公开(公告)号：WO2018203230A1

公开(公告)日：2018-11-08

申请号：PCT/IB2018/053008

申请日：2018-05-01

Applicant: WATERS TECHNOLOGIES CORPORATION

Inventor： TARAFDER, Abhijit ,  FOGWILL, Michael O. ,  SHREVE, Joshua A. ,  MICHIENZI, Joseph D. ,  CIAVARINI, Steven J.

IPC: G01N30/32 ,  B01D15/40

CPC classification number: G01N30/28 ,  B01D15/10 ,  B01D15/16 ,  B01D15/40 ,  G01N30/32

Abstract: The present disclosure relates generally to a system and a method for improving performance of a chromatography system using a highly-compressible fluid based mobile phase (e.g., CO 2 ). In particular, the present disclosure relates to a system that uses a conduit, such s a convergent-divergent nozzle, for reducing pressure noise in a chromatography system using a highly-compressible fluid based mobile phase. The chromatography system can include a conduit, such as a convergent-divergent nozzle, disposed downstream of the column to reduce or prevent the propagation of pressure or density pulses from a back pressure regulator.

公开(公告)号：WO2018189654A1

公开(公告)日：2018-10-18

申请号：PCT/IB2018/052464

申请日：2018-04-09

Applicant: WATERS TECHNOLOGIES CORPORATION

Inventor： MICHIENZI, Joseph D. ,  SHREVE, Joshua A. ,  HILL, Jason F. ,  TARAFDER, Abhijit ,  FOGWILL, Michael O. ,  FADGEN, Keith

IPC: G01N30/86 ,  G01N30/32 ,  B01D15/40

Abstract: Methods for transferring a carbon dioxide based separation procedure from a reference chromatographic system to a target chromatographic system involve alternative techniques for determining system pressure drops not attributable to the column. One technique involves leveraging experimental chromatography to develop a correction factor that is a function of at least one correction coefficient and at least one ratio of the differential analyte retention time to the retention time in the reference system. Another technique involves leveraging other experimental measurements of tubing pressure drops under various condition to develop a lookup table that can be used to identify likely tubing pressure drops in the target system. A third technique leverages knowledge of the separation procedure and the target system and the likely nature of the relevant flow to calculate tubing pressure drops in the target system.

公开(公告)号：WO2014143419A1

公开(公告)日：2014-09-18

申请号：PCT/US2014/013153

申请日：2014-01-27

Applicant: WATERS TECHNOLOGIES CORPORATION

Inventor： FOGWILL, Michael O. ,  MICHIENZI, Joseph D. ,  MURPHY, James P.

IPC: G01N30/32

CPC classification number: G01N30/30 ,  B01D15/163 ,  B01D15/40 ,  G01N30/32 ,  G01N30/6004 ,  G01N2030/3038 ,  G01N2030/324 ,  G01N2030/6008

Abstract: Thermally modulated variable restrictors used in chromatography systems enable independent control of system pressure and linear velocity of a compressible mobile phase passing through a chromatographic column. The restrictors include a restrictor body having a fluidic channel with an inlet that receives the mobile phase from the column and an outlet through which the mobile phase leaves the fluidic channel. A restrictor tip, disposed adjacent the outlet of the fluidic channel, has an egress opening that is smaller than an internal diameter of the fluidic channel. A heating element, thermally coupled to a subsection of the fluidic channel between its inlet and outlet, heats the mobile phase passing through that subsection of the fluidic channel. The restriction produced by the restrictor tip in response to the heating of the mobile phase enables independent control of system pressure and linear velocity of the mobile phase within the column.

Abstract translation: 色谱系统中使用的热调制可变限制器可独立控制通过色谱柱的可压缩流动相的系统压力和线速度。 限流器包括具有流体通道的限流器主体，其具有从柱接收流动相的入口和流动相离开流体通道的出口。 设置在流体通道出口附近的限制器尖端具有小于流体通道的内径的出口开口。 热连接到流体通道在其入口和出口之间的子部分的加热元件加热通过流体通道的该部分的流动相。 限制器尖端响应于流动相的加热而产生的限制使得能够独立地控制柱内的流动相的系统压力和线性速度。

公开(公告)号：WO2013032834A2

公开(公告)日：2013-03-07

申请号：PCT/US2012/051976

申请日：2012-08-23

Applicant: WATERS TECHNOLOGIES CORPORATION ,  MICHIENZI, Joseph D.

Inventor： MICHIENZI, Joseph D.

IPC: G01N30/60

CPC classification number: B05B5/16 ,  B01D15/10 ,  B01D15/1871 ,  B01D15/22 ,  G01N30/60 ,  G01N30/6004 ,  G01N30/6026 ,  G01N30/603 ,  G01N30/6039 ,  G01N30/6052 ,  G01N30/6095 ,  G01N30/7266 ,  Y10T29/49908

Abstract: Described is a chromatography a chromatography apparatus that includes a microfluidic substrate, a coupler and a sealing fitting. The microfluidic substrate can include one or more chromatography columns, such as analytical columns or trap columns, and an inlet in communication with the one or more chromatography columns. The coupler is diffusion bonded to the surface of the microfluidic substrate so that an opening in the coupler is aligned to the inlet in the microfluidic substrate. The sealing fitting includes a heat-resistant sealant disposed in the opening of the coupler and in contact with the surface of the substrate. The coupler and sealing fitting enable a compact fluid-tight connection to the inlet of the microfluidic substrate that exhibits high tensile and torsional strength, and does not require the use of adhesives.

Abstract translation: 描述了一种色谱分离装置，其包括微流体基板，耦合器和密封配件。 微流体底物可以包括一个或多个色谱柱，例如分析柱或捕集柱，以及与一个或多个色谱柱连通的入口。 耦合器扩散接合到微流体衬底的表面，使得耦合器中的开口与微流体衬底中的入口对准。 密封配件包括设置在耦合器的开口中并与衬底的表面接触的耐热密封剂。 联接器和密封配件能够实现紧凑的流体密封连接到微流体衬底的入口，其显示出高的拉伸和扭转强度，并且不需要使用粘合剂。

公开(公告)号：WO2013032832A1

公开(公告)日：2013-03-07

申请号：PCT/US2012/051972

申请日：2012-08-23

Applicant: WATERS TECHNOLOGIES CORPORATION ,  MICHIENZI, Joseph D. ,  FADGEN, Keith ,  LEVEILLE, SR., Wade P. ,  FISK, Raymond P. ,  MARZALKOWSKI, JR., Frank John

Inventor： MICHIENZI, Joseph D. ,  FADGEN, Keith ,  LEVEILLE, SR., Wade P. ,  FISK, Raymond P. ,  MARZALKOWSKI, JR., Frank John

IPC: B01D15/08 ,  B23P19/00

CPC classification number: B05B5/16 ,  B01D15/10 ,  B01D15/1871 ,  B01D15/22 ,  G01N30/60 ,  G01N30/6004 ,  G01N30/6026 ,  G01N30/603 ,  G01N30/6039 ,  G01N30/6052 ,  G01N30/6095 ,  G01N30/7266 ,  Y10T29/49908

Abstract: Described is a chromatography column assembly that includes a permanently deformable outer tube, an intermediate tube, an inner tube and a sorbent bed disposed within the inner tube. The sorbent bed may be in the form of packed chromatographic particles or a porous monolithic structure. A radial seal is provided by one or more uniform radial crimps at longitudinal locations on the assembly. The uniform radial crimp compresses the outer tube and underlying intermediate tube onto the inner tube to achieve a high pressure liquid tight seal between the three tubes. The length and depth of each crimp is accurately formed to accommodate the requirements of the particular application. Leakage along the tubing assembly is prevented and void volume is reduced or eliminated. No external ferrule or ferrule swaging mechanism is needed; therefore the chromatography column assembly is easily adapted for use in various chromatographic column configurations.

Abstract translation: 描述了一种色谱柱组件，其包括永久变形的外管，中间管，内管和设置在内管内的吸附剂床。 吸附剂床可以是填充色谱颗粒或多孔整体结构的形式。 在组件的纵向位置处由一个或多个均匀的径向卷曲提供径向密封。 均匀的径向卷曲将外管和下面的中间管压缩到内管上，以实现三管之间的高压液密封。 精确地形成每个卷曲的长度和深度以适应特定应用的要求。 防止管道组件的泄漏，减少或消除空隙体积。 不需要外部套圈或套圈型锻机构; 因此色谱柱组件易于适用于各种色谱柱配置。

公开(公告)号：WO2022164775A1

公开(公告)日：2022-08-04

申请号：PCT/US2022/013629

申请日：2022-01-25

Applicant: WATERS TECHNOLOGIES CORPORATION

Inventor： CORMIER, Sylvain Gilles ,  MURPHY, Charles T. ,  MICHIENZI, Joseph D.

IPC: G01N30/20 ,  B01L3/00 ,  F16K99/00 ,  F16K11/072 ,  G01N30/46

Abstract: Described is a rotary valve that includes a stator, a rotor and a plurality of sample channels. The stator includes a stator surface having an inlet port, an outlet port and a plurality of selectable ports. The rotor includes a rotor surface having a first rotor channel and a second rotor channel. The rotor is configurable in a plurality of rotor positions, each of which couples the inlet port to one of the selectable ports through the first rotor channel and couples the outlet port to another one of the selectable ports through the second rotor channel. The two selectable ports are coupled to each other through one of the sample channels. The rotor has a bypass state defined by a rotor position, or angular range of rotor positions, at which the inlet port is coupled to the outlet port through the second rotor channel.

公开(公告)号：WO2021236928A1

公开(公告)日：2021-11-25

申请号：PCT/US2021/033399

申请日：2021-05-20

Applicant: WATERS TECHNOLOGIES CORPORATION

Inventor： CORMIER, Syvlain Gilles ,  MURPHY, Charles T. ,  MICHIENZI, Joseph D.

IPC: G01N30/20

Abstract: Described is a multi-channel fluidic device that includes a diffusion-bonded body having a device surface and a plurality of fluid channels. Each fluid channel includes a channel segment defined in a plane that is parallel to the device surface and parallel to each of the planes of the other channel segments. The plane of each channel segment is at a depth below the device surface that is different from the depth below the device surface for the other planes. Each channel segment may have a volume equal to the volume of each of the other channel segments. One of the fluid channels may include a plurality of channel segments serially connected to each other and each defined in a plane that is different from the planes of the other channel segments.

公开(公告)号：WO2021222055A1

公开(公告)日：2021-11-04

申请号：PCT/US2021/029055

申请日：2021-04-26

Applicant: WATERS TECHNOLOGIES CORPORATION

Inventor： LEVEILLE, Wade P. ,  MICHIENZI, Joseph D. ,  ANTOCCI, Joseph D. ,  MUSACCHIO, Jeffrey

IPC: G01N30/60

Abstract: A clamp assembly includes a rail 62 extending along a length and configured to receive a first fluidic assembly, and a carriage 64 movably attachable to the rail 62 such that the carriage moves along the rail, the carriage 64 configured to receive a second fluidic assembly, the carriage including an actuator 65 and a stop mechanism. The stop mechanism is configured to selectively prevent and allow movement of the carriage 64 relative to the rail 62. The stop mechanism is configured to be independently operable from the actuator assembly, and the actuator is configured: to move a chromatography column received by the clamp assembly relative to the rail to create a first fluid tight seal between the chromatography column and the first fluidic assembly, and move the second fluidic assembly relative to the carriage body to create a second fluid tight seal between the second fluidic assembly and the chromatography column.

公开(公告)号：WO2020041315A1

公开(公告)日：2020-02-27

申请号：PCT/US2019/047268

申请日：2019-08-20

Applicant: WATERS TECHNOLOGIES CORPORATION

Inventor： EGGERTSON, Michael ,  FADGEN, Keith ,  MICHIENZI, Joseph D. ,  SHANG, Zongren ,  KOZIOL, Stanislaw

IPC: G01N30/32 ,  F16K99/00 ,  G01N30/60 ,  G01N30/20

Abstract: A variable fluidic restrictor of a liquid chromatography system including a stator body (50), the stator body include a plurality of fluidic channels (5, 5', 6, 6', 10, 10', 17, 17', 27, 27', 37, 37') located within the stator body, wherein each fluidic channel of the plurality of fluidic channels includes a restrictor element (15, 15', 25, 25', 35, 35'), wherein a flow of a fluid through the variable fluidic restrictor is selectively restricted based on a position of an external element (70,70') coupled to the stator body is provided. Furthermore, an associated method is also provided.

公开(公告)号：WO2019171151A1

公开(公告)日：2019-09-12

申请号：PCT/IB2018/051530

申请日：2018-03-08

Applicant: WATERS TECHNOLOGIES CORPORATION ,  FOGWILL, Michael O. ,  FADGEN, Keith ,  KELLEY, Scott ,  MICHIENZI, Joseph D.

Inventor： FOGWILL, Michael O. ,  FADGEN, Keith ,  KELLEY, Scott ,  MICHIENZI, Joseph D.

IPC: B01D11/02

Abstract: Exemplary embodiments are directed to a method for diffusing fluid flow within a modular extraction vessel. A modular extraction vessel can be assembled using a plurality of extraction vessel chambers, and each extraction vessel chamber is associated with at least one diffuser element. An extracting solvent is introduced into the modular extraction vessel, and the extracting solvent flows through the extraction vessel chambers. By flowing through the extraction vessel chambers and diffusers, the flow path of the extracting solvent is diffused along an extraction path.