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公开(公告)号：KR1020150111080A
公开(公告)日：2015-10-05
申请号：KR1020140034495
申请日：2014-03-25
Applicant: 가톨릭대학교 산학협력단
CPC classification number: A61K49/146 , A61K47/52 , A61K49/101 , A61K49/1812
Abstract: 본발명은종양과같은질병부위의약산성 pH에반응하여선택적으로질병부위에축적될수 있어자기공명영상의조영효과를증진시키는표면전하스위칭나노복합체의제조방법에관한것으로, 라이신단량체를기반으로하여폴리라이신을합성한후, 소수성물질과 pH 민감성물질을화학적으로접합시키고내부에자성산화철입자를봉입하여새로운형태의나노입자를제조하였다. 제조된나노입자는생체내 pH 보다낮은산성환경에서 pH 민감성물질이제거되어표면전하가스위칭되어산성환경에서만작용할수 있다. 이를통해질병부위로조영제를효과적으로전달하고조영효과를극대화시킬수 있는효과가있다.
Abstract translation: 本发明涉及一种表面电荷切换纳米复合材料的制备方法，其通过使病变部位的弱酸pH作为肿瘤反应而选择性地积累，从而增强磁共振成像的对比效果。 产生的是新型纳米颗粒，其在合成基于赖氨酸单体的聚赖氨酸之后化学结合疏水性材料和表面电荷并插入磁性氧化铁颗粒。 所产生的纳米颗粒只能在酸性环境中通过在较低的酸性环境中除去体内pH值来切换表面电荷。 对比介质有效转移到病变部位，可以最大化对比效果。
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公开(公告)号：KR1020140080084A
公开(公告)日：2014-06-30
申请号：KR1020120149513
申请日：2012-12-20
Applicant: 가톨릭대학교 산학협력단
CPC classification number: A61K47/60 , A61K9/0002 , A61K49/00
Abstract: The present invention relates to a composition, mPEG-b-PLLA-BC (methoxy-polyethylene-glycol-b-poly-L-lactic acid-benzyl chloroformate), more particularly, to a polymeric composition, a manufacturing method thereof and a usage as drug delivery and diagnosis polymer. The present invention relates to a micelle for discharging drug and generating gas, developed by using biopolymer PLLA and mPEG (methoxy-polyethylene-glycol), which are biopolymers, wherein carbonate bond for generating gas is added to the micelle for resolving the problem of biodegradability of the PLLA and enhancing the discharging speed of the drug. Further, the discharging speed of encapsulated drug can be enhanced by using carbon dioxide gas generated by the hydrolysis of the carbonate bond and particle decay thereby.
Abstract translation: 本发明涉及一种组合物，mPEG-b-PLLA-BC（甲氧基聚乙二醇-b-聚-L-乳酸 - 氯甲酸苄酯），更具体地说，涉及聚合物组合物，其制造方法和用途 作为药物递送和诊断聚合物。 本发明涉及一种用于排出药物和产生气体的胶束，其通过使用作为生物聚合物的生物聚合物PLLA和mPEG（甲氧基聚乙二醇）显影，其中用于产生气体的碳酸酯键被添加到胶束中以解决生物降解性问题 的PLLA并提高药物的排出速度。 此外，通过使用通过碳酸酯键的水解产生的二氧化碳和由此造成的颗粒衰减，可以提高包封药物的排出速度。
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公开(公告)号：KR1020120105116A
公开(公告)日：2012-09-25
申请号：KR1020110022705
申请日：2011-03-15
Applicant: 가톨릭대학교 산학협력단
IPC: A61K9/00 , A61K9/16 , A61K31/352
CPC classification number: A61K9/0073 , A61K9/1641 , A61K9/1647 , A61K9/1652 , A61K31/352
Abstract: PURPOSE: A porous microgranules for treating pulmonary diseases is provided to is effectively attached to alveolus and to enhance antioxidant safety. CONSTITUTION: A porous microgranules for treating pulmonary diseases contains biodegradable polymers, antioxidant, gum materials, and a porosity inducing material. The biodegradable polymers are polyglycolic acid(PGA), poly lactic acid(PLA), polylactide glycolide(PLGA), poly-epsilone-caprolactone(PCL), poly amino acids, poly anhydride, polyorthoester, a derivative or copolymer thereof. A method for preparing the porous microgranules for treating pulmonary diseases comprises: a step of dissolving the antioxidant in distilled water containing porosity inducing materials and gum materials to prepare an internal aqueous phase; a step of dissolving the biodegradable polymers in the inorganic solvent to prepare an organic phase(O); a step of mixing the internal aqueous phase and organic phase to form a primary emulsion(W/O); and a step of dispersing the primary emulsion to an outer aqueous W2.
Abstract translation: 目的：提供用于治疗肺部疾病的多孔微粒，有效附着于肺泡，增强抗氧化的安全性。 构成：用于治疗肺部疾病的多孔微粒含有可生物降解的聚合物，抗氧化剂，胶质材料和孔隙率诱导材料。 可生物降解的聚合物是聚乙醇酸（PGA），聚乳酸（PLA），聚丙交酯乙交酯（PLGA），聚ε-己内酯（PCL），聚氨基酸，聚酐，聚原酸酯，其衍生物或共聚物。 一种制备用于治疗肺部疾病的多孔微粒的方法包括：将抗氧化剂溶解在含有孔隙率诱导材料和胶质材料的蒸馏水中以制备内部水相的步骤; 将可生物降解的聚合物溶解在无机溶剂中以制备有机相（O）的步骤; 将内部水相和有机相混合以形成初级乳液（W / O）的步骤; 以及将主乳液分散到外部水分W2的步骤。
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公开(公告)号：KR1020110068663A
公开(公告)日：2011-06-22
申请号：KR1020090125727
申请日：2009-12-16
Applicant: 가톨릭대학교 산학협력단
CPC classification number: A61K9/5161 , A61K9/0002 , A61K9/5192 , A61K38/00 , A61K47/36 , B82Y5/00
Abstract: PURPOSE: A method for manufacturing a nanocomposite for pH sensitive drug delivery is provided to easily and quickly penetrate the nanocomposite into a target cells. CONSTITUTION: A nanocomposite for pH sensitive drug delivery contains a polymer having a 2,3-dimethylmaleic acid induced to am amine group of polysaccharide. The polysaccharide is pullulan, cudlan, hyaluronic acid, pectin, chitosan, dextrin, heparin, or starch. A nanocomposite has a drug with pharmacological activity. The drug is a protein, peptide, or synthetic compound. A method for manufacturing the nanocomposite comprises: a step of dissolving polysaccharides in a solvent; a step of adding 2,3-dimethylmaleic acid to a solution in which polysaccharides are dissolved; and a step of dialyzing and freeze-drying the synthesized polymers.
Abstract translation: 目的：提供用于制备用于pH敏感药物递送的纳米复合材料的方法，以容易且快速地将纳米复合材料渗透到靶细胞中。 构成：用于pH敏感药物递送的纳米复合物包含具有诱导为多糖胺基团的2,3-二甲基马来酸的聚合物。 多糖是支链淀粉，ud兰，透明质酸，果胶，壳聚糖，糊精，肝素或淀粉。 纳米复合材料具有药理活性的药物。 该药物是蛋白质，肽或合成化合物。 制造纳米复合材料的方法包括：将多糖溶解在溶剂中的步骤; 向其中溶解多糖的溶液中加入2,3-二甲基马来酸的步骤; 以及透析和冷冻干燥合成聚合物的步骤。
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公开(公告)号：KR102253393B1
公开(公告)日：2021-05-20
申请号：KR1020140130410
申请日：2014-09-29
Applicant: 가톨릭대학교 산학협력단
Abstract: 본발명은생체적합성/생분해성고분자, pH 민감성 poly(Lys-DEAP) 고분자, 및티오트로피움약물을포함하는폐 질환치료용서방형미세입자와이의제조방법에관한것이다. 본발명에따르면, 생체적합성/생분해성고분자(폴리락트산-글리콜산공중합체)와 pH 민감성 poly(Lys-DEAP) 고분자, 및기관지확장제인티오트로피움약물을이용하여 pH 민감성고분자를함유한폴리락트산-글리콜산공중합체기반미세입자를제조할수 있다. 또한, 본발명에따른 pH 민감성고분자를함유한폴리락트산-글리콜산공중합체기반미세입자는폐포호흡산증환경에서효과적으로약물을방출하여호흡산증과관련된만성폐 질환치료에효과적으로적용될수 있다.
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Patent Agency Ranking
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公开(公告)号：KR101923919B1
公开(公告)日：2018-11-30
申请号：KR1020160138355
申请日：2016-10-24
Applicant: 가톨릭대학교 산학협력단
IPC: C12N15/115 , G01N33/574 , G01N33/58 , A61K47/48 , A61K41/00 , A61K49/00
Abstract: 본발명은압타머; 고분자; 및광응답제로이루어진압타머-친수성고분자-광응답제접합체에관한기술로, 보다상세하게는상기압타머-친수성고분자-광응답제접합체는수용액상에서안정하게분산되어광응답제의난용성부작용을감소시킬수 있으며, 특정암세포와특이적으로결합하는압타머에의해광응답제의암세포표적화를증가시켰으며, 광조사시암세포와결합된광응답제가생성하는일항산소로인하여효과적인항암치료가가능하다.
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公开(公告)号：KR101700519B1
公开(公告)日：2017-01-31
申请号：KR1020150102115
申请日：2015-07-20
Applicant: 가톨릭대학교 산학협력단
Abstract: 본발명은카보네이트결합을이용한광역학치료용고분자나노접합체및 이의용도에관한것으로, 보다상세하게는상기고분자나노접합체는친수성고분자쉘과콜레스테릴클로로포르메이트및 클로린 e6가결합되어있는소수성코어로자가조립되어있는나노입자이며, 친수성고분자쉘은나노입자의세포내흡수를증가시키고, 나노입자소수성코어에존재하는카보네이트결합은종양의산성 pH 조건에서분해되면서이산화탄소기포를발생시켜고분자나노접합체를붕괴시킴으로써광감작제를종양에선택적으로탈퀀칭시키고일항산소발생을유도함으로써향상된광역학종양세포사멸효과를나타내며정상세포에는독성이거의없기때문에, 효과적인광역학항암치료용약학조성물로제공될수 있다.
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公开(公告)号：KR101586866B1
公开(公告)日：2016-01-21
申请号：KR1020100034298
申请日：2010-04-14
Applicant: 가톨릭대학교 산학협력단
Abstract: 본발명은 pH 민감성약물전달용나노복합체및 이의제조방법에관한것으로서, 보다구체적으로본 발명은다당류의아민기에 3-디에틸아미노프로필(3-diethylaminopropyl,DEAP)이도입되어있는 pH 민감성약물전달용나노복합체에관한것이다. 본발명에따른 pH 민감성약물전달용나노복합체는나노크기의약물전달체로서표적세포내로쉽고빠르게침투할수 있는효과가있으며, 약산성조건의환경변화를가지는특정질병부위에대해선택적및 효율적으로약물을전달하여치료효과를높일수 있으므로각종질환을치료하기위한약물전달체로서유용하게사용할수 있는효과가있다.
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公开(公告)号：KR1020150054356A
公开(公告)日：2015-05-20
申请号：KR1020130136711
申请日：2013-11-12
Applicant: 가톨릭대학교 산학협력단
CPC classification number: A61K9/113 , A61K9/0002 , A61K31/439 , A61K47/34 , A61K47/36
Abstract: 본발명은만성폐쇄성폐질환치료를위한티오트로피움의서방형방출을위한다공성 PLGA 미세입자및 이의제조방법에관한것이다. 본발명의다공성 PLGA 미세입자는, a) 티오트로피움, 중탄산암모늄(ammonium bicarbonate; AB) 및생분해성다당류를물에용해시켜내부수상을제조하는단계; b) 생분해성고분자를유기용매에가하여유기상을제조하는단계; c) 상기단계 a)에서얻어진내부수상과단계 b)에서얻어진유기상을유화하여유중수적형(water in oil emulsion; W/O )을제조하는단계; 및 d) 상기단계 c)에서얻어진유중수적형을수성코팅물질이포함된외부수성상에주입하여복합유제(water in oil in water; W/O/W) 형태로다중유화시키는단계;를포함하여이루어지는것을특징으로한다. 본발명의티오트로피움의서방형방출을위한다공성미세입자의경우낮은밀도와큰 입자크기를갖는다공성미세입자를제공하여식세포로인한제거를막고폐 내부에미세입자가길게잔존하는효과를가진다.
Abstract translation: 本发明涉及用于治疗慢性阻塞性肺疾病的持续噻托溴铵释放的多孔PLGA微粒及其制备方法。 根据本发明，PLGA微粒子制备方法包括以下步骤：a）将噻托铵，碳酸氢铵（AB）和可生物降解的多糖溶解在水中以制备内部水相; b）将可生物降解的聚合物施加到有机溶剂中以制备有机相; c）乳化步骤a）中获得的内部水相和步骤b）中获得的有机相以制备油包水乳液（W / O）; 和d）将步骤c）中获得的W / O注入包含水性涂料的外部水相中，通过多乳液获得水中的水（W / O / W）。 用于持续噻托溴铵释放的多孔PLGA微粒子具有低密度和大粒径的粒子，由巨噬细胞去除并长时间保留在肺中。
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