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    Aminoalkyl-substituted 1,2,3,4-tetrahydronaphthalenes and compositions containing them
    38.
    发明专利
    Aminoalkyl-substituted 1,2,3,4-tetrahydronaphthalenes and compositions containing them 未知

    公开(公告)号：DE3207086A1

    公开(公告)日：1982-11-04

    申请号：DE3207086

    申请日：1982-02-26

    Applicant: ABBOTT LAB

    Inventor： DEBERNARDIS JOHN J ,  KYNCL JOHN J ,  WINN MARTIN

    IPC: C07D295/096 ,  C07D295/185 ,  C07D317/70 ,  C07C93/14 ,  A61K31/135 ,  A61K31/445 ,  A61K31/495 ,  A61K31/535 ,  C07C87/457 ,  C07C91/23 ,  C07C103/38 ,  C07D295/04 ,  C07D317/58

    Abstract: Mono- or disubstituted naphthalenes represented by the formula are described, in which R, R1 and R2 are each identical or different radicals from the group consisting of hydrogen, hydroxyl, lower alkoxy and halogen, with the proviso that at least one of the radicals R, R1 or R2 must be other than hydrogen, with the exception of the case in which R3 or R4 are phenyl-lower alkyl or substituted phenyl-lower alkyl, or R1 and R2 or R and R1 together are able to form a methylene bridge; n is 1 to 4; and R3 and R4 are identical or different radicals from the group consisting of hydrogen, lower alkyl, halo-lower alkyl, lower acyl, benzyl, phenyl-lower alkyl and substituted phenyl-lower alkyl or R3 and R4 together form a piperazino, piperidino or morpholino radical, and the pharmaceutically utilisable acid addition salts thereof. Due to their ability to react specifically with various types of adrenergic and dopaminergic tissue receptors, these compounds are suitable as therapeutic agents in the treatment of hypertension.

    39.
    发明专利
    未知

    公开(公告)号：FI60007C

    公开(公告)日：1981-11-10

    申请号：FI102774

    申请日：1974-04-03

    Applicant: ABBOTT LAB

    Inventor： WINN MARTIN

    IPC: C07C37/055 ,  C07D295/14 ,  C07D295/15 ,  C07D311/80 ,  C07D311/94 ,  C07D405/12

    Abstract: Heterocyclic esters of benzopyrans represented by the formula wherein n is 1 or 2; each R and R1 are the same or different members of the group consisting of hydrogen or loweralkyl; R2 is loweralkyl; R3 is WITH Y' being a straight or branched chain alkylene group having from one to eight carbon atoms, a is an integer from 1 to 4, b is an integer from 1 to 4, X is CH2, O, S or NR7 with R7 being hydrogen or loweralkyl, with the limitation that when X is O, S, or NR7, a and b each must be 2; R8 is hydrogen or loweralkyl; Y is a straight or branched chain alkylene group having from one to ten carbon atoms; and each R4 and R5 and R6 are the same or different members of the group consisting of hydrogen, halo, trifluoromethyl or loweralkyl; and the pharmaceutically acceptable salts thereof.

    40.
    发明专利
    未知

    公开(公告)号：NO143943B

    公开(公告)日：1981-02-02

    申请号：NO741140

    申请日：1974-03-29

    Applicant: ABBOTT LAB

    Inventor： WINN MARTIN ,  LYNN KATHLEEN RILEY ,  MARTIN YVONNE CONNOLLY

    IPC: C07C37/055 ,  C07D213/30 ,  C07D213/50 ,  C07D311/80 ,  C07D311/94

    Abstract: 1459564 Derivatives of dibenzopyran and cyclopentabenzopyran ABBOTT LABORATORIES 1 April 1974 [2 April 1973 13 Feb 1974] 14404/74 Heading C2C The invention comprises compounds of formulµ and the pharmaceutically acceptable salts of (I), (II) and (III), wherein n is 1 or 2; R and R 1 are each H or C 1-6 alkyl [but in the pyrone compound (XIII), H or Me]; R 2 is C 1-6 alkyl; Y is C 1-10 alkylene; R 4 , R 5 , R 6 are each H, halogen, CF 3 or C 1-6 alkyl; and Z is C or N. In examples, (XIII) are prepared by reacting an ethyl cyclopentanone (or cyclohexanone)-2-carboxylate with an appropriate 5-aralkylresorcinol (A), and converted into (I) and (II) by reaction with R 2 MgBr, followed optionally by hydrogenation to give (III). Starting materials prepared are the dimethyl ethers of (A), the benzene compounds where Q is CH : CHCO 2 H, CH 2 CH 2 CO 2 H, (CH 2 ) 3 OH, (CH 2 ) 3 Br, (CH 2 ) 5 OH and (CH 2 ) 3 Br, and the compounds 3,5-(MeO) 2 C 6 H 3 CR 0 R 0 - alkylene-Ar where CR 0 R 0 is CO or one R‹ is Me and the other is OH, and Ar is R 4 R 5 R 6 C 5 HZ-. Therapeutic compositions for oral, parenteral or rectal administration comprise the above compounds (Ia), which are analgesics, mild tranquillizers and antidiarrhoeals.

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