Abstract:
본 발명은 제니스타인 또는 이의 약리학적으로 허용되는 염을 유효성분으로 함유하는 프랙탈카인 발현에 의해 야기되는 혈관염 치료용 조성물을 제공하며, 상기 본 발명에 의하면 혈관내피세포에서 프랙탈카인의 발현을 억제하여 이로부터 야기되는 혈관내 염증을 억제함으로써 각종 혈관내질환의 치료용 조성물로서 제공될 수 있다.
Abstract:
PURPOSE: A novel K-59 Lactobacillus acidophilus strain and fermented ginseng extract using the same are provided to promote insulin secretion and to prevent or treat diabetes. CONSTITUTION: A ginseng fermentation is prepared by fermenting K-59 Lactobacillus acidophilus(KFCC11467P) or an alpha-rhamnosidase prepared from the strain. A method for preparing fermented ginseng extract comprises: a step of fermenting ginseng with the fermentation at 35-37°C for 3-10 days to prepare the fermentation; and a step of preparing an extract of the fermentation. The extract is an ethanol or ethanol solution extract. A composition for maintaining or improving glucose homeostasis contains the ginseng fermentation or the extract as an active ingredient.
Abstract:
PURPOSE: A pharmaceutical composition containing benzylisothiocyanate is provided to suppress differentiation into adipocytes and to prevent and treat obesity and lipid-associated metabolic diseases. CONSTITUTION: A pharmaceutical composition for preventing and treating obesity and lipid-associated metabolic diseases contains benzyl isothiocyanate as an active ingredient. The metabolic diseases are diabetes, hyperlipidemia, fatty liver, artheriosclerosis, hypertension, cardiovascular diseases or combination thereof. The pharmaceutical composition is manufactured in the form of powder, granules, tablets, capsules, suspension, emulsion, syrup, external use, suppository, or sterilized injection solution. A health food for preventing and treating obesity and lipid-associated metabolic diseases contains benzylisothiocyanate as an active ingredient. The health food is a capsule, tablet, granule, powder, or drink.
Abstract:
본 발명은 비만 또는 비만관련질환 여부의 진단 및 치료에 필요한 정보를 제공하기 위하여 피험체로부터 분리된 혈액에서 아르기닌, 타이로신, 피페콜린산, 벤조산, 판토테닌산, 요산, 페닐피루빈산, 페닐아세타마이드, 세로토닌, L-카르니틴, 데카노일카르니틴, 미리스토일카르니틴, 헥사데케노일카르니틴, 리놀레일카르니틴, 바세닐카르니틴, 스테아로일카르니틴, lysoPC(C14:0), lysoPC(C15:0), lysoPC(C16:0), lysoPC(C16:1), lysoPC(C17:0), lysoPC(C17:1), lysoPC(C18:0), lysoPC(C18:1), lysoPC(C18:2), lysoPC(C18:3), lysoPC(C19:0), lysoPC(C20:1), lysoPC(C20:4), lysoPC(C20:5), lysoPE(C18:2), lysoPE(C20:4) 및 PCs에서 선택된 적어도 하나의 마커, 또는 간의 추출물에서 글루코즈, 글리세롤, 타이로신, 발린, 7-케토데옥시콜린산, 판토테닌산, 베타인, L-카르니틴, 3-메틸구타릴카르니틴, 팔미텔라이딘산, 팔미틴산, 리� ��레인산, 올레인산, 스테아린산, 멜리비오즈, lysoPC(C14:0), lysoPC(C16:0), lysoPC(C16:1), lysoPC(C18:0), lysoPC(C18:3), lysoPC(C20:4), lysoPC(C22:6), 및 PCs의 군에서 선택된 적어도 하나의 마커의 농도를 검출하는 방법 및 이를 이용한 비만억제활성을 갖는 식품 내지 약물의 스크리닝방법을 제공한다.
Abstract:
PURPOSE: An anti-diabetic composition containing biochanin A or salt thereof is provided to concentration-dependently increase phosphorylation of AMPK. CONSTITUTION: An anti-diabetic composition contains biochanin A or salt thereof as an active ingredient. A pharmaceutical composition for preventing and treating diabetes contains biochanin A or pharmacologically acceptable salt thereof as an active ingredient. A food composition for preventing and treating diabetes contains biochanin A or sitologically acceptable salt thereof as an active ingredient. Biochanin A or salt thereof is contained in 1-10 wt%.
Abstract:
PURPOSE: A novel Enterococcus faecalis K-60(KFCC11460P) is provided to maintain glucose homeostasis and to treat diabetes. CONSTITUTION: A novel Enterococcus faecalis K-60 strain(KFCC 11460P) is used for fermenting ginseng. A method for preparing the ginseng fermentation extract comprises: a step of fermenting ginseng with Enterococcus faecalis K-60 strain to obtain a fermentation; and a step of extracting the fermentation with a solvent and filtering. A pharmaceutical composition for maintaining or improving glucose homeostasis contains the ginseng fermentation extract. A health food for maintaining or improving glucose homeostasis contains ginseng fermentation extract.