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    STABLE NAD/NADH DERIVATIVES
    32.
    发明专利
    STABLE NAD/NADH DERIVATIVES 未知

    公开(公告)号：CA2737123A1

    公开(公告)日：2007-02-01

    申请号：CA2737123

    申请日：2006-07-28

    Applicant: HOFFMANN LA ROCHE

    Inventor： HOENES JOACHIM ,  HEINDL DIETER ,  HORN CARINA ,  GAESSLER-DIETSCHE CLAUDIA

    IPC: C12Q1/32 ,  C07H19/207 ,  C07H21/02 ,  C12Q1/54

    Abstract: Test element for the determination of an analyte, comprising a coenzyme dependent enzyme or a substrate of the enzyme, and a coenzyme compound (I) and its salt or optionally its reduced form, is new. Test element for the determination of an analyte, comprises a coenzyme dependent enzyme or a substrate of the enzyme, and a coenzyme of pyridine compound of formula (I) and its salt or optionally its reduced form. A : adenine or their analog; T : O or S; U 1> : OH, SH, BH 3 -> or BCNH 2 ->; V 1> : OH or phosphate group; W 1> : COOR, CON(R) 2, COR, CSN(R) 2; R : H or 1-2C-alkyl; X 1, X 2 : O, CH 2, CHCH 3, C(CH 3) 2, NH or NCH 3; Y 1> : NH, S, O or CH 2; Z : cyclic group with 5C atom optionally substituted with heteroatom of O, S or N and CR 4, where C(R 4) 2 is a cyclic group with X 2; and R 4 : H, F, Cl or CH 3. Where Z and pyridine are not connected by a glycosidic bond. Independent claims are included for: (1) a pyridine compound (I); (2) an enzyme-coenzyme-complex comprising (I) in combination with an enzyme; (3) a reagent kit comprising (I), optionally an enzyme or enzyme complex and optionally a reaction buffer; and (4) a method for the determination of analyte comprising contacting the sample with the test element or reagent kit comprising coenzyme, and detecting the analyte. [Image].

    35.
    发明专利
    未知

    公开(公告)号：BR0311175A

    公开(公告)日：2005-03-15

    申请号：BR0311175

    申请日：2003-05-16

    Applicant: HOFFMANN LA ROCHE

    Inventor： HORN CARINA ,  HOENES JOACHIM ,  KNAPPE WOLFGANG-REINHOLD

    IPC: C12M1/34 ,  C08F2/00 ,  C12M1/40 ,  C12Q1/00 ,  C12Q1/26 ,  C12Q1/32 ,  C12Q1/54 ,  G01N21/78 ,  G01N27/327 ,  G01N33/543

    Abstract: A method for producing a polymer layer on a transparent support. A photopolymerizable liquid composition is applied to the support. The photopolymerizable liquid composition is irradiated through the support such that polymerization of the liquid composition starts at the surface of the support and ends at a predetermined distance over the surface of the support. Only partial polymerization of the liquid composition takes place. A polymer layer with a predetermined thickness is formed on the support wherein the predetermined thickness is less than the thickness of the photopolymerizable liquid composition. The remaining photopolymerizable liquid composition is removed from the entire polymer layer.

    36.
    发明专利
    未知

    公开(公告)号：BR0309947A

    公开(公告)日：2005-03-01

    申请号：BR0309947

    申请日：2003-05-16

    Applicant: HOFFMANN LA ROCHE

    Inventor： HORN CARINA ,  HOENES JOACHIM ,  KNAPPE WOLFGANG-REINHOLD

    IPC: C12M1/34 ,  C08F2/00 ,  C12M1/40 ,  C12Q1/00 ,  C12Q1/26 ,  C12Q1/32 ,  C12Q1/54 ,  G01N21/78 ,  G01N27/327 ,  G01N33/543

    Abstract: A method for producing a polymer layer on a transparent support. A photopolymerizable liquid composition is applied to the support. The photopolymerizable liquid composition is irradiated through the support such that polymerization of the liquid composition starts at the surface of the support and ends at a predetermined distance over the surface of the support. Only partial polymerization of the liquid composition takes place. A polymer layer with a predetermined thickness is formed on the support wherein the predetermined thickness is less than the thickness of the photopolymerizable liquid composition. The remaining photopolymerizable liquid composition is removed from the entire polymer layer.

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