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    AN IMPROVED LATCHING PIERCING PIN FOR USE WITH FLUID VIALS OF VARYING SIZES
    371.
    发明申请
    AN IMPROVED LATCHING PIERCING PIN FOR USE WITH FLUID VIALS OF VARYING SIZES 审中-公开
    改进的拼接引脚与流体尺寸变化的使用

    公开(公告)号：WO1994008549A1

    公开(公告)日：1994-04-28

    申请号：PCT/US1993009594

    申请日：1993-10-12

    Applicant: ABBOTT LABORATORIES

    Inventor： ABBOTT LABORATORIES ,  POLI, Robert, G. ,  THOMAS, V., Stanton ,  ADOLF, Wayne, F. ,  RUDZENA, William, L.

    IPC: A61J01/00

    CPC classification number: A61J1/2089 ,  A61J1/201 ,  A61J1/2055 ,  A61J1/2075

    Abstract: A latching piercing pin (20) usable to retain the pin and an associated fluid vial (37) in latching relation. Latching members (32) provided on the pin engage a peripheral lip provided on the end cap of the vial to maintain the latching relation between the pin and the vial. The pin is usable with vials and end caps of varying sizes, although larger end caps may require the mounting of a locking ring on the end cap of the vial to receive and engage the latching piercing pin.

    Abstract translation: 一种可用于将销和相关联的流体小瓶（37）保持在闩锁关系中的闩锁穿孔销（20）。 设置在销上的锁定构件（32）接合设置在小瓶的端盖上的外围唇缘，以保持销和小瓶之间的闩锁关系。 该针可用于不同尺寸的小瓶和端盖，尽管较大的端盖可能需要在小瓶的端盖上安装锁定环以接收和接合闩锁穿孔销。

    PHENYLMETHYL DERIVATIVES HAVING LIPOXYGENASE INHIBITORY ACTIVITY
    372.
    发明申请
    PHENYLMETHYL DERIVATIVES HAVING LIPOXYGENASE INHIBITORY ACTIVITY 审中-公开
    具有LIPOXYGENASE抑制活性的苯乙烯衍生物

    公开(公告)号：WO1994005281A1

    公开(公告)日：1994-03-17

    申请号：PCT/US1993008094

    申请日：1993-08-27

    Applicant: ABBOTT LABORATORIES

    Inventor： ABBOTT LABORATORIES ,  DELLARIA, Joseph, F. ,  CHERNESKY, Linda, Jean ,  BROOKS, Dee, W.

    IPC: A61K31/335

    CPC classification number: C07D405/12 ,  C07D305/06 ,  C07D309/04 ,  C07D309/06 ,  C07D309/10

    Abstract: Compounds of structure (1) where Ar is optionally substituted carbocyclic aryl, 5- or 6-membered heterocyclic aryl, 10-membered bicyclic heterocyclic aryl containing one or two nitrogen atoms, 9- or 10-membered heterocyclic containing one or two nitrogen atoms and optionally containing a further nitrogen or oxygen atom and one oxo or thioxo substituent, benzo(b)furyl, benzo(b)thienyl, A1 is propynylene, methylene, or a valence bond, X is O, S, SO2,or NR2, Y is selected from alkyl, haloalkyl, alkoxy, halogen, and hydrogen, A2 is selected from (a), (b) and methylene, where Z is OR5 or NHR5 where R5 is hydrogen or alkyl, R1 is hydrogen, alkyl, or OR5, and m and n are integers having a value of 1 or 2 are potent inhibitors of lipoxygenase enzymes and thus inhibit the biosynthesis of leukotrienes. These compounds are useful in the treatment or amelioration of allergic and inflammatory disease states.

    Abstract translation: 结构（1）的化合物，其中Ar是任选取代的碳环芳基，5-或6-元杂环芳基，含有一个或两个氮原子的10元双环杂环芳基，含有一个或两个氮原子的9元或10元杂环和 任选地含有另外的氮或氧原子和一个氧代或硫代取代基，苯并（b）呋喃基，苯并（b）噻吩基，A1是亚丙炔基，亚甲基或价键，X是O，S，SO2或NR2，Y 选自烷基，卤代烷基，烷氧基，卤素和氢，A2选自（a），（b）和亚甲基，其中Z是OR 5或NHR 5，其中R 5是氢或烷基，R 1是氢，烷基或OR 5， 并且m和n是具有值1或2的整数是脂氧合酶的有效抑制剂，从而抑制白细胞三烯的生物合成。 这些化合物可用于治疗或改善过敏和炎症疾病状态。

    TUBE PLACEMENT VERIFIER SYSTEM
    373.
    发明申请
    TUBE PLACEMENT VERIFIER SYSTEM 审中-公开
    管布置验证系统

    公开(公告)号：WO1994002079A1

    公开(公告)日：1994-02-03

    申请号：PCT/US1993006518

    申请日：1993-07-12

    Applicant: ABBOTT LABORATORIES ,  WHITE'S ELECTRONICS, INC.

    Inventor： ABBOTT LABORATORIES ,  WHITE'S ELECTRONICS, INC. ,  HIRSCHI, Richard, Edward ,  KARBOWSKI, James, Patrick ,  TIEFENTHAL, James, Lawrence ,  ISAAC, Ronald, Mark

    IPC: A61B19/00

    CPC classification number: A61M25/0127 ,  A61B17/3403 ,  Y10S128/903

    Abstract: A system for detecting the position of an object within a body of biological tissue includes a resonant circuit attached to the object and a probe (10) including a receiver/transmitter that operates at the resonant frequency of the object. The resonant circuit rings in response to pulses transmitted from the probe (10) thereby activating receiver circuits which control a visual display (24) indicating the direction the probe should be moved to center it over the object. When the object is centered a second visual display (22) provides confirmation.

    Abstract translation: 用于检测物体在生物组织体内的位置的系统包括附接到物体的谐振电路和包括在物体的谐振频率下操作的接收器/发射器的探针（10）。 谐振电路响应于从探针（10）传输的脉冲而响应，从而启动接收器电路，其控制指示探针应该被移动以将其置于物体上方的视觉显示（24）。 当对象居中时，第二个视觉显示（22）提供确认。

    METHODS AND REAGENTS FOR THE DETERMINATION OF IMMUNOSUPPRESSIVE AGENTS
    374.
    发明申请
    METHODS AND REAGENTS FOR THE DETERMINATION OF IMMUNOSUPPRESSIVE AGENTS 审中-公开
    用于确定免疫抑制剂的方法和试剂

    公开(公告)号：WO1993025533A1

    公开(公告)日：1993-12-23

    申请号：PCT/US1993005197

    申请日：1993-06-01

    Applicant: ABBOTT LABORATORIES

    Inventor： ABBOTT LABORATORIES ,  LANE, Benjamin, Clay ,  LULY, Jay, Richard ,  SMITH, Allan, H. ,  BOLLING, Timothy, J. ,  MANDECKI, Wldozimierz ,  PILOT-MATIAS, Tami, J.

    IPC: C07D221/18

    CPC classification number: C07D498/18 ,  C07K14/715 ,  C07K2319/32 ,  C07K2319/61 ,  C12N9/1241

    Abstract: Assay methods and reagents for determining the presence or amount of immunophilin ligands and immunophilins thereof employing a recombinant fusion protein comprising (i) an immunosuppressant binding protein and (ii) a heterologous protein are disclosed. The recombinant fusion protein can also be employed for the evaluation of immunosuppressive activities of immunosuppressive agents in order to determine the efficacy of an immunosuppressive agent during the course of therapeutic treatment of a patient therewith. Preferably, the recombinant fusion protein comprises a macrolide immunosuppressive agent and CTP:CMP-3-deoxy-D-manno-octulosonate cytidylyl transferase. When employed in a binding assay format, the recombinant fusion protein provides higher reactivity for the immunophilin ligand under determination than does the native immunosuppressant binding protein. In particular, an immunosuppressant assay reagent comprising FK-506 binding protein (FKBP) and CKS immobilized to a solid support material provides a higher signal-to-noise ratio when employed in a competitive heterogeneous assay format than when native FKBP immobilized to a solid support material is employed in such assay format.

    Abstract translation: 公开了使用包含（i）免疫抑制剂结合蛋白和（ii）异源蛋白质）的重组融合蛋白来测定免疫亲和素配体及其免疫亲和物的存在或量的测定方法和试剂。 重组融合蛋白也可以用于评估免疫抑制剂的免疫抑制活性，以确定免疫抑制剂在其患者治疗过程中的功效。 优选地，重组融合蛋白包含大环内酯免疫抑制剂和CTP：CMP-3-脱氧-D-壬烯 - 辛酸酯胞苷酰转移酶。 当以结合测定形式使用时，重组融合蛋白质在测定时比天然免疫抑制剂结合蛋白提供更高的免疫亲和素配体的反应性。 特别地，当以竞争性异质测定格式使用时，固定在固体支持物质上的包含FK-506结合蛋白（FKBP）和CKS的免疫抑制剂测定试剂提供比当固定在固体支持物上的天然FKBP时更高的信噪比 材料以这种测定形式使用。

    METHOD OF MULTIPLEX LIGASE CHAIN REACTION
    377.
    发明申请
    METHOD OF MULTIPLEX LIGASE CHAIN REACTION 审中-公开
    多反应链反应的方法

    公开(公告)号：WO1993020227A1

    公开(公告)日：1993-10-14

    申请号：PCT/US1993003034

    申请日：1993-03-31

    Applicant: ABBOTT LABORATORIES ,  BOUMA, Stanley, R. ,  GORDON, Julian ,  HOIJER, Joannel ,  JOU, Cynthia ,  RHOADS, James

    Inventor： ABBOTT LABORATORIES

    IPC: C12P19/34

    CPC classification number: C12Q1/6813 ,  C07K14/4712 ,  C12N15/10 ,  C12Q1/6862 ,  C12Q1/6883 ,  C12Q2600/156 ,  C12Q2600/16 ,  G01N33/558

    Abstract: The invention relates to multiplex ligase chain reaction (LCR). Two or more putative target sequences are selected. For each one, a set of four probes is used simultaneously to amplify the putative sequence if it is present in the sample. Preferably, all the amplicons are labeled with a common label/hapten and, for each different target, with a unique label/hapten. The invention also relates to an immunochromatographic strip device and method employing a diagonal array of capture spots.

    Abstract translation: 本发明涉及多重连接酶链反应（LCR）。 选择两个或多个推定的靶序列。 对于每一个，如果样品中存在，则同时使用一组四个探针来放大推定序列。 优选地，所有扩增子用公共标记/半抗原标记，并且对于每个不同的靶标，用唯一的标记/半抗原标记。 本发明还涉及使用捕获点的对角线阵列的免疫色谱条带装置和方法。

    ONE-STEP COMPETITIVE IMMUNOASSAY FOR THE SEMIQUANTITATIVE DETERMINATION OF PLASMA LIPOPROTEIN(A)
    379.
    发明申请
    ONE-STEP COMPETITIVE IMMUNOASSAY FOR THE SEMIQUANTITATIVE DETERMINATION OF PLASMA LIPOPROTEIN(A) 审中-公开
    一级竞争性免疫测定法测定血浆脂蛋白（A）

    公开(公告)号：WO1993017340A1

    公开(公告)日：1993-09-02

    申请号：PCT/US1993001008

    申请日：1993-02-05

    Applicant: ABBOTT LABORATORIES

    Inventor： ABBOTT LABORATORIES ,  LUO, Sheng-Chang ,  PATEL, Chandu, B.

    IPC: G01N33/543

    CPC classification number: G01N33/558 ,  G01N33/92 ,  G01N2800/044 ,  G01N2800/52 ,  Y10S436/815 ,  Y10S436/825

    Abstract: A competitive immunoassay to measure lipoprotein a [Lp(a)] levels semiquantitatively and identify individuals with elevated plasma Lp(a) protein levels (greater than 7 mg/dl) who have an increased risk for coronary artery disease is performed using a teststrip. The teststrip includes an application pad (10) attached to the top side of a porous strip (20) containing an immobilized antibody. The antibody is immobilized in a measurement region (30) which can involve a plurality of capture sites (35). Typically, the upper surface of the application pad (10) and porous strip (20) are laminated with an impermeable membrane (40) and the assembled device is attached to the top of a support material (50). In addition, the device may optionally include an end of assay indicator (60) which produces a detectable signal upon contact with the test sample or an assay reagent. The assay provides a quick, reliable, easy to use and inexpensive method to measure plasma Lp(a) level with serum, plasma or whole blood.

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