公开(公告)号：DD156262A5

公开(公告)日：1982-08-11

申请号：DD22758981

申请日：1981-02-12

Applicant: BASF AG

Inventor： THIEME PETER C ,  FRANKE ALBRECHT ,  LENKE DIETER ,  LEHMANN HANS D ,  GRIES JOSEF

IPC: C07D413/12 ,  A61K31/495 ,  A61K31/496 ,  A61P9/12 ,  C07D271/10 ,  C07D405/12

Abstract: Novel phenylpiperazinylpropanols of 1,3,4-oxadiazolylphenols and their physiologically tolerated addition salts with acids, processes for their preparation, and pharmaceutical formulations which contain these compounds and are useful in the treatment of hypertonia.

公开(公告)号：CA1128050A

公开(公告)日：1982-07-20

申请号：CA325385

申请日：1979-04-11

Applicant: BASF AG

Inventor： THIEME PETER C ,  FRICKEL FRITZ-FRIEDER ,  HAGEN HELMUT ,  FRANKE ALBRECHT ,  LENKE DIETER ,  GRIES JOSEF

IPC: A61K31/41 ,  A61K31/433 ,  A61P9/00 ,  A61P9/06 ,  A61P9/12 ,  C07D285/12 ,  C07D417/12

Abstract: ;; The present invention relates to novel alkylaminopropanol derivatives of 2-methyl-5-(2-hydroxystyryl)-1,3,4-thia-diazole corresponding to the general formula (I) (I) where R is hydrogen, alkyl of 1 to 8 carbon atoms, which is unsubstituted or substituted by hydroxyl, alkoxy of 1 to 3 carbon atoms or cycloalkyl with 3 to 8 carbon atoms in the ring, alkenyl or alkynyl of 2 to 8 carbon atoms, or cycloalkyl or cycloalkenyl with 3 to 8 carbon atoms in the ring, the cycloalkyl rings being unsubstituted or mono- or di-substituted by alkyl of 1 to 3 carbon atoms, and their addition salts with physiologically acceptable acids. The invention is also directed to their process of preparation. These compounds thus obtained may be used for the treatment of coronary diseases of the heart, of hypertonia and of cardiac arrhythmias.

公开(公告)号：FI821252A0

公开(公告)日：1982-04-07

申请号：FI821252

申请日：1982-04-07

Applicant: BASF AG

Inventor： EHRMANN OSKAR ,  RASCHACK MANFRED ,  GRIES JOSEF ,  KRETZSCHMAR ROLF ,  LEHMANN HANS DIETER ,  FRIEDRICH LUDWIG ,  WUPPERMANN DIRK ,  ZIMMERMANN FRANK ,  SEITZ WERNER ,  TREIBER HANS JOERG ,  DENGEL FERDINAND ,  FRANK WOLFRAM ,  KURBJUWEIT HANS-GEORG ,  MYLLER CLAUS D

IPC: C07C255/42 ,  A61K31/275 ,  A61K31/277 ,  A61K31/335 ,  A61P9/06 ,  A61P9/10 ,  A61P37/08 ,  C07C253/30 ,  C07C255/32 ,  C07C255/53 ,  C07C255/58 ,  C07D317/06 ,  C07D317/58 ,  C07D317/60 ,  C07D319/02 ,  C07D319/08 ,  C07D319/18 ,  C07C

公开(公告)号：NO803176L

公开(公告)日：1981-04-27

申请号：NO803176

申请日：1980-10-24

Applicant: BASF AG

Inventor： FRICKEL FRITZ-FRIEDER ,  THIEME PETER C ,  FRANKE ALBRECHT ,  THEOBALD HANS ,  LENKE DIETER ,  GRIES JOSEF

IPC: A61K31/42 ,  A61P9/00 ,  A61P9/12 ,  A61P25/02 ,  C07C43/12 ,  C07C45/61 ,  C07C45/64 ,  C07C45/70 ,  C07D261/08 ,  C07F9/653 ,  C07D

Abstract: Novel aminopropanol derivatives of 5-(2-hydroxystyryl)-isoxazole and their addition salts with acids, their preparation, pharmaceutical formulations containing these compounds, and their use in the treatment of hypertonia, coronary heart disease and cardiac arrhythmias.

公开(公告)号：HU175881B

公开(公告)日：1980-11-28

申请号：HUBA003627

申请日：1978-02-03

Applicant: BASF AG

Inventor： FRICKEL FRITZ-FRIEDER ,  HAGEN HELMUT ,  OHNSORGE ULRICH ,  FRANKE ALBRECHT ,  LENKE DIETER ,  GRIES JOSEF ,  LEHMANN HANS D

IPC: A61K31/428 ,  C07D275/04 ,  C07D417/12

Abstract: New aminopropanol derivatives of 4-hydroxy-1,2-benzisothiazole and their addition salts with acids, their preparation, and pharmaceutical formulations which contain the said compounds and may be used for the treatment and prophylaxis of cardiac and circulatory disorders.

公开(公告)号：FI793552A

公开(公告)日：1980-05-19

申请号：FI793552

申请日：1979-11-13

Applicant: BASF AG

Inventor： FRANKE ALBRECHT ,  LENKE DIETER ,  GRIES JOSEF ,  LEHMANN DIETER

IPC: A61K31/55 ,  C07D223/16 ,  C07D405/12 ,  C07D

公开(公告)号：NO791427A

公开(公告)日：1979-10-30

申请号：NO791427

申请日：1979-04-27

Applicant: BASF AG

Inventor： THIEME PETER C ,  FRICKEL FRITZ-FRIEDER ,  HAGEN HELMUT ,  FRANKE ALBRECHT ,  LENKE DIETER ,  GRIES JOSEF

IPC: A61K31/41 ,  A61K31/433 ,  A61P9/00 ,  A61P9/06 ,  A61P9/12 ,  C07D285/12 ,  C07D

CPC classification number: C07D285/12 ,  Y10S514/821

公开(公告)号：NO164771C

公开(公告)日：1990-11-14

申请号：NO844778

申请日：1984-11-30

Applicant: BASF AG

Inventor： FRANKE ALBRECHT ,  SPIEGLER WOLFGANG ,  SIEGEL HARDO ,  MUELLER CLAUS D ,  PHILIPSBORN GERDA VON ,  LENKE DIETER ,  GRIES JOSEF

IPC: A61K31/34 ,  A61K31/341 ,  A61K31/38 ,  A61K31/381 ,  A61K31/40 ,  A61K31/41 ,  A61K31/415 ,  A61K31/44 ,  A61K31/4402 ,  A61K31/4406 ,  A61K31/4409 ,  A61K31/4418 ,  A61K31/495 ,  A61P9/06 ,  C07D207/32 ,  C07D207/333 ,  C07D213/50 ,  C07D231/12 ,  C07D307/46 ,  C07D333/22 ,  C07D409/12

公开(公告)号：FI81347C

公开(公告)日：1990-10-10

申请号：FI852730

申请日：1985-07-10

Applicant: BASF AG

Inventor： GEISS KARL-HEINZ ,  SCHMIED BERNHARD ,  RASCHACK MANFRED ,  LEHMANN HANS-DIETER ,  GRIES JOSEF ,  RUEBSAMEN KLAUS

IPC: A61K31/50 ,  A61K31/55 ,  A61P1/04 ,  A61P7/02 ,  A61P9/04 ,  A61P9/12 ,  C07D237/00 ,  C07D403/04 ,  C07D403/10

公开(公告)号：ES2015273B3

公开(公告)日：1990-08-16

申请号：ES87100041

申请日：1987-01-03

Applicant: BASF AG

Inventor： GEISS KARL-HEINZ ,  SCHMIED BERNHARD ,  KROPP RUDOLF ,  BALDINGER VERENA ,  GRIES JOSEF ,  LEHMANN HANS DIETER ,  RUEBSAMEN KLAUS

IPC: C07D237/00 ,  A61K31/50 ,  A61P1/04 ,  A61P7/02 ,  A61P9/04 ,  A61P9/12 ,  C07D403/04 ,  C07D403/10