公开(公告)号：EP0358250A3

公开(公告)日：1990-09-12

申请号：EP89201949.8

申请日：1989-07-25

Applicant: INSTRUMENTATION LABORATORY S.p.A.

Inventor： Calzi, Claudio

IPC: G01N27/416

CPC classification number: G01N27/4163 ,  Y10T436/102499

Abstract: A pre-determined amount of solubilized reagent is reacted to release CO₂ in a controlled-temperature reaction vessel and a controlled-pressure area adjacent the reaction vessel. The devices that enable the system to be maintained in the liquid phase, and the reaction vessel itself, are controlled, assuming that the O₂ in the solution is such as that deriving from the presence of O₂ in the atmosphere, if necessary corrected for the effect of the reaction producing CO₂. Thus, the amount of reagent taking part in the reaction being known, either by assay or by controlling the reaction time, by controlling the amount of O₂ in the solution containing the reagent, the barometric pressure, the temperature in the reaction vessel, and the coefficients of solubility of the two gases, it becomes possible to predict the partial pressures of O₂ and CO₂ in the liquid phase produced, which liquid phase is suitable for use as a calibration substance for an apparatus for measuring blood gases.

公开(公告)号：EP0355896A3

公开(公告)日：1990-09-12

申请号：EP89202034.8

申请日：1989-08-03

Applicant: INSTRUMENTATION LABORATORY S.p.A.

Inventor： Calabrese, Gary Stephen ,  Calzi, Claudio

IPC: G01N27/416

CPC classification number: G01N27/4163

Abstract: Electrodes for the measurement of pCO2 and/or pO2 are calibrated with an exposed aliquot of a calibration liquid. A constituent such as a ferrioxalate salt in the calibration liquid is converted to the gas in a reproducible concentration by exposure of the aliquot to light. In some instances, the calibration liquid is equilibrated with air prior to exposure. Some mechanisms of light generation of carbon dioxide also consume oxygen, so as to depress the pO2 value by a reproducible amount. The use of two different calibration liquids enables both one-point and two-point calibration of the Clark oxygen electrode and the Severinghaus pCO2 electrode of a blood gas instrument. Aqueous acidic ferrioxalate compositions are disclosed for use as calibrants of pCO2 and of pO2 after photodecomposition. Compositions with high iron(III) to oxalate molar ratios (e.g., 5:1 to 100:1 with 0.3 to 15 millimolar oxalate) produce carbon dioxide on exposure without oxygen consumption. Compositions with low iron(III) to oxalate ratios (e.g., 1:1000 to 1:2000) with 0.1 to 5 millimolar iron(III) produce carbon dioxide on exposure with concurrent oxygen consumption. Use of the two types of compositions enables calibration values to be established with varying pCO2 values and with, respectively, high and low pO2 values.

公开(公告)号：EP0358250A2

公开(公告)日：1990-03-14

申请号：EP89201949.8

申请日：1989-07-25

Applicant: INSTRUMENTATION LABORATORY S.p.A.

Inventor： Calzi, Claudio

IPC: G01N27/416

CPC classification number: G01N27/4163 ,  Y10T436/102499

Abstract: A pre-determined amount of solubilized reagent is reacted to release CO₂ in a controlled-temperature reaction vessel and a controlled-pressure area adjacent the reaction vessel.
The devices that enable the system to be maintained in the liquid phase, and the reaction vessel itself, are controlled, assuming that the O₂ in the solution is such as that deriving from the presence of O₂ in the atmosphere, if necessary corrected for the effect of the reaction producing CO₂.
Thus, the amount of reagent taking part in the reaction being known, either by assay or by controlling the reaction time, by controlling the amount of O₂ in the solution containing the reagent, the barometric pressure, the temperature in the reaction vessel, and the coefficients of solubility of the two gases, it becomes possible to predict the partial pressures of O₂ and CO₂ in the liquid phase produced, which liquid phase is suitable for use as a calibration substance for an apparatus for measuring blood gases.

Abstract translation: 增溶的试剂的预确定的量进行反应在受控温度下的反应容器和一个受控压力区域相邻的反应容器，以释放CO 2。 设备确实使被保持在液相中的系统中，并且将反应容器本身被控制，假设没有象从O2的在大气中的存在推导O2在溶液中进行检查，如果需要校正的效果 的反应生产CO 2。 因此，试剂的参与反应的量是已知的，或者通过测定或通过控制反应时间，通过控制在溶液中的O 2的量的含有试剂，气压，在反应容器中的温度，并且 两种气体的溶解度系数，能够预测O2和CO2的分压在所产生的液体相，其液相是适合用作在设备中的校准物质用于测量血液气体。

公开(公告)号：EP0354604A2

公开(公告)日：1990-02-14

申请号：EP89201744.3

申请日：1989-06-29

Applicant: INSTRUMENTATION LABORATORY S.p.A.

Inventor： Calzi, Claudio ,  Premoli, Pietro

IPC: G01N27/416

CPC classification number: G01N27/4162

Abstract: A system is disclosed for measuring the partial pressure of a gas, and in particular of carbon dioxide (p CO ). The system uses an electrolytic solution of weak ionic strenght which is circulated between an ion-selective electrode and a membrane permeable to gases but not to the ions and substantially distant from the electrode. The partial pressure of the gas is measured after a fraction of the electrolytic solution has been permeated by the gas present in the sample and subsequently has been transferred on the sensible portion of the electrode.

Abstract translation: 一种系统是游离缺失盘用于测量气体的分压，和在二氧化碳（CO P）的具体。 该系统使用弱离子实力的电解液的所有其在离子选择性电极和膜透过气体但不与离子和从电极基本上遥远之间循环的。 后的电解液的一小部分已经通过样品中存在的气体透过，并随后已经转移上的电极的敏感部分的气体的局部压力被测量。

公开(公告)号：EP0299661A2

公开(公告)日：1989-01-18

申请号：EP88306089.9

申请日：1988-07-04

Applicant: INSTRUMENTATION LABORATORY S.p.A.

Inventor： Geiselman, Theodore S. ,  Rasmussen, James

IPC: G01N35/08

CPC classification number: G01N35/085

Abstract: A liquid handling system includes flow network module structure that defines a contained array of flow channels and a plurality of valves for controlling liquid flow through the flow channel array. The flow network module structure is adapted to be connected to an external source for applying a pressure differential to the flow network array to produce liquid flow within passages of the array. Also incorporated in the flow network module is chamber structure that is connected to the flow channel array and that has port structure in an outer surface of the module structure. Valve structure on the module structure is movable between a first position in which the port structure is closed and a second position in which the port structure is opened, the valve structure including actuator structure for moving a valve member between the first and second positions. Liquid transfer structure, including transport structure and probe structure carried on the transport structure, is adapted to cause movement of the valve structure from its first position to its second position concurrently with the movement of the probe structure into alignment with the chamber port structure for delivery of a quantity of sample material to the sample chamber and subsequent flow through the flow network array for interaction with an auxiliary fluid and transfer to an associated utilization device under the influence of an external pressure source.

Abstract translation: 液体处理系统包括流网络模块结构，其限定流体通道阵列和用于控制通过流动通道阵列的液体流的多个阀。 流网络模块结构适于连接到外部源，用于向流动网络阵列施加压差以在阵列的通道内产生液体流。 还包括在流动网络模块中的腔室结构连接到流动通道阵列并且在模块结构的外表面中具有端口结构。 模块结构上的阀结构可在端口结构关闭的第一位置和端口结构打开的第二位置之间移动，该阀结构包括用于在第一位置和第二位置之间移动阀构件的致动器结构。 液体转移结构，包括运输结构上承载的输送结构和探针结构，适于引起阀结构从其第一位置到其第二位置的运动，同时探针结构的运动与腔室结构对准以进行输送 的一定量的样品材料到样品室，随后流过流动网络阵列以与辅助流体相互作用并在外部压力源的影响下转移到相关联的利用装置。

公开(公告)号：EP0185405A1

公开(公告)日：1986-06-25

申请号：EP85201844.9

申请日：1985-11-12

Applicant: INSTRUMENTATION LABORATORY S.p.A.

Inventor： Bonfiglio, Paolo ,  Calzi, Claudio

IPC: G01N21/25

CPC classification number: G01N21/255 ,  G01J1/1626 ,  G01N21/07 ,  G01N21/314 ,  G01N2201/0696 ,  G01N2201/08

Abstract: In an analytical photometer, in particular multi-channel,for the simultaneous analysis of a multiplicity of samples, the light source provided is a flash tube for producing light pulses in which a permanent preionization discharge is maintained and the light energy is derived by optical fibres to be sent to optical systems where the beam is divided into an analysis beam which travels through the sample and a reference beam, both finally delivered to photodetectors. Both the divided beams pass through identical filtering systems for selection of a narrow spectral band of relevance for analytical purposes.

公开(公告)号：EP0123178A3

公开(公告)日：1985-08-14

申请号：EP84103733

申请日：1984-04-04

Applicant: INSTRUMENTATION LABORATORY S.p.A.

Inventor： Calzi, Claudio

IPC: G01N21/07 ,  B04B05/04

CPC classification number: G01N21/07

Abstract: Analytical photometer for the practically simultaneous determination of the presence of different substances in a certain number of discrete samples. The photometer (10) is equipped with a centrifugal type rotor (16), already known in the art, containing a large number of chambers with inlet holes (20, 22) for the sample/samples and reagents and with axially aligned transparent windows, thereby forming a system of rotating cuvettes (18). The rotor compartments (16) serve as receptacles for the solutions and are designed and dimensioned as already known in the art, such as to retain the liquid when said rotor (16) is at rest and to transfer said liquid into the cuvettes (18) when the rotor (16) rotates. A single or multiple light source (L) is provided, which is transmitted in a novel manner through a system of suitable means, in particular, optical fibres (30-35) to various photodetector units (60 to 65), suitably aligned with the transparent windows of the cuvettes (18) by means of the same number of interference filters (50to 55) and appropriate holes (40 to 45) situated in the base (15) of the rotor (16). Thus it is possible to determine for the first time, concentrations of chemical solutions through the absorbance in the sample/samples plus reagent/reagents contained in the cuvettes (18) at various wave lengths, with wave energy being delivered from source (L). Hence it is possible to examine more than one cuvette (18) almost simultaneously and singly, each one for a different analytical parameter, and consequently to examine the transmittance and/or absorbance of the samples contained in the cuvettes at optimum wave length.

公开(公告)号：EP0341793B1

公开(公告)日：1993-09-01

申请号：EP89201165.1

申请日：1989-05-08

Applicant: INSTRUMENTATION LABORATORY S.p.A.

Inventor： Manzoni, Angelo ,  Belluati, Mario

IPC: G01N27/416

CPC classification number: G01N33/492 ,  G01N33/84

公开(公告)号：EP0184242B1

公开(公告)日：1993-05-05

申请号：EP85201845.6

申请日：1985-11-12

Applicant: INSTRUMENTATION LABORATORY S.p.A.

Inventor： Calzi, Claudio ,  Preda, Luigi

IPC: G01N21/51 ,  G01N33/86 ,  G01N33/48 ,  G01N21/07 ,  G01N21/82

CPC classification number: G01N21/82 ,  G01N21/07 ,  G01N21/51 ,  G01N33/4905 ,  Y10S436/909 ,  Y10T436/111666 ,  Y10T436/25375

公开(公告)号：EP0530871A1

公开(公告)日：1993-03-10

申请号：EP92202343.7

申请日：1992-07-29

Applicant: INSTRUMENTATION LABORATORY S.p.A.

Inventor： Tancredi, Gabrio ,  Calzi, Claudio

IPC: G01N33/00 ,  G01N27/416 ,  G01N33/49

CPC classification number: G01N33/4925 ,  G01N27/4163 ,  G01N33/0006 ,  Y10T436/10 ,  Y10T436/100833 ,  Y10T436/102499 ,  Y10T436/106664 ,  Y10T436/108331 ,  Y10T436/109163

Abstract: A method for producing a liquid phase substance having a pre-established concentration of CO₂ suitable for calibrating analytical instruments such as hemogasanalyzers consists in:

preparing an aqueous solution of precisely known strength of a water-soluble salt of carbonic acid (bicarbonate or alkaline carbonate),
then transferring said solution to a flow reactor containing a cation exchange resin in hydrogenionic form,
passing the aforesaid solution of carbonic acid salt through the aforesaid cation resin,
thereby achieving the reaction of producing a pre-established quantity of CO₂, and
transferring the eluate thus obtained directly to the analytical instrument for calibration.

Abstract translation: 如hemogasanalyzers besteht中：一种制造具有适合用于校准分析仪器CO 2的预先建立的浓度的液体相物质的方法准备wässrige的碳酸的水溶性盐的精确的已知浓度的溶液（碳酸氢盐或碱金属碳酸盐） ，然后转移环所述溶液的流动反应器包含在hydrogenionic形式的阳离子交换树脂，使碳酸盐的上述溶液通过上述阳离子树脂，由此实现生产CO 2的预先建立的量的反应，并传递环的洗脱液 从而直接获得用于校准的分析仪器。 我