公开(公告)号：CA2188228A1

公开(公告)日：1997-04-26

申请号：CA2188228

申请日：1996-10-18

Applicant: HOECHST AG

Inventor： SCHWAB WILFRIED ,  CZECH JOERG ,  BOSLETT KLAUS

IPC: C07D213/75 ,  A61K31/275 ,  A61K31/42 ,  A61K31/422 ,  A61K31/44 ,  A61K31/4418 ,  A61P35/00 ,  A61P35/02 ,  C07D261/18 ,  C07D413/12 ,  C07D213/06 ,  A61K31/198 ,  C07C255/22

Abstract: The use of isoxazole and crotonamide derivatives for the treatment of carcinomatous disorders The compound of the formula ? or ?? (?) (??) is suitable for the production of a pharmaceutical for the treatment of carcinomatous disorders, where R1 is (C3-C5)-cycloalkyl, (C2-C6)-alkenyl or (C2-C6)-alkynyl, R~ is CF3, OCF3, SCF3, OH, N?, halogen, benzyl, phenyl, CN or O-phenyl, R3 is (C1-C4)-alkyl, halogen or a hydrogen atom and X is a -CH group or a nitrogen atom.

公开(公告)号：CA2199664C

公开(公告)日：2008-05-20

申请号：CA2199664

申请日：1997-03-11

Applicant: HOECHST AG

Inventor： CZECH JOERG ,  BOSSLET KLAUS ,  FLORENT JEAN-CLAUDE ,  SCHMIDT FREDOERIC ,  MONNERET CLAUDE ,  GERKEN MANFRED ,  STRAUB RAINER

IPC: C07H15/203 ,  C07H15/26 ,  A61K31/70 ,  A61K31/7012 ,  A61K31/7028 ,  A61K31/7034 ,  A61K47/48 ,  A61P29/00 ,  A61P35/00 ,  A61P37/00 ,  A61P43/00

Abstract: Compounds of the formula I glycosyl-Y[-C(=Y)-X-]p-W(R)n-Z-C(=Y)-active compound (I) are described which are suitable for the treatment of carcinomatous diseases , autoimmune diseases and chronic inflammatory diseases such as rheumatoid arthritis. >

公开(公告)号：PL193478B1

公开(公告)日：2007-02-28

申请号：PL32633698

申请日：1998-05-15

Applicant: HOECHST AG

Inventor： BOSLET KLAUS ,  CZECH JOERG ,  GERKEN MANFRED ,  STRAUB RAINER ,  BLUMRICH MATTHIAS

IPC: A61K31/70 ,  C07H15/20 ,  A61K9/20 ,  A61K9/48 ,  A61K31/047 ,  A61K31/7004 ,  A61K31/7028 ,  A61K31/7034 ,  A61K31/704 ,  A61K31/715 ,  A61K47/10 ,  A61K47/26 ,  A61K47/36 ,  A61K47/48 ,  A61P29/00 ,  A61P35/00 ,  A61P37/00 ,  A61P43/00 ,  C07H5/06 ,  C07H15/244 ,  C07H15/252

公开(公告)号：DK175228B1

公开(公告)日：2004-07-19

申请号：DK537289

申请日：1989-10-27

Applicant: HOECHST AG

Inventor： NAIK RAMCHANDRA GANAPATI ,  LAL BANSI ,  RUPP RICHARD HELMUT ,  SEDLACEK HANS HARALD ,  DICKNEITE GERHARD ,  CZECH JOERG

IPC: A61K31/35 ,  A61K31/40 ,  A61K31/443 ,  A61K31/4433 ,  A61K31/445 ,  A61K31/55 ,  A61P35/00 ,  C07D405/04 ,  C07D405/14 ,  C07D409/14 ,  C12N9/99 ,  A61K31/352

Abstract: Compounds of the formula I in which the substituents R1-R5 and n and m have the said meanings, are suitable for controlling tumours. The present invention relates to the use of 4H-1-benzopyran-4-one derivatives, to 4H-1-benzopyran-4-one derivatives and to medicines containing same. Benzopyran derivatives have already been disclosed in European Patent No. 0137193 and German Offenlegungsschrift 36 12 337. In the latter, compounds of the formula a) are disclosed.

公开(公告)号：DE69425356T2

公开(公告)日：2002-04-18

申请号：DE69425356

申请日：1994-09-09

Applicant: HOECHST AG ,  HOECHST HOUDE S A LAB

Inventor： BOSSLET KLAUS ,  CZECH JOERG ,  HOFFMANN DIETER ,  TILLEQUIN FRANCOIS ,  FLORENT JEAN-CLAUDE ,  AZOULAY MICHEL ,  MONNERET CLAUDE ,  JACQUESY JEAN-CLAUDE ,  GESSON JEAN-PIERRE ,  KOCH MICHEL

IPC: C07H15/244 ,  A61K31/70 ,  A61K31/7028 ,  A61K31/7034 ,  A61K31/704 ,  A61K47/48 ,  A61P43/00

Abstract: Substrate-spacer-prodrug compounds (pro-prodrugs) suited for site specific delivery of drugs, a process of preparing them and their use are described.

公开(公告)号：DK0501215T3

公开(公告)日：2000-09-18

申请号：DK92102197

申请日：1992-02-10

Applicant: HOECHST AG

Inventor： SEEMANN GERHARD ,  BOSSLET KLAUS ,  CZECH JOERG ,  KOLAR CENEK ,  HOFFMANN DIETER ,  SEDLACEK HANS-HARALD

IPC: C12N15/09 ,  A61K38/00 ,  A61K39/395 ,  A61K47/48 ,  A61P35/00 ,  C07K1/113 ,  C07K16/00 ,  C07K16/30 ,  C07K19/00 ,  C12N1/15 ,  C12N9/24 ,  C12N15/56 ,  C12N15/62 ,  C12P21/02 ,  C12P21/08 ,  C12R1/91 ,  C07K15/00

公开(公告)号：PT590530E

公开(公告)日：2000-08-31

申请号：PT93115418

申请日：1993-09-24

Applicant: HOECHST AG

Inventor： CZECH JOERG ,  SEEMANN GERHARD ,  BOSSLET KLAUS ,  GEHEMANN MATHIAS

IPC: A01K67/027 ,  A61K38/00 ,  A61P35/00 ,  C07K14/00 ,  C07K14/705 ,  C07K16/00 ,  C07K16/18 ,  C07K19/00 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N9/00 ,  C12N9/24 ,  C12N15/09 ,  C12N15/62 ,  C12N15/81 ,  C12P21/02 ,  C12R1/865 ,  G01N33/53 ,  G01N33/68

Abstract: The invention relates to compounds which contain an antigen binding region which is bound to at least one enzyme which is able to metabolise a compound which has little or no cytotoxicity (prodrug) into a cytotoxic compound (drug), where the antigen binding region consists of a single polypeptide chain. Covalently bonded carbohydrates are advantageously present on the polypeptide chain.

公开(公告)号：AT194920T

公开(公告)日：2000-08-15

申请号：AT94114195

申请日：1994-09-09

Applicant: HOECHST AG ,  HOECHST HOUDE S A LAB

Inventor： BOSSLET KLAUS ,  CZECH JOERG ,  HOFFMANN DIETER ,  TILLEQUIN FRANCOIS ,  FLORENT JEAN-CLAUDE ,  AZOULAY MICHEL ,  MONNERET CLAUDE ,  JACQUESY JEAN-CLAUDE ,  GESSON JEAN-PIERRE ,  KOCH MICHEL

IPC: C07H15/244 ,  A61K31/70 ,  A61K31/7028 ,  A61K31/7034 ,  A61K31/704 ,  A61K47/48 ,  A61P43/00

Abstract: Substrate-spacer-prodrug compounds (pro-prodrugs) suited for site specific delivery of drugs, a process of preparing them and their use are described.

公开(公告)号：HU9801087A2

公开(公告)日：1998-12-28

申请号：HU9801087

申请日：1998-05-14

Applicant: HOECHST AG

Inventor： BLUMRICH MATTHIAS ,  BOSSLET KLAUS ,  CZECH JOERG ,  GERKEN MANFRED ,  STRAUB RAINER

IPC: C07H15/20 ,  A61K9/20 ,  A61K9/48 ,  A61K31/047 ,  A61K31/70 ,  A61K31/7004 ,  A61K31/7028 ,  A61K31/7034 ,  A61K31/704 ,  A61K31/715 ,  A61K47/10 ,  A61K47/26 ,  A61K47/36 ,  A61K47/48 ,  A61P29/00 ,  A61P35/00 ,  A61P37/00 ,  A61P43/00 ,  C07H5/06 ,  C07H15/244 ,  C07H15/252

Abstract: Compositions containing a glycosylated drug derivative of formula (I) and/or its salts, a carrier and optionally divalent ions, is new. G-Y-(C(=Y)-X)p-W(R)n-X-C(=Y)-A (I) Also claimed is the production of the preparation by processing the ingredients into a pharmaceutical dosage form. G = enzymatically cleavable poly-, oligo- or monosaccharide residue; W = aromatic or heteroaromatic residue, aliphatic residue containing conjugated double bonds or amino acid residue which cyclises after cleavage of G; R = H, Me, OMe, COOH, CN, COOMe, OH, NO2, F, Cl, Br, sulphonyl, sulphonamide or (1-4C alkyl)-sulphonamide; p = 0 or 1; n = integer; X = O, NH, methyleneoxy, methyleneamino or methylene-(1-4C) alkylamino; Y = O or NH; and A = biologically active agent bonded via a hydroxy, amino or imino group.

公开(公告)号：TR199800848A2

公开(公告)日：1998-12-21

申请号：TR9800848

申请日：1998-05-13

Applicant: HOECHST AG

Inventor： BOSSLET KLAUS ,  CZECH JOERG ,  GERKEN MANFRED ,  STRAUB RAINER ,  BLUMRICH MATTHIAS

IPC: C07H15/20 ,  A61K9/20 ,  A61K9/48 ,  A61K31/047 ,  A61K31/70 ,  A61K31/7004 ,  A61K31/7028 ,  A61K31/7034 ,  A61K31/704 ,  A61K31/715 ,  A61K47/10 ,  A61K47/26 ,  A61K47/36 ,  A61K47/48 ,  A61P29/00 ,  A61P35/00 ,  A61P37/00 ,  A61P43/00 ,  C07H5/06 ,  C07H15/244 ,  C07H15/252

Abstract: Compositions containing a glycosylated drug derivative of formula (I) and/or its salts, a carrier and optionally divalent ions, is new. G-Y-(C(=Y)-X)p-W(R)n-X-C(=Y)-A (I) Also claimed is the production of the preparation by processing the ingredients into a pharmaceutical dosage form. G = enzymatically cleavable poly-, oligo- or monosaccharide residue; W = aromatic or heteroaromatic residue, aliphatic residue containing conjugated double bonds or amino acid residue which cyclises after cleavage of G; R = H, Me, OMe, COOH, CN, COOMe, OH, NO2, F, Cl, Br, sulphonyl, sulphonamide or (1-4C alkyl)-sulphonamide; p = 0 or 1; n = integer; X = O, NH, methyleneoxy, methyleneamino or methylene-(1-4C) alkylamino; Y = O or NH; and A = biologically active agent bonded via a hydroxy, amino or imino group.