公开(公告)号：KR1020120118978A

公开(公告)日：2012-10-30

申请号：KR1020110036667

申请日：2011-04-20

Applicant: 가톨릭대학교 산학협력단

Inventor： 조미라 ,  김호연 ,  박진실 ,  임미애 ,  오혜좌 ,  유준걸 ,  변재경

IPC: A61K31/428 ,  A61K38/17 ,  A61P19/02 ,  A61P17/00

CPC classification number: A61K38/1758 ,  Y10S514/885 ,  Y10S530/868

Abstract: PURPOSE: A composition for preventing or treating immunization diseases including P53 is provided to suppress inflammatory cytokine IL-17 which causes the immunization diseases. CONSTITUTION: A composition for preventing or treating immunization diseases includes P53 as an active ingredient. The P53 has the activity of preventing or treating the immunization diseases through the formation inhibition of the inflammatory cytokine. The inflammatory cytokine is IL-17. The composition additionally includes substances for promoting the express of the p53 or for promoting the activity of protein. The composition for preventing or treating includes polynucleotide which codes the P53. The polynucleotide ciphering the p53 protein is provided in a recombinant vector type which is connected to a vector which expresses the same. The expression vector which expresses the P53 protein is a non-virus vector or a viral vector.

Abstract translation: 目的：提供用于预防或治疗包括P53在内的免疫疾病的组合物，以抑制引起免疫疾病的炎性细胞因子IL-17。 构成：用于预防或治疗免疫疾病的组合物包括P53作为活性成分。 P53具有通过炎性细胞因子的形成抑制来预防或治疗免疫疾病的活性。 炎性细胞因子是IL-17。 该组合物还包括用于促进p53表达或促进蛋白质活性的物质。 用于预防或治疗的组合物包括编码P53的多核苷酸。 加密p53蛋白质的多核苷酸以连接到表达相同的载体的重组载体类型提供。 表达P53蛋白的表达载体是非病毒载体或病毒载体。

公开(公告)号：KR1020120095063A

公开(公告)日：2012-08-28

申请号：KR1020110014466

申请日：2011-02-18

Applicant: 가톨릭대학교 산학협력단

Inventor： 조미라 ,  박진실 ,  임미애 ,  이선영 ,  오혜좌 ,  류준걸

IPC: A61K38/16 ,  A61K38/20 ,  A61P37/00

CPC classification number: A61K38/1758 ,  A61K38/20 ,  C07K14/4713 ,  C07K14/4746

Abstract: PURPOSE: A composition for preventing or treating immunization diseases including p53 induced by il-27 is provided to increase expression of p53 by getting stimulation of the IL-27 and to enhance arthritis in animal models according to the expression of p53. CONSTITUTION: A composition for preventing or treating immunization diseases includes p53. The p53 has amino acid sequence described in the sequence number 1(SEQ ID NO:1) or 2. The composition additionally includes the interleukin-27(IL-27). The interleukin-27(IL-27) multiplies the activities of the gene expression of p53 or the p53 protein. The composition for preventing or treating immunization diseases includes a promoter and a vector containing polynucleotide which codes the p53. The polynucleotide has the base sequence described in the sequence number 3 or 4.

Abstract translation: 目的：提供一种用于预防或治疗由il-27诱导的免疫疾病包括p53的组合物，以通过刺激IL-27并根据p53的表达增强动物模型中的关节炎来增加p53的表达。 构成：用于预防或治疗免疫疾病的组合物包括p53。 p53具有序列号1（SEQ ID NO：1）或2所述的氨基酸序列。该组合物另外包括白细胞介素-27（IL-27）。 白介素-27（IL-27）将p53或p53蛋白的基因表达的活性相乘。 用于预防或治疗免疫疾病的组合物包括编码p53的启动子和含有多核苷酸的载体。 多核苷酸具有序列号3或4中描述的碱基序列。

公开(公告)号：KR1020120029342A

公开(公告)日：2012-03-26

申请号：KR1020110092596

申请日：2011-09-14

Applicant: 가톨릭대학교 산학협력단

Inventor： 조미라 ,  박미경 ,  오혜좌 ,  박민정 ,  전은주 ,  조석구

IPC: A61K31/225 ,  A61K31/21 ,  A61P35/00

Abstract: PURPOSE: A composition containing retinal for preventing or treating cancer or immune diseases is provided to enhance immune-modulating T cell activity. CONSTITUTION: A composition for preventing or treating cancer or immune disease contains retinal compounds of pharmaceutically acceptable salt thereof as an active ingredient. The retinal promotes or enhances regulatory T cell activity or proliferation. A method for reducing or suppressing differentiation of immature T cell into Th17 cell in vitro comprises a step of treating retinal compound or pharmaceutically acceptable salt to the undifferentiated T cells.

Abstract translation: 目的：提供含有用于预防或治疗癌症或免疫疾病的视网膜的组合物，以增强免疫调节T细胞活性。 构成：用于预防或治疗癌症或免疫疾病的组合物含有其药学上可接受的盐的视黄醛化合物作为活性成分。 视网膜促进或增强调节性T细胞活性或增殖。 用于在体外降低或抑制未成熟T细胞分化成Th17细胞的方法包括将视黄醛化合物或药学上可接受的盐处理至未分化的T细胞的步骤。

公开(公告)号：KR101099021B1

公开(公告)日：2011-12-28

申请号：KR1020090035796

申请日：2009-04-24

Applicant: 가톨릭대학교 산학협력단 ,  에이치 엘 지노믹스(주)

Inventor： 민준기 ,  조미라 ,  박미경 ,  허유정 ,  박진실 ,  김호연 ,  오혜좌 ,  우윤주 ,  류종현 ,  김현규 ,  이근혁 ,  박진하 ,  곽은영 ,  전주연

IPC: A61K36/87 ,  A61P19/02

CPC classification number: A61K36/87

Abstract: 본 발명은 유럽종 포도(
Vitis vinifera )의 씨 추출물 및 약학적으로 허용가능한 담체를 포함하는 골관절염(osteoarthritis)의 예방 또는 치료용 약학 조성물을 제공한다.
유럽종 포도의 씨 추출물, 골관절염

公开(公告)号：KR101096574B1

公开(公告)日：2011-12-20

申请号：KR1020080126216

申请日：2008-12-12

Applicant: 가톨릭대학교 산학협력단 ,  에이치 엘 지노믹스(주)

Inventor： 김호연 ,  민준기 ,  조미라 ,  박미경 ,  오혜좌 ,  허유정 ,  박진실 ,  우윤주 ,  류종현 ,  김현규 ,  이근혁 ,  박진하 ,  곽은영

IPC: A61K36/87 ,  A61P19/10

CPC classification number: A61K36/87

Abstract: 본 발명은 유럽종 포도(
Vitis vinifera )의 씨 추출물 및 약제학적으로 허용가능한 담체를 포함하는 골다공증의 예방 또는 치료용 약학 조성물을 제공한다.
유럽종 포도, 골다공증

公开(公告)号：KR101004362B1

公开(公告)日：2010-12-28

申请号：KR1020100024699

申请日：2010-03-19

Applicant: 한국생명공학연구원 ,  가톨릭대학교 산학협력단

Inventor： 박영우 ,  조기원 ,  유석호 ,  유정 ,  김동진 ,  윤선하 ,  송은정 ,  이은경 ,  오진미 ,  조규원 ,  조미라 ,  김호연 ,  박미경 ,  오혜좌 ,  박진실 ,  우윤주

IPC: C07K19/00 ,  C12N15/62 ,  C12N15/63 ,  A61P37/00

CPC classification number: C07K14/525 ,  C07K14/70575 ,  C07K2319/32 ,  Y10S514/814 ,  Y10S514/885 ,  Y10S514/886 ,  Y10S514/903

Abstract: PURPOSE: A TNFR2-TWEAKR fusion protein is provided to ensure antagonistic function to TNFR2 and TWEAK which is a cause of autoimmune arthritis and to reduce IL-17 secretion. CONSTITUTION: A composition for preventing and treating autoimmune disease contains fusion protein of a fragment having an extracellular region of TNFR2(Tumor necrosis factor receptor type 2) or TNFR2 and a fragment having an extracellular region of TWEAKR(TNF-related weak inducer of apoptosis receptor) protein or TWEAKR as an active ingredient. The extracellular region fragment of TNFR2 has a polypeptide having an amino acid sequence of sequence number 2. The fusion protein has an amino acid sequence of sequence number 1.

Abstract translation: 目的：提供TNFR2-TWEAKR融合蛋白，以确保TNFR2和TWEAK的拮抗作用，这是导致自身免疫性关节炎和降低IL-17分泌的原因。 构成：用于预防和治疗自身免疫性疾病的组合物含有具有TNFR2细胞外区域（2型肿瘤坏死因子受体）或TNFR2的片段的融合蛋白和具有TWEAKR胞外区域的片段（TNF相关的凋亡受体弱诱导剂 ）蛋白质或TWEAKR作为活性成分。 TNFR2的细胞外区片段具有序列号为2的氨基酸序列的多肽。融合蛋白具有序列号1的氨基酸序列。