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31.发明专利
公开(公告)号：AU2004275764B2
公开(公告)日：2010-01-14
申请号：AU2004275764
申请日：2004-09-22
Applicant: BAXTER HEALTHCARE SA , BAXTER INT
Inventor： RABINOW BARRETT E , KONKEL JAMIE , RODRIGUEZ ALFREDO , DOTY MARK
Abstract: The present invention provides a process for sterilizing a system, preferably a pharmaceutical preparation such as a dispersion of small particles or droplets of a pharmaceutically active compound using high pressure terminal sterilization techniques and products therefrom.
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公开(公告)号：ZA200603547B
公开(公告)日：2007-04-25
申请号：ZA200603547
申请日：2006-05-04
Applicant: BAXTER INT
Inventor： MAHESH CHAUBAL , JANE WERLING , RABINOW BARRETT E
IPC: A61K20090101 , A61K9/10 , A61K9/127 , A61K9/14 , A61K9/16 , A61K31/12 , A61K31/337 , A61K31/495 , A61K31/496 , A61K31/55 , A61K31/573
Abstract: The present invention is concerned with the formation of submicron particles of an antineoplastic agent, particularly paclitaxel, by precipitating the antineoplastic agent in an aqueous medium to form a pre-suspension followed by homogenization. Surfactants with phospholipids conjugated with a water soluble or hydrophilic polymer such as PEG are used as coating for the particles. The particles produced generally have an average particle size of less than about 1000 nm and are not rapidly soluble.
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公开(公告)号：BRPI0409929A
公开(公告)日：2006-04-25
申请号：BRPI0409929
申请日：2004-04-29
Applicant: BAXTER INT
Inventor： RABINOW BARRETT E , WHITE RANDY , SUN CHONG-SON , WONG JOSEPH CHUNG TAK , KIPP JAMES E , DOTY MARK J , REBBECK CHRISTINE L , PAPADOPOULOS PAVLOS
IPC: A61K9/50 , A61K9/51 , A61K31/496 , A61K9/14
Abstract: The present invention relates to compositions of submicron- to micron-size particles of antimicrobial agents. More particularly the invention relates to a composition of an antimicrobial agent that renders the agent potent against organisms normally considered to be resistant to the agent. The composition comprises an aqueous suspension of submicron-tomicron-size particles containing the agent coated with at least one surfactant selected from the group consisting of: ionic surfactants, non-ionic surfactants, biologically derived surfactants, and amino acids and their derivatives. The particles have a volume-weighted mean particle size of less than 5 µm as measured by laser diffractonetry.
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公开(公告)号：NO20061674A
公开(公告)日：2006-04-12
申请号：NO20061674
申请日：2006-04-12
Applicant: BAXTER INT
Inventor： DOTY MARK J , RABINOW BARRETT E , KONKEL JAMIE TERESA , RODRIGUEZ ALFREDO
CPC classification number: B65B55/02 , A61L2/0011 , A61L2/0023 , A61L2/02 , A61L2/04
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公开(公告)号：AU2005209243A1
公开(公告)日：2005-08-11
申请号：AU2005209243
申请日：2005-01-21
Applicant: BAXTER HEALTHCARE SA , BAXTER INT
Inventor： CHAUBAL MAHESH V , RABINOW BARRETT E , WERLING JANE , KIPP JAMES E
IPC: A61K9/10 , A61K9/14 , A61K9/51 , A61K31/00 , A61K31/551 , A61K31/7072 , A61K31/7076
Abstract: The present invention provides compositions comprising dispersions of anti-retroviral agents and methods of manufacture. The nanosuspensions are made by the process of microprecipitation and energy addition. Preferably, the nanosuspensions are made by the tandem process of microprecipitation-homogenization.
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Patent Agency Ranking36.发明专利
公开(公告)号：DK1663321T3
公开(公告)日：2012-11-19
申请号：DK04784813
申请日：2004-09-22
Applicant: BAXTER INT , BAXTER HEALTHCARE SA
Inventor： RODRIGUEZ ALFREDO , RABINOW BARRETT E , DOTY MARK , KONKEL JAMIE
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37.发明专利
公开(公告)号：PT1663321E
公开(公告)日：2012-11-15
申请号：PT04784813
申请日：2004-09-22
Applicant: BAXTER INT , BAXTER HEALTHCARE SA
Inventor： RODRIGUEZ ALFREDO , RABINOW BARRETT E , DOTY MARK , KONKEL JAMIE
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公开(公告)号：PL1682116T3
公开(公告)日：2012-10-31
申请号：PL04810266
申请日：2004-11-03
Applicant: BAXTER INT
Inventor： CHAUBAL MAHESH , WERLING JANE , RABINOW BARRETT E
IPC: A61K31/337 , A61K9/10 , A61K9/127 , A61K9/133 , A61K9/14 , A61K9/16 , A61K31/12 , A61K31/495 , A61K31/496 , A61K31/55 , A61K31/573
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公开(公告)号：MXPA06011171A
公开(公告)日：2007-01-25
申请号：MXPA06011171
申请日：2005-06-08
Applicant: BAXTER INT
Inventor： KIPP JAMES E , RABINOW BARRETT E
Abstract: La presente invencion concierne a un metodo para preparar y entregar particulas pequenas de un material farmaceuticamente activo a un sujeto mamifero para tratar enfermedades o desordenes. Una modalidad preferida abarca: (i) la recoleccion de celulas de tejido de un donador animal, (ii) crecimiento selectivo o no selectivo de estas celulas en un medio de cultivo celular al cual se adicionan particulas solidas de un compuesto terapeuticamente activo, en su mayoria libre de un portador de medicamento (aproximadamente 10% o menos, en proceso), y teniendo un tamano de particula promedio de menos de aproximadamente 100 micras, (iii) contactar las celulas en el medio de cultivo celular con las particulas solidas de compuesto terapeuticamente activo, que provoca que las particulas sean captadas por las celulas ya sea en en el compartimiento intracelular de las celulas cultivadas, union del compuesto activo como particulas a la periferia de tales celulas, o una combinacion de captacion intracelular y union a la superficie celular, (iv) opcionalmente, aislamiento y/o resuspension de las celulas preparadas en los pasos i a iii, (v) administrar las celulas al sujeto mamifero. El material farmaceuticamente activo puede ser administrado de manera intravenosa, intramuscular, subcutanea, intradermica, intra-articular, intratecal, epidural, intracerebral, via ruta bucal, rectal, topica, transdermica, oral, intranasal, via ruta pulmonar, intraperitoneal o combinaciones de las mismas. Despues de la administracion, las celulas cargadas transportan la composicion farmaceutica como particulas.
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公开(公告)号：NO20062552A
公开(公告)日：2006-06-02
申请号：NO20062552
申请日：2006-06-02
Applicant: BAXTER INT
Inventor： WERLING JANE , RABINOW BARRETT E , CHAUBAL MAHESH
IPC: A61K9/14 , A61K9/10 , A61K9/127 , A61K9/16 , A61K31/12 , A61K31/337 , A61K31/495 , A61K31/496 , A61K31/55 , A61K31/573
CPC classification number: A61K9/1271 , A61K9/10 , A61K9/14 , A61K9/145 , A61K9/146 , A61K9/1688 , A61K31/12 , A61K31/337 , A61K31/495 , A61K31/496 , A61K31/55 , A61K31/573
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