公开(公告)号：CA2852064A1

公开(公告)日：2013-04-18

申请号：CA2852064

申请日：2012-10-12

Applicant: STC UNM ,  SANDIA CORP

Inventor： ASHLEY CARLEE ERIN ,  BRINKER C JEFFREY ,  CARNES ERIC C ,  FEKRAZAD MOHAMMAD HOUMAN ,  FELTON LINDA A ,  NEGRETE OSCAR ,  PADILLA DAVID PATRICK ,  WILKINSON BRIAN S ,  WILKINSON DAN C ,  WILLMAN CHERYL L

IPC: A61K9/16 ,  A61K31/7088 ,  A61K31/7105 ,  A61K38/17 ,  A61K47/48 ,  A61K48/00 ,  A61K49/08

Abstract: The present invention is directed to protocells for specific targeting of hepatocellular and other cancer cells which comprise a nanoporous silica core with a supported lipid bilayer; at least one agent which facilitates cancer cell death (such as a traditional small molecule, a macromolecular cargo (e.g. siRNA or a protein toxin such as ricin toxin A-chain or diphtheria toxin A-chain) and/or a histone-packaged plasmid DNA disposed within the nanoporous silica core (preferably supercoiled in order to more efficiently package the DNA into protocells) which is optionally modified with a nuclear localization sequence to assist in localizing protocells within the nucleus of the cancer cell and the ability to express peptides involved in therapy (apoptosis/cell death) of the cancer cell or as a reporter, a targeting peptide which targets cancer cells in tissue to be treated such that binding of the protocell to the targeted cells is specific and enhanced and a fusogenic peptide that promotes endosomal escape of protocells and encapsulated DNA. Protocells according to the present invention may be used to treat cancer, especially including hepatocellular (liver) cancer using novel binding peptides (c-MET peptides) which selectively bind to hepatocellular tissue or to function in diagnosis of cancer, including cancer treatment and drug discovery.

公开(公告)号：CA2789674A1

公开(公告)日：2011-09-15

申请号：CA2789674

申请日：2011-03-09

Applicant: STC UNM

Inventor： SELVAM PARTHIBAN ,  SMYTH HUGH D C ,  DONOVAN MARTIN

IPC: B05B7/14 ,  B05B7/02 ,  B05B7/24 ,  B05B15/00

Abstract: A device for coating dry powder microparticles onto a surfacemay include a jet mill configured to mill dry powder particles into microparticles having a desired aerodynamic diameter and to deaggregate the microparticles, a feed hopper structured and arranged to feed dry powder particles to the jet mill, a surface configured to receive dry powder microparticles and an exit nozzle associated with the jet mill. The exit nozzle may be arranged to direct deaggregated micronized dry powder particles from the jet mill to the surface to be coated. The device may further include a holder structured and arranged to hold an item, wherein the item includes the surface. In some aspects of the device, the item may be a film.

公开(公告)号：CA2785992A1

公开(公告)日：2011-07-07

申请号：CA2785992

申请日：2010-12-31

Applicant: STC UNM

Inventor： PEABODY DAVID S ,  CHACKERIAN BRYCE

IPC: C12N7/01 ,  A61K39/12 ,  C07K14/005 ,  C12N15/33

Abstract: The present invention relates to a system and method for controlling peptide display valency on virus-like particles (VLPs), especially including MS2 VLPs. In this method, large amounts of wild-type and low quantities of single-chain dimer coat proteins may be produced from a single RNA. Valency is controlled in immunogen (vaccine) production by providing a system that allows the production of large amounts of wild-type and low quantities of single-chain dimer coating proteins from a single RNA, allowing facile adjustment of display valency levels on VLPs, especially MS2 VLPS over a wide range, from few than one- on average- to as many as ninety per particle. This facilitates the production of immunogens and vaccines, including VLPs exhibiting low valency. Nucleic acid constructs useful in the expression of virus-like particles are disclosed, comprised of a coat polypeptide of MS2 modified by insertion of a heterologous peptide, wherein the heterologous peptide is displayed on the virus-like particle and encapsidates MS2 niRNA. Nucleic acid constructs are also disclosed which are useful in the expression of virus-like particles comprised of a coat polypeptide of PP7 modified by insertion of a heterologous peptide, wherein the heterologous peptide is displayed on the virus-like particle and encapsidates PP7 mRNA.

公开(公告)号：CA2732585A1

公开(公告)日：2010-02-04

申请号：CA2732585

申请日：2009-07-30

Applicant: STC UNM

Inventor： SMYTH HUGH D C ,  DONOVAN MARTIN

IPC: A61K9/14

Abstract: A dry powder inhaler may include a drug chamber configured to contain a formulation including carrier particles and working agent particles, a mouthpiece configured to direct flow of working agent particles to a user, and a retaining member proximal the mouthpiece. The retaining member be sized and arranged to prevent flow of substantially all carrier particles to the user while permitting flow of working agent particles to a user. The inhaler may include a formulation including carrier particles for delivering working agent to the pulmonary system of a patient. The carrier particles may have an average sieve diameter greater than about 500 µm. The carrier particles may be one of polystyrene, PTFE, silicone glass, and silica gel or glass.

公开(公告)号：AU2009276498A1

公开(公告)日：2010-02-04

申请号：AU2009276498

申请日：2009-07-30

Applicant: STC UNM

Inventor： SMYTH HUGH D C ,  DONOVAN MARTIN

IPC: A61K9/14

Abstract: A dry powder inhaler may include a drug chamber configured to contain a formulation including carrier particles and working agent particles, a mouthpiece configured to direct flow of working agent particles to a user, and a retaining member proximal the mouthpiece. The retaining member be sized and arranged to prevent flow of substantially all carrier particles to the user while permitting flow of working agent particles to a user. The inhaler may include a formulation including carrier particles for delivering working agent to the pulmonary system of a patient. The carrier particles may have an average sieve diameter greater than about 500 μm. The carrier particles may be one of polystyrene, PTFE, silicone glass, and silica gel or glass.

公开(公告)号：AU2008335144A1

公开(公告)日：2009-06-18

申请号：AU2008335144

申请日：2008-12-10

Applicant: STC UNM

Inventor： CHEN JINGKUANG

IPC: A61B8/00

公开(公告)号：GB2430267B

公开(公告)日：2008-11-26

申请号：GB0622266

申请日：2005-06-01

Applicant: UNIV NEW MEXICO ,  SCIENCE & TECHNOLOGY CORP AT U ,  STC UNM A NON PROFIT CORP UNDE

Inventor： TIMMINS GRAHAM S

IPC: A61B5/055 ,  A61B5/05 ,  A61B5/103 ,  G01R33/60

Abstract: Embodiments of methods and apparatus use electron paramagnetic resonance spectroscopy to provide a signal from melanin to image a melanoma. Embodiments of methods and apparatus use electron paramagnetic resonance spectroscopy to provide a signal from melanin to detect metastatic melanoma in a sentinel lymph node. Embodiments of methods and apparatus use electron paramagnetic resonance spectroscopy to provide a signal from melanin to measure light penetration in melanocytes in skin.

公开(公告)号：CA2648291A1

公开(公告)日：2007-11-01

申请号：CA2648291

申请日：2007-04-03

Applicant: STC UNM

Inventor： SMYTH HUGH D ,  DONOVAN MARTIN J

IPC: A61K9/22 ,  A61K31/195

Abstract: Swellable particles for delivering a working agent to the pulmonary system comprise a plurality of biodegradable particles each formed from a polymer network, each of the plurality of biodegradable particles having a mass mean aerodynamic diameter not exceeding 5 mum, the particles being swellable by hydration to a size that is greater than 6 mum volume mean diameter, and a working agent entrapped in the polymer network of each of the plurality of biodegradable particles.

公开(公告)号：IL154997D0

公开(公告)日：2003-10-31

申请号：IL15499701

申请日：2001-09-21

Applicant: STC UNM

IPC: H01L29/06 ,  H01S5/12 ,  H01S5/14 ,  H01S5/183 ,  H01S5/34 ,  H01S5/343 ,  H01S5/40 ,  H01L

Abstract: Quantum dot active region structures are disclosed. In a preferred embodiment, the distribution in dot size and the sequence of optical transition energy values associated with the quantum confined states of the dots are selected to facilitate forming a continuous optical gain spectrum over an extended wavelength range. In one embodiment, the quantum dots are self-assembled quantum dots with a length-to-width ratio of at least three along the growth plane. In one embodiment, the quantum dots are formed in quantum wells for improved carrier confinement. In other embodiments, the quantum dots are used as the active region in laser devices, including tunable lasers and monolithic multi-wavelength laser arrays.

公开(公告)号：CA2424468A1

公开(公告)日：2002-03-28

申请号：CA2424468

申请日：2001-09-21

Applicant: STC UNM

Inventor： LI HUA ,  NEWELL TIMOTHY C ,  VARANGIS PETROS N ,  STINTZ ANDREAS ,  LESTER LUKE F ,  MALLOY KEVIN J

IPC: H01L29/06 ,  H01S5/12 ,  H01S5/14 ,  H01S5/183 ,  H01S5/34 ,  H01S5/343 ,  H01S5/40 ,  H01L33/00

Abstract: Quantum dot active region structures are disclosed. In a preferred embodimen t, the distribution in dot size and the sequence of optical transition energy values associated with the quantum confined states of the dots are selected to facilitate forming a continuous optical gain spectrum over an extended wavelength range. In one embodiment, the quantum dots are self-assembled quantum dots with a length-to-width ratio of at least three along the growth plane. In one embodiment, the quantum dots are formed in quantum wells for improved carrier confinement. In other embodiments, the quantum dots are use d as the active region in laser devices, including tunable lasers and monolith ic multi-wavelength laser arrays.