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公开(公告)号:CA2229312A1
公开(公告)日:1997-03-20
申请号:CA2229312
申请日:1996-09-09
Applicant: BASF AG
Inventor: DITRICH KLAUS , BALKENHOHL FRIEDHELM , LADNER WOLFGANG
IPC: C12M1/40 , B01J23/04 , C07B53/00 , C07B61/00 , C07C69/708 , C07C209/62 , C07C211/27 , C12P41/00 , C12P13/00 , C07C51/06 , C07C59/125
Abstract: The invention concerns a method of separating optically active amides to form carboxylic acids and optically active amines such thatsthe centre of chirality is maintained. The method is characterized in that the amides are hydrolyzed in the presence of a polyol or an aminoalcohol and an alkali or alkaline earth hydroxide.
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公开(公告)号:CA2261628C
公开(公告)日:2008-04-22
申请号:CA2261628
申请日:1997-07-14
Applicant: BASF AG
Inventor: SEITZ WERNER , MACK HELMUT , PFEIFFER THOMAS , LANGE UDO , BALKENHOHL FRIEDHELM , ZIERKE THOMAS
IPC: C07D207/22 , C12P17/04 , C07D401/12 , C12P17/10 , C12P41/00
Abstract: A process is disclosed for preparing 3-pyrroline-2-carboxylic acid derivativ es of formula (I), in which R1 stands for H, C1-C6-alkyl, benzyl, benzyl substituted at the phenyl radical, allyloxycarbonyl, C1-C6- alkyloxycarbonyl, benzyloxycarbonyl, in which the benzyl radical can be substituted by OCH3 radicals, or for C1-C4-alkylcarbonyl; or R1 stand s for an amino acid radical which can be alkylated or acylated at the nitrogen and is linked by the C-terminal; and R2 stands for OH, C1-C4 - alkyloxy, benzyloxy or an N3R4 group, in which R3 and R4 represent independently from each other H, C1-C4-alkyl, benzyl, phenyl or pyridyl, in which the aromatic compounds in R3 and R4 can be substituted by up to three identical or different substituents selected from the group composed of methyl, methoxy, hydroxy, cyano or halogen. According to this process, the sulphonic acid radical is eliminated by means of a base from a compound having the formula (II), in which R1 and R2 have the above meanings and R5 stands for C1-C6-alkyl, benzy l, trifluoromethyl, naphthyl or phenyl optionally substituted by radicals from the group composed of methyl, nitro and halogen.
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33.
公开(公告)号:CA2210519C
公开(公告)日:2006-03-21
申请号:CA2210519
申请日:1996-01-20
Applicant: BASF AG
Inventor: NUBLING CHRISTOPH , BALKENHOHL FRIEDHELM , DITRICH KLAUS
Abstract: A process for preparing optically active primary and secondary heteroatom- substituted amines from the corresponding racemates is characterised in that (a) a racemic heteroatom-substituted amine is enantioselectively acylated in the presence of a hydrolase with an ester whose acid component bear a fluorine, nitrogen, phosphorus, oxygen or sulphu r atom next to the carbonyl carbon atom; (b) the mixture of optically active heteroatom-substituted amine and optically active acylated heteroatom-substituted amine is separated in order to produce an enantiomer of the heteroatom-substituted amine; (c) the other enantiomer of the heteroatom-substituted amine is optionally extracted from the acylated heteroatom-substituted amine by amide cleavage.
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公开(公告)号:CA2166563C
公开(公告)日:2006-01-10
申请号:CA2166563
申请日:1994-06-24
Applicant: BASF AG
Inventor: PRESSLER UWE , BALKENHOHL FRIEDHELM , HAUER BERNHARD , LADNER WOLFGANG , SCHNELL URSULA , STAUDENMAIER HORST RALF
IPC: C12P17/00 , C07D319/06 , C12P7/02 , C12P7/04 , C12P7/22 , C12P7/24 , C12P7/40 , C12P13/00 , C12P17/06 , C12P17/10 , C12P17/12 , C12P17/14 , C12R1/01 , C12R1/06 , C12R1/07 , C12R1/13 , C12R1/15 , C12R1/265 , C12R1/365 , C12R1/44
Abstract: A biotechnological process is disclosed for producing alcohols, aldehydes an d carboxylic acids by oxidising compounds having the formula R1-C(CH3)=CR2R2, in which R1, R2 and R3 have the meanings given in t he description, by means of micro-organisms.
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公开(公告)号:PT801683E
公开(公告)日:2002-09-30
申请号:PT96900601
申请日:1996-01-20
Applicant: BASF AG
Inventor: BALKENHOHL FRIEDHELM , DITRICH KLAUS , NUBLING CHRISTOPH
Abstract: A process for preparing optically active primary and secondary heteroatom-substituted amines from the corresponding racemates, which comprisesa) enantioselective acylation of a racemic heteroatom-substituted amine with an ester whose acid component carries a fluorine, nitrogen, phosphorus, oxygen or sulfur atom in the vicinity of the carbonyl carbon, in the presence of a hydrolase,b) separation of the mixture of optically active heteroatom-substituted amine and optically active acylated heteroatom-substituted amine to obtain one enantiomer of the heteroatom-substituted amine,c) if required isolation of the other enantiomer of the heteroatom-substituted amine from the acylated heteroatom-substituted amine by amide cleavage.
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公开(公告)号:PT720655E
公开(公告)日:2000-04-28
申请号:PT94928365
申请日:1994-09-16
Applicant: BASF AG
Inventor: HAUER BERNHARD , LADNER WOLFGANG , PRESSLER UWE , BALKENHOHL FRIEDHELM , NUBLING CHRISTOPH
Abstract: PCT No. PCT/EP94/03102 Sec. 371 Date Mar. 11, 1996 Sec. 102(e) Date Mar. 11, 1996 PCT Filed Sep. 16, 1994 PCT Pub. No. WO95/08636 PCT Pub. Date Mar. 30, 1995A process for producing optically active primary and secondary amines from the corresponding racemates is characterised in that (a) a racemic amine is enantioselectively acylated in the presence of a hydrolase with an ester whose acid component bears a fluorine, nitrogen, oxygen or sulphur atom at the proximity of the carbonyl carbon atom; (b) the mixture of optically active amine and optically active acylated amine is separated so that an enantiomer of amine is produced; (c) if desired the other enantiomer of the amine is extracted from the acylated amine by amide cleavage.
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公开(公告)号:AT191451T
公开(公告)日:2000-04-15
申请号:AT96931783
申请日:1996-09-09
Applicant: BASF AG
Inventor: DITRICH KLAUS , BALKENHOHL FRIEDHELM , LADNER WOLFGANG
IPC: C12M1/40 , B01J23/04 , C07B53/00 , C07B61/00 , C07C69/708 , C07C209/62 , C07C211/27
Abstract: PCT No. PCT/EP96/03948 Sec. 371 Date Jan. 27, 1998 Sec. 102(e) Date Jan. 27, 1998 PCT Filed Sep. 9, 1996 PCT Pub. No. WO97/10201 PCT Pub. Date Mar. 20, 1997The present invention relates to a process for cleaving optically active amides to carboxylic acids and optically active amines with retention of the center of chirality, wherein the amides are hydrolyzed in the presence of a polyol or of an amino alcohol and of an alkali metal or alkaline earth metal hydroxide.
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公开(公告)号:PL331330A1
公开(公告)日:1999-07-05
申请号:PL33133097
申请日:1997-07-14
Applicant: BASF AG
Inventor: MACK HELMUT , PFEIFFER THOMAS , SEITZ WERNER , ZIERKE THOMAS , BALKENHOHL FRIEDHELM , LANGE UDO
IPC: C12P17/04 , C07D207/22 , C07D401/12 , C12P17/10
Abstract: PCT No. PCT/EP97/03752 Sec. 371 Date Jan. 22, 1999 Sec. 102(e) Date Jan. 22, 1999 PCT Filed Jul. 14, 1997 PCT Pub. No. WO98/04523 PCT Pub. Date Feb. 5, 19983-Pyrroline-2-carboxylic acid derivatives of the formula I are prepared by eliminating the sulfonic acid residue, with the aid of a base, from a compound of the formula II
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公开(公告)号:DE59406846D1
公开(公告)日:1998-10-08
申请号:DE59406846
申请日:1994-06-24
Applicant: BASF AG
Inventor: PRESSLER UWE , BALKENHOHL FRIEDHELM , HAUER BERNHARD , LADNER WOLFGANG , SCHNELL URSULA , STAUDENMAIER HORST
IPC: C07D319/06 , C12P7/04 , C12P7/24 , C12P7/40 , C12P17/00
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公开(公告)号:CA2274247A1
公开(公告)日:1998-08-27
申请号:CA2274247
申请日:1998-02-09
Applicant: BASF AG
Inventor: HOLMAN NICHOLAS JOHN , BALKENHOHL FRIEDHELM , KOSER STEFAN
IPC: C07D487/04 , C12P17/18 , C12P41/00
Abstract: The invention relates to a method for producing enantiomer-free esters of formula (I) (Ia or Ib), where the substituents represent the following: R1 is a hydrogen or a substituted or unsubstituted C1-C6-alkyl-, C1-C6-alkoxy-, or C1-C6-alkanoyl; R2 and R3 independently of each other are hydrogen or a substituted or unsubstituted C1-C6-alkyl-, C1-C6-alkoxy-, or C1-C6-alkanoyl-, C1-C6-alkylthio-, C1-C6-alkyl sulfinyl or C1-C6-alkyl sulfonyl-; R4 is not equal to R5 and independently of each other they are either hydrogen or an substituted or unsubstituted C1-C6-alkyl-, or together with the hydrogen atoms, to which they are bound, form a substituted or unsubstituted C3-C6-cyclo alkylidene; and R6 is a substituted or unsubstituted aryl-, C1-C20-alkyl-, C3-C20-alkenyl-, C3-C20-alkynyl-, C1-C20-alkoxy-C1-C20-alkyl. The method is characterized in that racemic compounds of the formula (II), in which the substituents R1 to R5 have the meanings given above, are reacted with a lipase or esterase in the presence of vinyl esters of formula (III), where R6 has the meaning given above and R7 represents hydrogen or methyl, to form compounds of formula (I).
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