公开(公告)号：KR1020130125736A

公开(公告)日：2013-11-19

申请号：KR1020130052669

申请日：2013-05-09

Applicant: 가톨릭대학교 산학협력단

Inventor： 최종영 ,  조미라 ,  전주연 ,  변재경 ,  임예빈 ,  정영옥 ,  이선영 ,  정정희

IPC: A61K31/122 ,  A61P29/00

Abstract: The present invention relates to a composition containing coenzyme Q10 as an active ingredient for preventing or treating inflammatory diseases or immune rejection. More particularly, coenzyme Q10 suppresses or reduces the activity of Th17 and effectively promotes or enhances the activity of regulatory T cells (Treg), thereby being used as a composition for preventing or treating immune rejection such as graft rejection or inflammatory diseases. In addition, coenzyme Q10 does not cause cytotoxicity and the side effects to the drug is not toxic, thereby being safely administered in the long-term and being stable in the body.

Abstract translation: 本发明涉及含有辅酶Q10作为预防或治疗炎性疾病或免疫排斥的活性成分的组合物。 更具体地，辅酶Q10抑制或降低Th17的活性，并且有效地促进或增强调节性T细胞（Treg）的活性，从而被用作预防或治疗免疫排斥反应例如移植排斥或炎性疾病的组合物。 此外，辅酶Q10不会引起细胞毒性，对药物的副作用是无毒性的，因此长期安全施用并且在体内稳定。

公开(公告)号：KR1020130116825A

公开(公告)日：2013-10-24

申请号：KR1020130041359

申请日：2013-04-16

Applicant: 가톨릭대학교 산학협력단

Inventor： 조미라 ,  민준기 ,  박진실 ,  전주연 ,  박민정 ,  정정희 ,  임미애 ,  이성희 ,  임예빈 ,  허양미

IPC: A61K31/4704 ,  A61K38/17 ,  C12N15/63 ,  C12N15/12

CPC classification number: A61K31/353 ,  A61K38/1709 ,  Y10S514/825

Abstract: PURPOSE: An antioxidant is provided to effectively enhance the expression of Rcan3 gene and to be used as an immunosuppressive agent for treating or preventing immune diseases because Rcan3 protein suppresses calcineurin pathway. CONSTITUTION: An antioxidant increases the expression of Rcan3 gene. The antioxidant is rebamipide or polyphenol compounds. The polyphenol compounds are proanthocyanidin. A method for increasing the expression of Rcan3 in vitro comprises the step of treating cells with the antioxidant. A composition for preventing or treating immune disease contains Rcan3 gene or protein as an active ingredient.

Abstract translation: 目的：提供抗氧化剂以有效增强Rcan3基因的表达，并用作免疫抑制剂，用于治疗或预防免疫疾病，因为Rcan3蛋白抑制钙调神经磷酸酶途径。 构成：抗氧化剂增加Rcan3基因的表达。 抗氧化剂是瑞巴派特或多酚化合物。 多酚化合物是原花色素。 在体外增加Rcan3表达的方法包括用抗氧化剂处理细胞的步骤。 用于预防或治疗免疫疾病的组合物含有Rcan3基因或蛋白质作为活性成分。