Abstract:
PROBLEM TO BE SOLVED: To provide a test strip with a sample-receiving chamber having a novel flared portion that terminates, in a sample-receiving opening. SOLUTION: The method for producing a test strip includes (a) a process which prepares a base substrate, a pitch layer and a cover layer; (b) a process which has an elongated section and a spherical section to form a space extending into the pitch layer; (c) a process which laminates a space layer on the base substrate used as the base and laminates the cover layer on the pitch layer to form a test strip precursor section; and (d) a cutting of a part of the precursor section, to produce the test strip, where a process is included, such that the cutting traverses a spherical section of the space formed at the process (b) to form a sample receiving edge of the test strip and the space demarcates the sample-receiving chamber which has an entrance section terminating within the sample receiving opening at the sample-receiving terminal edge of the test strip. COPYRIGHT: (C)2011,JPO&INPIT
Abstract:
An electrochemical biosensor (210) with electrode elements (274, 276) that possess smooth, high-quality edges (281, 283, 285, 287) with an edge definition better than 6µm. These smooth edges define gaps between electrodes, electrode traces and contact pads. Due to the remarkable edge smoothness achieved, the gaps can be quite small, which provides marked advantages in terms of test accuracy, speed and the number of different functionalities that can be packed into a single biosensor. Further, the present application provides a biosensor production method in which entire electrode patterns for the inventive biosensors can be formed all at one, in nanoseconds - without regard to the complexity of the electrode patterns or the amount of conductive material that must be ablated to form them.
Abstract:
A method of manufacturing a plurality of biosensors, comprises: (a) providin g a web of base substrate material having a metal conductive layer formed thereo n; (b) projecting an image of an electrode pattern onto the metal conductive layer with a laser apparatus, wherein an electrode pattern that corresponds to the image is formed by laser ablation on the web of base substrate material, (c) moving one of the laser apparatus and the web of base substrate material and repeating step (b) a plurality of tim es to produce a plurality of the electrode patterns at spaced intervals along the web of bas e substrate material; (d) depositing a reagent on the web of base substrate material and at least partially covering each electrode pattern of the plurality of electrode patterns with the reagent; (e) laminating at least one web of a covering layer or a spacing layer over the web of base substrate material, thereby forming a cover and a sample-receivi ng chamber for each biosensor; and (f) cutting through the at least one web of the covering layer or the spacing layer and the web of base substrate material to form the plurali ty of biosensors. The biosensors so produced possess smooth, high-quality edges wi th a good edge definition. These smooth edges define gaps between electrodes, electrod etraces and contact pads and the gaps can be quite small, which provides marked advantages in terms of test accuracy, speed and the number of different functionalities th at can be packed into a single biosensor The biosensor production method permits entir e electrode patterns to be formed all at one, in nanoseconds and without regard to the complexity of the electrode patterns or the amount of conductive material that must be ablated to form them.
Abstract:
A biosensor having multiple electrical functionalities located both within a nd outside of the measurement zone in which a fluid sample is interrogated. Incredibly small and complex electrical patterns with high quality edges provide electrical functionalities in the biosensor and also provide the electrical wiring for the various other electrical devices provided in the inventive biosensor. In addition to a measurement zone with multiple and various electrical functionalities, biosensors of the present invention may be provided with a user interface zone, a digital device zone and/or a power generation zone. The inventive biosensors offer improved ease of use and performance, and decrease the computational burden and associated cost of th e instruments that read the biosensors by adding accurate yet cost-effective functionalities to the biosensors themselves.
Abstract:
A system for testing for analytes in a sample of biological fluid includes a test strip that defines a cavity for receiving the sample. At least two sets of electrodes are adjacent the sample cavity, including one for measuring one property of the sample, and another for measuring one or more other properties of the sample, such as temperature and/or the presence or magnitude of confounding variables. The measurements are combined to yield the desired result. At least one set of working and counter electrodes each have a plurality of elongated "fingers" interdigitated with those of the other electrode in the set. The gaps between fingers can be quite small, so that the two electrode sets together can operate in a small measurement volume of sample. Additional electrodes can be included that measure the presence or sufficiency of the sample, and additional traces on the strip can act as configuration identifiers.
Abstract:
An electrochemical biosensor (210) with electrode elements (274, 276) that possess smooth, high-quality edges (281, 283, 285, 287) with an edge definition better than 6~m. These smooth edges define gaps between electrode s, electrode traces and contact pads. Due to the remarkable edge smoothness achieved, the gaps can be quite small, which provides marked advantages in terms of test accuracy, speed and the number of different functionalities th at can be packed into a single biosensor. Further, the present application provides a biosensor production method in which entire electrode patterns fo r the inventive biosensors can be formed all at one, in nanoseconds - without regard to the complexity of the electrode patterns or the amount of conducti ve material that must be ablated to form them.
Abstract:
A test strip with a sample receiving chamber having a novel flared portion that terminates in a sample receiving opening. The flared portion provides a reservoir from which sample fluid can be drawn into the capillary or sample receiving chamber. The wider opening provided by the present invention is easier to "target" with a sample fluid. In preferred embodiments, the hydrophilic reagent layer extends to the dosing end or side of the test strip and further promotes wicking of the sample into the sample receiving chamber and thus reduces dose hesitation. In other preferred embodiments, a tapered dosing end is provided on the test strip in combination with the flared portion, and this combination create a test strip that will draw sample fluid into the sample receiving chamber regardless of where along the dosing edge of the test strip the fluid sample makes contact.