公开(公告)号：NO940600A

公开(公告)日：1994-08-24

申请号：NO940600

申请日：1994-02-22

Applicant: HOECHST AG

Inventor： ENGLERT HEINRICH CHRISTIAN ,  MANIA DIETER ,  HARTUNG JENS ,  GOEGELEIN HEINZ ,  KAISER JOACHIM ,  LINZ WOLFGANG ,  WETTLAUFER DAVID

IPC: A61K31/18 ,  A61K31/64 ,  A61P9/00 ,  A61P9/04 ,  A61P9/10 ,  C07C303/40 ,  C07C311/46 ,  C07C311/58 ,  C07C323/67 ,  C07C335/42

CPC classification number: C07C311/46 ,  C07C311/58 ,  C07C335/42 ,  Y10S514/821

公开(公告)号：CA2116165A1

公开(公告)日：1994-08-24

申请号：CA2116165

申请日：1994-02-22

Applicant: HOECHST AG

Inventor： ENGLERT HEINRICH ,  MANIA DIETER ,  HARTUNG JENS ,  GOEGELEIN HEINZ ,  KAISER JOACHIM ,  LINZ WOLFGANG ,  WETTLAUFER DAVID

IPC: A61K31/18 ,  A61K31/64 ,  A61P9/00 ,  A61P9/04 ,  A61P9/10 ,  C07C303/40 ,  C07C311/46 ,  C07C311/58 ,  C07C323/67 ,  C07C335/42

Abstract: Substituted benzenesulfonylureas and -thioureas processes for their preparation and their use as pharmaceuticals Benzenesulfonylureas and -thioureas of the formula I I where R(1) is H or (fluoro)methyl, R(2) is H, Hal or (fluoro)(mercapto)alk(oxy)yl, E is O or S; Y is -¢CR(3)2!n-, where R(3) = H or alkyl and n = 1 - 4, X is H, Hal or alkyl and Z is Hal, NO2 or alk(yl)oxy, are described. The compounds I are used for treatment of disturbances in cardiac rhythm and prevention of sudden cardiac death caused by arrhythmia, and can therefore be used as antiarrhythmics. They are particularly suitable for those cases where arrhythmias are a consequence of a narrowing of a coronary vessel, such as angina pectoris or acute cardiac infarction.

公开(公告)号：PL164167B1

公开(公告)日：1994-06-30

申请号：PL28674790

申请日：1990-09-05

Applicant: HOECHST AG

Inventor： ENGLERT HEINRICH CH ,  LANG HANS-JOCHEN ,  LINZ WOLFGANG ,  SCHOLKENS BERNWARD ,  SCHOLZ WOLFGANG

IPC: A61K31/155 ,  C07C279/22 ,  A61K31/18 ,  A61K31/40 ,  A61K31/403 ,  A61K31/404 ,  A61K31/445 ,  A61K31/455 ,  A61K31/535 ,  A61K31/5375 ,  A61P9/06 ,  A61P9/08 ,  A61P9/10 ,  C07C277/00 ,  C07C279/10 ,  C07C311/15 ,  C07C311/47 ,  C07C317/42 ,  C07C317/44 ,  C07C323/60 ,  C07C323/62 ,  C07C323/65 ,  C07C323/67 ,  C07D209/08 ,  C07D211/28 ,  C07D295/14 ,  C07D295/155 ,  C07D295/195 ,  C07D295/22 ,  C07D295/26

Abstract: Benzoylguanidines of the formula I (* CHEMICAL STRUCTURE *) (I) where R(1) or R(2) is equal to R(6)-S(O)n- or R(7)R(8)N-O2S- and the other substituent R(1) or R(2) is in each case equal to H, F, Cl, Br, I, alkyl, alkoxy or phenoxy, R(6)-S(O)n or R(7)R(8)N- and R(6) is equal to alkyl, cycloalkyl, cyclopentylmethyl, cyclohexylmethyl or phenyl, R(7) and R(8) are equal to alkyl or phenylalkyl or phenyl, and in which R(7) and R(8) may also together be a C4-C7 chain, and in which R(7) and R(8), together with the nitrogen atom to which they are bonded, may be a dihydroindole, tetrahydroquinoline or tetrahydroisoquinoline system, and where R(3), R(4) and R(5) are equal to hydrogen or alkyl, or R(3) and R(4) are together an alkylene chain or R(4) and R(4) are together an alkylene chain, and where n is equal to zero, 1 or 2 and their pharmaceutically tolerable salts are outstanding antiarrhythmics.

公开(公告)号：NO932391D0

公开(公告)日：1993-06-30

申请号：NO932391

申请日：1993-06-30

Applicant: HOECHST AG

Inventor： HEITSCH HOLGER ,  LINZ WOLFGANG ,  WAGNER ADALBERT ,  KLEEMANN HEINZ-WERNER

IPC: A61K31/00 ,  A61K31/40 ,  A61K31/41 ,  A61K31/415 ,  A61K31/435 ,  A61K31/44 ,  A61K31/495 ,  A61K31/505 ,  A61K31/53 ,  A61K45/00 ,  A61P9/00 ,  A61P9/06 ,  A61P9/10 ,  A61P43/00 ,  C07D207/16 ,  C07D207/32 ,  C07D233/70 ,  C07D233/84 ,  C07D233/90 ,  C07D249/04 ,  C07D249/06 ,  C07D249/08 ,  C07D249/10 ,  C07D249/12 ,  C07D249/14 ,  C07D257/02 ,  C07D257/04 ,  C07D403/10 ,  C07D471/04 ,  C07D487/04 ,  A61K

Abstract: Antagonists of angiotensin II receptors of the AT1 subtype can be used to control cardiac arrhythmias, employing, for example, azole derivatives of the formula (I)

公开(公告)号：HU9300368D0

公开(公告)日：1993-04-28

申请号：HU9300368

申请日：1993-02-12

Applicant: HOECHST AG

Inventor： ENGLERT HEINRICH ,  MANIA DIETER ,  LANG HANS-JOCHEN ,  SCHOLZ WOLFGANG ,  LINZ WOLFGANG ,  ALBUS UDO

IPC: A61K31/155 ,  A61K31/165 ,  A61K31/445 ,  A61P1/16 ,  A61P3/08 ,  A61P3/10 ,  A61P9/00 ,  A61P9/04 ,  A61P9/06 ,  A61P9/08 ,  A61P9/10 ,  A61P9/12 ,  A61P13/02 ,  A61P15/00 ,  A61P35/00 ,  C07C279/22 ,  C07D213/65 ,  C07D295/14 ,  C07D295/155

Abstract: There are described benzoylguanidines of the formula I in which R(1) or R(2) is an amino group -NR(3)R(4), where R(3) and R(4) are equal to H, (cyclo)alkyl or R(3) is equal to phenyl-(CH2)p- where p = 0, 1, 2, 3 or 4, or phenyl, or R(3) and R(4) together can also be a methylene chain, and in which the other substituent R(1) or R(2) in each case is H, F, Cl, alkyl, alkoxy, CF3, CmF2m+1-CH2-, benzyl or phenoxy, and their pharmaceutically tolerable salts. The compounds according to the invention have very good antiarrhythmic properties, such as they show, for example, in the case of oxygen deficiency symptoms. The compounds are used as antiarrhythmic medicaments having a cardioprotective component for infarct prophylaxis and infarct treatment and also for the treatment of angina pectoris, where they preventively inhibit or strongly decrease the pathophysiological processes during the formation of ischaemically induced damage, in particular during the induction of ischaemically induced cardiac arrhythmias.

公开(公告)号：HUT61744A

公开(公告)日：1993-03-01

申请号：HU9202062

申请日：1992-06-19

Applicant: HOECHST AG

Inventor： HEITSCH HOLGER ,  HENNING RAINER ,  URBACH HANSJOERG ,  RUPPERT DIETER ,  LINZ WOLFGANG

IPC: A61K31/33 ,  A61K31/415 ,  A61K31/445 ,  A61K31/495 ,  A61K31/535 ,  A61P9/00 ,  A61P9/12 ,  A61P31/12 ,  A61P43/00 ,  C07D213/30 ,  C07D213/40 ,  C07D401/12 ,  C07D401/14 ,  C07D413/14 ,  C07D417/14 ,  A61K31/44

Abstract: Compounds of the formula (I) in which X and Y are, for example, N, R , R and R are, for example, hydrogen, A and L are, for example, CH2 or CO, Z is, for example, hydrogen, R is, for example, cyclohexylmethyl, R is, for example, hydroxyl, R is, for example, n is, for example, zero or 1, are active renin-inhibiting compounds which have a high in-vitro and in-vivo activity.

公开(公告)号：NO930512D0

公开(公告)日：1993-02-12

申请号：NO930512

申请日：1993-02-12

Applicant: HOECHST AG

Inventor： ENGLERT HEINRICH ,  MANIA DIETER ,  LANG HANS-JOCHEN ,  SCHOLZ WOLFGANG ,  LINZ WOLFGANG ,  ALBUS UDO

IPC: A61K31/155 ,  A61K31/165 ,  A61K31/445 ,  A61P1/16 ,  A61P3/08 ,  A61P3/10 ,  A61P9/00 ,  A61P9/04 ,  A61P9/06 ,  A61P9/08 ,  A61P9/10 ,  A61P9/12 ,  A61P13/02 ,  A61P15/00 ,  A61P35/00 ,  C07C279/22 ,  C07D213/65 ,  C07D295/14 ,  C07D295/155 ,  C07C

Abstract: There are described benzoylguanidines of the formula I in which R(1) or R(2) is an amino group -NR(3)R(4), where R(3) and R(4) are equal to H, (cyclo)alkyl or R(3) is equal to phenyl-(CH2)p- where p = 0, 1, 2, 3 or 4, or phenyl, or R(3) and R(4) together can also be a methylene chain, and in which the other substituent R(1) or R(2) in each case is H, F, Cl, alkyl, alkoxy, CF3, CmF2m+1-CH2-, benzyl or phenoxy, and their pharmaceutically tolerable salts. The compounds according to the invention have very good antiarrhythmic properties, such as they show, for example, in the case of oxygen deficiency symptoms. The compounds are used as antiarrhythmic medicaments having a cardioprotective component for infarct prophylaxis and infarct treatment and also for the treatment of angina pectoris, where they preventively inhibit or strongly decrease the pathophysiological processes during the formation of ischaemically induced damage, in particular during the induction of ischaemically induced cardiac arrhythmias.

公开(公告)号：MX9203076A

公开(公告)日：1992-12-01

申请号：MX9203076

申请日：1992-06-19

Applicant: HOECHST AG

Inventor： HEITSCH HOLGER ,  HENNING RAINER ,  URBACH HANSJORG ,  RUPPERT DIETER ,  LINZ WOLFGANG

IPC: A61K31/495 ,  A61P9/12 ,  A61P43/00 ,  C07D241/10 ,  C07D249/08 ,  C07D401/04 ,  C07D487/04 ,  C07D519/00 ,  C07D473/00

Abstract: Heterocyclic compounds of the formula (I) in which the radicals have the following meanings: R is, for example, propyl or isobutyl, R is, for example, phenyl or pyridyl, R is, for example, hydrogen, R is, for example, cyclohexylmethyl, R is, for example, hydrogen or hydroxyl, R is, for example, a radical of the formula (II> (CH2)5-CHR -Z (II> where R is, for example, hydrogen, Z represents a 5- to 7-membered heterocyclic ring and s denotes 0, 1, 2, 3 or 4; are potent renin-inhibiting compounds.

公开(公告)号：HUT60249A

公开(公告)日：1992-08-28

申请号：HU9200021

申请日：1992-01-03

Applicant: HOECHST AG

Inventor： WAGNER ADALBERT ,  ENGLER HEINRICH ,  KLEEMANN HEINZ-WERNER ,  GERHARDS HERMANN ,  SCHOELKENS BERNWARD ,  BECKER REINHARD ,  LINZ WOLFGANG

IPC: A61K31/40 ,  A61K31/415 ,  A61K31/425 ,  A61K31/435 ,  A61K31/44 ,  A61K31/4427 ,  A61K31/443 ,  A61K31/4433 ,  A61K31/445 ,  A61K31/505 ,  A61K31/535 ,  A61K31/54 ,  A61K31/64 ,  A61P9/00 ,  A61P9/08 ,  A61P9/10 ,  A61P9/12 ,  A61P13/02 ,  A61P15/00 ,  A61P43/00 ,  C07D207/34 ,  C07D207/36 ,  C07D233/54 ,  C07D233/66 ,  C07D233/68 ,  C07D233/70 ,  C07D233/84 ,  C07D233/90 ,  C07D249/02 ,  C07D255/02 ,  C07D257/02 ,  C07D257/04 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D409/12 ,  C07D417/12 ,  C07D453/02 ,  C07D521/00 ,  C07D413/12 ,  C07D471/08

Abstract: Azole derivative of the general formula (I) in which A, L, O, R , X, Y, Z and q have the meanings given, a process for their preparation, pharmaceutical preparations and the use of the compounds are described. Azole derivatives of the formula I where the symbols have, for example, the following meanings: R = (C2-C10)-alkyl Z = nitrogen X and Y = independently of one another CR L = -CH2- q = zero or 1 A = biphenyl radical which is substituted, for example, by R R = halogen or hydrogen R = SO2-NH-CO-OR and R = phenyl, are highly active antagonists of angiotensin II receptors.

公开(公告)号：ZA9109056B

公开(公告)日：1992-07-29

申请号：ZA9109056

申请日：1991-11-15

Applicant: HOECHST AG

Inventor： HEITSCH HOLGER ,  HOLGER HEITSCH ,  LINZ WOLFGANG ,  WOLFGANG LINZ ,  URBACH HANSJOERG ,  HANSJOERG URBACH ,  HENNING RAINER ,  RAINER HENNING ,  SCHOELKENS BERNWARD ,  BERNWARD SCHOELKENS

IPC: A61K31/41 ,  A61K31/415 ,  A61K31/495 ,  A61K31/675 ,  A61P9/00 ,  A61P9/08 ,  A61P9/10 ,  A61P9/12 ,  A61P13/02 ,  A61P15/00 ,  A61P43/00 ,  C07D233/64 ,  C07D233/68 ,  C07D233/90 ,  C07D249/04 ,  C07D249/08 ,  C07D257/04 ,  C07D403/10 ,  A61K

CPC classification number: A61K31/415 ,  A61K31/41