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公开(公告)号：AU3665199A
公开(公告)日：1999-11-16
申请号：AU3665199
申请日：1999-04-26
Applicant: VERTEX PHARMA
Inventor： SAUNDERS JEFFREY , ELBAUM DANIEL , NOVAK PERRY , NAEGELE DOUGLAS , BETHIEL SCOTT , RONKIN STEVEN , BADIA MICHAEL , FRANK CATHARINE , STAMOS DEAN , WALTERS WILLIAM , PEARLMAN DAVID
IPC: A61K31/167 , A61K31/18 , A61K31/235 , A61K31/277 , A61K31/357 , A61K31/36 , A61K31/421 , A61K31/422 , A61P1/18 , A61P9/08 , A61P9/10 , A61P11/00 , A61P11/06 , A61P19/02 , A61P29/00 , A61P31/12 , A61P35/00 , A61P35/02 , A61P37/06 , A61P43/00 , C07C217/84 , C07C233/75 , C07C235/66 , C07C235/88 , C07C237/48 , C07C255/60 , C07C309/75 , C07C311/21 , C07C311/29 , C07C317/40 , C07C323/42 , C07C333/08 , C07D213/75 , C07D263/32 , C07D271/06 , C07D307/91 , C07D317/68 , C07D413/12 , C07C235/56 , A61K31/135 , A61K31/165 , A61K31/395
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公开(公告)号：AP1498A
公开(公告)日：2005-11-21
申请号：AP2001002298
申请日：2000-03-17
Applicant: VERTEX PHARMA
Inventor： STAMOS DEAN , TRUDEAU MARTIN , BETHIEL SCOTT , BADIA MICHAEL C , SAUNDERS JEFFREY
IPC: C07D307/20 , A61K31/27 , A61K31/275 , A61K31/341 , A61K31/421 , A61K31/422 , A61K31/454 , A61K31/5377 , A61K31/541 , A61K45/00 , A61P1/18 , A61P9/10 , A61P11/06 , A61P19/02 , A61P29/00 , A61P31/12 , A61P35/00 , A61P37/02 , A61P43/00 , C07C275/40 , C07C275/42 , C07D263/32 , C07D413/12 , C07D417/12 , C07F9/653 , A61K31/277 , C07C275/34
Abstract: The present invention relates to compounds which inhibit IMPDH. This invention also relates to pharmaceutical compositions comprising these compounds. The compounds and pharmaceutical compositions of this invention are particularly well suited for inhibiting IMPDH enzyme activity and consequently, may be advantageously used as therapeutic agents for IMPDH-mediated processes. This invention also relates to methods for inhibiting the activity of IMPDH using the compounds of this invention and related compounds.
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公开(公告)号：EA004141B1
公开(公告)日：2004-02-26
申请号：EA200100992
申请日：2000-03-17
Applicant: VERTEX PHARMA
Inventor： STAMOS DEAN , TRUDEAU MARTIN , BETHIEL SCOTT , BADIA MICHAEL , SAUNDERS JEFFREY
IPC: C07D307/20 , A61K31/27 , A61K31/275 , A61K31/341 , A61K31/421 , A61K31/422 , A61K31/454 , A61K31/5377 , A61K31/541 , A61K45/00 , A61P1/18 , A61P9/10 , A61P11/06 , A61P19/02 , A61P29/00 , A61P31/12 , A61P35/00 , A61P37/02 , A61P43/00 , C07C275/40 , C07C275/42 , C07D263/32 , C07D413/12 , C07D417/12 , C07F9/653 , A61K31/277 , C07C275/34 , A61P31/04
Abstract: Настоящееизобретениеотноситсяк соединениям, ингибирующим IMPDH. Данноеизобретениетакжеотноситсяк фармацевтическимкомпозициям, включающимуказанныесоединения. Соединенияи фармацевтическиекомпозициив соответствиис даннымизобретениемособеннохорошоподходятдляингибированияактивностифермента IMPDH и, следовательно, могутбытьнаилучшимобразомиспользованыв качестветерапевтическихагентовдля IMPDH-опосредуемыхпроцессов. Данноеизобретениетакжеотноситсяк способамингибированияактивности IMPDH сприменениемсоединенийв соответствиис настоящимизобретениеми родственныхимсоединений.
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Patent Agency Ranking
公开(公告)号：AU769383B2
公开(公告)日：2004-01-22
申请号：AU3757700
申请日：2000-03-17
Applicant: VERTEX PHARMA
Inventor： STAMOS DEAN , TRUDEAU MARTIN , BETHIEL SCOTT , BADIA MICHAEL , SAUNDERS JEFFREY
IPC: C07D307/20 , A61K31/27 , A61K31/275 , A61K31/341 , A61K31/421 , A61K31/422 , A61K31/454 , A61K31/5377 , A61K31/541 , A61K45/00 , A61P1/18 , A61P9/10 , A61P11/06 , A61P19/02 , A61P29/00 , A61P31/12 , A61P35/00 , A61P37/02 , A61P43/00 , C07C275/40 , C07C275/42 , C07D263/32 , C07D413/12 , C07D417/12 , C07F9/653 , A61K31/277 , C07C275/34
Abstract: The present invention relates to compounds which inhibit JMPDH. This invention also relates to pharmaceutical compositions comprising these compounds. The compounds and pharmaceutical compositions of this invention are particularly well suited for inhibiting JMPDH enzyme activity and consequently, may be advantageously used as therapeutic agents for IMPDH-mediated processes. This invention also relates to methods for inhibiting the activity of I1VIPDH using the compounds of this invention and related compounds.
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公开(公告)号：BG106020A
公开(公告)日：2002-06-28
申请号：BG10602001
申请日：2001-10-16
Applicant: VERTEX PHARMA
Inventor： STAMOS DEAN , TRUDEAU MARTIN , BETHIEL SCOTT , BADIA MICHAEL , SAUNDERS JEFFREY
IPC: C07D307/20 , A61K31/27 , A61K31/275 , A61K31/341 , A61K31/421 , A61K31/422 , A61K31/454 , A61K31/5377 , A61K31/541 , A61K45/00 , A61P1/18 , A61P9/10 , A61P11/06 , A61P19/02 , A61P29/00 , A61P31/12 , A61P35/00 , A61P37/02 , A61P43/00 , C07C275/40 , C07C275/42 , C07D263/32 , C07D413/12 , C07D417/12 , C07F9/653 , A61K31/277 , C07C275/34
Abstract: The present invention relates to compounds, which inhibit IMPDH with formula This invention also relates to pharmaceutical compositions comprising these compounds. The compounds are pharmaceutical compositions of this invention are particularly well suited for inhibiting IMPDH enzyme activity and consequently, may be advantageously use as therapeutic agents for IMPDH-mediated processes. This invention also relates to methods for inhibiting the activity of IMPDH using the compounds of this invention and related compounds. 28 claims
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公开(公告)号：SK13332001A3
公开(公告)日：2002-02-05
申请号：SK13332001
申请日：2000-03-17
Applicant: VERTEX PHARMA
Inventor： STAMOS DEAN , TRUDEAU MARTIN , BETHIEL SCOTT , BADIA MICHAEL , SAUNDERS JEFFREY
IPC: C07D307/20 , A61K31/27 , A61K31/275 , A61K31/341 , A61K31/421 , A61K31/422 , A61K31/454 , A61K31/5377 , A61K31/541 , A61K45/00 , A61P1/18 , A61P9/10 , A61P11/06 , A61P19/02 , A61P29/00 , A61P31/12 , A61P35/00 , A61P37/02 , A61P43/00 , C07C275/40 , C07C275/42 , C07D263/32 , C07D413/12 , C07D417/12 , C07F9/653 , A61K31/277 , C07C275/34
Abstract: The present invention relates to compounds which inhibit JMPDH. This invention also relates to pharmaceutical compositions comprising these compounds. The compounds and pharmaceutical compositions of this invention are particularly well suited for inhibiting JMPDH enzyme activity and consequently, may be advantageously used as therapeutic agents for IMPDH-mediated processes. This invention also relates to methods for inhibiting the activity of I1VIPDH using the compounds of this invention and related compounds.
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公开(公告)号：NO20014535L
公开(公告)日：2001-11-19
申请号：NO20014535
申请日：2001-09-18
Applicant: VERTEX PHARMA
Inventor： STAMOS DEAN , TRUDEAU MARTIN , BETHIEL SCOTT , BADIA MICHAEL C , SAUNDERS JEFFREY
IPC: C07D307/20 , A61K31/27 , A61K31/275 , A61K31/341 , A61K31/421 , A61K31/422 , A61K31/454 , A61K31/5377 , A61K31/541 , A61K45/00 , A61P1/18 , A61P9/10 , A61P11/06 , A61P19/02 , A61P29/00 , A61P31/12 , A61P35/00 , A61P37/02 , A61P43/00 , C07C275/40 , C07C275/42 , C07D263/32 , C07D413/12 , C07D417/12 , C07F9/653
Abstract: The present invention relates to compounds which inhibit JMPDH. This invention also relates to pharmaceutical compositions comprising these compounds. The compounds and pharmaceutical compositions of this invention are particularly well suited for inhibiting JMPDH enzyme activity and consequently, may be advantageously used as therapeutic agents for IMPDH-mediated processes. This invention also relates to methods for inhibiting the activity of I1VIPDH using the compounds of this invention and related compounds.
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公开(公告)号：NO20014535D0
公开(公告)日：2001-09-18
申请号：NO20014535
申请日：2001-09-18
Applicant: VERTEX PHARMA
Inventor： STAMOS DEAN , TRUDEAU MARTIN , BETHIEL SCOTT , BADIA MICHAEL C , SAUNDERS JEFFREY
IPC: C07D307/20 , A61K31/27 , A61K31/275 , A61K31/341 , A61K31/421 , A61K31/422 , A61K31/454 , A61K31/5377 , A61K31/541 , A61K45/00 , A61P1/18 , A61P9/10 , A61P11/06 , A61P19/02 , A61P29/00 , A61P31/12 , A61P35/00 , A61P37/02 , A61P43/00 , C07C275/40 , C07C275/42 , C07D263/32 , C07D413/12 , C07D417/12 , C07F9/653 , A61K
Abstract: The present invention relates to compounds which inhibit JMPDH. This invention also relates to pharmaceutical compositions comprising these compounds. The compounds and pharmaceutical compositions of this invention are particularly well suited for inhibiting JMPDH enzyme activity and consequently, may be advantageously used as therapeutic agents for IMPDH-mediated processes. This invention also relates to methods for inhibiting the activity of I1VIPDH using the compounds of this invention and related compounds.
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