公开(公告)号：AU600131B2

公开(公告)日：1990-08-02

申请号：AU1615188

申请日：1988-05-13

Applicant: BASF AG

Inventor： DOERPER THOMAS ,  MOELLER ACHIM ,  HILLEN HEINZ ,  KEILHAUER GERHARD ,  EMLING FRANZ ,  DAUM LOTHAR

IPC: C12N15/09 ,  A61K38/00 ,  A61P35/00 ,  C07K1/20 ,  C07K14/00 ,  C07K14/52 ,  C07K14/525 ,  C07K14/78 ,  C07K19/00 ,  C12P21/02 ,  C12R1/19 ,  C12N15/00 ,  C07K13/00 ,  A61K37/02 ,  A61K37/43 ,  C12N15/62

Abstract: Tumor necrosis factor (TNF) produced from the TNF molecule by modification at the amino terminus are prepared as described and are suitable for controlling diseases.

公开(公告)号：CA2005053A1

公开(公告)日：1990-06-23

申请号：CA2005053

申请日：1989-12-11

Applicant: BASF AG

Inventor： DAUM LOTHAR ,  DOERPER THOMAS ,  HILLEN HEINZ ,  MOELLER ACHIM ,  SCHOLLMEIER KLAUS ,  WALKER NIGEL ,  KEILHAUER GERHARD

IPC: A61K38/00 ,  C07K14/525 ,  C12N1/21 ,  C12N15/28 ,  C12N15/63

Abstract: - 25 - O.Z. 0050/40432 of the disclosure: TNF polypeptides which differ from natural TNF by the replacement and/or deletion of amino acids are described. The novel polypeptides are suitable for controlling diseases.

公开(公告)号：FI882283A0

公开(公告)日：1988-05-16

申请号：FI882283

申请日：1988-05-16

Applicant: BASF AG

Inventor： DOERPER THOMAS ,  MOELLER ACHIM ,  HILLEN HEINZ ,  KEILHAUER GERHARD ,  EMLING FRANZ ,  DAUM LOTHAR

IPC: C12N15/09 ,  A61K38/00 ,  A61P35/00 ,  C07K1/20 ,  C07K14/00 ,  C07K14/52 ,  C07K14/525 ,  C07K14/78 ,  C07K19/00 ,  C12P21/02 ,  C12R1/19 ,  C12N

Abstract: Tumor necrosis factor (TNF) produced from the TNF molecule by modification at the amino terminus are prepared as described and are suitable for controlling diseases.

公开(公告)号：HRP931504B1

公开(公告)日：2001-04-30

申请号：HRP931504

申请日：1993-12-16

Applicant: BASF AG

Inventor： HAUPT ANDREAS ,  JANSSEN BERND ,  RITTER KURT ,  KLINGE DAGMAR ,  KEILHAUER GERHARD ,  ROMERDAHL CYNTHIA ,  BARLOZZARI TERESA ,  QUIAN XIAO-DONG

IPC: A61K38/00 ,  A61K38/08 ,  A61P35/00 ,  C07K1/00 ,  C07K5/02 ,  C07K5/027 ,  C07K7/02 ,  C07K7/06 ,  A61K38/07

公开(公告)号：DK0691962T3

公开(公告)日：2000-10-16

申请号：DK94911931

申请日：1994-03-19

Applicant: BASF AG

Inventor： JANSSEN BERND ,  KLING ANDREAS ,  MUELLER STEFAN ,  RITTER KURT ,  KEILHAUER GERHARD ,  ROMERDAHL CYNTHIA ,  TRAUGOTT ULRICH ,  SCHLECKER RAINER

IPC: C07D295/08 ,  A61K31/34 ,  A61K31/341 ,  A61K31/357 ,  A61K31/36 ,  A61K31/40 ,  A61K31/403 ,  A61K31/41 ,  A61K31/42 ,  A61K31/421 ,  A61K31/4245 ,  A61K31/425 ,  A61K31/426 ,  A61K31/433 ,  A61K31/44 ,  A61K31/4402 ,  A61K31/4406 ,  A61K31/4409 ,  A61K31/4412 ,  A61K31/4418 ,  A61K31/445 ,  A61K31/451 ,  A61K31/47 ,  A61K31/495 ,  A61K31/496 ,  A61P35/00 ,  C07D207/32 ,  C07D207/333 ,  C07D209/52 ,  C07D211/14 ,  C07D213/30 ,  C07D215/14 ,  C07D261/08 ,  C07D261/18 ,  C07D263/14 ,  C07D263/32 ,  C07D271/06 ,  C07D271/10 ,  C07D277/24 ,  C07D285/12 ,  C07D295/092 ,  C07D307/42 ,  C07D307/58 ,  C07D317/58 ,  C07D317/66 ,  C07D333/06 ,  C07D333/16 ,  C07D413/12 ,  C07D417/12 ,  C07D521/00 ,  C07F9/6509

Abstract: This invention relates to 1-amino-3-phenoxy-propane-derivatives of formula 1: 1 (in which A, B, R, Rx, X and Z are defined as in the specification described) and methods for their preparation. These compounds may be used as modulators of multidrug resistance in cancer chemotherapy and for circumvention of resistance in the treatment of malaria.

公开(公告)号：CZ286752B6

公开(公告)日：2000-06-14

申请号：CZ157595

申请日：1993-12-04

Applicant: BASF AG

Inventor： HAUPT ANDREAS ,  JANSSEN BERND ,  RITTER KURT ,  KLINGE DAGMAR ,  KEILHAUER GERHARD ,  ROMERDAHL CYNTHIA ,  BARLOZZARI TERESA ,  QIAN XIAO-DONG

IPC: A61K38/00 ,  A61K38/08 ,  A61P35/00 ,  C07K1/00 ,  C07K5/02 ,  C07K5/027 ,  C07K7/02 ,  C07K7/06 ,  A61K38/07

Abstract: In the present invention there are disclosed peptides of the general formula I, in which the substituents and variables have specific meanings, further pharmaceutical preparation in which the peptides are comprised. These substances can be used for treating neoplastic diseases.

公开(公告)号：NZ258882A

公开(公告)日：1997-06-24

申请号：NZ25888293

申请日：1993-12-04

Applicant: BASF AG

Inventor： HAUPT ANDREAS ,  JANSSEN BERND ,  RITTER KURT ,  KLINGE DAGMAR ,  KEILHAUER GERHARD ,  ROMERDAHL CYNTHIA ,  BARLOZZARI TERESA ,  QIAN XIAO-DONG

IPC: A61K38/00 ,  A61K38/08 ,  A61P35/00 ,  C07K1/00 ,  C07K5/02 ,  C07K5/027 ,  C07K7/02 ,  C07K7/06 ,  A61K38/02

公开(公告)号：HRP931504A2

公开(公告)日：1997-02-28

申请号：HRP931504

申请日：1993-12-16

Applicant: BASF AG

Inventor： HAUPT ANDREAS ,  JANSSEN BERND ,  RITTER KURT ,  KLINGE DAGMAR ,  KEILHAUER GERHARD ,  ROMENDAHL CYNTHIA ,  BARLOZZARI TERESA ,  QUIAN XIAO-DONG

IPC: A61K38/00 ,  A61K38/08 ,  A61P35/00 ,  C07K1/00 ,  C07K5/02 ,  C07K5/027 ,  C07K7/02 ,  C07K7/06 ,  A61K38/03

公开(公告)号：HUT73529A

公开(公告)日：1996-08-28

申请号：HU9600360

申请日：1994-08-08

Applicant: BASF AG

Inventor： BOUSQUET PETER ,  CASTELLANO BERLANGA JOSE MARIA ,  FERNANDEZ BRANA MIGUEL ,  KEILHAUER GERHARD ,  MORAN MOSET MARINA ,  PEREZ DE VEGA MARIA JESUS ,  QIAN XIAO-DONG ,  ROMERDAHL CYNTHIA

IPC: A61K31/47 ,  A61K31/473 ,  A61P35/00 ,  C07D221/14 ,  A61K31/435

Abstract: Disclosed herein are compounds pharmaceutical compositions containing same of the formula 1. A compound of the Formula wherein X, X', X'' and X''', A, B, D, R, and R' are as identified in the specification and their preparation. Pharmaceutical compositions containing same can be used in the treatment of cancer.

公开(公告)号：PL313078A1

公开(公告)日：1996-05-27

申请号：PL31307894

申请日：1994-08-08

Applicant: BASF AG

Inventor： KEILHAUER GERHARD ,  ROMERDAHL CYNTHIA ,  FERNANDEZ BRANA MIGUEL ,  QIAN XIAO-DONG ,  BOUSQUET PETER ,  CASTELANO BERLANGA JOSE MARIA ,  MORAN MOSET MARINA ,  PEREZ DE VEGA MARIA JESUS

IPC: A61K31/47 ,  A61K31/473 ,  A61P35/00 ,  C07D221/14 ,  A61K31/435

Abstract: Disclosed herein are compounds pharmaceutical compositions containing same of the formula 1. A compound of the Formula wherein X, X', X'' and X''', A, B, D, R, and R' are as identified in the specification and their preparation. Pharmaceutical compositions containing same can be used in the treatment of cancer.