment and/or function of the samples, and that promote or assist in their analyses. Use of the plate advantageously enables the selection and sorting of cells based on dynamic phenomena and the rapid establishment of stable tranfectants.

公开(公告)号：MX2007004068A

公开(公告)日：2007-06-04

申请号：MX2007004068

申请日：2005-10-04

Applicant: UNIV CALIFORNIA

Inventor： BACHMAN MARK ,  LI GUANN-PYNG ,  ALLBRITTON NANCY ,  SIMS CHRISTOPHER

IPC: C12M1/00 ,  C12Q1/00

Abstract: Una placa fabricada para permitir que muestras de celulas, microorganismos, proteinas, ADN, biomoleculas y otros medios biologicos se coloquen en ubicaciones o sitios especificos sobre la placa con el proposito de realizar analisis direccionables en las muestras; de preferencia, algunos o todos los sitios se construyen a partir de un material removible o como tarimas para que un subconjunto de las muestras de interes se pueda aislar facilmente de la placa para procesamiento o analisis posterior; la placa puede contener estructuras o tratamientos quimicos que mejoran o promueven la fijacion y/o funcion de las muestras, y que promueven o ayudan en sus analisis.