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公开(公告)号：DK2408749T3
公开(公告)日：2018-08-13
申请号：DK10710748
申请日：2010-03-19
Applicant: VERTEX PHARMA
Inventor： YANG XIAOQING , HADIDA RUAH SARA S , GROOTENHUIS PETER D J , VAN GOOR FREDRICK F , BOTFIELD MARTYN C , ZLOKARNIK GREGOR
IPC: C07D215/233 , A61K31/47 , A61P3/00
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22.发明专利
公开(公告)号：CY1119796T1
公开(公告)日：2018-06-27
申请号：CY171101344
申请日：2017-12-22
Applicant: VERTEX PHARMA
Inventor： DEMATTEI JOHN , LOOKER ADAM R , NEUBERT-LANGILLE BOBBIANA , TRUDEAU MARTIN , ROPER STEFANIE , RYAN MICHAEL , YAP DAHRIKA MILFRED LAO , KRUEGER BRIAN R , GROOTENHUIS PETER D J , VAN GROOR FREDERICK F , BOTFIELD MARTYN C , ZLOKARNIK GREGOR
IPC: C07D215/233
Abstract: ΗεφεύρεσηπαρέχειμίαμέθοδογιατηνπαρασκευήμίαςένωσηςΤύπου 1˙πουπεριλαμβάνεισύζευξηενόςκαρβοξυλικούοξέοςΤύπου 2 μεμίαανιλίνηΤύπου 3˙παρουσίαενόςπαράγοντασύζευξης.
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23.发明专利
公开(公告)号：HRP20171901T1
公开(公告)日：2018-02-23
申请号：HRP20171901
申请日：2017-12-07
Applicant: VERTEX PHARMA
Inventor： DEMATTEI JOHN , LOOKER ADAM R , NEUBERT LANGILLE BOBBIANA , TRUDEAU MARTIN , ROPER STEFANIE , RYAN MICHAEL , YAP DAHRIKA MILFRED LAO , KRUEGER BRIAN R , GROOTENHUIS PETER D J , VAN GROOR FREDERICK F , BOTFIELD MARTYN C , ZLOKARNIK GREGOR
IPC: C07D215/233
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公开(公告)号：DK2821400T3
公开(公告)日：2018-01-02
申请号：DK14182117
申请日：2010-03-19
Applicant: VERTEX PHARMA
Inventor： DEMATTEI JOHN , NEUBERT-LANGILLE BOBBIANA , TRUDEAU MARTIN , RYAN MICHAEL , YAP DAHRIKA MILFRED LAO , KRUEGER BRIAN R , GROOTENHUIS PETER D J , VAN GROOR FREDERICK F , BOTFIELD MARTYN C , LOOKER ADAM R , ROPER STEFANIE , ZLOKARNIK GREGOR
IPC: C07D215/233
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公开(公告)号：AU2016244296A1
公开(公告)日：2016-11-03
申请号：AU2016244296
申请日：2016-10-13
Applicant: VERTEX PHARMA
Inventor： DEMATTEI JOHN , LOOKER ADAM R , NEUBERT-LANGILLE BOBBIANNA J , TRUDEAU MARTIN , ROEPER STEFANIE , RYAN MICHAEL P , GUERETTE DAHRIKA MILFRED LAO YAP , KRUEGER BRIAN R , GROOTENHUIS PETER D J , VAN GOOR FREDRICK F , BOTFIELD MARTYN C , ZLOKARNIK GREGOR
IPC: C07D215/233
Abstract: The invention provides a process for the preparation of a compound of Formula 1, N H (Rx-X H R2 Formula 1 comprising coupling a carboxylic acid of Formula 2 (Rx-X OH Formula 2 with an aniline of Formula 3 Formula 3 in the presence of a coupling agent.
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Patent Agency Ranking
公开(公告)号：BRPI1012549A8
公开(公告)日：2016-10-04
申请号：BRPI1012549
申请日：2010-03-19
Applicant: VERTEX PHARMA
Inventor： GOOR FREDRICK F VAN , ZLOKARNIK GREGOR , BOTFIELD MARTYN C , GROOTENHUIS PETER D J , RUAH SARA S HADIDA , YANG XIAOQING
IPC: A61K31/47 , A61P3/00 , C07D215/233
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公开(公告)号：AU2010226400B2
公开(公告)日：2016-07-14
申请号：AU2010226400
申请日：2010-03-19
Applicant: VERTEX PHARMA
Inventor： DEMATTEI JOHN , LOOKER ADAM R , NEUBERT-LANGILLE BOBBIANNA , TRUDEAU MARTIN , ROEPER STEFANIE , RYAN MICHAEL P , YAP GUERETTE DAHRIKA MILFRED LAO , KRUEGER BRIAN R , GROOTENHUIS PETER D J , VAN GOOR FREDRICK F , BOTFIELD MARTYN C , ZLOKARNIK GREGOR
IPC: C07D215/233
Abstract: The invention provides a process for the preparation of a compound of Formula 1; comprising coupling a carboxylic acid of Formula 2; with an aniline of Formula 3; in the presence of a coupling agent.
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28.发明专利
公开(公告)号：BRPI1011506A8
公开(公告)日：2016-07-05
申请号：BRPI1011506
申请日：2010-03-19
Applicant: VERTEX PHARMA
Inventor： LOOKER ADAM R , NEUBERT-LANGILLE BOBBIANNA , KRUEGER BRIAN R , YAP DAHRIKA MILFRED LAO , GOOR FREDERICK F VAN , ZLOKARNIK GREGOR , DEMATTEI JOHN , TRUDEAU MARTIN , BOTFIELD MARTYN C , RYAN MICHAEL P , GROOTENHUIS PETER D J , ROEPER STEFANIE
IPC: C07D215/233
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29.发明专利
公开(公告)号：PL2408750T3
公开(公告)日：2016-02-29
申请号：PL10710749
申请日：2010-03-19
Applicant: VERTEX PHARMA
Inventor： DEMATTEI JOHN , LOOKER ADAM R , NEUBERT-LANGILLE BOBBIANNA , TRUDEAU MARTIN , ROEPER STEFANIE , RYAN MICHAEL P , YAP DAHRIKA MILFRED LAO , KRUEGER BRIAN R , GROOTENHUIS PETER D J , VAN GOOR FREDERICK F , BOTFIELD MARTYN C , ZLOKARNIK GREGOR
IPC: C07D215/233
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30.发明专利
公开(公告)号：DK2408750T3
公开(公告)日：2015-10-05
申请号：DK10710749
申请日：2010-03-19
Applicant: VERTEX PHARMA
Inventor： DEMATTEI JOHN , LOOKER ADAM R , NEUBERT-LANGILLE BOBBIANNA , TRUDEAU MARTIN , ROEPER STEFANIE , RYAN MICHAEL P , YAP DAHRIKA MILFRED LAO , KRUEGER BRIAN R , GROOTENHUIS PETER D J , VAN GOOR FREDERICK F , BOTFIELD MARTYN C , ZLOKARNIK GREGOR
IPC: C07D215/233
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