Patent search ap:("VERTEX PHARMA") AND inv:"FENG YUSHI" Page 3

21.

发明专利
SOLID FORMS OF N-[2,4-BIS(1,1-DIMETHYLETHYL)-5-HYDROXYPHENYL]-1,4-DIHYDRO-4-OXOQUINOLINE-3-CARBOXAMIDE 未知

公开(公告)号：AU2020201314B2

公开(公告)日：2022-02-03

申请号：AU2020201314

申请日：2020-02-21

Applicant: VERTEX PHARMA

Inventor： HURTER PATRICIA , CONNELLY PATRICK , ROWE WILLIAM , YOUNG CHRISTOPHER R , COSTACHE ADRIANA , KRAWIEC MARIUSZ , GONG YUCHUAN , FENG YUSHI , TRUDEAU MARTIN

IPC: A61K31/445

Abstract: The present invention relates to solid state forms of N-[2,4-bis(1,1-dimethylethyl)-5 hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide (Compound 1), pharmaceutical compositions thereof and methods therewith.

22.

发明专利
FARMACEUTSKI SASTAVI AMORFNOG OBLIKA N-[2,4-BIS(1,1-DIMETILETIL)-5-HIDROKSIFENIL]-1,4-DIHIDRO-4-OKSOKINOLIN-3-KARBOKSAMIDA 未知

公开(公告)号：HRP20200708T1

公开(公告)日：2020-07-24

申请号：HRP20200708

申请日：2020-05-04

Applicant: VERTEX PHARMA

Inventor： HURTER PATRICIA , GONG YUCHUAN , YOUNG CHRISTOPHER R , CONNELLY PATRICK , ROWE WILLIAM , COSTACHE ADRIANA , KRAWIEC MARIUSZ , FENG YUSHI , TRUDEAU MARTIN

IPC: C07D215/56 , A61K31/445

23.

发明专利
KRUTI OBLICI N-[2,4-BIS(1,1-DIMETILETIL)-5-HIDROKSIFENIL]-1,4-DIHIDRO-4-OKSOKINOLIN-3-KARBOKSAMIDA 未知

公开(公告)号：HRP20170682T1

公开(公告)日：2017-07-14

申请号：HRP20170682

申请日：2017-05-05

Applicant: VERTEX PHARMA

Inventor： HURTER PATRICIA , GONG YUCHUAN , YOUNG CHRISTOPHER R , CONNELLY PATRICK , ROWE WILLIAM , COSTACHE ADRIANA , KRAWIEC MARIUSZ , FENG YUSHI , TRUDEAU MARTIN

IPC: C07D215/56 , A61K31/445

24.

发明专利
FASTE FORMER AF N-[2,4-BIS(1,1-DIMETHYLETHYL)-5-HYDROXYPHENYL]-1,4-DIHYDRO-4-OXOQUINOLIN-3-CARBOXAMID 未知

公开(公告)号：DK1993360T3

公开(公告)日：2017-05-22

申请号：DK06848237

申请日：2006-12-28

Applicant: VERTEX PHARMA

Inventor： HURTER PATRICIA , GONG YUCHUAN , YOUNG CHRISTOPHER R , CONNELLY PATRICK , ROWE WILLIAM , COSTACHE ADRIANA , KRAWIEC MARIUSZ , FENG YUSHI , TRUDEAU MARTIN

IPC: C07D215/56 , A61K31/445

25.

发明专利
Solid forms of N-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide 未知

公开(公告)号：AU2008301907B2

公开(公告)日：2014-02-20

申请号：AU2008301907

申请日：2008-09-15

Applicant: VERTEX PHARMA

Inventor： ZHANG YUEGANG , LOOKER ADAM , DEMATTEI JOHN , ROEPER STEFANIE , HARRISON CRISTIAN , FENG YUSHI , MUDUNURI PRAVEEN

IPC: C07D215/233

Abstract: Solid forms of N-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide are described herein, including crystalline forms thereof.

26.

发明专利
Solid forms of n-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide 未知

公开(公告)号：NZ600865A

公开(公告)日：2014-01-31

申请号：NZ60086508

申请日：2008-09-15

Applicant: VERTEX PHARMA

Inventor： FENG YUSHI , LOOKER ADAM , ZHANG YUEGANG , DEMATTEI JOHN , MUDUNURI PRAVEEN , ROEPER STEFANIE , HARRISON CRISTIAN

IPC: A61K31/47 , A61P3/00 , A61P3/10 , A61P25/28 , A61P27/02 , A61P35/00 , C07D215/233

Abstract: 600865 Disclosed is N-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide (Compound 1)• PEG 400 (polyethylene glycol)•KOAc (potassium acetate). Also disclosed are crystalline form and x-ray powder diffraction patterns of Compound 1•PEG 400•KOAc, pharmaceutical combinations comprising Compound 1•PEG 400•KOAc, methods of making Compound 1•PEG 400•KOAc and the use of Compound 1•PEG 400•KOAc in the manufacture of a medicament. The medicament is useful in the treatment of cystic fibrosis, hereditary emphysema, hereditary hemochromatosis, coagulation- fibrinolysis deficiencies, lipid processing deficiencies, lysosomal storage diseases, neurodegenerative diseases, polyglutamine neurological disorders, spongiform encephalopathies, COPD, dry-eye disease, and Sjogren’s disease.

27.

发明专利
SOLID FORMS OF N-[2,4-BIS(1,1-DIMETHYLETHYL)-5-HYDROXYPHENYL]-1,4-DIHYDRO-4-OXOQUINOLINE-3-CARBOXAMIDE 未知

公开(公告)号：CA2635581A1

公开(公告)日：2007-07-12

申请号：CA2635581

申请日：2006-12-28

Applicant: VERTEX PHARMA

Inventor： CONNELLY PATRICK , COSTACHE ADRIANA , KRAWIEC MARIUSZ , GONG YUCHUAN , HURTER PATRICIA , YOUNG CHRISTOPHER R , FENG YUSHI , TRUDEAU MARTIN , ROWE WILLIAM

IPC: A01N43/40 , A61K31/445

Abstract: The present invention relates to solid state forms of N-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide (Compound 1), pharmaceutical compositions thereof and methods therewith.

28.

发明专利
ΦΑΡΜΑΚΕΥΤΙΚΕΣ ΣΥΝΘΕΣΕΙΣ ΤΗΣ ΑΜΟΡΦΗΣ ΜΟΡΦΗΣ Ν-[2,4-ΔΙΣ(1,1-ΔΙΜΕΘΥΛΑΙΘΥΛ)-5-ΥΔΡΟΞΥΦΑΙΝΥΛ]-1,4-ΔΙΥΔΡΟ-4-ΟΞΟΚΙΝΟΛΙΝΟ-3-ΚΑΡΒΟΞΑΜΙΔΙΟΥ 未知

公开(公告)号：CY1122861T1

公开(公告)日：2021-05-05

申请号：CY201100244

申请日：2020-03-17

Applicant: VERTEX PHARMA

Inventor： HURTER PATRICIA , GONG YUCHUAN , YOUNG CHRISTOPHER R , CONNELLY PATRICK , ROWE WILLIAM , COSTACHE ADRIANA , KRAWIEC MARIUSZ , FENG YUSHI , TRUDEAU MARTIN

IPC: C07D215/56 , A61K31/445

Abstract: ΗπαρούσαεφεύρεσηαφοράσεστερεάςκατάστασηςμορφέςτουΝ-[2,4-δις(1,1-διμεθυλαιθυλ)-5-υδροξυφαινυλ]-1,4-διυδρο-4-οξοκινολινο-3-καρβοξαμιδίου (Ένωση 1), φαρμακευτικέςσυνθέσειςαυτούκαιμεθόδουςμεαυτό.

29.

发明专利
KOMPOZYCJE FARMACEUTYCZNE AMORFICZNYCH POSTACI N-[2,4-BIS(1,1-DIMETYLOETYLO)-5-HYDROKSYFENYLO]-1,4-DIHYDRO-4-OKSOCHINOLINO-3-KARBOKSYAMIDU 未知

公开(公告)号：PL3219705T3

公开(公告)日：2020-08-10

申请号：PL17154944

申请日：2006-12-28

Applicant: VERTEX PHARMA

Inventor： KRAWIEC MARIUSZ , FENG YUSHI , TRUDEAU MARTIN , HURTER PATRICIA , GONG YUCHUAN , YOUNG CHRISTOPHER R , CONNELLY PATRICK , ROWE WILLIAM , COSTACHE ADRIANA

IPC: C07D215/56 , A61K31/445

30.

发明专利
N-[2,4-BIS(1,1-DIMETILEN)-5-HIDROKSIFENIL]-1,4-DIHIDRO-4-OKSOCHINOLIN-3-KARBOKSAMIDO AMORFINĖS FORMOS FARMACINĖS KOMPOZICIJOS 未知

公开(公告)号：LT3219705T

公开(公告)日：2020-04-27

申请号：LT17154944

申请日：2006-12-28

Applicant: VERTEX PHARMA

Inventor： HURTER PATRICIA , GONG YUCHUAN , YOUNG CHRISTOPHER R , CONNELLY PATRICK , ROWE WILLIAM , COSTACHE ADRIANA , KRAWIEC MARIUSZ , FENG YUSHI , TRUDEAU MARTIN

IPC: C07D215/56 , A61K31/445

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