公开(公告)号：DE3347173A1

公开(公告)日：1985-07-04

申请号：DE3347173

申请日：1983-12-27

Applicant: HOECHST AG

Inventor： HENNING RAINER DR ,  LERCH ULRICH DR ,  KAISER JOACHIM DR

IPC: A61K31/54 ,  A61K31/5415 ,  A61P3/00 ,  A61P9/00 ,  C07D279/16 ,  C07D317/00 ,  C07D417/04 ,  C07D417/12 ,  C07D417/10

Abstract: Benzothiazine derivatives of the formula I (I) with (R(1), R(1)', R(1)'', R(4) and R(4)' equal to hydrogen, alkyl, alkoxy, halogen, nitro, hydroxyl, acetamido or amino; R(2) equal to hydrogen, alkyl, alkenyl, phenyl; R(3) equal to hydrogen, alkyl, alkenyl, phenyl; R(5) equal to hydrogen or (C1-C3)-alkyl; R(6) equal to one of the following groups, with R(7) and R(8) equal to hydrogen, alkyl, cycloalkyl, phenyl; R(9) equal to hydrogen, alkyl, phenyl, pyridyl, pyrimidinyl or benzoyl; R(10) equal to hydrogen, alkyl, phenyl; R(11) equal to hydrogen, hydroxyl, alkoxy or, together with R(12), a bond; and R(12) equal to hydrogen or, together with R(11), a bond; m equal to 1, 2, 3 or 4; n equal to 0 or 1; p equal to 0, 1, 2, 3 or 4, and X equal to oxygen or two hydrogen atoms, and salts of the compounds of the formula I with physiologically tolerated acids and a process for the preparation of compounds I, likewise a method of treatment of disturbances of the calcium balance of a human body are described.

公开(公告)号：DE3163510D1

公开(公告)日：1984-06-14

申请号：DE3163510

申请日：1981-09-03

Applicant: HOECHST AG

Inventor： KONZ ELMAR DR ,  HOCK FRANZ DR ,  KAISER JOACHIM DR ,  KRUSE HANSJORG DR

IPC: C07D217/14 ,  A61K31/47 ,  A61K31/495 ,  A61K31/505 ,  A61K31/55 ,  A61P9/12 ,  A61P25/00 ,  C07D217/22 ,  C07D401/04 ,  C07D401/12 ,  C07D405/02 ,  C07D405/12 ,  C07D409/12 ,  C07D413/12

Abstract: New isoquinoline derivatives of the general formula (I) and their physiologically acceptable salts, which exert pharmacological actions on the central nervous system and the heart circulation system, a process for the preparation of these compounds, medicaments containing them, and their use as neuroleptic, antihypertonic and antiarrhythmic agents, are described.

公开(公告)号：DE2910195A1

公开(公告)日：1980-09-25

申请号：DE2910195

申请日：1979-03-15

Applicant: HOECHST AG

Inventor： LATTRELL RUDOLF DIPL CHEM DR ,  BARTMANN WILHELM DIPL CHEM DR ,  KAISER JOACHIM DR

IPC: C07D405/14 ,  C07D409/14 ,  C07D401/04 ,  A61K31/47

Abstract: Dihydroquinoline derivs. of formula (I) and their pharmaceutically acceptable salts are new. In (I), n is 1-3, each R1 is H, 1-6C alkyl or alkoxy, benzyloxy, methylenedioxy, halo, CF3, OH, NH2, NO2, 1-6C alkoxycarbonyl or sulphamoyl. R2 is H, phenyl, benzyl or 1-4C alkyl, R3 is 1-6C alkyl, 2-6C alkenyl, 1-6C alkoxy (opt. substd. by OH), 2-6C alkenyloxy, 5-7C cycloalkyl or cycloalkoxy, aryl, mono- or di-aryl-(1-6C) alkyl, aryl-(1-6C)alkoxy, aryloxy; 'aryl' is phenyl, furyl, thienyl or pyridyl and may be substd. by 1-3R1 gps.). Also new are intermediates (IV) of similar structure with NH2 replacing NHCOR3. (I) have cardiac/Circulatory activity, esp. hypotensive and antiarrhythmic activities. (IV) have the same effects. Pref. oral dose is 60-1000 (esp. 100-500) mg/day.

公开(公告)号：DE2831447A1

公开(公告)日：1980-01-31

申请号：DE2831447

申请日：1978-07-18

Applicant: HOECHST AG

Inventor： LATTRELL RUDOLF DIPL CHEM DR ,  BARTMANN WILHELM DIPL CHEM DR ,  KAISER JOACHIM DR

IPC: A61K31/435 ,  A61P9/00 ,  C07D401/04 ,  C07D401/14 ,  C07D405/14 ,  C07D409/14 ,  A61K31/47

公开(公告)号：DE2253554A1

公开(公告)日：1974-05-16

申请号：DE2253554

申请日：1972-11-02

Applicant: HOECHST AG

Inventor： KAMPE KLAUS-DIETER DR ,  BABEJ MILOS DR ,  KAISER JOACHIM DR

IPC: C07B31/00 ,  C07B57/00 ,  C07C67/00 ,  C07D263/28 ,  C07D263/52 ,  C07D263/58 ,  C07D263/60 ,  C07D85/36

Abstract: New 2-amino-2-oxazolines and their salts with physiologically tolerated acids which may be used as medicaments, in particular as antihypotonics, diuretics or antiphlogistics, and process for preparing them.

公开(公告)号：HU224211B1

公开(公告)日：2005-06-28

申请号：HU9503932

申请日：1995-12-29

Applicant: HOECHST AG

Inventor： CRAUSE PETER DR ,  KAISER JOACHIM DR ,  ENGLERT HEINRICH DR ,  GOEGELEIN HEINZ DR ,  MANRIA DIETER DR ,  GERLACH UWE DR

IPC: C07D333/20 ,  A61K31/18 ,  A61K31/34 ,  A61K31/35 ,  A61K31/38 ,  A61K31/381 ,  A61K31/395 ,  A61K31/40 ,  A61K31/425 ,  A61K31/426 ,  A61K31/64 ,  A61P9/00 ,  A61P9/04 ,  A61P9/06 ,  A61P9/10 ,  C07C233/00 ,  C07C303/40 ,  C07C311/58 ,  C07C327/40 ,  C07C335/42 ,  C07D207/32 ,  C07D207/335 ,  C07D213/40 ,  C07D277/28 ,  C07D307/52 ,  C07C311/51

Abstract: Substd. benzenesulphonylurea or -thiourea cpds. of formula (I) are new: R1 = H, 1-6C alkyl, or 3-6C cycloalkyl; R2 = 1-6C alkyl, 1-6C alkoxy, 1-6C mercaptoalkyl, 3-6C cycloalkyl, or a 1-8C chain in which 1-3C may be replaced by O, NH or S; R3, R4 = H or 1-6C alkyl; or R3 + R4 = (CH2)p; p = 2-5; E, X = O or S; Y = ÄC(R5)2Üm; R5 = H, Me or Et; m = 1 or 2; Ar = phenyl, thienyl, furyl, pyrrolyl, thiazolyl, naphthyl or pyridyl (all opt. substd. by 1-3 Me, Et, MeO, EtO, Cl, Br or F).

公开(公告)号：DK0729954T3

公开(公告)日：2003-12-01

申请号：DK96101096

申请日：1996-01-26

Applicant: HOECHST AG

Inventor： ENGLERT HEINRICH DR ,  HARTUNG JENS DR ,  CRAUSE PETER DR ,  MANIA DIETER DR ,  GOEGELEIN HEINZ DR ,  KAISER JOACHIM DR

IPC: A61K31/38 ,  A61K31/381 ,  A61K31/64 ,  A61P9/00 ,  A61P9/04 ,  A61P9/06 ,  A61P9/10 ,  A61P43/00 ,  C07C335/00 ,  C07D333/34

Abstract: N-((2-Benzamidoethyl)- thiophene-sulphonyl)-urea or-thiourea derivs. of formula (I) are new. R1 = H, halogen, Me, Et, OMe, OEt, SMe, SEt, 1-2C fluoroalkyl or 1-2C fluoroalkoxy; X = O or S; R2 = H, Me or CF3; Y, Z = H, F, Cl, Br, I, Me, Et, OMe or OEt.

公开(公告)号：CZ290809B6

公开(公告)日：2002-10-16

申请号：CZ38296

申请日：1996-02-08

Applicant: HOECHST AG

Inventor： ENGLERT HEINRICH DR ,  GERLACH UWE DR ,  CRAUSE PETER DR ,  MANIA DIETER DR ,  GOGELEIN HEINZ DR ,  KAISER JOACHIM DR

IPC: C07D333/20 ,  A61K31/18 ,  A61K31/34 ,  A61K31/35 ,  A61K31/38 ,  A61K31/381 ,  A61K31/395 ,  A61K31/40 ,  A61K31/425 ,  A61K31/426 ,  A61K31/64 ,  A61P9/00 ,  A61P9/04 ,  A61P9/06 ,  A61P9/10 ,  C07C233/00 ,  C07C303/40 ,  C07C311/58 ,  C07C327/40 ,  C07C335/42 ,  C07D207/32 ,  C07D207/335 ,  C07D213/40 ,  C07D277/28 ,  C07D307/52

Abstract: In the present invention, there are disclosed substituted benzenesulfonyl ureas and benzenesulfonyl thioureas of the general formula I. These compounds as well as their pharmaceutically acceptable salts are valuable medicaments that are suitable not only as antiarrhythmic but also as compounds used for prophylaxis of cardiovascular system disorders, heart insufficiency, heart transplantations or cerebral vascular diseases in humans or animals.

公开(公告)号：AT189213T

公开(公告)日：2000-02-15

申请号：AT96101976

申请日：1996-02-12

Applicant: HOECHST AG

Inventor： ENGLERT HEINRICH CHRISTIAN DR ,  GERLACH UWE DR ,  MANIA DIETER DR ,  GOEGELEIN HEINZ DR ,  KAISER JOACHIM DR

IPC: A61K31/18 ,  A61K31/64 ,  A61P9/00 ,  A61P9/04 ,  A61P9/06 ,  A61P9/10 ,  C07C233/00 ,  C07C303/40 ,  C07C311/58 ,  C07C311/59 ,  C07C327/40 ,  C07C335/42

Abstract: Substd. benzene sulphonyl urea and thiourea derivs. of formula (I) and their salts are new. R1 = H, Me or CF3; R2 = 4-10C alkoxy with 1-6C replaced by O, S or NH; Q = O or S; Y = ÄC(R3)2Üm; R3 = H, Me or Et; R' = H, halo or 1-6C alkyl; R" = halo, 1-4C alkoxy or 1-4C alkyl; and m = 1-4.

公开(公告)号：GR3029768T3

公开(公告)日：1999-06-30

申请号：GR990400855

申请日：1999-03-23

Applicant: HOECHST AG

Inventor： ENGLERT HEINRICH DR ,  MANIA DIETER DR ,  HARTUNG JENS DR ,  GOEGELEIN HEINZ DR ,  KAISER JOACHIM DR

IPC: A61K31/64 ,  A61P9/06 ,  A61P9/08 ,  A61P9/10 ,  C07C303/36 ,  C07C311/57 ,  C07C311/58 ,  C07C335/42 ,  C07D295/135

Abstract: Amino-substituted benzenesulphonylureas and -thioureas of the formula I are described. The compounds I are used for treating cardiac dysrhythmias and for preventing sudden heart death due to arrhythmias and can therefore be used as antiarrhythmics. They are particularly suitable for cases in which arrhythmias are the consequence of a constriction of a coronary vessel, such as in angina pectoris or acute myocardial infarct.