公开(公告)号：HK1211699A1

公开(公告)日：2016-05-27

申请号：HK15112414

申请日：2015-12-17

Applicant: HOFFMANN LA ROCHE

Inventor： DIEBOLD ERIC R ,  GERBER MARTIN T

IPC: G01N20060101 ,  A61B20060101

Abstract: Systems and methods for multiple analyte analysis are provided. In one embodiment, a method includes determining concentrations of first and second analytes in a sample. The first and second analytes may be, for example, glucose and hydroxybutyrate. In this form, an indication related to the measured concentration of hydroxybutyrate is provided in response to determining that the concentration of hydroxybutyrate is above a predetermined value. In a further aspect of this form, a quantitative indication representative of the measured glucose concentration is automatically provided regardless of the value of the measured glucose concentration. In another embodiment, a system includes a meter configured to interact with a test element to assess first and second analytes in a sample. Further embodiments, forms, objects, features, advantages, aspects, and benefits shall become apparent from the description and drawings.

公开(公告)号：CA2638973A1

公开(公告)日：2005-07-21

申请号：CA2638973

申请日：2004-06-18

Applicant: HOFFMANN LA ROCHE

Inventor： SURRIDGE NIGEL A ,  BHULLAR RAGHBIR SINGH ,  DIEBOLD ERIC R ,  WALLING PAUL DOUGLAS ,  HILL BRIAN S

IPC: G01N27/403 ,  B23K26/36 ,  B32B15/00 ,  C12Q1/00 ,  C12Q1/25 ,  G01N27/30 ,  G01N27/327 ,  G01N33/487 ,  G01N33/49 ,  G01N33/543 ,  H05K1/00 ,  H05K3/02

Abstract: A method of manufacturing a plurality of biosensors, comprises: (a) providin g a web of base substrate material having a metal conductive layer formed thereo n; (b) projecting an image of an electrode pattern onto the metal conductive layer with a laser apparatus, wherein an electrode pattern that corresponds to the image is formed by laser ablation on the web of base substrate material, (c) moving one of the laser apparatus and the web of base substrate material and repeating step (b) a plurality of tim es to produce a plurality of the electrode patterns at spaced intervals along the web of bas e substrate material; (d) depositing a reagent on the web of base substrate material and at least partially covering each electrode pattern of the plurality of electrode patterns with the reagent; (e) laminating at least one web of a covering layer or a spacing layer over the web of base substrate material, thereby forming a cover and a sample-receivi ng chamber for each biosensor; and (f) cutting through the at least one web of the covering layer or the spacing layer and the web of base substrate material to form the plurali ty of biosensors. The biosensors so produced possess smooth, high-quality edges wi th a good edge definition. These smooth edges define gaps between electrodes, electrod etraces and contact pads and the gaps can be quite small, which provides marked advantages in terms of test accuracy, speed and the number of different functionalities th at can be packed into a single biosensor The biosensor production method permits entir e electrode patterns to be formed all at one, in nanoseconds and without regard to the complexity of the electrode patterns or the amount of conductive material that must be ablated to form them.

公开(公告)号：CA2529579A1

公开(公告)日：2005-02-10

申请号：CA2529579

申请日：2004-06-18

Applicant: HOFFMANN LA ROCHE

Inventor： HILL BRIAN S ,  BUCK HARVEY B ,  BHULLAR RAGHBIR S ,  WALLING PAUL DOUGLAS ,  DIEBOLD ERIC R ,  BEATY TERRY A ,  BURKE DAVID W

IPC: G01N33/487 ,  B01L3/02 ,  C12Q1/00 ,  G01N1/00 ,  G01N27/00 ,  G01N27/30

Abstract: A biosensor having multiple electrical functionalities located both within a nd outside of the measurement zone in which a fluid sample is interrogated. Incredibly small and complex electrical patterns with high quality edges provide electrical functionalities in the biosensor and also provide the electrical wiring for the various other electrical devices provided in the inventive biosensor. In addition to a measurement zone with multiple and various electrical functionalities, biosensors of the present invention may be provided with a user interface zone, a digital device zone and/or a power generation zone. The inventive biosensors offer improved ease of use and performance, and decrease the computational burden and associated cost of th e instruments that read the biosensors by adding accurate yet cost-effective functionalities to the biosensors themselves.