公开(公告)号：WO1995017659A1

公开(公告)日：1995-06-29

申请号：PCT/US1994013452

申请日：1994-11-21

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  BARNES, Thomas, Lee ,  COLBURN, James, Wright ,  DANIAL, Catherine, Louise ,  JONES, William, Ralph, Jr. ,  LONGMAN, Willard Dumas

IPC: G01N15/12

CPC classification number: G01N15/1218 ,  Y10T29/49945

Abstract: A method of making a count probe for counting particles comprises the following steps. A count wafer is formed along with a core member having an opening for accepting the count wafer. The count wafer is applied to the opening in the core member to form an interference fit between the count wafer and the core member. After application of the count wafer to the opening in the core member, the core member is annealed to relieve stress in the core member.

Abstract translation: 制备用于计数颗粒的计数探针的方法包括以下步骤。 计数晶片与具有用于接受计数晶片的开口的芯构件一起形成。 将计数晶片施加到芯构件中的开口以在计数晶片和芯构件之间形成干涉配合。 在将计数晶片应用于芯构件的开口之后，将芯构件退火以减轻芯构件中的应力。

公开(公告)号：WO1995017252A1

公开(公告)日：1995-06-29

申请号：PCT/US1994013559

申请日：1994-11-22

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  SALDIVAR, Louis, Jr. ,  RUTNARAK, Sangvorn

IPC: B01L03/00

CPC classification number: B01L3/502715 ,  B01L3/0275 ,  B01L2400/0406 ,  G01N15/12 ,  G01N15/1218

Abstract: Methods of using a disposable reagent pack (10) with an analytical instrument to analyze a blood sample are provided. According to one embodiment, a disposable reagent pack (10) comprising a sample well (120), a lysing solution well (28, 118), and a red blood cell analytic sample well (22, 112) is used. A blood sample is placed into the sample well (120) and the red blood cell analytic sample well (22, 112). Fluid is selectively transferred between the sample well (120) and the lysing solution well (118). Both the lysing solution well (28, 118) and the red blood cell analytic sample well (22, 112) are simultaneously presented to the analytical instrument for analysis.

Abstract translation: 提供了使用一次性试剂包（10）与分析仪器分析血液样品的方法。 根据一个实施例，使用包括样品阱（120），裂解溶液阱（28,118）和红细胞分析样品阱（22,112）的一次性试剂包（10）。 将血液样品放入样品孔（120）和红细胞分析样品（22,112）中。 流体在样品阱（120）和裂解溶液阱（118）之间选择性转移。 裂解溶液（28,118）和红细胞分析样品孔（22,112）均同时呈现给分析仪器进行分析。

公开(公告)号：WO1995016920A1

公开(公告)日：1995-06-22

申请号：PCT/US1994014455

申请日：1994-12-16

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  MARCH, Steven, C. ,  JENG, Tzyy-Wen

IPC: G01N33/74

CPC classification number: G01N33/743 ,  G06F19/00 ,  G16H40/63

Abstract: Provided is a highly reliable method to predict the beginning and/or ending of the fertile period for a female for each menstrual cycle. The methods and means provided advantageously address the day-to-day, cycle-to-cycle, and women-to-women variability in fertility hormone levels by analyzing the measurements of serial hormone concentrations in the midst of daily hormonal variations to determine when an actual and significant increase in the concentration of the monitored hormone has begun. Thus the present disclosure is directed to a method that combines existing hormone assay methods with calculation procedures to optimize the predictive values of daily hormonal changes. In this way a reliable and useful prediction of the fertile period is achieved with the concomitant assurance that the beginning and/or end of the fertile period has been reached so that such declarations are sufficient to provide both fertility enhancement and contraceptive utility.

Abstract translation: 提供了一种高度可靠的方法来预测每个月经周期中女性的肥沃期的开始和/或结束。 提供的方法和手段有利地通过分析日常激素变异中的连续激素浓度的测量来确定生育激素水平的日常，周期与周期以及妇女与女性的变异性，以确定何时 监测的激素的浓度的实际和显着增加已经开始。 因此，本公开涉及将现有激素测定方法与计算程序组合以优化每日激素变化的预测值的方法。 以这种方式，可以有效地预测肥沃期，同时确保已经达到肥沃期的开始和/或结束，以便这种声明足以提供生育能力和避孕效用。

公开(公告)号：WO1995016871A1

公开(公告)日：1995-06-22

申请号：PCT/US1994013584

申请日：1994-11-25

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  POLI, Robert, G.

IPC: F16K17/18

CPC classification number: F16K7/00 ,  A61M39/24 ,  A61M39/281 ,  A61M2039/242 ,  A61M2039/2426 ,  F16K15/185 ,  F16K17/18 ,  Y10T137/7771 ,  Y10T137/7877 ,  Y10T137/7881

Abstract: A bi-directional cracking valve that can be selectively opened. Bi-directional cracking valve (10, 70) is formed using an elastomeric membrane (34). Centered within the elastomeric membrane is a slit (36) that remains closed, blocking fluid flow through the device until a differential pressure across the elastomeric membrane exceeds a predefined cracking pressure, sufficient to force fluid through the slit. The elastomeric membrane is an integral part of an elastomeric cylinder (28), which is mounted in a valve carrier (12). The valve carrier includes ports disposed at opposite ends and the ports are adapted to couple to tubing. An operator can selectively enable fluid flow through the device by squeezing side tabs (40, 42) disposed on opposite sides of the elastomeric membrane together, forcing the slit open. A latch (46) is provided to keep the bi-directional cracking valve in an open state.

Abstract translation: 可以有选择地打开的双向开关阀。 使用弹性体膜（34）形成双向开裂阀（10,70）。 以弹性体膜为中心的是狭缝（36），其保持关闭，阻止流体流过该装置，直到穿过弹性体膜的压差超过预定的开启压力，足以迫使流体穿过狭缝。 弹性膜是弹性体圆柱体（28）的组成部分，其被安装在阀载体（12）中。 阀载体包括设置在相对端部的端口，并且端口适于联接到管道。 操作者可以通过将设置在弹性体膜的相对侧上的侧突片（40,42）挤压在一起来迫使狭缝打开，从而可以选择性地使液体流过装置。 提供一个闩锁（46）以保持双向开启阀处于打开状态。

公开(公告)号：WO1995016687A1

公开(公告)日：1995-06-22

申请号：PCT/US1994014112

申请日：1994-12-08

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  SUMMERS, James, B., Jr. ,  DAVIDSEN, Steven, K. ,  CURTIN, Michael, L. ,  HEYMAN, H., Robin ,  SHEPPARD, George, S. ,  XU, Lianhong ,  CARRERA, George, M., Jr. ,  GARLAND, Robert, B.

IPC: C07D471/04

CPC classification number: C07D403/10 ,  C07D471/04

Abstract: The present invention relates to compounds of formula (I) and the pharmaceutically acceptable salts thereof which are potent antagonists of PAF and are useful in the treatment of PAF-related disorders including asthma, shock, respiratory distress syndrome, acute inflammation, transplanted organ rejection, gastrointestinal ulceration, allergic skin diseases, delayed cellular immunity, parturition, fetal lung maturation, and cellular differentiation.

Abstract translation: 本发明涉及作为PAF的有效拮抗剂的式（I）化合物及其药学上可接受的盐，可用于治疗PAF相关疾病，包括哮喘，休克，呼吸窘迫综合征，急性炎症，移植器官排斥反应， 胃肠溃疡，过敏性皮肤病，延迟的细胞免疫，分娩，胎儿肺成熟和细胞分化。

公开(公告)号：WO1995014023A1

公开(公告)日：1995-05-26

申请号：PCT/US1994012777

申请日：1994-11-07

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  OR, Yat, Sun ,  LULY, Jay, R. ,  WAGNER, Rolf

IPC: C07D498/18

CPC classification number: C07D498/18

Abstract: Novel macrolide compounds, semisynthetic analogs of Rapamycin, of formula (I) and pharmaceutically acceptable salts, esters, amides and prodrugs thereof, processes for the preparation of the compounds of the invention, intermediates useful in these processes, a pharmaceutical composition, and a method of treating immunomodulatory disorders are disclosed.

Abstract translation: 新型大环内酯类化合物，式（I）的雷帕霉素的半合成类似物及其药学上可接受的盐，酯，酰胺和前药，制备本发明化合物的方法，可用于这些方法的中间体，药物组合物和方法 公开了治疗免疫调节性疾病的方法。

公开(公告)号：WO1995011224A1

公开(公告)日：1995-04-27

申请号：PCT/US1994010852

申请日：1994-09-26

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  STUK, Timothy, L. ,  KERDESKY, Francis, A., J. ,  LIJEWSKI, Linda, M. ,  NORBECK, Daniel, W. ,  SCARPETTI, David ,  TIEN, Jien-Heh, J. ,  ALLEN, Michael, S. ,  LANGRIDGE, Denton, C. ,  MELCHER, Laura ,  RENO, Daniel, S. ,  SHAM, Hing, Leung ,  ZHAO, Chen ,  HAIGHT, Anthony, R. ,  LEANNA, M., Robert ,  MORTON, Howard, E. ,  ROBBINS, Timothy, A. ,  SOWIN, Thomas, J.

IPC: C07C225/16

CPC classification number: C07D221/14 ,  C07B2200/07 ,  C07C213/00 ,  C07C215/28 ,  C07C225/16 ,  C07C251/40 ,  C07C255/42 ,  C07C269/06 ,  C07C271/20 ,  C07D209/44 ,  C07C215/08

Abstract: Intermediates and processes are disclosed which are useful for the preparation of a substantially pure compound of formula (3), wherein R6 and R7 are each hydrogen or R6 and R7 are independently selected from (i), wherein Ra and Rb are independently selected from hydrogen, loweralkyl and phenyl and Rc, Rd and Re are independently selected from hydrogen, loweralkyl, trifluoromethyl, alkoxy, halo and phenyl; and (ii) wherein the naphthyl ring is unsubstituted or substituted with one, two or three substituents independently selected from loweralkyl, trifluoromethyl, alkoxy and halo; or R6 is as defined above and R7 is R7aOC (O)-wherein R7a is loweralkyl or benzyl; or R6 and R7 taken together with the nitrogen atom to which they are bonded are (a) or (b), wherein Rf, Rg, Rh and Ri are independently selected from hydrogen, loweralkyl, alkoxy, halogen and trifluoromethyl and R8 is hydrogen or -C(O)R" wherein R" is loweralkyl, alkoxy, benzyloxy or phenyl wherein the phenyl ring is unsubstituted or substituted with one, two or three substituents independently selected from loweralkyl, trifluoromethyl, alkoxy and halo; or an acid addition salt thereof.

Abstract translation: 公开了可用于制备基本上纯的式（3）化合物的中间体和方法，其中R 6和R 7各自为氢或R 6和R 7独立地选自（ⅰ），其中R a和R b独立地选自氢 ，低级烷基和苯基，Rc，Rd和Re独立地选自氢，低级烷基，三氟甲基，烷氧基，卤素和苯基; 和（ii）其中萘基环是未取代的或被一个，两个或三个独立地选自低级烷基，三氟甲基，烷氧基和卤素的取代基取代; 或R 6如上所定义，且R 7为R 7 a OC（O） - 其中R 7a为低级烷基或苄基; 或R 6和R 7与它们所键合的氮原子一起是（a）或（b），其中R f，R g，Rh和R 1独立地选自氢，低级烷基，烷氧基，卤素和三氟甲基，并且R 8是氢或 -C（O）R“其中R”是低级烷基，烷氧基，苄氧基或苯基，其中苯环是未取代的或被一个，两个或三个独立地选自低级烷基，三氟甲基，烷氧基和卤素的取代基取代; 或其酸加成盐。

公开(公告)号：WO1995011083A2

公开(公告)日：1995-04-27

申请号：PCT/US1994012125

申请日：1994-10-21

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  HANLEY, Kathleen, A. ,  HOFFERBERT, A., David ,  LEE, Helen, H. ,  PEPE, Curtis, J. ,  PERKO, Timothy, J. ,  ZUREK, Thomas, F.

IPC: B01L07/00

CPC classification number: B01L3/50825 ,  B01L7/52

Abstract: A disposable reaction vessel for performing nucleic acid amplification assay. The disposable reaction vessel has a penetrable cap that can be penetrated by an automated pipettor to aspirate a portion of an amplified reaction product. The disposable reaction vessel contains the reagents necessary to perform a nucleic acid amplification assay. A patient speciment is added to the unit dose reagents in the disposable reaction vessel and the penetrable cap is closed. The disposable reaction vessel containing the reaction mixture and the specimen undergoes amplification, typically by placing it in a thermal cycler. After amplification the intact disposable reaction vessel is transferred to an automated analyzer where an automated pipettor penetrates the closure membrane and aspirates a portion of the amplified sample for further processing, without removal of the reaction vessel cap. This avoids the generation of potentially contaminating aerosols or droplets.

Abstract translation: 用于进行核酸扩增测定的一次性反应容器。 一次性反应容器具有可穿透的帽，其可被自动移液器穿透以吸收一部分经扩增的反应产物。 一次性反应容器含有执行核酸扩增测定所必需的试剂。 将患者物质加入到一次性反应容器中的单位剂量试剂中，并将可穿透盖封闭。 含有反应混合物和样品的一次性反应容器通常通过将其放置在热循环仪中进行扩增。 扩增后，将完整的一次性反应容器转移至自动分析器，其中自动移液器渗透封闭膜并抽吸一部分扩增的样品用于进一步处理，而不需要移除反应容器盖。 这避免了潜在的污染气溶胶或液滴的产生。

公开(公告)号：WO1995008974A1

公开(公告)日：1995-04-06

申请号：PCT/US1994010366

申请日：1994-09-14

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  KARAS, Peter, J. ,  OSWALD, Timothy, J.

IPC: A61J01/05

CPC classification number: A61J1/10 ,  Y10S604/905

Abstract: A parenteral solution container having a dual use access port used for both the administration of fluids to a patient as well as for the addition of fluids to the container, includes a generally cylindrical wall with an axial passage therethrough. A fluid-tight sealing means, having a reseal member that includes a slit therein to enable the reseal member to be pierced with a blunt, metal cannula, or sharp needle is removably attached to the dual use access port. When the dual use access port is used in its fluid addition capacity, the reseal member is attached to the wall and a blunt cannula is passed through the reseal member. Once the blunt cannula has been completely inserted, fluids may be added to the container. To use the dual use access port in its administration capacity, the sealing means is completely removed from the wall. A piercing pin is inserted into the wall creating a fluid-tight seal so that fluids may be administered to a patient.

Abstract translation: 具有用于向患者施用流体以及将流体添加到容器中的双重用途进入口的肠胃外溶液容器包括具有穿过其中的轴向通道的大致圆柱形的壁。 一种流体密封的密封装置，其具有包括其中的狭缝的重新密封装置，以使得能够用钝的金属套管或尖锐的针刺穿重新密封构件，以可拆卸地连接到双重用途的进入口。 当双重使用进入口以其流体添加能力使用时，重新密封构件附接到壁上，并且钝头套管穿过重新密封构件。 一旦钝头插管完全插入，流体可以被添加到容器中。 为了在其管理能力中使用双重使用的接入端口，密封装置被完全从墙壁上移除。 刺穿的针被插入到壁中，产生流体密封，使得可以向患者施用流体。

公开(公告)号：WO1995007696A1

公开(公告)日：1995-03-23

申请号：PCT/US1994009788

申请日：1994-08-30

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  AL-RAZZAK, Laman, A. ,  MARSH, Kennan, C. ,  MANNING, Lourdes, P. ,  KAUL, Dilip

IPC: A61K31/425

CPC classification number: A61K31/635 ,  A61K9/4858 ,  A61K31/00 ,  A61K31/425 ,  A61K31/426 ,  A61K31/427 ,  A61K31/47 ,  A61K31/472 ,  A61K31/4725 ,  A61K31/496 ,  A61K31/551

Abstract: A pharmaceutical composition is disclosed which comprises a solution of an HIV protease inhibiting compound in a pharmaceutically acceptable organic solvent comprising a pharmaceutically acceptable alcohol. The composition can optionally comprise a pharmaceutically acceptable acid or a combination of pharmaceutically acceptable acids. The solution can optionally be encapsulated in hard gelating capsule or soft elastic gelating capsules. The solution can optionally be granulated with a pharmaceutically acceptable granulating agent.

Abstract translation: 公开了一种药物组合物，其包含HIV蛋白酶抑制化合物在包含药学上可接受的醇的药学上可接受的有机溶剂中的溶液。 组合物可以任选地包含药学上可接受的酸或药学上可接受的酸的组合。 该溶液可任选地包封在硬胶凝胶囊或软弹性凝胶胶囊中。 该溶液可以任选地用药学上可接受的制粒剂造粒。