公开(公告)号：KR100307724B1

公开(公告)日：2001-09-24

申请号：KR1019990010847

申请日：1999-03-29

Applicant: 한국과학기술연구원

Inventor： 송수창 ,  손연수

IPC: A61K33/24

Abstract: 본발명은일반식(VI)의당질의알카리토금속염과일반식(VII)의황산백금(II)유도체를 1:1 몰비로반응시킨후 부산물인황산바륨을제거하여얻어지는일반식(I)의당질-백금(II)착물복합체의제조에관한것이다. 다음일반식(I)로표시되는당질-백금(II)착물복합체. 상기일반식(I)에서 R은당질및 당질유도체로서글루코스아민(CHNO), 만노스아민(CHNO), β-갈락토스유도체인 N-아미노부틸-O-β-D-갈락토피라노실-(1→ 4)-D-글루콘아미드(CHNO), α-글루코스유도체인 N-아미노부틸-O-α-D-글루코피라노실-(1→4)-D-글루콘아미드(CHNO), β-글루코스유도체인N-아미노부틸-O-β -D-글루코피라노실-(1→4)-D-글루콘아미드(CHNO)중에서선택되며, n은 1 또는 2이다.

公开(公告)号：KR1020000061478A

公开(公告)日：2000-10-25

申请号：KR1019990010532

申请日：1999-03-26

Applicant: 한국과학기술연구원 ,  일양약품주식회사

Inventor： 손연수 ,  백형기 ,  이정옥

IPC: A61K33/24 ,  C07F15/00 ,  C07F9/00

CPC classification number: A61K31/282 ,  A61K31/66 ,  C07F9/65815 ,  C07F15/0093

Abstract: PURPOSE: Novel platinum complex derivatives introduced to phosphazen trimer are provided which show an excellent anti-cancer effect and also, a preparing method thereof is provided. CONSTITUTION: Novel platinum complex derivatives introduced to phosphazen trimer are represented by formula (1): wherein N3P3 represents a cyclic phosphazen trimer; R represents a solubilizer selected from methylamine group, methoxy group or amino acid; A represents NH3 or two site chelate type amine selected from 2,2-dimethyl-1,3-propandiamine, 2,2-bisaminomethylpropandiol or 1,2-diaminocyclohexane; n indicating type of diaminodicarboxylic acid represents 0 when diaminodicarboxylic acid is aminomalonic acid derivative, 1 when diaminodicarboxylic acid is aspartic acid derivative and 2 when diaminodicarboxylic acid is glutamic acid derivative; and X represents 0 to 3. The platinum complex derivatives introduced to phosphazen trimer is prepared by following steps: introducing aminodicarboxylic acid derivative to hexacyclotriphosphazen, to obtain compound of chemical formula 2; hydrolyzing amino acid ester, to obtain alkali metal salt, of chemical formula 3; reacting the salt with alkaline earth metal salt, to obtain alkaline earth metal salt of chemical formula 4; and reacting the salt with platinum salt.

Abstract translation: 目的：提供引入磷氮烯三聚体的新型铂络合物衍生物，其具有优异的抗癌作用，并提供其制备方法。 引入磷氮烯三聚体的新型铂络合物衍生物由式（1）表示：其中N 3 P 3表示环状磷腈三聚体; R表示选自甲胺基，甲氧基或氨基酸的增溶剂; A表示NH 3或选自2,2-二甲基-1,3-丙二胺，2,2-双氨基甲基丙二醇或1,2-二氨基环己烷的两个位点螯合型胺; 当二氨基二羧酸为氨基马来酸衍生物时，表示二氨基二羧酸类型为0，当二氨基二羧酸为天冬氨酸衍生物时为1，当二氨基二羧酸为谷氨酸衍生物时为2; X表示0〜3。通过以下步骤制备引入磷腈三聚体的铂络合物衍生物：将氨基二羧酸衍生物引入六环三磷腈，得到化学式2的化合物; 水解氨基酸酯，得到化学式3的碱金属盐; 使盐与碱土金属盐反应，得到化学式4的碱土金属盐; 并使该盐与铂盐反应。

公开(公告)号：KR1020000002785A

公开(公告)日：2000-01-15

申请号：KR1019980023695

申请日：1998-06-23

Applicant: 한국과학기술연구원

Inventor： 손연수 ,  송수창 ,  이상범

IPC: C08G79/02

CPC classification number: C08G79/02 ,  C08L83/10

Abstract: PURPOSE: Polyphosphagen and temperature sensitive and biodegradable properties are given by substituting polydichlorophosphagen with methoxypolyethyleneglycol and amino acid ester. CONSTITUTION: The title compound(I) is manufactured. In formula, NHA is amino acid group selected from glycine(-NHCH2COO¬-), alanine(-NHCH(CH3)COO¬-), beta-alanine(-NHCH2CH2COO¬-), aminomalonic acid(-NHCH(COO¬-)2), aspartic acid(NHCH(CH2COO¬-)COO¬-), and glutamic acid(-NHCCH(CH2CH2COO¬-)COO¬-), R is methyl, ethyl, or benzyl, m is repeat unit of polyethyleneglycol and integer selected from 2, 7 and 16, x is 0.2-1.8 of mole content of polyethyleneglycol, and n is 10-100 of degree of polymerization.

Abstract translation: 目的：聚磷酸酯和温度敏感和可生物降解性质是用甲氧基聚乙二醇和氨基酸酯代替聚二氯磷酸酯。 构成：制备标题化合物（I）。 在式中，NHA是选自甘氨酸（-NHCH 2 COO-），丙氨酸（-NHCH（CH 3）COO-），β-丙氨酸（-NHCH 2 CH 2 COO-），氨基马来酸（-NHCH（COO-） 2），天冬氨酸（NHCH（CH 2 COO-）COO-））和谷氨酸（-NHCCH（CH 2 CH 2 COO-））COO-），R是甲基，乙基或苄基，m是聚乙二醇和整数的重复单元 选自2,7和16，x是聚乙二醇的摩尔含量为0.2-1.8，n为10-100聚合度。

公开(公告)号：KR100197162B1

公开(公告)日：1999-06-15

申请号：KR1019970003910

申请日：1997-02-10

Applicant: 한국과학기술연구원

Inventor： 손연수 ,  정옥상 ,  이영아

IPC: C07F15/00

Abstract: 치환말론산을 음이온 리간드로 하는 다음 일반식 (I)의 신규한 치환 백금 착화합물과 그 제조방법이 제공된다. 본 발명의 화합물은 종래 항암계보다 독성이 낮으면서 우수한 항암효과를 갖는다.

公开(公告)号：KR100197158B1

公开(公告)日：1999-06-15

申请号：KR1019960048238

申请日：1996-10-25

Applicant: 한국과학기술연구원

Inventor： 손연수 ,  김진규

IPC: D21H27/20

Abstract: 본 발명에 따라 벽지용 원지의 난연화 공정, 연질 비닐수지의 난연화공정, 및 난연 처리된 벽지용 난연 원지 위에 난연 처리된 연질 비닐수지를 코팅하는 단계로 이루어지는 난연성 비닐벽지의 제조방법이 제공된다. 본 발명에 따라 제조된 난연성 비닐 벽지는 우수한 내열성과 일광견뢰도를 갖는다.

公开(公告)号：KR100091196B1

公开(公告)日：1995-11-03

申请号：KR1019920016603

申请日：1992-09-09

Applicant: 한국과학기술연구원

Inventor： 손연수 ,  조양하

IPC: C01B21/098 ,  C01B25/10

公开(公告)号：KR1019890002091B1

公开(公告)日：1989-06-18

申请号：KR1019860006181

申请日：1986-07-28

Applicant: 한국과학기술연구원

Inventor： 손연수

IPC: C01F7/62

CPC classification number: C01F7/748 ,  C01F7/00 ,  C01F7/62 ,  C01F7/66 ,  C22B3/0031 ,  Y02P10/234

Abstract: Iron and transition metals (e.g. Cr) are removed from aluminate soln. (i.e. Al-sulfate, chloride and nitrate) by use of chelate precipitant i.e. alkyldithiocarbamate salt of formula RR1NCS2M or alkylenebisdithiocarbamate salt of formula MS2CNH(CH2)nNHCS2M. Where R and R1=H, Me, Et, or (iso) propyl, same or not, M=Na, K or NH4+, n=2-4 integer.

Abstract translation: 从铝酸盐溶胶中除去铁和过渡金属（如Cr）。 （即，硫酸盐，氯化物和硝酸盐），通过使用螯合沉淀剂，即式RR1NCS2M的烷基二硫代氨基甲酸盐或式MS2CNH（CH2）nNHCS2M的亚烷基二硫代氨基甲酸盐。 其中R和R1 = H，Me，Et或（异）丙基，相同或不同，M = Na，K或NH4 +，n = 2-4整数。

公开(公告)号：KR1019830000788A

公开(公告)日：1983-04-18

申请号：KR1019790001915

申请日：1979-06-12

Applicant: 한국과학기술연구원 ,  풍농비료공업주식회사

Inventor： 손연수 ,  이윤환 ,  변종흥 ,  주영제

IPC: F04D7/00

公开(公告)号：KR1020020090770A

公开(公告)日：2002-12-05

申请号：KR1020010029784

申请日：2001-05-29

Applicant: 한국과학기술연구원

Inventor： 손연수 ,  송릿다 ,  김관묵 ,  김영상

IPC: C07D487/22

Abstract: PURPOSE: Provided are tumor targeting water soluble porphyrin derivatives which form a complex with other anticancer agents and are thus used for delivering the anticancer agents to tumor tissues, and their preparation method and use, thereby minimizing an ill effect of an anticancer agent and increasing water-solubility. CONSTITUTION: The porphyrin derivative is represented by the formula(2), wherein m is zinc or two of hydrogen ions; Y is 0 or RX; R is selected from alkyl amine or alkylcarboxylate; and X is a halide ion.

Abstract translation: 目的：提供与其它抗癌剂形成复合物的肿瘤靶向水溶性卟啉衍生物，因此用于将抗癌剂递送至肿瘤组织及其制备方法和用途，从而最小化抗癌剂的不良作用和增加水 -solubility。 构成：卟啉衍生物由式（2）表示，其中m为锌或两个氢离子; Y为0或RX; R选自烷基胺或烷基羧酸盐; X为卤离子。

公开(公告)号：KR1020020015180A

公开(公告)日：2002-02-27

申请号：KR1020000048360

申请日：2000-08-21

Applicant: 한국과학기술연구원

Inventor： 손연수 ,  송수창 ,  이상범

IPC: C07F9/02

CPC classification number: C07F9/65815 ,  C07F15/0093

Abstract: PURPOSE: Provided are a temperature sensitive phosphagen trimer-platinum complex, its producing method and a composition of an anticancer agent containing it as an active ingredient, thereby developing an anticancer agent which has an excellent anticancer activity with less toxicity. CONSTITUTION: The temperature sensitive phosphagen trimer-platinum complex is represented by formula(1), in which m is an integer of 2, 7 and 12; n is an integer of 0, 1, 2 and 3; x is an integer of 0, 1 and 2; A2 is double figures chelate amine selected from 2,2-dimethyl-1,3-propanediamine, 1,2-diaminocyclohexane or 1,1-diaminomthylcyclohexane. The method for producing the temperature sensitive phosphagen trimer-platinum complex comprises the steps of: hydrolyzing the intermediate of cyclic phosphagen trimer represented by the formula(2) with alkali earth metals of formula(3) or alkali metals of formula(4) to produce alkali earth metal salts of formula(5) or alkali metal salts of formula(6); and reacting the cyclic phosphagen trimer-alkali metal salts with (diamine) platinum (II) acidic salts of formula(7) in a ratio of 1:3.

Abstract translation: 目的：提供一种温敏磷酸三聚体 - 铂络合物，其制备方法和含有它作为活性成分的抗癌剂的组合物，从而开发出具有优异的抗癌活性和较低毒性的抗癌剂。 构成：温度敏感的磷酸酯三聚体 - 铂络合物由式（1）表示，其中m是2,7和12的整数; n是0,1,2和3的整数; x是0，1和2的整数; A2是选自2,2-二甲基-1,3-丙二胺，1,2-二氨基环己烷或1,1-二氨基乙基环己烷的双重数字螯合胺。 生产温敏磷酸三聚体 - 铂络合物的方法包括以下步骤：用式（3）的碱土金属或式（4）的碱金属水解由式（2）表示的环状磷酸酯三聚体的中间体，以产生 式（5）的碱土金属盐或式（6）的碱金属盐; 并使环状磷酸酯三聚体 - 碱金属盐与（二胺）式（7）的铂（II）酸性盐以1:3的比例反应。