公开(公告)号：BRPI0014115B1

公开(公告)日：2015-05-05

申请号：BR0014115

申请日：2000-09-21

Applicant: BASF AG

Inventor： YOCUM R ROGERS ,  PATTERSON THOMAS A ,  HERMANN THERON ,  PERO JANICE G

IPC: C12N9/00 ,  C12N15/09 ,  C12N1/21 ,  C12N9/02 ,  C12N9/12 ,  C12N9/88 ,  C12N15/52 ,  C12P13/02 ,  C12P13/04 ,  C12P13/06 ,  C12P17/04 ,  C12Q1/48 ,  C12R1/125

公开(公告)号：MX2008000480A

公开(公告)日：2008-03-07

申请号：MX2008000480

申请日：2006-07-18

Applicant: BASF AG

Inventor： PATTERSON THOMAS A ,  HERMANN THERON ,  PERO JANICE G ,  SCHRODER HARTWIG ,  ZELDER OSKAR ,  KLOPPROGGE CORINNA ,  HAEFNER STEFAN ,  HEROLD ANDREA ,  YOCUM ROGERS R ,  WILLIAMS MARK K

IPC: C12P13/12

Abstract: Esta invencion se refiere a microorganismos recombinantes productores de metionina. Especificamente, esta invencion se refiere a cepas recombinantes de Corynebacterium que producen niveles incrementados de metionina comparado con sus contrapartes tipo silvestre y ademas a metodos para generar dichos organismos.

公开(公告)号：ZA200500949B

公开(公告)日：2006-12-27

申请号：ZA200500949

申请日：2005-02-02

Applicant: BASF AG ,  YOCUM R ROGERS ,  PATTERSON THOMAS A ,  PERO JANICE G ,  HERMANN THERON

Inventor： YOCUM R ROGERS ,  PATTERSON THOMAS A ,  PERO JANICE G ,  HERMANN THERON

IPC: C12N15/09 ,  C07H21/04 ,  C12N1/20 ,  C12N1/21 ,  C12N9/02 ,  C12N9/10 ,  C12N9/88 ,  C12N15/10 ,  C12N15/52 ,  C12P13/02 ,  C12P13/04 ,  C12R1/125

Abstract: The present invention features improved methods for the enhanced production of pantoate and pantothenate utilizing microorganisms having modified pantothenate biosynthetic enzyme activities and having modified methylenetetrahydrofolate (MTF) biosynthetic enzyme activities. In particular, the invention features methods for enhancing production of desired products by increasing levels of a key intermediate, ketopantoate, by increasing enzymes or substrates that contribute directly or indirectly to its synthesis. Recombinant microorganisms and conditions for culturing same are also featured. Also featured are compositions produced by such microorganisms.

公开(公告)号：HU0501185A2

公开(公告)日：2006-10-28

申请号：HU0501185

申请日：2002-01-18

Applicant: BASF AG

Inventor： YOCUM R ROGERS ,  PATTERSON THOMAS A ,  PERO JANICE G ,  HERMANN THERON

IPC: C12N1/21 ,  C12N9/04 ,  C12N9/00 ,  C12N15/09 ,  C12N9/10 ,  C12N9/88 ,  C12P13/02 ,  C12P13/04 ,  C12R1/125

Abstract: The present invention features improved methods for the enhanced production of pantoate and pantothenate utilizing microorganisms having modified pantothenate biosynthetic enzyme activities and having modified methylenetetrahydrofolate (MTF) biosynthetic enzyme activities. In particular, the invention features methods for enhancing production of desired products by increasing levels of a key intermediate, ketopantoate by enzymes that contribute to its synthesis. Recombinant microorganisms and conditions for culturing same are also are featured. Also featured are compositions produced by such microorganisms.

公开(公告)号：BR0206586A

公开(公告)日：2006-01-24

申请号：BR0206586

申请日：2002-01-18

Applicant: BASF AG

Inventor： YOCUM R ROGERS ,  PATTERSON THOMAS A ,  PERO JANICE G ,  HERMANN THERON

IPC: C12N15/09 ,  C12N1/21 ,  C12N9/00 ,  C12N9/04 ,  C12N9/10 ,  C12N9/88 ,  C12P13/02 ,  C12P13/04 ,  C12R1/125 ,  C12N15/03 ,  C07C235/12

Abstract: The present invention features improved methods for the enhanced production of pantoate and pantothenate utilizing microorganisms having modified pantothenate biosynthetic enzyme activities and having modified methylenetetrahydrofolate (MTF) biosynthetic enzyme activities. In particular, the invention features methods for enhancing production of desired products by increasing levels of a key intermediate, ketopantoate by enzymes that contribute to its synthesis. Recombinant microorganisms and conditions for culturing same are also are featured. Also featured are compositions produced by such microorganisms.

公开(公告)号：HU0500383A2

公开(公告)日：2005-08-29

申请号：HU0500383

申请日：2002-07-03

Applicant: BASF AG

Inventor： YOCUM R ROGERS ,  PATTERSON THOMAS A ,  PERO JANICE G ,  HERMANN THERON

IPC: C12N15/09 ,  C07H21/04 ,  C12N1/20 ,  C12N1/21 ,  C12N9/02 ,  C12N9/10 ,  C12N9/88 ,  C12N15/10 ,  C12N15/52 ,  C12P13/02 ,  C12P13/04 ,  C12R1/125

Abstract: The present invention features improved methods for the enhanced production of pantoate and pantothenate utilizing microorganisms having modified pantothenate biosynthetic enzyme activities and having modified methylenetetrahydrofolate (MTF) biosynthetic enzyme activities. In particular, the invention features methods for enhancing production of desired products by increasing levels of a key intermediate, ketopantoate, by increasing enzymes or substrates that contribute directly or indirectly to its synthesis. Recombinant microorganisms and conditions for culturing same are also featured. Also featured are compositions produced by such microorganisms.

公开(公告)号：AU2003251792A8

公开(公告)日：2004-01-23

申请号：AU2003251792

申请日：2003-07-03

Applicant: BASF AG

Inventor： PERO JANICE G ,  PATTERSON THOMAS A ,  HERMANN THERON ,  YOCUM R ROGERS

IPC: C12P1/00 ,  C07H21/04 ,  C12N1/21 ,  C12N9/00 ,  C12N9/10 ,  C12P13/02 ,  C12P19/02

Abstract: The present invention features improved methods for the enhanced production of pantoate and pantothenate utilizing microorganisms having modified pantothenate biosynthetic enzyme activities and having modified methylenetetrahydrofolate (MTF) biosynthetic enzyme activities. In particular, the invention features methods for enhancing production of desired products by increasing levels of a key intermediate, ketopantoate, by increasing enzymes or substrates that contribute directly or indirectly to its synthesis. Recombinant microorganisms and conditions for culturing same are also are featured. Also featured are compositions produced by such microorganisms.

公开(公告)号：AU2002316575A1

公开(公告)日：2004-01-23

申请号：AU2002316575

申请日：2002-07-03

Applicant: BASF AG

Inventor： YOCUM R ROGERS ,  PATTERSON THOMAS A ,  PERO JANICE G ,  HERMANN THERON

IPC: C12N15/09 ,  C07H21/04 ,  C12N1/20 ,  C12N1/21 ,  C12N9/02 ,  C12N9/10 ,  C12N9/88 ,  C12N15/10 ,  C12N15/52 ,  C12P13/02 ,  C12P13/04 ,  C12R1/125

Abstract: The present invention features improved methods for the enhanced production of pantoate and pantothenate utilizing microorganisms having modified pantothenate biosynthetic enzyme activities and having modified methylenetetrahydrofolate (MTF) biosynthetic enzyme activities. In particular, the invention features methods for enhancing production of desired products by increasing levels of a key intermediate, ketopantoate, by increasing enzymes or substrates that contribute directly or indirectly to its synthesis. Recombinant microorganisms and conditions for culturing same are also featured. Also featured are compositions produced by such microorganisms.

公开(公告)号：NO20033240A

公开(公告)日：2003-09-17

申请号：NO20033240

申请日：2003-07-17

Applicant: BASF AG

Inventor： YOCUM R ROGERS ,  PATTERSON THOMAS A ,  PERO JANICE G ,  HERMANN THERON

IPC: C12N15/09 ,  C12N1/21 ,  C12N9/00 ,  C12N9/04 ,  C12N9/10 ,  C12N9/88 ,  C12P13/02 ,  C12P13/04 ,  C12R1/125 ,  C12P13/025 ,  C12N1/20

CPC classification number: C12N9/0006 ,  C12N9/1014 ,  C12N9/1022 ,  C12N9/88 ,  C12N9/93 ,  C12P13/02 ,  C12Y201/02011 ,  C12Y401/01011 ,  C12Y603/02001

公开(公告)号：ZA200203116B

公开(公告)日：2003-04-22

申请号：ZA200203116

申请日：2002-04-19

Applicant: BASF AG

Inventor： HERMANN THERON ,  PATTERSON THOMAS A ,  PERO JANICE G ,  ROGERS YOCUM R

IPC: C12N20060101 ,  C12N