Abstract:
PURPOSE: A composition of treating diarrhea in mammals containing buforin II which is separated a Korean toad and has an antimicrobial effect against cause bacteria of diarrhea is provided. The composition exhibits high susceptibility against cause bacteria of diarrhea and kills cause bacteria by inhibition of intracellular physiological action of the diarrhea cause bacteria. CONSTITUTION: The composition for prevention and treatment of diarrhea contains 0.01 to 20% by weight of buforin II, based on the total weight of the composition. The composition is powder, a drug, a tablet or injectable formulation and can be also used as a vaccine preparation, a feed additive or a beverage additive. Daily dose of between about 400μg to 4mg/day is sufficient to treat diarrhea in mammals.
Abstract:
PURPOSE: A composition of treating mastitis in mammals containing buforin II having an antimicrobial effect against microorganism causing mastitis of a lactating cow is provided. The composition is excellent in stability as well as mastitis treating effect, inhibits generation of antibiotic resistant strains of bacteria and repels cause bacteria. CONSTITUTION: The mastitis treating composition contains 0.01 to 20% by weight of buforin II and additionally an excipient, based on the total weight of the composition. The excipient is one or more selected from the group consisting of an aqueous ointment base material, oily ointment base material, olive oil and white bee'wax. Daily dosages of between about 8 and 80mg/day are sufficient to treat mastitis in mammals.