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公开(公告)号：MX9805499A
公开(公告)日：1998-11-30
申请号：MX9805499
申请日：1998-07-07
Applicant: BASF AG
Inventor： TREIBER HANS-JOERG , BLANK STEFAN , STARCK DOROTHEA , UNGER LILIANE , TESCHENDORF HANS-JUERGEN , WICKE KARSTEN
IPC: A61K31/00 , A61K31/40 , A61K31/4025 , A61K31/41 , A61K31/44 , A61K31/4427 , A61K31/4433 , A61K31/4439 , C07D243/08 , A61K31/505 , A61K31/506 , A61K31/55 , A61K31/551 , A61K31/5513 , A61P25/18 , A61P43/00 , C07D213/73 , C07D223/04 , C07D245/02 , C07D401/04 , C07D401/14 , C07D403/02 , C07D403/04 , C07D403/06 , C07D403/10 , C07D403/12 , C07D403/14 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/14 , C07D417/06 , C07D417/12 , C07D417/14
Abstract: La presente invencion se refiere a compuestos de azacicloheptano y diazacicloheptano y ciclooctano de la siguiente formula (I) Ar1-A-B-Ar2 donde Ar1; A; B y Ar2 tienen los significados proporcionados en la descripcion. Los compuestos de conformidad con la presente invencion poseen una alta afinidad con los receptores de dopamina D3 y pueden por consiguiente emplearse para el tratamiento de enfermedades que reaccionan con ligandos de dopamina D3.
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公开(公告)号：ZA9700209B
公开(公告)日：1998-07-10
申请号：ZA9700209
申请日：1997-01-10
Applicant: BASF AG
Inventor： TREIBER HANS-JOERG , BLANK STEFAN , STARCK DOROTHEA , UNGER LILIANE , TESCHEDORF HANS-JUERGEN , WICKE KARSTEN
IPC: C07D243/08 , A61K31/00 , A61K31/40 , A61K31/4025 , A61K31/41 , A61K31/44 , A61K31/4427 , A61K31/4433 , A61K31/4439 , A61K31/505 , A61K31/506 , A61K31/55 , A61K31/551 , A61K31/5513 , A61P25/18 , A61P43/00 , C07D213/73 , C07D223/04 , C07D245/02 , C07D401/04 , C07D401/14 , C07D403/02 , C07D403/04 , C07D403/06 , C07D403/10 , C07D403/12 , C07D403/14 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/14 , C07D417/06 , C07D417/12 , C07D417/14 , C07D , A61K
CPC classification number: C07D403/04 , C07D403/12 , C07D403/14 , C07D417/14
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公开(公告)号：CA2359948C
公开(公告)日：2010-09-21
申请号：CA2359948
申请日：2000-01-12
Applicant: BASF AG
Inventor： STARCK DOROTHEA , TREIBER HANS-JORG , UNGER LILIANE , NEUMANN-SCHULTZ BARBARA , BLUMBACH KAI , SCHOBEL DIETMAR
IPC: C07D249/14 , C07D403/06 , A61K31/41 , A61K31/4196 , A61K31/422 , A61K31/4245 , A61K31/427 , A61K31/436 , A61K31/4439 , A61K31/4725 , A61K31/473 , A61K31/496 , A61K31/497 , A61K31/5377 , A61K31/55 , A61P3/04 , A61P9/00 , A61P9/10 , A61P13/12 , A61P15/10 , A61P25/00 , A61P25/08 , A61P25/14 , A61P25/16 , A61P25/18 , A61P25/20 , A61P25/22 , A61P25/24 , A61P25/28 , A61P25/30 , A61P25/32 , A61P25/34 , A61P25/36 , A61P43/00 , C07D249/12 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D403/14 , C07D405/06 , C07D405/14 , C07D409/04 , C07D409/14 , C07D413/14 , C07D417/04 , C07D417/12 , C07D417/14 , C07D491/04 , C07D491/052
Abstract: The invention relates to triazole compounds of formula (I), in which R1, R2, A and B have the meanings given in the description. The compounds provided for in the invention have a high affinity for the dopamine-D3-receptor and can therefore be used for the treatment of diseases which respond to the influence of dopamine-D3-ligands.
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公开(公告)号：HU0200520A2
公开(公告)日：2002-07-29
申请号：HU0200520
申请日：1999-12-22
Applicant: BASF AG
Inventor： DR EMLING FRANZ , GARCIA-LADONA FRANCISCO JAVIER , DR HOFMANN HANS-PETER , HOLZENKAMP UTA , LUBISCH WILFRIED , SCHELLHAAS KURT , STARCK DOROTHEA , DR STEINER GERD , DR SZABO LASZLO , DR UNGER LILIANE
IPC: C07D275/06 , A61K31/4439 , A61K31/454 , A61K31/496 , A61K31/502 , A61K31/517 , A61K31/519 , A61K31/522 , A61K31/55 , A61K31/551 , A61P9/10 , A61P25/28 , C07D401/12 , C07D417/12 , C07D471/04
Abstract: The invention relates to the utilisation of compounds of formula (I) wherein the substituents have the meanings given in the description. The invention also relates to the salts thereof comprising pharmacologically compatible acids for producing medicaments for the prophylaxis and therapy of cerebral ischaemia and strokes.
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35.发明专利
公开(公告)号：AU749575B2
公开(公告)日：2002-06-27
申请号：AU9342698
申请日：1998-08-14
Applicant: BASF AG
Inventor： BLANK STEFAN , STARCK DOROTHEA , TREIBER HANS-JORG , KOSER STEFAN , SCHAFER BERND , THYES MARCO , HOGER THOMAS
IPC: C07D239/56 , A61K20060101 , A61K31/395 , A61K31/497 , A61K31/505 , A61K31/506 , A61P1/08 , A61P25/16 , A61P25/18 , A61P25/20 , A61P25/24 , A61P43/00 , C07D20060101 , C07D239/42 , C07D239/46 , C07D295/125 , C07D403/00 , C07D403/12 , C07D403/14
Abstract: The fumaric acid salt (A) of 2-{3-[4-(2-tert. butyl-6-trifluoromethyl- pyrimidin-4-yl)piperazin-1- yl]propylmercapto}pyrimidin-4-ol (I) is new. The fumarate salt (A) of the pyrimidin-4-ol derivative of formula (I) is new. The tautomers, solvates and hydrates of (A) are also new. ACTIVITY : Neuroleptic; antidepressant; antiemetic; antihistamine. MECHANISM OF ACTION : Dopamine D 3 receptor ligand. (A) has a selectivity Ki D 2/Ki D 3 of 120.
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Patent Agency Ranking
公开(公告)号：AU749539B2
公开(公告)日：2002-06-27
申请号：AU9068398
申请日：1998-07-23
Applicant: BASF AG
Inventor： STEINER GERD , DULLWEBER UTA , STARCK DOROTHEA , BACH ALFRED , WICKE KARSTEN , TESCHENDORF HANS-JURGEN , GARCIA-LADONA FRANCISCO JAVIER , EMLING FRANZ
IPC: A61K31/435 , A61P25/24 , C07D495/14
Abstract: 3-Substituted 3,4,5,7-tetrahydropyrrolo[3',4':4,5]thieno-[2,3-d]pyrimidine derivatives of the formula Iin which the substituents have the meanings stated in the description, their preparation and their use as drugs.
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公开(公告)号：SI0994865T1
公开(公告)日：2002-04-30
申请号：SI9830098
申请日：1998-07-03
Applicant: BASF AG
Inventor： STARCK DOROTHEA , BLANK STEFAN , TREIBER HANS-JOERG , UNGER LILIANE , NEUMANN-SCHULTZ BARBARA , LE BRIS THEOPHILE-MARIE , TESCHENDORF HANS-JUERGEN , WICKE KARSTEN
IPC: A61K31/33 , A61K31/41 , A61K31/4196 , A61K31/454 , A61K31/506 , A61K31/53 , A61K31/551 , A61P25/00 , A61P25/16 , A61P25/18 , A61P25/22 , A61P25/24 , A61P43/00 , C07D249/08 , C07D249/12 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14
Abstract: Triazole compounds of the following formula:where Ar1, A, B and Ar2 have the meanings given in the description, possess a high affinity for the dopamine D3 receptor and can therefore be used for treating diseases which respond to dopamine D3 ligands.
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公开(公告)号：BG105783A
公开(公告)日：2002-03-29
申请号：BG10578301
申请日：2001-08-03
Applicant: BASF AG
Inventor： STARCK DOROTHEA , TREIBER HANS-JOERG , UNGER LILIANE , NEUMANN-SCHULZ BARBARA , BLUMBACH KAI , SCHOEBEL DIETMAR
IPC: C07D249/14 , A61K31/41 , A61K31/4196 , A61K31/422 , A61K31/4245 , A61K31/427 , A61K31/436 , A61K31/4439 , A61K31/4725 , A61K31/473 , A61K31/496 , A61K31/497 , A61K31/5377 , A61K31/55 , A61P3/04 , A61P9/00 , A61P9/10 , A61P13/12 , A61P15/10 , A61P25/00 , A61P25/08 , A61P25/14 , A61P25/16 , A61P25/18 , A61P25/20 , A61P25/22 , A61P25/28 , A61P25/30 , A61P25/32 , A61P25/34 , A61P25/36 , A61P43/00 , C07D249/12 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/12 , C07D403/14 , C07D405/06 , C07D405/14 , C07D409/04 , C07D409/14 , C07D413/14 , C07D417/04 , C07D417/12 , C07D417/14 , C07D491/04 , C07D491/052 , A61P25/24 , C07D413/12
Abstract: The invention relates to triazole compounds of formula in which R1, R2, A and B have the meanings given in the description. The compounds provided for in the invention have a high affinity for the dopamine-D3-receptor and can therefore be used for the treatment of diseases which respond to the influence of dopamine-D3-ligands. 10 claims
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公开(公告)号：TR200102026T2
公开(公告)日：2001-12-21
申请号：TR200102026
申请日：2000-01-12
Applicant: BASF AG
Inventor： STARCK DOROTHEA , TREIBER HANS-JOERG , UNGER LILIANE , NEUMANN-SCHULTZ BARBARA , BLUMBACH KAI , SCHOEBEL DIETMAR
IPC: A61K31/41 , A61K31/4196 , A61K31/422 , A61K31/4245 , C07D249/14 , A61K31/427 , A61K31/436 , A61K31/4439 , A61K31/4725 , A61K31/473 , A61K31/496 , A61K31/497 , A61K31/5377 , A61K31/55 , A61P3/04 , A61P9/00 , A61P9/10 , A61P13/12 , A61P15/10 , A61P25/00 , A61P25/08 , A61P25/14 , A61P25/16 , A61P25/18 , A61P25/20 , A61P25/22 , A61P25/28 , A61P25/30 , A61P25/32 , A61P25/34 , A61P25/36 , A61P43/00 , C07D249/12 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/12 , C07D403/14 , C07D405/06 , C07D405/14 , C07D409/04 , C07D409/14 , C07D413/14 , C07D417/04 , C07D417/12 , C07D417/14 , C07D491/04 , C07D491/052 , A61P24
Abstract: Triazole compounds of the following formulawhere R1, R2, A and B have the meanings given in the description are described. The compounds according to the invention possess a high affinity for the dopamine D3 receptor and can therefore be used for treating diseases which respond to the influence of dopamine D3 ligands.
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公开(公告)号：ID29552A
公开(公告)日：2001-09-06
申请号：ID20011681
申请日：2000-01-12
Applicant: BASF AG
Inventor： STARCK DOROTHEA , TREIBER HANS-JORG , UNGER LILANE , SCHULTZ BARBARA NEUMANN , BLUMBACH KAI , SCHOBEL DIETMAR
IPC: C07D249/14 , A61K31/41 , A61K31/4196 , A61K31/422 , A61K31/4245 , A61K31/427 , A61K31/436 , A61K31/4439 , A61K31/4725 , A61K31/473 , A61K31/496 , A61K31/497 , A61K31/5377 , A61K31/55 , A61P3/04 , A61P9/00 , A61P9/10 , A61P13/12 , A61P15/10 , A61P25/00 , A61P25/08 , A61P25/14 , A61P25/16 , A61P25/18 , A61P25/20 , A61P25/22 , A61P25/28 , A61P25/30 , A61P25/32 , A61P25/34 , A61P25/36 , A61P43/00 , C07D249/12 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/12 , C07D403/14 , C07D405/06 , C07D405/14 , C07D409/04 , C07D409/14 , C07D413/14 , C07D417/04 , C07D417/12 , C07D417/14 , C07D491/04 , C07D491/052 , A61P25/24
Abstract: Triazole compounds of the following formulawhere R1, R2, A and B have the meanings given in the description are described. The compounds according to the invention possess a high affinity for the dopamine D3 receptor and can therefore be used for treating diseases which respond to the influence of dopamine D3 ligands.
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