公开(公告)号：NO20030142L

公开(公告)日：2003-08-26

申请号：NO20030142

申请日：2003-01-10

Applicant: ACADEMIA SINICA

Inventor： WU JEN-LEIH ,  HONG JIANN-RUEY

IPC: C07K14/08 ,  C12N20060101 ,  C12N15/09 ,  C12N15/40

公开(公告)号：ZA200205086B

公开(公告)日：2003-02-12

申请号：ZA200205086

申请日：2002-06-25

Applicant: ACADEMIA SINICA ,  NAT HEALTH RESEACH INST ,  UNIV NAT TAIWAN

Inventor： CHEN JEREMY J W ,  HONG TSE-MING ,  PECK KONAN ,  WU CHENG-WEN ,  YANG PAN-CHYR ,  YANG SHUENN-CHEN

IPC: G01N33/50 ,  C12N15/09 ,  C12Q1/68 ,  C12Q1/6886 ,  G01N33/15 ,  G01N33/574 ,  G01N37/00 ,  C07K ,  C08H

Abstract: Many genes are identified as being metastasis associated. Identifying and profiling of these genes expression can be used to evaluate a sample, to diagnose tumor invasive potential or metastatic development in a sample, or screen for a test compound useful in the prevention or treatment of tumor metastasis.

公开(公告)号：AU7242200A

公开(公告)日：2001-12-13

申请号：AU7242200

申请日：2000-12-20

Applicant: ACADEMIA SINICA

Inventor： YU SU-MAY ,  CHENG KUO-JOAN ,  LIU LI-FEI ,  SHAW JEI-FU

IPC: C12N9/16 ,  C12N9/44 ,  C12N15/82 ,  C12N15/55 ,  A01H5/00 ,  C12N5/04

公开(公告)号：NL1011688C2

公开(公告)日：2001-09-13

申请号：NL1011688

申请日：1999-03-29

Applicant: ACADEMIA SINICA

Inventor： FENG TENG-YUNG ,  LIN HAO-JAN

IPC: C07K14/245 ,  C07K14/415 ,  C12N15/29 ,  C12N15/82 ,  A01H5/00 ,  A01N65/00

Abstract: This invention relates to amphipathic protein-1 polypeptides and genes encoding them. The amphipathic protein-1 polypeptides of the invention protect plants from tissue damage caused by the hypersensitive response, which is often elicited by bacterial infection in higher plants.

公开(公告)号：AU6250000A

公开(公告)日：2001-04-12

申请号：AU6250000

申请日：2000-10-05

Applicant: ACADEMIA SINICA

Inventor： HWANG JAULANG ,  TING CHUN-JEN ,  HSU CHIA-TSE

IPC: A61K39/00 ,  C07K7/23 ,  C07K14/07 ,  C07K14/21 ,  C12N15/16 ,  C12N15/31 ,  C12N15/39 ,  C07K14/575 ,  C07H21/02 ,  C07H21/04 ,  C07K16/26 ,  C07K19/00 ,  A61K38/22 ,  A61P37/02

Abstract: A polypeptide comprising, (1) a receptor binding domain of a Pseudomonas exotoxin A or a functional variant thereof, and (2) at least two copies of a peptide sequence.

公开(公告)号：BR112022022558A2

公开(公告)日：2022-12-13

申请号：BR112022022558

申请日：2021-05-07

Applicant: ACADEMIA SINICA

Inventor： CHI-HUEY WONG ,  HSIN-YU LIAO ,  SHIH-CHI WANG ,  YI-AN KO ,  KUO-I LIN ,  CHE MA ,  TING-JEN CHENG

IPC: A61K38/16 ,  A61K39/155 ,  C12N7/04

Abstract: POLIPEPTÍDEO DE HEMAGLUTININA (HA) DO VÍRUS INFLUENZA QUIMÉRICO, COMPOSIÇÃO IMUNOGÊNICA, MÉTODO DE IMUNIZAÇÃO DE UM INDIVÍDUO CONTRA O VÍRUS INFLUENZA OU PREVENÇÃO DE UMA DOENÇA DO VÍRUS INFLUENZA, POLINUCLEOTÍDEO RECOMBINANTE, VETOR E CÉLULA HOSPEDEIRA. A presente descrição refere-se a um polipeptídeo de hemaglutinina (HA) do vírus influenza quimérico, compreendendo uma ou mais sequências de domínio tronco, cada uma tendo pelo menos 60% de homologia com uma sequência consenso de domínio tronco do subtipo H1 HA (H1 HA) e/ou subtipo H5 HA (H5 HA), fundido com uma ou mais sequências de domínio de cabeça globular, cada uma tendo pelo menos 60% de homologia com uma sequência de consenso de domínio de cabeça globular do subtipo H1 HA (H1 HA) ou subtipo H5 HA (H5 HA).

公开(公告)号：AU2021268212A1

公开(公告)日：2022-12-08

申请号：AU2021268212

申请日：2021-05-07

Applicant: ACADEMIA SINICA

Inventor： LIAO HSIN-YU ,  WANG SHIH-CHI ,  KO YI-AN ,  LIN KUO-I ,  MA CHE ,  CHENG TING-JEN

IPC: A61K38/16 ,  A61K39/155 ,  C12N7/04

Abstract: The present disclosure relates to a chimeric influenza virus hemagglutinin (HA) polypeptide, comprising one or more stem domain sequence, each having at least 60% homology with a stem domain consensus sequence of HI subtype HA (HI HA) and/or H5 subtype HA (H5 HA), fused with one or more globular head domain sequence, each having at least 60% homology with a globular head domain consensus sequence of HI subtype HA (HI HA) or H5 subtype HA (H5 HA).

公开(公告)号：CA3034876C

公开(公告)日：2022-10-04

申请号：CA3034876

申请日：2017-08-23

Applicant: CHO PHARMA INC ,  ACADEMIA SINICA ,  LIN NAN HORNG

Inventor： LIN NAN-HORNG ,  HUANG LIN-YA ,  SHIVATARE SACHIN S ,  CHEN LI-TZU ,  WONG CHI-HUEY ,  WU CHUNG-YI ,  CHENG TING

IPC: A61K38/47 ,  C12N9/24 ,  C12P21/02

Abstract: A mutant of EndoS2 includes one or more mutations in the sequence of a wild-type EndoS2 (SEQ ID NO:1), wherein the one or more mutations are in a peptide region located within residues 133-143, residues 177-182, residues 184-189, residues 221-231, and/or residues 227-237, wherein the mutant of EndoS2 has a low hydrolyzing activity and a high transglycosylation activity, as compared to those of the wild-type EndoS2. A method for preparing an engineered glycoprotein using the mutant of EndoS2 includes coupling an activated oligosaccharide to a glycoprotein acceptor. The activated oligosaccharide is a glycan oxazoline.

公开(公告)号：BR112022015086A2

公开(公告)日：2022-09-20

申请号：BR112022015086

申请日：2020-09-14

Applicant: ACADEMIA SINICA

Inventor： FU-LIANG YANG ,  CHANG-KUEI CHUNG

IPC: A61B5/00 ,  A61B5/02 ,  A61B5/022 ,  A61B5/0225 ,  A61B5/024

Abstract: SISTEMA DE CONTRAPULSAÇÃO EXTERNA DE ALTA EFICIÊNCIA E MÉTODO DE TRATAMENTO UTILIZANDO O SISTEMA. A presente invenção refere-se a um sistema de contrapulsação externa (ECP) e método para utilização do sistema para aperfeiçoar a circulação, além de doenças cardiovasculares relacionadas. O sistema ECP da presente invenção compreende uma bolsa de ar helicoidal para modular o fluxo sanguíneo das principais veias e artérias da coxa. A alta eficiência é realizada com o formato helicoidal da bolsa de ar para se reduzir o custo, peso e tamanho da ECP da presente invenção.

公开(公告)号：AU2020430123A1

公开(公告)日：2022-09-15

申请号：AU2020430123

申请日：2020-09-14

Applicant: ACADEMIA SINICA

Inventor： YANG FU-LIANG ,  CHUNG CHANG-KUEI

IPC: A61B5/00 ,  A61B5/02 ,  A61B5/022 ,  A61B5/0225 ,  A61B5/024

Abstract: An external counter pulsation system (ECP) and method for using the system to improve circulation as well as cardiovascular related diseases. The ECP system of the present invention comprises a helical air bladder for modulating blood flow of major veins and arteries of the thigh. High efficiency is realized with the helical shape of the air bladder to lower the cost, weight and size of the ECP of the present invention.